• Cat-intel
  • MedIntelliX
  • Resources
  • About Us
  • Request Free Sample ×

    Kindly complete the form below to receive a free sample of this Report

    Leading companies partner with us for data-driven Insights

    clients tt-cursor
    Hero Background

    Overt Hepatic Encephalopathy Market

    ID: MRFR/Pharma/0280-HCR
    95 Pages
    Kinjoll Dey
    October 2025

    Overt Hepatic Encephalopathy Market Research Report By Treatment Type (Lactulose, Rifaximin, Ammonia Scavengers, Probiotics), By Route of Administration (Oral, Intravenous, Rectal), By Diagnosis Method (Clinical Assessment, Laboratory Tests, Imaging Techniques), By Patient Type (Adults, Pediatrics, Geriatrics) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2035

    Share:
    Download PDF ×

    We do not share your information with anyone. However, we may send you emails based on your report interest from time to time. You may contact us at any time to opt-out.

    Overt Hepatic Encephalopathy Market Infographic
    Purchase Options

    Overt Hepatic Encephalopathy Market Summary

    As per Market Research Future analysis, the Overt Hepatic Encephalopathy Market Size was estimated at 1.67 USD Billion in 2023. The market is projected to grow from 1.74 USD Billion in 2024 to 2.8 USD Billion by 2035, with a CAGR of approximately 4.43% during the forecast period from 2025 to 2035. The growth is driven by the rising incidence of liver diseases, advancements in treatment options, and increased awareness initiatives.

    Key Market Trends & Highlights

    The Global Overt Hepatic Encephalopathy Market is witnessing significant trends driven by various factors.

    • Market Size in 2024: 1.74 USD Billion; projected to reach 2.8 USD Billion by 2035.
    • Lactulose market value in 2024: 0.84 USD Billion; expected to grow to 1.32 USD Billion by 2035.
    • Rifaximin market value in 2024: 0.62 USD Billion; projected to increase to 1.02 USD Billion by 2035.
    • North America market valuation in 2024: 0.75 USD Billion; expected to rise to 1.22 USD Billion by 2035.

    Market Size & Forecast

    2023 Market Size USD 1.67 Billion
    2024 Market Size USD 1.74 Billion
    2035 Market Size USD 2.8 Billion
    CAGR (2025-2035) 4.43%

    Major Players

    Key players include Horizon Therapeutics, Pfizer, Salix Pharmaceuticals, Roche, AbbVie, Sobi, Gilead Sciences, Eisai, Novartis, Mylan, Teva Pharmaceuticals, Bristol Myers Squibb, Merck, AstraZeneca, and Amgen.

    Overt Hepatic Encephalopathy Market Trends

    The Global Overt Hepatic Encephalopathy Market is witnessing significant trends driven by various factors and opportunities. One of the key market drivers is the rising incidence of liver diseases, particularly cirrhosis, which is largely attributed to lifestyle changes, increasing alcohol consumption, and a growing prevalence of viral hepatitis and metabolic disorders. As healthcare providers aim to address this increasing burden on health systems, there is a strong push to enhance awareness and improve diagnosis and treatment options for hepatic encephalopathy. In recent times, trends indicate a shift towards more innovative therapeutics, including advancements in pharmacological treatments and novel drug formulations.

    The development of non-invasive diagnostic tools is also gaining traction, which aids in early detection and management of the condition. Furthermore, ongoing clinical research is uncovering new insights into the physiological mechanisms that underpin overt hepatic encephalopathy, leading to an emphasis on individualized treatment strategies and personalized medicine approaches. Opportunities in the market can be leveraged through increased collaboration between pharmaceutical companies and research institutions to accelerate the development of effective therapies. The integration of digital health solutions, including telemedicine and mobile health applications, can also enhance patient management and engagement.

    Moreover, the rising focus on healthcare infrastructure in various regions around the globe is creating pathways for improved access to treatment and support for patients. The combination of these trends and opportunities presents a dynamic landscape for stakeholders in the Global Overt Hepatic Encephalopathy Market to explore and capture growth.

     

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    The increasing prevalence of liver diseases globally suggests a corresponding rise in the demand for effective management strategies for overt hepatic encephalopathy, highlighting the need for innovative therapeutic solutions.

