Protein Chip Market Research Report: Information by Type (Analytical Microarrays, Functional Protein Microarrays and Reverse Phase Protein Microarrays), by Application (Protein Identification, Clinical Diagnostics, Proteomics and Others), by End User (Hospitals & Clinics, Diagnostic Laboratories, Academic & Research Institutes, Pharmaceutical & Biotechnology Companies), by Region (North America, Europe, Asia-Pacific, and Rest of the World) - Forecast till 2030.

Protein Chip Market Overview

The protein chip market size is projected to be worth USD 1.53 billion by 2030, registering a CAGR of 6.71% during the forecast period (2022 - 2030)

A protein chip is a high-throughput method of immobilizing numerous proteins on a solid support and using miniaturized assays to describe protein interactions. Protein chips are an emerging technology that help overcome the limitations of DNA microarrays. It is used in a variety of applications, including proteomic applications, multi-parameter clinical diagnostic tests, the development of new assays, the detection of protein-binding properties, the identification of biomarkers, and others. The market of protein chip has been segmented based on type, application, and end user. The market is driven by factors such as the rising incidence and prevalence of cancer, advancement in protein chip assays, and the increasing application of protein chips in infectious disease. However, the complications associated with protein chips and the less availability of proteins could hamper the growth of the protein chip market.

COVID-19 Analysis

The global market of protein chip has been negatively affected by the COVID-19 pandemic during the first half of 2020. During this period, various governments took steps to enforce lockdowns and shutdowns. As a result, the supply chain and manufacturing chain of the protein chip market was disturbed.

In the post pandemic phase, there was an increasing demand for protein chip technology for application in COVID-19 vaccine development. A SARS-CoV-2 multi-antigen protein chip is utilized for thorough analysis of antibody responses in COVID-19 patients. The protein chip's quick, multiplexed, and sensitive capabilities make it one of the best platforms for profiling the antibodies in blood. It assists in the detecting of illnesses such as cancer, autoimmune disorders, and other infectious diseases. As a result, the protein chip market showed positive market growth thereafter supporting the sales of the related products.

Market Dynamics

Drivers

• 
  Rising incidences and prevalence of cancer
  
  
  
  • Protein chip technology has proved to be an important tool in cancer research and diagnosis. There is an increasing incidence and prevalence of cancer worldwide. For instance, according to the Centers for Disease Control and Prevention, in the year 2019, a large number of new cancer cases were reported in the US. A variety of cancers can be cured if they are detected early and treated effectively. Additionally, according to Cancer Research UK, there were millions of new cases for cancer around the globe in 2018.
  
  
  • Protein chip, a robust and versatile platform, is highly preferred in cancer proteomics research because of its advantageous features such as miniaturized specifications, high throughput, and sensitive detection. It is a potential tool for early detection, therapeutic monitoring, and prognostic evaluation of cancer. This increasing role of protein chips in cancer detection, progression, diagnosis, and treatment is fueling the global protein chip market.
  
  
  
  


• Increasing application of protein chip in infectious disease


• Developments in protein chip assays

Market Opportunities

• 
  Growing demand for personalized medicine
  
  
  
  • Personalized medicine, also known as precision medicine, is a medical model that uses an individual's genetic profile to guide decisions made regarding the prevention, diagnosis, and treatment of disease. There is a growing demand for personalized medicine due to its advantages, such as a reduction in trial-and-error prescribing, he ability to avoid drug reactions, and improved cost effectiveness.
  
  
  • Protein chip technology plays a vital role in personalized medicine. Predictive and prognostic biomarkers are particularly important for developing personalized drugs. In addition, protein chips have accelerated the innovation and development of biomarkers in recent years. This technology enables physicians to evaluate patients before prescribing a certain medication in order to rule out probable side effects or establish the best dose. Thus, growing demand for personalized medicine is creating lucrative opportunities for the players operating in the global protein chip market.
  
  
  
  


• Increasing investments by key companies in the R&D activities

Market Restraints

• 
  Complications associated with protein chip
  
  
  
  • There are various complexities associated with protein chip applications. A protein chip requires two specific antibodies for each target in the sample of interest and a still challenging task to multiplex, related to the feasibility of designing arrays with thousands of analytes. It also has a high production cost.
  
  
  • There are also chances of false results in protein chip applications. These factors may restrain the growth of the global market of protein chip in the forecasted period.
  
