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US DNA Synthesis Market

ID: MRFR/HC/51009-HCR
200 Pages
Rahul Gotadki
February 2026

US DNA Synthesis Market Research Report: Size, Share, Trend Analysis By Applications (Gene Therapy, Synthetic Biology, Molecular Diagnostics, Vaccine Development), By Product Type (Oligonucleotides, Gene Fragments, Gene Libraries), By End Users (Academic Research Institutions, Pharmaceutical Companies, Biotechnology Companies, Clinical Laboratories) and By Technology (Solid-Phase Synthesis, Liquid-Phase Synthesis, PCR-Based Synthesis) - Growth Outlook & Industry Forecast 2025 To 2035

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US DNA Synthesis Market Infographic
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US DNA Synthesis Market Summary

As per Market Research Future analysis, the US DNA Synthesis Market Size was estimated at 888.64 USD Million in 2024. The US dna synthesis market is projected to grow from 1161.9 USD Million in 2025 to 16960.94 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 30.7% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The US DNA synthesis market is experiencing robust growth driven by technological advancements and increasing applications across various sectors.

  • The market is witnessing a rise in personalized medicine, which is reshaping treatment paradigms.
  • Integration of automation and AI is enhancing efficiency and accuracy in DNA synthesis processes.
  • The regulatory framework is evolving, adapting to the rapid advancements in synthetic biology.
  • Key drivers include advancements in synthetic biology and growing demand for gene therapies, which are propelling market expansion.

Market Size & Forecast

2024 Market Size 888.64 (USD Million)
2035 Market Size 16960.94 (USD Million)
CAGR (2025 - 2035) 30.75%

Major Players

Thermo Fisher Scientific (US), Illumina (US), Integrated DNA Technologies (US), Eurofins Genomics (DE), GenScript (CN), Twist Bioscience (US), Synthetic Genomics (US), Bioneer (KR), DNA Script (FR)

Our Impact
Enabled $4.3B Revenue Impact for Fortune 500 and Leading Multinationals
Partnering with 2000+ Global Organizations Each Year
30K+ Citations by Top-Tier Firms in the Industry

US DNA Synthesis Market Trends

The DNA Synthesis Market is currently experiencing a dynamic evolution, driven by advancements in biotechnology and increasing demand for synthetic biology applications. This sector is characterized by a growing interest in personalized medicine, where tailored therapies are developed based on individual genetic profiles. Furthermore, the integration of automation and artificial intelligence in synthesis processes is enhancing efficiency and accuracy, thereby attracting a diverse range of stakeholders, including academic institutions and pharmaceutical companies. As research and development efforts intensify, the market is likely to witness a surge in innovative products and services that cater to various applications, from drug discovery to agricultural biotechnology. In addition, the regulatory landscape is evolving, with government agencies focusing on establishing guidelines that ensure safety and efficacy in synthetic biology. This regulatory framework may foster a more conducive environment for investment and collaboration among industry players. Moreover, the increasing availability of funding for research initiatives is expected to further propel growth in the dna synthesis market. As the landscape continues to shift, stakeholders must remain agile and responsive to emerging trends and technologies that could redefine the future of this sector.

Rise of Personalized Medicine

The dna synthesis market is witnessing a notable shift towards personalized medicine, where therapies are customized based on individual genetic information. This trend is driven by advancements in genomics and a growing understanding of the human genome, leading to more effective treatments tailored to specific patient needs.

Integration of Automation and AI

The incorporation of automation and artificial intelligence in dna synthesis processes is transforming the market. These technologies enhance efficiency, reduce errors, and streamline workflows, making it easier for researchers and companies to produce high-quality synthetic DNA at a faster pace.

Evolving Regulatory Framework

The regulatory environment surrounding dna synthesis is becoming more structured, with government agencies developing guidelines to ensure safety and efficacy. This evolution may encourage investment and collaboration, fostering innovation and growth within the market.