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    Overt Hepatic Encephalopathy Market Drivers

    Market Growth Projections

    The Global Overt Hepatic Encephalopathy Market Industry is projected to experience substantial growth over the next decade. With an estimated market value of 1.74 USD Billion in 2024, it is expected to reach approximately 2.8 USD Billion by 2035, reflecting a robust CAGR of 4.42% from 2025 to 2035. This growth trajectory indicates a rising demand for effective treatment options and increased investment in research and development. The market's expansion is likely to be driven by various factors, including advancements in diagnostics, growing awareness, and an aging population, all of which contribute to a more favorable environment for market players.

    Growing Awareness and Education

    There is a noticeable increase in awareness and education regarding liver health and hepatic encephalopathy among both healthcare professionals and the general public. Campaigns aimed at educating individuals about liver diseases and their complications are gaining traction, which may lead to earlier diagnosis and treatment of overt hepatic encephalopathy. This heightened awareness is expected to drive demand for therapeutic options, thereby positively impacting the Global Overt Hepatic Encephalopathy Market Industry. As more individuals seek medical advice and treatment, the market is projected to grow at a CAGR of 4.42% from 2025 to 2035.

    Increasing Geriatric Population

    The aging population worldwide is contributing to the rise of chronic liver diseases, which in turn drives the Global Overt Hepatic Encephalopathy Market Industry. Older adults are more susceptible to liver dysfunction due to various factors, including comorbidities and polypharmacy. As the global population aged 65 and older continues to expand, the incidence of hepatic encephalopathy is likely to increase. This demographic shift necessitates enhanced healthcare services and treatment options, positioning the market for substantial growth. The Global Overt Hepatic Encephalopathy Market is expected to reflect this trend as it adapts to the needs of an aging population.

    Rising Prevalence of Liver Diseases

    The increasing incidence of liver diseases, particularly cirrhosis and hepatitis, is a primary driver of the Global Overt Hepatic Encephalopathy Market Industry. As liver function deteriorates, the risk of developing overt hepatic encephalopathy escalates, leading to a greater need for effective treatment options. According to recent data, liver diseases are projected to affect millions globally, with an estimated prevalence rate of 1 in 5 adults in certain regions. This growing patient population is expected to propel the market, with the Global Overt Hepatic Encephalopathy Market anticipated to reach 1.74 USD Billion in 2024.

    Advancements in Diagnostic Techniques

    Technological innovations in diagnostic methods are significantly influencing the Global Overt Hepatic Encephalopathy Market Industry. Enhanced imaging techniques and biomarkers are facilitating earlier and more accurate diagnosis of hepatic encephalopathy. For instance, the introduction of non-invasive tests has improved the detection rates of this condition, allowing for timely intervention. As awareness of these advancements spreads, healthcare providers are increasingly adopting these technologies, which is likely to contribute to market growth. The Global Overt Hepatic Encephalopathy Market is set to benefit from these developments, potentially reaching 2.8 USD Billion by 2035.

    Regulatory Support for Treatment Innovations

    Regulatory bodies are increasingly supporting the development of new treatments for hepatic encephalopathy, which is a crucial factor for the Global Overt Hepatic Encephalopathy Market Industry. Initiatives aimed at expediting the approval process for innovative therapies are encouraging pharmaceutical companies to invest in research and development. This regulatory environment fosters a pipeline of new products that could address unmet medical needs in the treatment of hepatic encephalopathy. As these innovations come to market, they are likely to enhance patient outcomes and drive market growth, contributing to the anticipated increase in market value.

    Market Segment Insights

    Overt Hepatic Encephalopathy Market Treatment Type Insights

    The Global Overt Hepatic Encephalopathy Market is increasingly defined by its Treatment Type segmentation, which showcases several pivotal components in addressing this neurological condition. In 2024, the market for Lactulose is valued at 0.84 USD Billion, making it a key player in this segment. By 2035, this value is projected to reach 1.32 USD Billion, signifying its majority holding in sales and treatment approaches for overt hepatic encephalopathy. Lactulose’s dominant position can be attributed to its effectiveness as a first-line treatment, helping to reduce ammonia levels and manage symptoms efficiently.

    Following Lactulose, Rifaximin emerges as another significant treatment with a 2024 valuation of 0.62 USD Billion, with expectations of growing to 1.02 USD Billion by 2035. Rifaximin’s role in addressing gut flora imbalance and its bactericidal properties make it crucial in developing effective treatment plans for patients. Ammonia Scavengers, while relatively smaller in market size at 0.18 USD Billion in 2024, are anticipated to see growth reaching 0.29 USD Billion by 2035, reflecting the importance of innovative therapies designed to chemically bind ammonia, thus providing supplementary benefits alongside other treatments.

