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US Drug Repurposing Market

ID: MRFR/Pharma/51010-HCR
200 Pages
Rahul Gotadki
February 2026

US Drug Repurposing Market Research Report By Types (Disease-centric, Target-centric, Drug-centric), By Therapeutic Area (Same Therapeutic Area, Different Therapeutic Area) and By Drug Molecules (Biologics, Small Molecule) - Growth & Industry Forecast 2025 To 2035

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US Drug Repurposing Market Infographic
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US Drug Repurposing Market Summary

As per Market Research Future analysis, the US drug repurposing market size was estimated at 70.0 USD Million in 2024. The US drug repurposing market is projected to grow from 80.37 USD Million in 2025 to 320.0 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 14.8% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The US drug repurposing market is experiencing robust growth driven by innovative research and regulatory support.

  • Investment in research is increasing, indicating a strong commitment to drug repurposing initiatives.
  • Regulatory frameworks are evolving, facilitating faster approval processes for repurposed drugs.
  • Collaboration among stakeholders is becoming more prevalent, enhancing the efficiency of drug development.
  • Rising healthcare costs and an aging population are key drivers propelling the market forward.

Market Size & Forecast

2024 Market Size 70.0 (USD Million)
2035 Market Size 320.0 (USD Million)
CAGR (2025 - 2035) 14.82%

Major Players

Novartis (CH), Pfizer (US), Bristol-Myers Squibb (US), Johnson & Johnson (US), AstraZeneca (GB), Eli Lilly and Company (US), Sanofi (FR), GSK (GB), Amgen (US)

Our Impact
Enabled $4.3B Revenue Impact for Fortune 500 and Leading Multinationals
Partnering with 2000+ Global Organizations Each Year
30K+ Citations by Top-Tier Firms in the Industry

US Drug Repurposing Market Trends

The drug repurposing market is currently experiencing notable growth, driven by the increasing need for cost-effective therapeutic solutions. This approach allows existing medications to be utilized for new indications, thereby reducing the time and resources typically required for drug development. Regulatory bodies have shown support for this strategy, recognizing its potential to expedite the availability of treatments for various conditions. Furthermore, advancements in technology, particularly in data analytics and genomics, are enhancing the ability to identify suitable candidates for repurposing. As a result, pharmaceutical companies are increasingly investing in this area, seeking to maximize the utility of their existing drug portfolios. In addition, the drug repurposing market is characterized by a collaborative environment, where academic institutions, biotech firms, and pharmaceutical companies work together to explore new applications for established drugs. This synergy not only fosters innovation but also helps in sharing the financial burden associated with research and development. The focus on patient-centric approaches is also evident, as stakeholders aim to address unmet medical needs more effectively. Overall, the landscape appears promising, with ongoing research and development efforts likely to yield new therapeutic options in the near future.

Increased Investment in Research

There is a growing trend of investment in research focused on drug repurposing. Pharmaceutical companies are allocating resources to explore new therapeutic uses for existing medications, which can lead to quicker market entry and reduced development costs.

Regulatory Support and Frameworks

Regulatory agencies are increasingly establishing frameworks that facilitate the repurposing of drugs. This support is crucial as it streamlines the approval process, making it easier for companies to bring repurposed drugs to market.

Collaboration Among Stakeholders

Collaboration between academic institutions, biotech firms, and pharmaceutical companies is becoming more prevalent. This trend enhances the sharing of knowledge and resources, ultimately accelerating the discovery of new applications for existing drugs.

US Drug Repurposing Market Drivers

Aging Population

The demographic shift towards an aging population in the US is a critical driver for the drug repurposing market. As individuals age, they often experience multiple chronic conditions, necessitating a diverse range of therapeutic options. The drug repurposing market can address these needs by providing existing medications that may be effective for new indications. For instance, the prevalence of Alzheimer's disease and other age-related disorders is increasing, creating a demand for innovative treatment strategies. This demographic trend suggests that the market for repurposed drugs could expand significantly, as healthcare providers look for effective solutions to manage complex health issues in older adults.

Rising Healthcare Costs

The escalating costs associated with healthcare in the US are driving interest in the drug repurposing market. As traditional drug development can exceed $2.6 billion and take over a decade, repurposing existing drugs offers a more cost-effective alternative. This approach not only reduces the financial burden on healthcare systems but also expedites the availability of treatments. The drug repurposing market is thus positioned to benefit from the need for affordable therapies, as stakeholders seek to optimize resources while addressing unmet medical needs. Furthermore, the potential for repurposed drugs to enter the market more rapidly can lead to significant savings for both patients and healthcare providers, making this a compelling driver for growth.