US DNA Synthesis Market Drivers

Emergence of Synthetic Genomics

The emergence of synthetic genomics is reshaping the landscape of the DNA Synthesis Market, as it focuses on the design and construction of entire genomes. This innovative approach has the potential to revolutionize various industries, including healthcare, energy, and materials. The synthetic genomics market is anticipated to grow significantly, with estimates suggesting a value of $5 billion by 2028 in the US. This growth is driven by the increasing interest in creating custom organisms for specific applications, which necessitates advanced dna synthesis capabilities. As research in synthetic genomics progresses, the dna synthesis market is likely to expand, providing new opportunities for companies involved in this cutting-edge field.

Advancements in Synthetic Biology

The DNA Synthesis Market is experiencing a surge due to advancements in synthetic biology, which enables the design and construction of new biological parts and systems. This field has seen substantial investment, with funding reaching approximately $1.5 billion in the US in recent years. These innovations facilitate the development of novel therapeutics, biofuels, and agricultural products, thereby expanding the applications of dna synthesis. As researchers continue to explore the potential of synthetic biology, the demand for high-quality, cost-effective dna synthesis services is likely to increase. This trend indicates a robust growth trajectory for the dna synthesis market, as companies strive to meet the evolving needs of the biotechnology sector.

Growing Demand for Gene Therapies

The increasing prevalence of genetic disorders and the rising interest in gene therapies are driving the DNA Synthesis Market. In the US, the gene therapy market is projected to reach $10 billion by 2026, reflecting a compound annual growth rate (CAGR) of over 30%. This growth is fueled by the need for innovative treatment options that address previously untreatable conditions. As gene therapies rely heavily on precise dna synthesis for the development of therapeutic agents, the market is poised for expansion. The collaboration between pharmaceutical companies and dna synthesis providers is likely to enhance the efficiency and effectiveness of gene therapy development, further propelling the dna synthesis market.

Rising Applications in Agriculture

The application of dna synthesis in agriculture is becoming increasingly prominent, driven by the need for sustainable farming practices and food security. The market for genetically modified organisms (GMOs) is projected to reach $40 billion by 2027 in the US, indicating a significant opportunity for dna synthesis providers. These applications include the development of crops with enhanced traits such as pest resistance and improved nutritional content. As agricultural biotechnology continues to evolve, the DNA Synthesis Market is expected to benefit from the demand for innovative solutions that address global food challenges. This trend suggests a promising future for the dna synthesis market as it aligns with the agricultural sector's goals.

Increased Investment in Biotechnology

Investment in biotechnology is a key driver of the DNA Synthesis Market, as funding for biotech startups and established companies continues to rise. In 2025, venture capital investments in the US biotech sector are expected to exceed $20 billion, highlighting the growing confidence in the industry's potential. This influx of capital supports research and development activities, particularly in areas such as genomics and personalized medicine, which rely on advanced dna synthesis techniques. As biotechnology firms seek to innovate and bring new products to market, the demand for dna synthesis services is likely to grow, thereby strengthening the overall market.

Market Segment Insights

By Application: Gene Therapy (Largest) vs. Synthetic Biology (Fastest-Growing)

In the US dna synthesis market, the application segment is prominently driven by gene therapy, which commands the largest market share due to its increasing adoption in clinical settings and ongoing advancements in technology. Synthetic biology follows as a rapidly growing segment, leveraging innovative approaches to redesign organisms for various applications, thus capturing significant interest and investment. Current trends indicate robust growth within these applications, especially fueled by rising gene therapy funding and an expanding pipeline of synthetic biology solutions. The vaccine development segment is also gaining traction, driven by the urgency and necessity for novel vaccines, particularly in response to global health challenges. Furthermore, molecular diagnostics continue to evolve, enhancing precision medicine capabilities, and contributing positively to the overall dynamics of the application segment.

Gene Therapy (Dominant) vs. Vaccine Development (Emerging)

Gene therapy stands out as the dominant application within the US dna synthesis market, characterized by its potential to address genetic disorders and diseases through targeted interventions. This segment is bolstered by significant investments from both public and private sectors, leading to a wealth of new therapies being developed. In contrast, vaccine development is an emerging application, increasingly important in the wake of global health challenges such as pandemics. This segment is witnessing accelerated growth as organizations strive to develop more efficient and rapid vaccine solutions, driving collaboration across biotech and pharmaceutical sectors to enhance public health outcomes. Both segments represent critical advancements in biotechnology, reflecting the evolving landscape of healthcare and therapeutic approaches.