    Probiotics, with a valuation of 0.1 USD Billion in 2024 and an increase to 0.17 USD Billion by 2035, hold a unique position as they offer an alternative approach to gut health and microbial balance, which is gaining traction in clinical settings and could represent an emerging trend within the market.

    Overt Hepatic Encephalopathy Market Route of Administration Insights

    The Global Overt Hepatic Encephalopathy Market, particularly in the context of the Route of Administration, showcases a diverse landscape that significantly influences treatment choices. In 2024, the overall market is valued at 1.74 USD Billion, reflecting a growing recognition and focus on effective management of this condition. Within the Routes of Administration, there are key methods, including Oral, Intravenous, and Rectal delivery. Oral administration plays a critical role due to its ease of use and patient compliance, making it a preferred choice in many cases.

    Intravenous delivery, on the other hand, often proves essential in acute settings, providing rapid treatment response necessary for critical care. Rectal administration emerges as a notable alternative, particularly for patients unable to take medications orally, thus ensuring that treatment is accessible regardless of the patient's condition. This diversity in routes not only enhances patient care but also highlights the importance of tailored approaches in the management of Overt Hepatic Encephalopathy. As the Global Overt Hepatic Encephalopathy Market evolves, the emphasis on these various routes indicates a robust growth opportunity driven by continued advancements in medical formulations and technologies.

    The importance of strategic market growth and its associated statistics will likely continue to shape the industry's trajectory within this segment.

    Overt Hepatic Encephalopathy Market Diagnosis Method Insights

    The Global Overt Hepatic Encephalopathy Market, specifically in the context of the Diagnosis Method, is witnessing notable developments, with a market valuedat 1.74 USD Billion in 2024, growing to 2.8 USD Billion by 2035. The Diagnosis Method segment includes Clinical Assessment, Laboratory Tests, and Imaging Techniques, contributing significantly to the overall market dynamics. Clinical Assessment, which relies on patient history and neurological examination, plays a crucial role in the early identification of hepatic encephalopathy, ensuring timely intervention.

    Laboratory Tests and Imaging Techniques are also paramount in confirming diagnosis and evaluating the severity, with Laboratory Tests aiding in detecting markers related to liver function impairment, while Imaging Techniques offer visual insights into structural brain changes, enhancing diagnostic accuracy. The growing prevalence of liver diseases globally and the rising awareness about hepatic encephalopathy contribute to the increased demand for effective diagnostic methods. Furthermore, advancements in diagnostic technologies and the establishment of standardized protocols thrive on the necessity for precise diagnosis, catering to the needs of healthcare providers and patients alike.

    This growth is fueled by an increase in healthcare expenditure and a focus on improving patient outcomes within the Global Overt Hepatic Encephalopathy Market.

    Overt Hepatic Encephalopathy Market Patient Type Insights

    The Global Overt Hepatic Encephalopathy Market is projected to experience significant growth, with a valuation of 1.74 Billion USD in 2024, climbing towards 2.8 Billion USD by 2035. This market features a rich segmentation based on Patient Type, including Adults, Pediatrics, and Geriatrics. Adults represent a vital segment due to the higher prevalence of liver diseases and associated complications in this age group, making them a primary focus for healthcare initiatives. The Pediatrics segment is crucial for addressing developmental and metabolic conditions, albeit comprising a smaller portion of the market.

    Geriatrics is anticipated to gain importance as aging populations worldwide face increased risks for hepatic conditions. The trends in the Global Overt Hepatic Encephalopathy Market data reflect a growing emphasis on tailored treatment methods for each Patient Type, alongside advancements in Research and Development efforts. Growth drivers include a rise in liver disease cases and heightened awareness among healthcare providers. However, challenges such as the complexities of treatment adherence and economic barriers exist. Overall, these factors contribute to a dynamic landscape, creating opportunities for targeted interventions and innovations tailored to these distinct patient groups.

    Get more detailed insights about Overt Hepatic Encephalopathy Market

    Regional Insights

    The Global Overt Hepatic Encephalopathy Market exhibits significant regional variations, with North America holding the majority with a valuation of 0.75 USD Billion in 2024, projected to rise to 1.22 USD Billion by 2035. This region benefits from advanced healthcare infrastructure and a rise in chronic liver diseases, leading to heightened demand for effective treatments. Europe follows as a significant contributor, valued at 0.55 USD Billion in 2024 and expected to reach 0.9 USD Billion in 2035, driven by an aging population and increasing awareness of hepatic conditions.

