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    US Organ on chip Market

    ID: MRFR/HC/13093-HCR
    100 Pages
    Garvit Vyas
    September 2025

    US Organ-on-Chip Market Research Report: By Organ Type (Lung-on-Chip, Heart-on-Chip, Liver-on-Chip, Intestine-on-Chip, Kidney-on-Chip, Human-on-Chip), By Application (Drug Discovery, Toxicology Research, Others) and By End-User (Pharmaceutical Companies, Research Organizations, Others) - Forecast to 2035

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    US Organ on chip Market Infographic
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    US Organ on chip Market Summary

    The US Organ-on-Chip market is poised for substantial growth, projected to reach 111.1 USD Million by 2035.

    Key Market Trends & Highlights

    US Organ-on-Chip Key Trends and Highlights

    • The market valuation for Organ-on-Chip in the United States is 18.4 USD Million in 2024.
    • By 2035, the market is expected to expand to 111.1 USD Million, indicating a robust growth trajectory.
    • The compound annual growth rate (CAGR) for the period from 2025 to 2035 is estimated at 17.74%.
    • Growing adoption of Organ-on-Chip technology due to increasing demand for advanced drug testing methods is a major market driver.

    Market Size & Forecast

    2024 Market Size 18.4 (USD Million)
    2035 Market Size 111.1 (USD Million)
    CAGR (2025-2035) 17.74%

    Major Players

    InSphero, VitroLabs, NCardia, Emulate, Ascendance Bio, Hurel Corporation, Organovo, CureMetrix, Mimic Technologies, Pulmodynamics, Biomimetic Solutions, TissUse, Synlogic, Tara Biosystems

    US Organ on chip Market Trends

    The US Organ-on-Chip Market is witnessing significant trends shaped by advancements in biotechnology and regulatory support. Key market drivers include the growing demand for more efficient drug development processes and the reduction of animal testing in research, aligning with ethical considerations and policies from organizations like the FDA that encourage alternative methods.

    Researchers are increasingly adopting organ-on-chip technology for its ability to mimic human physiology, leading to faster and more effective drug screening and toxicity testing. Opportunities in this market are emerging due to the increasing collaboration between academic institutions and biotechnology firms in the United States.

    This partnership is fostering innovation and addressing specific healthcare needs, such as personalized medicine and tailored drug therapies. As universities and research facilities continue to develop sophisticated organ-on-chip models, it opens the door for new applications in regenerative medicine and disease modeling, leading to further investment and interest in this technology.

    Recent trends highlight a growing acceptance of organ-on-chip systems by regulatory bodies in the US, which is crucial for their integration into the broader biomedical research landscape. There is also an increasing focus on developing multi-organ systems that can provide a more comprehensive understanding of human biology and drug responses.

    Furthermore, advancements in microengineering and materials science are enhancing the capabilities of organ-on-chip devices, making them more accessible for various applications in pharmaceutical research and toxicology. As these trends continue to evolve, the US organ-on-chip market is poised for significant growth and innovation in the coming years.

    Market Segment Insights

    Organ-on-Chip Market Organ Type Insights

    The US Organ-on-Chip Market is gaining significant traction, driven by innovations in biomedical engineering and the urgent need for more effective drug development and testing platforms. The Organ Type segment includes crucial models such as the Lung-on-Chip, Heart-on-Chip, Liver-on-Chip, Intestine-on-Chip, Kidney-on-Chip, and Human-on-Chip, each playing a pivotal role in advancing research and development across various healthcare applications.

    The Lung-on-Chip mimics human lung physiology, providing an invaluable tool for studying respiratory diseases and drug responses, reflecting the critical nature of respiratory health in the United States, where chronic lung diseases significantly impact public health. The Heart-on-Chip model serves as an essential platform to assess cardiac drug safety and efficacy, addressing the growing burden of cardiovascular diseases in the nation.

    Liver-on-Chip is particularly significant in the realm of pharmacokinetics, allowing researchers to study drug metabolism and toxicity, which is vital given that liver-related ailments account for a substantial percentage of healthcare costs. The Intestine-on-Chip system offers insights into gastrointestinal disorders and can improve the understanding of gut microbiome interactions with drugs, showcasing the rising focus on personalized medicine and microbiome research.

    Kidney-on-Chip technology plays an important role in renal drug toxicity studies and disease modeling, which correlates with the increasing prevalence of kidney disorders among the US population. Lastly, the Human-on-Chip represents the convergence of multiple organ systems, enabling more holistic assessments of therapeutic interventions, which is pivotal for regulatory compliance and patient safety in drug development processes.

