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US Protein Sequencing Market

ID: MRFR/LS/17284-HCR
100 Pages
Garvit Vyas
October 2025

US Protein Sequencing Market Research Report By Technology (Mass Spectrometry, Edman Degradation, Protein Chip Technology, Nucleic Acid Sequencing), By Application (Biomedical Research, Drug Discovery, Diagnostics, Proteomics), By End Use (Academic Institutions, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations) and By Product Type (Instruments, Reagents, Software, Consumables) - Forecast to 2035

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US Protein Sequencing Market Summary

As per MRFR analysis, the US protein sequencing market size was estimated at 411.6 USD Million in 2024. The US protein sequencing market is projected to grow from 471.08 USD Million in 2025 to 1816.56 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 14.45% during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The US protein sequencing market is poised for substantial growth driven by technological advancements and increasing demand for personalized medicine.

  • Technological advancements are enhancing the accuracy and efficiency of protein sequencing methods.
  • The largest segment in the market is driven by applications in drug discovery, while the fastest-growing segment focuses on personalized medicine.
  • Automation and high-throughput solutions are becoming increasingly prevalent, streamlining workflows in laboratories.
  • Rising investment in biotechnology and the emergence of advanced bioinformatics tools are key drivers propelling market expansion.

Market Size & Forecast

2024 Market Size 411.6 (USD Million)
2035 Market Size 1816.56 (USD Million)
CAGR (2025 - 2035) 14.45%

Major Players

Thermo Fisher Scientific (US), Illumina (US), Agilent Technologies (US), Waters Corporation (US), PerkinElmer (US), Bio-Rad Laboratories (US), Bruker Corporation (US), Genomatix Software (DE), Oxford Nanopore Technologies (GB)

US Protein Sequencing Market Trends

The protein sequencing market is currently experiencing notable growth, driven by advancements in technology and increasing applications in various fields such as biotechnology, pharmaceuticals, and agriculture. The demand for precise and efficient sequencing methods is rising, as researchers and companies seek to enhance their understanding of protein structures and functions. This trend is further supported by the growing emphasis on personalized medicine, where tailored treatments based on individual protein profiles are becoming more prevalent. As a result, investments in research and development are likely to increase, fostering innovation and expanding the market's potential. Moreover, the protein sequencing market is witnessing a shift towards automation and high-throughput technologies. These innovations are streamlining workflows, reducing costs, and improving accuracy in sequencing processes. The integration of artificial intelligence and machine learning into sequencing platforms is also emerging, offering enhanced data analysis capabilities. This evolution suggests that the market will continue to evolve, adapting to the needs of researchers and industries alike, while potentially leading to breakthroughs in various scientific domains.

Technological Advancements

Recent innovations in sequencing technologies are transforming the protein sequencing market. Techniques such as mass spectrometry and next-generation sequencing are becoming more sophisticated, enabling researchers to obtain detailed insights into protein structures and functions. These advancements are likely to enhance the accuracy and efficiency of sequencing processes, making them more accessible to a broader range of applications.

Increased Demand for Personalized Medicine

The growing focus on personalized medicine is significantly influencing the protein sequencing market. As healthcare shifts towards tailored treatments, the need for precise protein analysis is becoming paramount. This trend suggests that companies and research institutions are investing more in sequencing technologies to develop individualized therapies, potentially leading to improved patient outcomes.

Automation and High-Throughput Solutions

The trend towards automation in the protein sequencing market is gaining momentum. High-throughput sequencing technologies are streamlining workflows, allowing for the rapid analysis of large sample sizes. This shift not only reduces operational costs but also enhances the overall efficiency of research processes, indicating a potential for increased productivity in laboratories.

US Protein Sequencing Market Drivers

Expansion of Research Institutions

The proliferation of research institutions and academic centers in the US is contributing to the growth of the protein sequencing market. With over 2,500 research institutions dedicated to life sciences, the demand for advanced protein sequencing technologies is on the rise. These institutions are increasingly adopting cutting-edge sequencing methods to support various research initiatives, including genomics, proteomics, and systems biology. The protein sequencing market is likely to benefit from this trend, as institutions invest in state-of-the-art equipment and technologies to enhance their research capabilities. This expansion not only increases the volume of protein sequencing projects but also fosters collaboration between academia and industry, creating a dynamic ecosystem that drives innovation.