    The Asia-Pacific (APAC) region, although smaller in comparison, shows promising growth, projected at 0.3 USD Billion in 2024 and increasing to 0.5 USD Billion in 2035, largely due to the rising prevalence of liver diseases and improving healthcare access. South America and the Middle East and Africa (MEA) regions present opportunities for growth as well, with valuations of 0.08 USD Billion and 0.06 USD Billion in 2024, respectively, indicating potential markets due to changes in lifestyle and diet.

    As the Global Overt Hepatic Encephalopathy Market evolves, regional factors, including demographic trends and healthcare advancements, will significantly influence growth trajectories across these regions.

    Overt Hepatic Encephalopathy Market Region

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    The Global Overt Hepatic Encephalopathy Market is characterized by a dynamic and competitive landscape, operating within a sector that addresses a crucial unmet medical need. The rising prevalence of liver disease, along with an increased understanding of the neurological implications of hepatic impairment, has driven innovation and strategic initiatives among key players in the market. Companies are engaged in the research and development of novel therapeutic agents aimed at mitigating the cognitive and functional decline associated with hepatic encephalopathy. 

    As the market evolves, competition intensifies, with firms leveraging advanced technologies and clinical trial outcomes to differentiate their product offerings, thereby enhancing their market share and customer retention strategies.

    Horizon Therapeutics is positioned as a strong competitor in the Global Overt Hepatic Encephalopathy Market, with a focus on its specialized product portfolio that addresses this condition effectively. The company's strengths lie in its robust pipeline of therapies designed for Hepatic Encephalopathy, backed by a dedicated research team and a sound understanding of market dynamics. Horizon Therapeutics has built a reputation for its patient-centric approach, focusing on improving treatment outcomes and enhancing the quality of life for individuals affected by liver diseases.

    This commitment is supported by strategic collaborations and partnerships that enhance its innovation capabilities, thereby solidifying its presence in the global arena.

    Pfizer has also established a significant footprint in the Global Overt Hepatic Encephalopathy Market, leveraging its expansive resources and extensive expertise in drug development. The company offers a range of therapies aimed at treating hepatic encephalopathy, backed by comprehensive clinical research that reinforces the efficacy and safety of its products. Pfizer's strengths are evident in its global reach and market presence, enhanced by a series of strategic mergers and acquisitions that have bolstered its research capabilities and expanded its product offerings. 

    As a recognized leader in the pharmaceutical sector, Pfizer aims to deliver quality care through innovative solutions while continually engaging in partnerships that align with its commitment to transforming health outcomes for patients suffering from hepatic encephalopathy.

    Key Companies in the Overt Hepatic Encephalopathy Market market include

    Industry Developments

    Recent developments in the Global Overt Hepatic Encephalopathy Market highlight increasing competition and innovation among key players such as Horizon Therapeutics, Pfizer, Salix Pharmaceuticals, Roche, AbbVie, Sobi, Gilead Sciences, Eisai, Novartis, Mylan, Teva Pharmaceuticals, Bristol Myers Squibb, Merck, AstraZeneca, and Amgen. In terms of market growth, factors such as the rising prevalence of liver diseases and advancements in treatment options are significantly contributing to the valuation of this market. For instance, in April 2023, AbbVie announced positive results from clinical trials involving its novel therapeutic approaches for hepatic encephalopathy

    Merger and acquisition activities have also shaped the landscape, with notable transactions in the past few years. In August 2022, Horizon Therapeutics acquired a promising drug candidate, enhancing its portfolio related to liver health. Additionally, the global emphasis on improving healthcare facilities has driven investments into R&D by multiple companies focused on finding better therapeutics for overt hepatic encephalopathy, fostering ongoing advancements in treatment efficacy and patient outcomes. This ongoing evolution in the market underscores the critical importance of addressing unmet needs in hepatic health worldwide.

    Future Outlook

    Overt Hepatic Encephalopathy Market Future Outlook

    The Global Overt Hepatic Encephalopathy Market is projected to grow at a 4.42% CAGR from 2024 to 2035, driven by increasing prevalence and advancements in treatment options.

    New opportunities lie in:

    • Develop innovative therapies targeting early-stage hepatic encephalopathy. Expand telehealth services for remote patient monitoring and management. Invest in educational programs to raise awareness among healthcare professionals.

    By 2035, the market is expected to demonstrate robust growth, reflecting advancements in treatment and increased awareness.