By Product Type: Oligonucleotides (Largest) vs. Gene Libraries (Fastest-Growing)

In the US dna synthesis market, the distribution of market share among product types reveals that oligonucleotides hold a significant portion due to their wide application in diagnostic and therapeutic fields. Gene fragments and gene libraries, while important, occupy smaller shares, yet they are crucial for research purposes. The market is characterized by a strong demand for custom oligonucleotides, driven by advancements in personalized medicine and biotechnological innovations. Growth trends indicate that while oligonucleotides continue to lead the market, gene libraries are emerging as the fastest-growing segment, fueled by the increasing demand for high-throughput sequencing and synthetic biology applications. The rapid advancements in gene synthesis technologies and an expanding user base in research institutions are key drivers of this growth, suggesting a dynamic shift towards gene libraries as critical tools in genomic research.

Oligonucleotides (Dominant) vs. Gene Libraries (Emerging)

Oligonucleotides are dominating the US dna synthesis market due to their extensive use in various applications, including diagnostics, therapeutics, and synthetic biology. Their flexibility allows for customization, enhancing their appeal to researchers and developers. On the other hand, gene libraries represent an emerging segment, gaining traction as they provide a comprehensive collection of genetic sequences for study and manipulation. This segment caters to the growing demands of genomics, enabling the discovery of novel genes and pathways. The integration of advanced technologies into gene library construction further supports their rapid market growth, making them essential tools for research and development.

By End User: Pharmaceutical Companies (Largest) vs. Academic Research Institutions (Fastest-Growing)

The US dna synthesis market is segmented into four primary end users: Academic Research Institutions, Pharmaceutical Companies, Biotechnology Companies, and Clinical Laboratories. Among these, Pharmaceutical Companies hold the largest market share due to their extensive applications in drug development and personalized medicine. Academic Research Institutions have emerged as a significant segment as well, driven by the growing emphasis on genetic research and development. Growth trends in the US dna synthesis market are notably influenced by the increasing focus on precision medicine and advancements in genomic research technology. Pharmaceutical Companies continue to invest heavily in synthetic DNA solutions, which enhances their research capabilities. Meanwhile, Academic Research Institutions are witnessing rapid growth as they adopt advanced synthesis technologies to support innovative studies, thereby positioning themselves as the fastest-growing segment within the market.

Pharmaceutical Companies (Dominant) vs. Academic Research Institutions (Emerging)

Pharmaceutical Companies dominate the US dna synthesis market mainly due to their substantial investment in research & development efforts, allowing for groundbreaking advancements in therapeutic solutions. They leverage cutting-edge dna synthesis technologies to create novel drugs tailored to specific patient needs, thus enhancing efficacy and safety. On the other hand, Academic Research Institutions are emerging rapidly as they prioritize DNA synthesis in their research activities. With increased funding and collaboration with biotech firms, these institutions are integrating advanced techniques into their curricula and research projects, thus contributing significantly to the growth and innovations in the market. This dynamic interplay between the two segments shapes a competitive landscape that encourages further advancements and applications.

By Technology: Solid-Phase Synthesis (Largest) vs. PCR-Based Synthesis (Fastest-Growing)

In the US dna synthesis market, Solid-Phase Synthesis dominates the sector, capturing a significant share due to its efficiency and cost-effectiveness in producing high-quality oligonucleotides. Liquid-Phase Synthesis, while valuable, is being overshadowed by the rapid advancements in Solid-Phase techniques that offer superior scalability and automation capabilities. On the other hand, PCR-Based Synthesis is recognized as the fastest-growing segment, driven by the increasing applications of PCR in diagnostics and research. The surge in demand for nucleic acids in therapeutic development and genetic research further propels the growth of this segment, making it a key area of focus for companies looking to innovate and capitalize on emerging market opportunities.