Rising Investment in Biotechnology

The protein sequencing market is experiencing a surge in investment from both public and private sectors, which is likely to drive innovation and development. In the US, funding for biotechnology research has increased significantly, with federal agencies allocating over $40 billion annually to support life sciences. This influx of capital is fostering advancements in protein sequencing technologies, enabling researchers to explore complex biological systems more effectively. As a result, the protein sequencing market is poised for growth, with projections indicating a compound annual growth rate (CAGR) of approximately 10% over the next five years. This investment trend not only enhances the capabilities of existing technologies but also encourages the emergence of novel solutions, thereby expanding the overall market landscape.

Growing Applications in Drug Discovery

The protein sequencing market is increasingly being utilized in drug discovery processes, which is a critical driver of market growth. Pharmaceutical companies are leveraging protein sequencing to identify potential drug targets and understand disease mechanisms at a molecular level. In the US, the pharmaceutical industry invests around $83 billion annually in research and development, with a significant portion directed towards protein-based therapeutics. This trend indicates a robust demand for protein sequencing technologies, as they provide essential insights that facilitate the development of new drugs. Consequently, the integration of protein sequencing into drug discovery workflows is expected to enhance efficiency and accuracy, further propelling the market forward.

Increased Focus on Precision Agriculture

The protein sequencing market is witnessing a growing interest in precision agriculture, which is reshaping agricultural practices in the US. As farmers seek to optimize crop yields and improve food quality, protein sequencing technologies are being employed to analyze plant proteins and understand their roles in growth and development. This trend is particularly relevant in the context of developing genetically modified organisms (GMOs) and enhancing crop resilience to environmental stressors. The agricultural biotechnology sector is projected to reach $50 billion by 2027, indicating a substantial market opportunity for protein sequencing applications. By integrating protein sequencing into agricultural research, stakeholders can make informed decisions that enhance productivity and sustainability.

Emergence of Advanced Bioinformatics Tools

The protein sequencing market is being significantly influenced by the emergence of advanced bioinformatics tools that facilitate data analysis and interpretation. As sequencing technologies generate vast amounts of data, the need for sophisticated software solutions becomes paramount. In the US, the bioinformatics market is expected to grow at a CAGR of 12% over the next five years, driven by the increasing complexity of biological data. These tools enable researchers to extract meaningful insights from protein sequencing data, thereby enhancing the overall efficiency of research projects. The integration of bioinformatics with protein sequencing is likely to streamline workflows and improve the accuracy of results, ultimately contributing to the growth of the protein sequencing market.

Market Segment Insights

By Technology: Mass Spectrometry (Largest) vs. Edman Degradation (Fastest-Growing)

The US protein sequencing market is characterized by a diverse range of technologies, where Mass Spectrometry holds the largest share, being the preferred choice for many researchers and laboratories due to its high accuracy and throughput. In contrast, Edman Degradation, although smaller in market share, is recognized for its rapid growth, attracting interest for its specificity in sequencing short peptide chains and facilitating detailed protein analysis. Growth trends in the US protein sequencing market are driven by increasing research activities in the fields of genomics and proteomics. Advancements in Mass Spectrometry technology enhance its performance, contributing to its established dominance. Meanwhile, the rise in personal genomics and customized medicine boosts the demand for Edman Degradation, as researchers seek precise sequencing for developing targeted therapies and diagnostics, positioning it as the fastest-growing technology in this segment.

Technology: Mass Spectrometry (Dominant) vs. Edman Degradation (Emerging)

Mass Spectrometry stands as the dominant technology in the US protein sequencing market, renowned for its ability to analyze complex biomolecules with precision and speed. Its applications span various fields, including drug development and disease research, making it a vital tool for scientists. On the other hand, Edman Degradation is emerging as a vital method for sequencing proteins due to its reliability in determining amino acid sequences from the N-terminus of proteins. While its market presence is smaller compared to Mass Spectrometry, its growth is fueled by advancements in techniques and increasing demand for specific sequencing capabilities, particularly in proteomics, where detailed protein structure information is essential for understanding biological functions.