Patient-Centric Approaches

The shift towards patient-centric healthcare models is influencing the drug repurposing market. Patients are increasingly involved in treatment decisions, and there is a growing demand for therapies that are not only effective but also tailored to individual needs. The drug repurposing market can leverage this trend by offering existing medications that have demonstrated efficacy in diverse patient populations. This approach not only enhances patient satisfaction but also aligns with the broader movement towards personalized medicine. As healthcare providers seek to improve outcomes and patient experiences, the repurposing of drugs presents a promising avenue for meeting these evolving expectations.

Technological Advancements

Technological innovations in data analytics and artificial intelligence are transforming the drug repurposing market. These advancements enable researchers to analyze vast datasets, identifying potential new uses for existing drugs more efficiently. The drug repurposing market is likely to see increased activity as machine learning algorithms and bioinformatics tools facilitate the discovery of novel therapeutic applications. For example, AI-driven platforms can predict drug interactions and efficacy, streamlining the repurposing process. This technological evolution not only enhances the speed of drug development but also reduces the associated costs, making it an attractive option for pharmaceutical companies and investors alike.

Increased Focus on Rare Diseases

The growing emphasis on rare diseases in the US healthcare landscape is propelling the drug repurposing market. Many rare conditions lack effective treatments, and repurposing existing drugs can provide a viable solution. The drug repurposing market is increasingly recognized for its potential to address these unmet needs, as it allows for quicker access to therapies that may already be approved for other indications. This focus aligns with regulatory incentives aimed at encouraging the development of treatments for rare diseases, further stimulating interest in repurposed drugs. As awareness and advocacy for rare diseases grow, the market for repurposed therapies is expected to expand.

Market Segment Insights

By Type: Disease-centric (Largest) vs. Target-centric (Fastest-Growing)

In the US drug repurposing market, the market share distribution shows that the Disease-centric approach holds the largest segment, effectively addressing multiple conditions and attracting significant investment. This segment's focus on utilizing existing drugs for known diseases allows for quicker development timelines, gaining a larger share due to its efficiency and established protocols in the industry. On the other hand, the Target-centric segment is recognized as the fastest-growing within the market. Its innovative strategy focuses on specific molecular targets, encouraging precision medicine approaches. The rise in personalized therapies and advancements in genomic technologies are driving this trend, as stakeholders prioritize treatments that are tailored to individual patient profiles.

Disease-centric: Dominant vs. Target-centric: Emerging

The Disease-centric approach dominates the US drug repurposing market, characterized by its ability to quickly pivot existing medications to treat a range of diseases, resulting in faster therapeutic availability. This segment leverages extensive clinical data and historical efficacy, mitigating the risks associated with new drug development. Conversely, the Target-centric approach is emerging rapidly, employing cutting-edge research methodologies such as high-throughput screening and biomarker development. This segment caters to the growing demand for personalized medicine, with a focus on targeting specific biological pathways. As healthcare becomes more individualized, the Target-centric segment is expected to gain prominence, driven by innovations in technology and a deeper understanding of disease mechanisms.

By Therapeutic Area: Same Therapeutic Area (Largest) vs. Different Therapeutic Area (Fastest-Growing)

The market for therapeutic areas in the US drug repurposing market showcases a diverse range of applications, with a significant share attributed to repurposing drugs within the same therapeutic area. This strategy not only maximizes existing drug profiles but also facilitates faster regulatory approvals due to recognized safety profiles. Meanwhile, repurposing drugs for different therapeutic areas offers a growing opportunity as researchers and companies explore innovative solutions to address unmet medical needs across various diseases. Growth trends indicate a robust increase in the repurposing of drugs for different therapeutic areas, driven by advancements in biotechnology and an urgent demand for novel treatment options. This trend is fueled by a rising focus on personalized medicine and the efficiency of utilizing existing drugs, which often allows for reduced development timelines. Consequently, while the same therapeutic area remains dominant, the different therapeutic area is emerging as the fastest-growing segment, attracting substantial investment and interest from pharmaceutical companies.