Technology: Solid-Phase Synthesis (Dominant) vs. PCR-Based Synthesis (Emerging)

Solid-Phase Synthesis is the leading technology in the market, characterized by its ability to produce oligonucleotides efficiently with a high degree of purity. This method enables modifications and complex sequences, which are essential for various applications, including gene synthesis and RNA interference. Conversely, PCR-Based Synthesis, while newer, is emerging rapidly due to its practical applications in research and clinical settings. This technology allows for the amplification of specific DNA sequences, making it invaluable for diagnostics and therapeutic innovations. Together, these methods represent the core technological advances shaping the landscape of the US dna synthesis market.

Get more detailed insights about US DNA Synthesis Market

Key Players and Competitive Insights

The dna synthesis market is characterized by a dynamic competitive landscape, driven by advancements in biotechnology and increasing demand for synthetic biology applications. Key players such as Thermo Fisher Scientific (US), Illumina (US), and Twist Bioscience (US) are at the forefront, each adopting distinct strategies to enhance their market positioning. Thermo Fisher Scientific (US) focuses on innovation through extensive R&D investments, aiming to expand its product portfolio and improve synthesis efficiency. Illumina (US) emphasizes partnerships with academic institutions to foster innovation in genomic research, while Twist Bioscience (US) leverages its proprietary silicon-based DNA synthesis technology to offer cost-effective solutions, thereby reshaping competitive dynamics in the market.The business tactics employed by these companies include localizing manufacturing and optimizing supply chains to enhance operational efficiency. The market structure appears moderately fragmented, with several players vying for market share. However, the collective influence of major companies like Thermo Fisher Scientific (US) and Illumina (US) suggests a trend towards consolidation, as these firms seek to leverage economies of scale and enhance their competitive edge.
In September Thermo Fisher Scientific (US) announced a strategic partnership with a leading biotech firm to co-develop next-generation sequencing technologies. This collaboration is poised to accelerate innovation in the field, allowing Thermo Fisher to enhance its offerings and maintain a competitive advantage in the rapidly evolving market. The partnership underscores the importance of collaboration in driving technological advancements and meeting the growing demand for high-throughput sequencing solutions.
In October Illumina (US) launched a new line of synthesis products aimed at improving the accuracy and speed of genomic sequencing. This product line is expected to significantly enhance the capabilities of researchers and clinicians, positioning Illumina as a leader in the market. The introduction of these advanced products reflects Illumina's commitment to innovation and its strategic focus on addressing the evolving needs of the genomics community.
In August Twist Bioscience (US) expanded its manufacturing capabilities by opening a new facility dedicated to high-throughput DNA synthesis. This expansion is anticipated to increase production capacity and reduce lead times for customers, thereby enhancing Twist's competitive position. The move aligns with the growing demand for synthetic DNA in various applications, including therapeutics and diagnostics, and highlights the company's proactive approach to scaling operations in response to market needs.
As of November current competitive trends in the dna synthesis market include a strong emphasis on digitalization, sustainability, and the integration of artificial intelligence in research and development processes. Strategic alliances are increasingly shaping the landscape, enabling companies to pool resources and expertise to drive innovation. Looking ahead, competitive differentiation is likely to evolve from traditional price-based competition towards a focus on technological innovation, supply chain reliability, and sustainable practices, reflecting the changing priorities of stakeholders in the industry.

Key Companies in the US DNA Synthesis Market include

Industry Developments

The US DNA Synthesis Market has seen notable advancements and developments recently. In September 2023, Agilent Technologies announced its expansion of synthetic biology capabilities, strengthening its position within the market and enhancing service offerings for clients. Concurrently, Thermo Fisher Scientific introduced new advancements to its GeneArt suite, enabling faster and more efficient DNA synthesis, which is likely to contribute to increasing market demand. Merger and acquisition activities are also noteworthy, with Twist Bioscience acquiring a leading synthetic biology firm in August 2023, thereby broadening its product portfolio.