By Application: Biomedical Research (Largest) vs. Proteomics (Fastest-Growing)

The market share distribution among the application segments reveals that Biomedical Research holds the largest share, driven by a high demand for advanced research capabilities in genomics and proteomics. Following this, Drug Discovery and Diagnostics have significant shares, with Proteomics emerging as a key player due to its innovative approaches that enhance protein analysis and understanding in various biological contexts. Current growth trends indicate that the US protein sequencing market is witnessing accelerated advancements, particularly in Proteomics, which is rapidly gaining traction. Factors contributing to this growth include the increasing adoption of personalized medicine, the rise in funding for biotechnology research, and the demand for more precise diagnostic tools in clinical settings. As technology evolves, these segments are expected to dominate and drive further innovation in the market.

Biomedical Research: Dominant vs. Drug Discovery: Emerging

Biomedical Research is characterized by its foundational role in advancing scientific knowledge, making it a dominant force in the market. It encompasses a wide range of research activities, including genetic studies and molecular biology, thus commanding significant resource allocation from both public and private sectors. Meanwhile, Drug Discovery is an emerging segment that leverages protein sequencing technologies to identify new therapeutic targets and biomarkers. This segment is gaining momentum due to increasing investments in pharmaceutical R&D and collaborations between academia and industry, paving the way for innovative drug development processes.

By End Use: Academic Institutions (Largest) vs. Pharmaceutical Companies (Fastest-Growing)

The market share distribution among the segment values reflects a significant emphasis on Academic Institutions, which command the largest share in the US protein sequencing market. This dominance can be attributed to their ongoing research initiatives and the rising number of grants aimed at advancing academic studies in genomics and protein analysis. Meanwhile, Pharmaceutical Companies are progressively increasing their share, driven by their focus on drug discovery and personalized medicine, increasingly integrating protein sequencing into their workflows. Growth trends within these segments highlight the accelerating pace of innovation and technological advancements. Academic Institutions continue to lead due to their extensive research programs and collaborations. In contrast, Pharmaceutical Companies are experiencing the fastest growth as they embrace protein sequencing technologies to enhance drug development processes. The drive for personalized treatments is propelling investment in advanced sequencing capabilities, allowing these companies to better understand disease mechanisms and drug responses.

Academic Institutions: Dominant vs. Pharmaceutical Companies: Emerging

Academic Institutions play a dominant role in the US protein sequencing market, owing to their extensive research capabilities and the fundamental role they play in basic and applied sciences. These institutions often have access to state-of-the-art technologies and significant funding, allowing them to pioneer various studies that shape the future of protein research. On the other hand, Pharmaceutical Companies, while currently emerging relative to the institutional giants, are rapidly adapting to incorporate protein sequencing into their pipelines. Their focus is on integrating sophisticated sequencing techniques into drug discovery and development processes, driven by the need for personalized medicine. As a result, we anticipate that innovative collaborations will flourish between these sectors, further bridging the gap in market dynamics.

By Product Type: Instruments (Largest) vs. Reagents (Fastest-Growing)

In the US protein sequencing market, the distribution of market share among product types reveals that instruments hold a significant position, making them the largest contributors to market revenue. Reagents, while not commanding the same market share, are rapidly catching up, particularly due to the increasing demand for personalized medicine and targeted therapies. The evolution of genomics and proteomics further emphasizes the need for innovative reagents that enhance the efficiency of protein sequencing processes. The growth trends within this segment are largely driven by advancements in technology and the surge in research activities across biotechnology and pharmaceutical sectors. As organizations prioritize precision in protein analysis, the demand for high-quality reagents is on the rise, marking them as the fastest-growing category. Increased investment in research and development (R&D) also propels the market forward, with a focus on developing novel reagents that can yield more accurate sequencing results.