Same Therapeutic Area: Dominant vs. Different Therapeutic Area: Emerging

The therapeutic area segment characterized by repurposing drugs within the same area is considered dominant, leveraging existing therapeutic profiles to enhance efficacy and reduce risks. This approach is particularly prominent in chronic disease management where established drugs can be repositioned with minimal alterations. Conversely, the emerging segment of repurposing drugs into different therapeutic areas is gaining traction. This strategy harnesses innovative technologies and extensive research to discover new applications for existing drugs, addressing various health challenges. Market participants are increasingly investing in this segment, drawn by the potential for high returns from rapid entry into new treatment markets and addressing pressing healthcare demands across differing patient populations.

By Drug Molecules: Biologics (Largest) vs. Small Molecule (Fastest-Growing)

In the US drug repurposing market, the distribution of market share between biologics and small molecules reveals a significant dominance by biologics, which hold a considerable share due to their complex nature and targeted therapeutic applications. Small molecules, while not as dominant, have been rapidly gaining traction as innovative therapeutic agents in various diseases, especially as they demonstrate versatility in repurposing for new indications. The growth trends in this segment are largely driven by increasing investments in biopharmaceutical research and development. Alongside advancements in biotechnology, there is a rising emphasis on personalized medicine which favors biologics for their ability to target specific disease pathways. Meanwhile, the small molecule segment is growing rapidly, propelled by advancements in synthetic chemistry and a flourishing interest in novel drug delivery systems that enhance their efficacy and safety profiles.

Biologics (Dominant) vs. Small Molecule (Emerging)

Biologics represent the dominant segment in the US drug repurposing market, characterized by large-scale production through biological processes and often requiring sophisticated manufacturing techniques. They include therapeutic proteins, monoclonal antibodies, and vaccines, which excel in treating complex conditions such as cancers and autoimmune disorders. Conversely, small molecules are emerging as a competitive force, known for their ease of manufacturing and comprehensive mechanism of action. They dominate a wide range of indications due to their ability to penetrate cells easily and inhibit specific biological pathways. The ongoing research to discover new applications for existing small molecules is contributing significantly to their rise within the market.

Get more detailed insights about US Drug Repurposing Market

Key Players and Competitive Insights

The drug repurposing market is characterized by a dynamic competitive landscape, driven by the need for cost-effective therapeutic solutions and accelerated drug development timelines. Major players such as Pfizer (US), Bristol-Myers Squibb (US), and Johnson & Johnson (US) are strategically positioned to leverage their extensive research capabilities and established market presence. Pfizer (US) focuses on innovation through its robust pipeline of repurposed drugs, while Bristol-Myers Squibb (US) emphasizes strategic partnerships to enhance its research capabilities. Johnson & Johnson (US) adopts a multifaceted approach, integrating digital transformation into its operations to streamline drug development processes. Collectively, these strategies foster a competitive environment that prioritizes rapid innovation and collaboration.Key business tactics within the market include localizing manufacturing and optimizing supply chains to enhance efficiency and reduce costs. The competitive structure appears moderately fragmented, with several key players exerting influence over market dynamics. This fragmentation allows for a diverse range of therapeutic options, although the presence of dominant firms like Pfizer (US) and Johnson & Johnson (US) suggests a concentration of resources and expertise that shapes overall market trends.

In October Pfizer (US) announced a collaboration with a leading biotech firm to explore the repurposing of existing therapies for rare diseases. This strategic move is significant as it not only expands Pfizer's portfolio but also aligns with the growing trend of addressing unmet medical needs through innovative approaches. The partnership is expected to enhance research capabilities and accelerate the development of new treatment options, thereby reinforcing Pfizer's competitive position in the market.

In September Bristol-Myers Squibb (US) launched a new initiative aimed at repurposing its existing oncology drugs for use in treating autoimmune diseases. This initiative reflects a strategic pivot towards leveraging existing assets to address broader therapeutic areas. By repurposing established drugs, the company aims to reduce development costs and timeframes, which could potentially lead to quicker patient access to new therapies, thus enhancing its market competitiveness.

In August Johnson & Johnson (US) unveiled a digital platform designed to facilitate the identification of potential drug repurposing opportunities. This platform utilizes advanced data analytics and machine learning to streamline the drug discovery process. The introduction of such technology underscores the company's commitment to digital transformation and positions it favorably in a market increasingly driven by data-driven decision-making.

As of November current competitive trends in the drug repurposing market are heavily influenced by digitalization, sustainability, and the integration of artificial intelligence (AI). Strategic alliances are becoming increasingly vital, as companies recognize the need for collaborative efforts to enhance research and development capabilities. Looking ahead, competitive differentiation is likely to evolve from traditional price-based competition towards a focus on innovation, technological advancements, and supply chain reliability. This shift suggests that companies that prioritize these elements will be better positioned to thrive in an increasingly complex market.