In the past couple of years, the market has witnessed significant growth, with a substantial increase in demand for custom DNA synthesis services due to rising investments in biotechnology and genomics, aligning with initiatives by the US government to promote innovation in life sciences. Companies like Illumina and Integrated DNA Technologies continue to expand their market presence through strategic collaborations and new product launches that address diverse needs within genomic research and therapeutic development. Overall, these factors contribute to a dynamic landscape in the US DNA Synthesis Market, reflective of ongoing technological advancements and increased applications in various sectors.

 

Future Outlook

US DNA Synthesis Market Future Outlook

The DNA synthesis Market is projected to grow at a 30.75% CAGR from 2025 to 2035, driven by advancements in biotechnology, personalized medicine, and synthetic biology applications.

New opportunities lie in:

  • Development of custom DNA synthesis platforms for personalized therapeutics. Expansion of automated synthesis technologies for high-throughput applications. Partnerships with biotech firms for integrated genomic solutions.

By 2035, the DNA synthesis market is expected to achieve substantial growth, positioning itself as a leader in biotechnological innovation.

Market Segmentation

US DNA Synthesis Market End User Outlook

  • Academic Research Institutions
  • Pharmaceutical Companies
  • Biotechnology Companies
  • Clinical Laboratories

US DNA Synthesis Market Technology Outlook

  • Solid-Phase Synthesis
  • Liquid-Phase Synthesis
  • PCR-Based Synthesis

US DNA Synthesis Market Application Outlook

  • Gene Therapy
  • Synthetic Biology
  • Molecular Diagnostics
  • Vaccine Development

US DNA Synthesis Market Product Type Outlook

  • Oligonucleotides
  • Gene Fragments
  • Gene Libraries

Report Scope

MARKET SIZE 2024 888.64(USD Million)
MARKET SIZE 2025 1161.9(USD Million)
MARKET SIZE 2035 16960.94(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 30.75% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Thermo Fisher Scientific (US), Illumina (US), Integrated DNA Technologies (US), Eurofins Genomics (DE), GenScript (CN), Twist Bioscience (US), Synthetic Genomics (US), Bioneer (KR), DNA Script (FR)
Segments Covered Application, Product Type, End User, Technology
Key Market Opportunities Advancements in personalized medicine drive demand for tailored solutions in the dna synthesis market.
Key Market Dynamics Technological advancements drive innovation and competition in the DNA synthesis market, enhancing product offerings and efficiency.
Countries Covered US
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FAQs

What is the expected market size of the US DNA Synthesis Market in 2024?

The US DNA Synthesis Market is expected to be valued at 1.13 billion USD in 2024.

What is the projected market size of the US DNA Synthesis Market by 2035?

By 2035, the US DNA Synthesis Market is projected to reach a value of 3.03 billion USD.

What is the expected compound annual growth rate (CAGR) for the US DNA Synthesis Market from 2025 to 2035?

The expected CAGR for the US DNA Synthesis Market from 2025 to 2035 is 9.343 percent.

Which application will have the largest market share in the US DNA Synthesis Market in 2035?

In 2035, Gene Therapy is projected to hold the largest market share, valued at 1.05 billion USD.

What are the market sizes for the Synthetic Biology application in 2024 and 2035?

The Synthetic Biology application is expected to be valued at 0.3 billion USD in 2024 and 0.8 billion USD by 2035.

Which company is one of the key players in the US DNA Synthesis Market?

Agilent Technologies is one of the notable key players in the US DNA Synthesis Market.

What is the expected market value for Molecular Diagnostics in 2035?

The expected market value for Molecular Diagnostics in 2035 is projected to be 0.65 billion USD.

What is the anticipated market size for Vaccine Development in 2024?

The anticipated market size for Vaccine Development in 2024 is valued at 0.18 billion USD.

What opportunities exist in the US DNA Synthesis Market for the period 2025 to 2035?

The growth in Gene Therapy, Synthetic Biology, and advancements in Molecular Diagnostics present significant opportunities from 2025 to 2035.

What is one of the challenges facing the US DNA Synthesis Market?

One of the challenges facing the US DNA Synthesis Market is the need for regulatory approvals in various applications.

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