Instruments: Dominant vs. Reagents: Emerging

Instruments have emerged as the dominant force within the US protein sequencing market, effectively setting the standard for accuracy and efficiency in sequencing technologies. This segment encompasses a range of sophisticated equipment that significantly enhances the speed and precision of protein analysis, thereby meeting the demands of various sectors including healthcare and biotechnology. On the other hand, reagents are characterized as an emerging segment, reflecting a dynamic and competitive landscape. The innovation in reagents is often driven by the need to accommodate advanced sequencing technologies, making them crucial for laboratories seeking improved performance and reliability. As research continues to expand, the relevance of high-quality reagents becomes increasingly pronounced, solidifying their status in the market.

Get more detailed insights about US Protein Sequencing Market

Key Players and Competitive Insights

The protein sequencing market is currently characterized by a dynamic competitive landscape, driven by advancements in technology and increasing demand for personalized medicine. Key players such as Thermo Fisher Scientific (US), Illumina (US), and Agilent Technologies (US) are at the forefront, each adopting distinct strategies to enhance their market presence. Thermo Fisher Scientific (US) focuses on innovation through continuous investment in R&D, aiming to develop cutting-edge sequencing technologies that cater to diverse applications. Meanwhile, Illumina (US) emphasizes strategic partnerships and collaborations to expand its product offerings and enhance its technological capabilities. Agilent Technologies (US) is leveraging its expertise in analytical instrumentation to integrate protein sequencing solutions into its broader portfolio, thereby enhancing its competitive positioning.

The market structure appears moderately fragmented, with several players vying for market share. Key business tactics include localizing manufacturing to reduce costs and optimize supply chains, which is particularly relevant in the context of increasing global demand. The collective influence of these major companies shapes the competitive environment, as they continuously adapt to emerging trends and consumer needs.

In September 2025, Thermo Fisher Scientific (US) announced the launch of a new high-throughput protein sequencing platform designed to accelerate research in proteomics. This strategic move is significant as it positions the company to capture a larger share of the growing proteomics market, which is increasingly recognized for its potential in drug discovery and biomarker identification. The introduction of this platform is likely to enhance Thermo Fisher's competitive edge by providing researchers with faster and more accurate sequencing capabilities.

In August 2025, Illumina (US) entered into a partnership with a leading biotechnology firm to develop next-generation sequencing solutions tailored for clinical applications. This collaboration underscores Illumina's commitment to expanding its reach in the clinical diagnostics space, where the demand for precise and rapid sequencing is surging. By aligning with a biotechnology leader, Illumina may enhance its technological offerings and accelerate the adoption of its sequencing technologies in clinical settings.

In October 2025, Agilent Technologies (US) unveiled a new suite of software tools designed to streamline data analysis in protein sequencing workflows. This initiative reflects Agilent's focus on integrating advanced analytics into its product offerings, thereby addressing the growing need for efficient data management in the sequencing process. By enhancing the user experience and simplifying data interpretation, Agilent is likely to strengthen its position in the market and attract a broader customer base.

As of November 2025, current trends in the protein sequencing market indicate a strong emphasis on digitalization, sustainability, and the integration of artificial intelligence (AI) into sequencing technologies. Strategic alliances are increasingly shaping the competitive landscape, as companies seek to combine their strengths to drive innovation. Looking ahead, it is anticipated that competitive differentiation will evolve, with a shift from price-based competition to a focus on technological innovation, reliability in supply chains, and the ability to deliver customized solutions. This transition may redefine the competitive dynamics, as companies that prioritize innovation and adaptability are likely to emerge as leaders in the market.

Key Companies in the US Protein Sequencing Market market include

Industry Developments

There have been significant developments in the US Protein Sequencing Market, particularly with leading companies like Illumina, BioRad Laboratories, and Thermo Fisher Scientific pushing technological advancements. In October 2023, Pacific Biosciences announced new protein sequencing methods that enhance sensitivity and accuracy, indicating a shift towards more efficient sequencing technologies. Additionally, Merck KGaA has been expanding its portfolio in this sector through partnerships, which showcases the growing collaborative landscape in the market.