  
  
  


• Less availability of proteins

Value Chain Analysis

The global protein chip market is projected to exhibit significant growth over the forecast period, which can be attributed to factors such as the rising incidence and prevalence of cancer, developments in protein chip assays, and the increasing application of protein chips in infectious disease. The value chain analysis for the market comprises five major components, which start with research & product development, followed by the manufacturing of the products, distribution & sales, and ends with post-marketing surveillance.

Segment Overview

By Type

• Analytical Microarrays

In order to profile a complex mixture of proteins and determine their binding affinities, specificities, and levels of protein expression, analytical microarrays are frequently used. In this method, a glass microscope slide is used to display a library of antibodies, aptamers, or affibodies. A protein solution is then used to probe the array. The most popular type of analytical microarray is the antibody microarray.

• Functional Protein Microarrays

Functional protein microarrays are different from analytical arrays. It is made up of arrays that include functional proteins that are used in a single experiment to examine the biochemical functions of the whole proteome.

• Reverse Phase Protein Microarrays

In a reverse phase protein microarray (RPA), cells from different target tissues are extracted and lysed. On a nitrocellulose slide, the lysate is arranged using a contact pin microarrayer. The target protein of interest is then probed into the slides using antibodies, and the antibodies are commonly found using chemiluminescent, fluorescent, or colorimetric tests.

By Application

• Protein Identification

Protein chips have been utilized for monitoring the interactions between different proteins, such as enzymes and substrates, proteins and antibodies, proteins and lipids, proteins, and peptides, as well as proteins and low-molecular-mass compounds.

• Clinical Diagnostics

Protein chip technology has also been applied for clinical diagnostics. It can be used for the detection of infectious diseases. For instance, coronavirus protein microarrays are produced for diagnosing severe acute respiratory syndrome (SARS). The array contained samples of five more contagious coronaviruses as well as the SARS coronavirus proteins.

• Proteomics

Proteomics involves the large-scale study of proteins, which is used to investigate the expression of proteins, rates of protein production, degradation, and steady-state abundance, proteins interaction with one another, and other applications. Protein chips can be used to study the biochemical activities of an entire proteome in a single experiment.

• Others

The other segment involves antibody characterization and prognosis. Protein chips can be used to profile the specificity of antibodies. Also, it plays a vital role in prognosis, including patient management and decision-making.

By End User

• Hospitals & Clinics

Protein chips can be used in hospitals & clinics to diagnose patients based on their unique genetic profiles and to screen for disease-specific mutations. An increasing number of hospitals and clinics around the globe is fueling the segment's growth in the market.

• Diagnostic Laboratories

Diagnostic laboratories offer information about the patient’s health after conducting a range of tests and screening procedures. Protein chips are significantly used to enhance diagnosing procedures. It is utilized in improving clinical diagnosis of complex ailments such as cancer, allergy, and autoimmunity.

• Academic & Research Institutes

The academic & research institutes segment is gaining a significant share in the global protein chip market due to a rise in the use of microarrays in drug discovery and research applications. Such factors augment the usage of protein chips in academic and research institutes.

• Pharmaceutical & Biotechnology Companies

Pharmaceutical & biotechnology companies are accounted to hold a significant share in the end use of protein chip products due to increasing investment in development of advanced drugs, strategic acquisitions made by leading companies to expand their product portfolio. Also, increasing usage of protein chip technology across pharmaceutical & biotechnology companies for gene expression and genetic variation analysis is accelerating the market demand.

Regional Analysis

The market of protein chip based on the region has been segmented into North America, Europe, Asia-Pacific, and the Rest of the World.

North America

The increasing incidences of various diseases such as cancer and established protein chip laboratories and research centers are fueling the growth of the North America protein chip market.

The North American region, comprising the US and Canada, held the largest market share in 2021. This is due to factors such as increasing incidences of various diseases such as cancer and the establishment of protein chip laboratories and research centers across the region. There is an increasing prevalence of cancer in the US and Canada. Cancer is a leading cause of death in the Canadian region. According to the government of Canada, an estimated 2 in 5 Canadians will be diagnosed with cancer in their lifetime and about 1 in 4 will die from cancer. Additionally, according to Canadian Cancer Statistics, 45% of Canadian men and 43% of Canadian women will develop cancer during their lifetime. Early detection of cancer in people increases the chances of survival. The protein chip technology plays an important role in early cancer detection. Thereby increasing the chances of higher life expectancy. Such aspects are expected to drive the market demand across North America.

Asia-Pacific

Increased awareness regarding personalized medicine among people and increasing prevalence of infectious diseases are anticipated to drive the market growth in the region.