Key Companies in the US Drug Repurposing Market include

Industry Developments

Significant developments in the US Drug Repurposing Market have emerged recently, particularly driven by large pharmaceutical companies such as AstraZeneca, Merck, and Roche, focusing on the potential of existing drugs for new therapeutic uses. In October 2023, Amgen announced a substantial partnership with a biotech firm to advance its drug repurposing initiatives, targeting conditions like neurodegenerative diseases. Furthermore, Bristol Myers Squibb has been actively exploring the potential of its existing oncology drugs to treat autoimmune disorders, demonstrating a growing trend in the industry.

Notably, Eli Lilly reported a successful trial of a repurposed diabetes medication for treating Alzheimer's disease in August 2023, signaling a pivotal shift in therapeutic applications.

 The market valuation for US Drug Repurposing Market continues to rise, fueled by innovations and cost-cutting strategies associated with leveraging existing therapies. Additionally, in September 2023, Regeneron Pharmaceuticals acquired a small company specializing in repurposing therapies for genetic disorders, enhancing its pipeline. Overall, the US Drug Repurposing Market remains vibrant, with ongoing investments and strategic collaborations among major players like Johnson and Johnson, Gilead Sciences, and AbbVie, fostering a robust environment for drug innovation.

Future Outlook

US Drug Repurposing Market Future Outlook

The Drug Repurposing Market is projected to grow at a 14.82% CAGR from 2025 to 2035, driven by technological advancements, regulatory support, and increasing healthcare costs.

New opportunities lie in:

  • Development of AI-driven drug screening platforms
  • Partnerships with biotech firms for accelerated trials
  • Expansion into niche therapeutic areas with unmet needs

By 2035, the market is expected to achieve substantial growth and innovation.

Market Segmentation

US Drug Repurposing Market Type Outlook

  • Disease-centric
  • Target-centric
  • Drug-centric

US Drug Repurposing Market Drug Molecules Outlook

  • Biologics
  • Small Molecule

US Drug Repurposing Market Therapeutic Area Outlook

  • Same Therapeutic Area
  • Different Therapeutic Area

Report Scope

MARKET SIZE 2024 70.0(USD Million)
MARKET SIZE 2025 80.37(USD Million)
MARKET SIZE 2035 320.0(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 14.82% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Novartis (CH), Pfizer (US), Bristol-Myers Squibb (US), Johnson & Johnson (US), AstraZeneca (GB), Eli Lilly and Company (US), Sanofi (FR), GSK (GB), Amgen (US)
Segments Covered Type, Therapeutic Area, Drug Molecules
Key Market Opportunities Emerging technologies enhance efficiency in drug repurposing, addressing unmet medical needs and regulatory pathways.
Key Market Dynamics Growing emphasis on regulatory compliance drives innovation and competition in the drug repurposing market.
Countries Covered US
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FAQs

What is the expected market size of the US Drug Repurposing Market in 2024?

The US Drug Repurposing Market is expected to be valued at 72.0 million USD in 2024.

What will be the market size of the US Drug Repurposing Market in 2035?

By 2035, the US Drug Repurposing Market is anticipated to reach a valuation of 365.0 million USD.

What is the expected CAGR for the US Drug Repurposing Market from 2025 to 2035?

The market is projected to grow at a CAGR of 15.901% from 2025 to 2035.

Which segments dominate the US Drug Repurposing Market?

The major types in the market include Disease-centric, Target-centric, and Drug-centric segments.

How much is the Disease-centric segment valued at in 2024?

The Disease-centric segment is valued at 25.0 million USD in 2024.

What is the projected value of the Drug-centric segment by 2035?

The Drug-centric segment is expected to be valued at 140.0 million USD by 2035.

What is the market value of the Target-centric segment in 2024?

The Target-centric segment is expected to be valued at 20.0 million USD in 2024.

Who are the key players in the US Drug Repurposing Market?

Major players include AstraZeneca, Merck, Roche, Amgen, and Bristol Myers Squibb among others.

What is the growth potential of the Drug-centric segment from 2024 to 2035?

The Drug-centric segment is projected to grow significantly, reaching 140.0 million USD by 2035.

What trends are currently influencing the US Drug Repurposing Market?

Key trends include increasing investment in research and development and a focus on faster drug approval processes.

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