A notable merger in late September 2023 involved BioRad Laboratories acquiring a complementary analytics startup, allowing it to bolster its offerings in quantitative protein analysis. This year, Agilent Technologies and Waters Corporation have also reported increased revenues driven by advancements in proteomics, reflecting robust market growth driven by rising R&D investment in pharmaceutical and biotechnology sectors. The US Protein Sequencing Market is anticipated to see continued growth due to increasing demand for personalized medicine and biopharmaceuticals.

Furthermore, advancements in automation and bioinformatics tools have been identified as key trends shaping the protein sequencing landscape, with companies like Bruker Corporation and PerkinElmer expanding their capabilities. The market's burgeoning valuation underscores the strategic importance of protein sequencing technologies in advancing scientific research.

Future Outlook

US Protein Sequencing Market Future Outlook

The Protein Sequencing Market is projected to grow at a 14.45% CAGR from 2024 to 2035, driven by advancements in technology, increasing demand for personalized medicine, and rising investments in research.

New opportunities lie in:

  • Development of AI-driven protein analysis software solutions.
  • Expansion of contract research organizations (CROs) for protein sequencing services.
  • Integration of protein sequencing with genomics for comprehensive health diagnostics.

By 2035, the protein sequencing market is expected to achieve substantial growth and innovation.

Market Segmentation

US Protein Sequencing Market End Use Outlook

  • Academic Institutions
  • Pharmaceutical Companies
  • Biotechnology Companies
  • Contract Research Organizations

US Protein Sequencing Market Technology Outlook

  • Mass Spectrometry
  • Edman Degradation
  • Protein Chip Technology
  • Nucleic Acid Sequencing

US Protein Sequencing Market Application Outlook

  • Biomedical Research
  • Drug Discovery
  • Diagnostics
  • Proteomics

US Protein Sequencing Market Product Type Outlook

  • Instruments
  • Reagents
  • Software
  • Consumables

Report Scope

MARKET SIZE 2024 411.6(USD Million)
MARKET SIZE 2025 471.08(USD Million)
MARKET SIZE 2035 1816.56(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 14.45% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Thermo Fisher Scientific (US), Illumina (US), Agilent Technologies (US), Waters Corporation (US), PerkinElmer (US), Bio-Rad Laboratories (US), Bruker Corporation (US), Genomatix Software (DE), Oxford Nanopore Technologies (GB)
Segments Covered Technology, Application, End Use, Product Type
Key Market Opportunities Advancements in protein sequencing technologies enhance precision medicine and personalized therapeutics opportunities.
Key Market Dynamics Technological advancements drive innovation and competition in the protein sequencing market, enhancing research capabilities and applications.
Countries Covered US

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FAQs

What is the projected market size of the US Protein Sequencing Market in 2024?

The US Protein Sequencing Market is anticipated to be valued at 482.0 USD Million in 2024.

What is the expected market value of the US Protein Sequencing Market by 2035?

By 2035, the US Protein Sequencing Market is projected to reach a valuation of 2230.0 USD Million.

What is the expected CAGR for the US Protein Sequencing Market from 2025 to 2035?

The expected compound annual growth rate for the US Protein Sequencing Market is 14.942 % from 2025 to 2035.

Which segment holds the largest market share in the US Protein Sequencing Market?

Mass Spectrometry is projected to hold a significant share, valued at 150.0 USD Million in 2024.

What is the market size of Edman Degradation in 2024?

The market size for Edman Degradation is expected to be 100.0 USD Million in 2024.

Who are the key players in the US Protein Sequencing Market?

Major players in this market include Illumina, BioRad Laboratories, Thermo Fisher Scientific, among others.

What is the projected growth rate for Nucleic Acid Sequencing from 2024 to 2035?

Nucleic Acid Sequencing is expected to grow significantly, from a valuation of 112.0 USD Million in 2024 to 510.0 USD Million in 2035.

What are some emerging trends in the US Protein Sequencing Market?

Emerging trends include advancements in technology, increased R&D investment, and expansion of applications in personalized medicine.

What challenges does the US Protein Sequencing Market face?

Challenges in the market include high costs associated with advanced technologies and the need for skilled professionals.

How does the US Protein Sequencing Market apply in various fields?

Applications of the US Protein Sequencing Market span various fields, including pharmaceuticals, biotechnology, and clinical diagnostics.

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