    This diverse range of organ models significantly enhances the US Organ-on-Chip Market segmentation by providing tailored solutions for drug testing, disease modeling, and personalized medicine, ultimately supporting the need for more effective and ethical alternatives to traditional animal testing methods. The demand for these sophisticated models also aligns with various governmental initiatives aimed at fostering innovative biotechnological advances and improving healthcare outcomes in the United States.

    As the landscape shifts towards more organ-specific analytical approaches, the Organ Type segment will likely witness continued growth, positioning itself as a cornerstone in the evolution of precision medicine and biopharmaceutical development. With these advancements at the forefront, the overall market dynamics promise a robust evolution, ultimately enhancing the efficiency and effectiveness of the healthcare system in the US.

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Organ-on-Chip Market Application Insights

    The Application segment of the US Organ-on-Chip Market is gaining attention due to its transformative potential in various fields, particularly Drug Discovery and Toxicology Research. This segment is vital as it offers innovative ways to model human organ systems, enabling researchers to study drug interactions and toxicological responses effectively.

    Drug Discovery holds a significant role in the market, as it enhances the efficiency of preclinical testing by reducing reliance on traditional animal models, thereby aligning with a growing demand for ethical and more predictive approaches in pharmaceuticals. Toxicology Research also plays an important role, allowing for safer and more precise evaluations of chemical exposures and their effects on human health.

    As the industry shifts towards personalized medicine, these applications facilitate tailored therapies and quicker drug approvals, addressing both market growth and regulatory demands. The US is at the forefront of such innovations, supported by various initiatives aimed at advancing biomedical research and improving healthcare outcomes. Overall, the Application segment is expected to continue developing as critical advancements transpire within the US Organ-on-Chip Market.

    Organ-on-Chip Market End-User Insights

    The US Organ-on-Chip Market is significantly influenced by its End-User segment, comprising Pharmaceutical Companies, Research Organizations, and others. Pharmaceutical Companies play a crucial role in leveraging organ-on-chip technology for drug development and testing, which enhances the accuracy of preclinical studies and reduces the reliance on animal testing.

    This segment's growth is driven by increasing investments in innovative drug delivery systems and a rising emphasis on personalized medicine. Research Organizations are also vital, as they utilize organ-on-chip platforms to explore disease mechanisms and therapeutic responses in a controlled environment, allowing for groundbreaking advancements in the field of biomedicine.

    By offering a more human-relevant model for research, they contribute significantly to the overall success of the technology. The presence of regulatory support and funding from various governmental agencies promotes the adoption of organ-on-chip systems in these sectors, leading to a broader market expansion. Meanwhile, other users of this technology, including academia and health institutions, are also becoming essential contributors, exploring various applications and driving further innovation within the US Organ-on-Chip Market landscape.

    Key factors such as increased demand for advanced in vitro models and the expansion of healthcare research are driving the overall market growth, making it a dynamic and promising industry segment.

    Get more detailed insights about US Organ on chip Market

    Key Players and Competitive Insights

    The US Organ-on-Chip Market has rapidly evolved, reflecting significant advancements in biotechnology and drug development processes. This market focuses on the integration of biological and mechanical systems to create microphysiological models that can mimic human organ functions. These models offer invaluable insights into drug efficacy and toxicity, thereby providing a powerful alternative to traditional testing methods.

    With increasing investment from both public and private sectors, the competitive landscape is marked by a diverse array of companies vying for market share and technological superiority, indicating a dynamic and rapidly growing sector. The race for developing more sophisticated and functional organ-on-chip systems has become a key driver of innovation, ultimately enhancing the capabilities of research and development within the pharmaceutical industry and other related sectors.

    In the context of the US Organ-on-Chip Market, InSphero has established a formidable presence, particularly known for its expertise in developing 3D cell culture technology that facilitates drug testing and toxicology studies. The company’s pioneering techniques enable researchers to replicate organ functionalities more accurately, thereby enhancing the predictive power of in vitro models.

    One of the cardinal strengths of InSphero lies in its customized solutions which cater to both research and commercial applications, effectively bridging the gap between basic research and clinical application. Their collaborative efforts with academic institutions and other biotech firms further underscore their commitment to advancing organ-on-chip technology, positioning them as a leader in this niche market segment.

    VitroLabs has carved a niche in the US Organ-on-Chip Market with its innovative approaches to regenerative medicine and organ modeling. Focusing on the development of organ-on-chip systems that mimic complex organ functions, VitroLabs provides key products and services that are particularly advantageous for pharmaceutical research and toxicology assessments.

    The company's strengths include advanced bioengineering capabilities and strategic partnerships which bolster its market presence. Notably, VitroLabs has engaged in various collaborations and potential mergers that enhance their research capabilities, all while maintaining a strong commitment to regulatory standards, further establishing confidence in their technology. Their continuous investment in R&D further solidifies their position as a noteworthy competitor in the rapidly evolving organ-on-chip landscape in the United States.