    Market Segmentation

    Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Overt Hepatic Encephalopathy Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Overt Hepatic Encephalopathy Market Patient Type Outlook

    • Adults
    • Pediatrics
    • Geriatrics

    Overt Hepatic Encephalopathy Market Treatment Type Outlook

    • Lactulose
    • Rifaximin
    • Ammonia Scavengers
    • Probiotics

    Overt Hepatic Encephalopathy Market Diagnosis Method Outlook

    • Clinical Assessment
    • Laboratory Tests
    • Imaging Techniques

    Overt Hepatic Encephalopathy Market Route of Administration Outlook

    • Oral
    • Intravenous
    • Rectal

    Report Scope

    Report Attribute/Metric Source:Details
    MARKET SIZE 20231.67(USD Billion)
    MARKET SIZE 20241.74(USD Billion)
    MARKET SIZE 20352.8(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR)4.43% (2025 - 2035)
    REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR2024
    MARKET FORECAST PERIOD2025 - 2035
    HISTORICAL DATA2019 - 2024
    MARKET FORECAST UNITSUSD Billion
    KEY COMPANIES PROFILEDHorizon Therapeutics, Pfizer, Salix Pharmaceuticals, Roche, AbbVie, Sobi, Gilead Sciences, Eisai, Novartis, Mylan, Teva Pharmaceuticals, BristolMyers Squibb, Merck, AstraZeneca, Amgen
    SEGMENTS COVEREDTreatment Type, Route of Administration, Diagnosis Method, Patient Type, Regional
    KEY MARKET OPPORTUNITIESIncreasing prevalence of liver diseases, Advancements in diagnostic technologies, Growing demand for effective therapies, Expansion of patient care programs, Rising awareness among healthcare providers
    KEY MARKET DYNAMICSRising prevalence of liver diseases, Increasing geriatric population, Growing healthcare expenditure, Advancements in drug therapies, High demand for effective treatments
    COUNTRIES COVEREDNorth America, Europe, APAC, South America, MEA

    Market Highlights

    Author
    Kinjoll Dey
    Research Analyst Level I

    He is an extremely curious individual currently working in Healthcare and Medical Devices Domain. Kinjoll is comfortably versed in data centric research backed by healthcare educational background. He leverages extensive data mining and analytics tools such as Primary and Secondary Research, Statistical Analysis, Machine Learning, Data Modelling. His key role also involves Technical Sales Support, Client Interaction and Project management within the Healthcare team. Lastly, he showcases extensive affinity towards learning new skills and remain fascinated in implementing them.

    Leave a Comment

    FAQs

    What is the projected market size of the Global Overt Hepatic Encephalopathy Market in 2024?

    The Global Overt Hepatic Encephalopathy Market is expected to be valued at 1.74 USD Billion in 2024.

    What is the expected market size for the Global Overt Hepatic Encephalopathy Market by 2035?

    By 2035, the Global Overt Hepatic Encephalopathy Market is anticipated to reach a value of 2.8 USD Billion.

    What is the expected CAGR for the Global Overt Hepatic Encephalopathy Market from 2025 to 2035?

    The market is expected to grow at a CAGR of 4.43% during the forecast period from 2025 to 2035.

    Which region is projected to dominate the Global Overt Hepatic Encephalopathy Market in 2024?

    North America is projected to dominate the market with a valuation of 0.75 USD Billion in 2024.

    What will be the market size for Rifaximin in 2035?

    The market size for Rifaximin is expected to be valued at 1.02 USD Billion by 2035.

    Which major players are involved in the Global Overt Hepatic Encephalopathy Market?

    Key players in the market include Horizon Therapeutics, Pfizer, and AbbVie, among others.

    What will the Lactulose market be valued at in 2035?

    The Lactulose segment is projected to be valued at 1.32 USD Billion in 2035.

    How much is the Overt Hepatic Encephalopathy Market in Europe expected to be valued in 2024?

    The European market for Overt Hepatic Encephalopathy is expected to be valued at 0.55 USD Billion in 2024.

    What is the anticipated market size for Ammonia Scavengers in 2035?

    The market for Ammonia Scavengers is expected to reach 0.29 USD Billion by 2035.

    What is the expected market value in the APAC region by 2035?

    The APAC region is projected to be valued at 0.5 USD Billion in 2035.

    Download Free Sample

    Kindly complete the form below to receive a free sample of this Report

    Case Study
    Chemicals and Materials