The Asia-Pacific region is expected to show the highest CAGR during the forecast period due to factors such as rise in people's awareness of personalized medicine and increased spread of infectious diseases, and growing government funding for the development of the healthcare sector. Growing awareness about advantages of personalized medicine over traditional healthcare procedures is fueling the Asia Pacific Protein Chip Market. Moreover, infectious diseases such as influenza, tuberculosis, and pneumonia are also prevalent in the region. For instance, according to the WHO, in 2020, nearly 4.3 million people fell ill of tuberculosis, and 700,000 individuals were expected to die by the end of the year. However, the public and private organizations are working together to minimize the lethal rate across the region by investing more on research activities and by developing customized drugs. This is anticipated to boost the market of protein chip in the region.

Competitive Landscape

Industry players are adopting several business strategies to increase their market presence. They are significantly investing in R&D activities to expand their product portfolio, further driving the protein chip market. In addition, the market players are adopting several strategic initiatives, such as new product launches, contractual agreements, mergers and acquisitions, increasing investments, and partnering with other players to expand their global footprint.

Thermo Fisher Scientific (US) is one of the key market players, founded in 1956. The company specializes in various biotechnology products, such as analytical instruments, laboratory equipment, lab services, specialty diagnostics, and others. Its protein chip products involve ProtoArray Human Protein Microarray. In April 2022, the company introduced its new GMP-manufactured Gibco CTA TrueCut Cas9 protein to support genome editing for research applications, including CAR T-cell therapy research and cell therapy developers' manufacturing needs.

List of companies covered in this report:

• Sengenics (US)


• Thermo Fisher Scientific Inc. (US)


• Microarrays Inc. (US)


• Agilent Technologies, Inc. (US)


• Bio-Rad Laboratories, Inc. (US)


• Full Moon BioSystems, Inc. (US)


• CDI Laboratories Inc. (US)


• OriGene Technologies, Inc. (US)


• Innopsys (France)


• Others

Recent Developments

• In March 2022, Sengenics commercially launched the i-Ome Protein Array Kit. The i-Ome Protein Array Kit contains slide-based, high-density protein microarrays comprised of 1600+ immobilized, full-length, correctly folded human proteins.


• In October 2020, Summa Equity, the purpose-driven private equity firm, acquired a majority stake in Sengenics, a functional proteomics company. This helps the company expand its position in the market and grow its business.

Report Overview

The study covers the existing short-term and long-term market effects. It helps decision-makers to draw short-term and long-term business plans by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's five forces, value chain, and impact of COVID-19 on the market.

Study Objectives

• To provide a detailed analysis of the market structure and forecast for the next seven years of the various segments and sub-segments of the market


• To provide insights about factors affecting the market growth


• To analyze the protein chip market based on various factors- price analysis, supply chain analysis, Porter's five force analysis, etc.


• To provide historical and forecast revenues of the market segments and sub-segments with respect to four main geographies and their countries- North America, Europe, Asia-Pacific, and the Rest of the World


• To provide country-level analysis of the market with respect to the current market size and future prospective


• To provide country-level analysis of the market for segments by type, application, and end user


• To provide strategic profiling of key players in the market, comprehensively analyze their core competencies, and draw a competitive market landscape


• To track and analyze competitive developments such as joint ventures, strategic alliances, mergers & acquisitions, new product developments, and R&D in the protein chip market

Market Segmentation:

Global Protein Chip Market, By Type

• Analytical Microarrays


• Functional Protein Microarrays


• Reverse Phase Protein Microarrays

Global Protein Chip Market, By Application

• Protein Identification


• Clinical Diagnostics


• Proteomics


• Others

Global Protein Chip Market, By End User

• Hospitals & Clinics


• Diagnostic Laboratories


• Academic & Research Institutes


• Pharmaceutical & Biotechnology Companies

Global Protein Chip Market, By Region

• North America
  
  
  
  • US
  
  
  • Canada
  
  
  
  


• Europe
  
  
  
  • Germany
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • Australia
  
  
  • South Korea
  
  
  • Rest of Asia-Pacific
  
  
  
  


• Rest of the World
  
  
  
  • Middle East
  
  
  • Africa
  
  
  • Latin America
  
  
  
  

Intended Audience

• Protein chip product manufacturers and suppliers


• Contract Research Organizations (CROs)


• Research and Development (R&D) Companies


• Biopharmaceutical Companies


• Government & Independent Research Laboratories


• Government and Independent Regulatory Authorities


• Market Research and Consulting Service Providers


• Academic Institutes and Universities