    Key Companies in the US Organ on chip Market market include

    Industry Developments

    The US Organ-on-Chip Market has seen significant developments recently, with companies like Emulate and Organovo making strides in their respective technologies to better mimic human organ functions for drug testing and disease modeling. In addition, InSphero has been advancing its 3D tissue models, enhancing the capabilities of Organ-on-Chip applications in pharmaceutical research.

    Critical partnerships have formed, such as between Mimic Technologies and industry leaders to expand their product offerings in tissue engineering solutions. As of September 2023, a merger was publicly announced involving Hurel Corporation and Naefin Technologies, aimed at enhancing their organ-on-chip systems to improve drug screening accuracy, which was positively viewed by investors.

    Market valuations in the Organ-on-Chip sector reflect a robust growth trajectory, driven by increasing adoption in Research and Development sectors, with many companies reporting accelerated revenue growth in recent quarters. Additionally, TissUse’s expansion into new markets has further solidified its position in the organ-on-chip space, supporting the overall industry momentum.

    Market Segmentation

    Organ-on-Chip Market End-User Outlook

    • Pharmaceutical Companies
    • Research Organizations
    • Others

    Organ-on-Chip Market Organ Type Outlook

    • Lung-on-Chip
    • Heart-on-Chip
    • Liver-on-Chip
    • Intestine-on-Chip
    • Kidney-on-Chip
    • Human-on-Chip

    Organ-on-Chip Market Application Outlook

    • Drug Discovery
    • Toxicology Research
    • Others

    Report Scope

    Report Scope:
    Report Attribute/Metric Source: Details
    MARKET SIZE 2018 16.5(USD Million)
    MARKET SIZE 2024 18.43(USD Million)
    MARKET SIZE 2035 111.09(USD Million)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 17.737% (2025 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    MARKET FORECAST PERIOD 2025 - 2035
    HISTORICAL DATA 2019 - 2024
    MARKET FORECAST UNITS USD Million
    KEY COMPANIES PROFILED InSphero, VitroLabs, NCardia, Emulate, Ascendance Bio, Hurel Corporation, Organovo, CureMetrix, Mimic Technologies, Pulmodynamics, Biomimetic Solutions, TissUse, Synlogic, Tara Biosystems
    SEGMENTS COVERED Organ Type, Application, End-User
    KEY MARKET OPPORTUNITIES Increased pharmaceutical R&D investment, Rising demand for personalized medicine, Advancements in biotechnology innovations, Strong government support for research, Growth in disease modeling applications
    KEY MARKET DYNAMICS Innovative drug development methods, Rising demand for personalized medicine, Increasing investment in biotechnology, Regulatory support for organ-on-chip, Growing prevalence of chronic diseases
    COUNTRIES COVERED US

    FAQs

    What is the expected market size of the US Organ-on-Chip Market in 2024?

    The US Organ-on-Chip Market is expected to be valued at 18.43 million USD in 2024.

    What will be the projected market valuation of the US Organ-on-Chip Market by 2035?

    By 2035, the market is projected to reach a valuation of 111.09 million USD.

    What is the expected CAGR for the US Organ-on-Chip Market from 2025 to 2035?

    The US Organ-on-Chip Market is anticipated to grow at a CAGR of 17.737 percent from 2025 to 2035.

    Which organ types dominate the US Organ-on-Chip Market?

    The market includes organ types such as Lung-on-Chip, Heart-on-Chip, Liver-on-Chip, Intestine-on-Chip, and Kidney-on-Chip.

    What is the forecast value of the Lung-on-Chip segment in 2035?

    The Lung-on-Chip segment is expected to be valued at 26.5 million USD in 2035.

    Who are the key players in the US Organ-on-Chip Market?

    Major players include InSphero, VitroLabs, NCardia, Emulate, Ascendance Bio, Hurel Corporation, and Organovo.

    What will the Heart-on-Chip segment be valued at in 2024?

    In 2024, the Heart-on-Chip segment is valued at 3.6 million USD.

    What is the projected market size for the Liver-on-Chip segment by 2035?

    The Liver-on-Chip segment is projected to reach a valuation of 26.0 million USD by 2035.

    How much is the Kidney-on-Chip segment expected to be valued in 2035?

    The Kidney-on-Chip segment is expected to be valued at 16.52 million USD in 2035.

    What challenges and opportunities exist in the US Organ-on-Chip Market?

    The market presents opportunities for innovation and development, while facing challenges related to regulatory approvals and technology adoption.

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