Chromatography Reagents Market Research Report—Global Forecast till 2027

Chromatography Reagents Market Research Report Information by Type (Solvents, Buffers, Derivatization Reagents, Ion-Pair Reagents), by Technology (Gas Chromatography {GC}Reagents, Liquid Chromatography {LC}Reagents, Supercritical Fluid Chromatography {SFC}Reagents, Thin Layer Chromatography {TLC}Reagents), by Separation Mechanism (Adsorption Chromatography, Partition Chromatography, Ion-Exchange Chromatography, Size-Exclusion Chromatography, Affinity Chromatography) and by Region (North America, Europe, Asia-Pacific, and Rest of the World)—

ID: MRFR/HC/7695-HCR | 150 Pages | Author: Kinjoll Dey | June 2023         

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Chromatography Reagents Market

Chromatography Reagents Market is expected to reach USD 10,494 million by 2027 at a CAGR of 6.8% during the forecast period of 2021 to 2027.

By Type Solvents Buffers Derivatization Reagents Ion-Pair Reagents
By Technology Gas Chromatography Reagents Liquid Chromatography Reagents Supercritical Fluid Chromatography Reagents Thin Layer Chromatography Reagents
By Separation Mechanism Adsorption Chromatography Partition Chromatography Ion-Exchange Chromatography Size-Exclusion Chromatography Affinity Chromatography
Key Players
Companies Profiled   Agilent Technologies Inc. (US)   Avantor (US)   Bio-Rad Laboratories Inc. (US)   Chiron AS (Norway)   Cytiva (US)   GFS Chemicals Inc (US)   Kanto Chemical (Japan)   Loba Chemie Pvt. Ltd (India)   Merck KGaA (Germany)   Regis Technologies Inc. (US)
Market Driving Forces   Rising applications of chromatography reagents for drug development in oncology   Increasing number of awards and funding
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Chromatography Reagents Market Overview

The chromatography reagents market is expected to cross USD 10,494 million by 2027 at a CAGR of 6.8% during the forecast period of 2021 to 2027. Chromatography reagents include solvents, buffers, derivatization reagents, ion-pair reagents, and other reagents.The increasing demand for chromatography reagents by researchers, biopharmaceutical companies, and contract manufacturing organizations is expected to generate steady growth for the global chromatography reagents market. Moreover, an increasing number of academic and research institutes focused on consuming chromatography reagents are anticipated to increase the global chromatography reagents market size during the forecast period.

COVID-19 Analysis

The growing utilization of chromatography in drug development and omics research is projected to influence market growth over the forecast period. Chromatographic methods are widely utilized for the separation and isolation of bioactive constituents having medicinal value. For example, a research paper cited in 2021 mentioned Waters Corporation (US) usedpaired chromatography-mass spectrometry method to gain threefold gradient peak capacity alongside a better resolution of the less abundant proteoforms. This study modifiedthe chromatographic method and analytical data on structural elements of the Sars-CoV-2 virus aided in developing improved therapeutics and vaccines. According to the WHO's COVID-19 vaccine tracker, there are 108 vaccines in clinical development and 184 in pre-clinical development as of 20th July 2021. According to the WHO Coronavirus (COVID-19) Dashboard, there have been 191.7 million confirmed cases of COVID-19 and a total of 3,568.8 million vaccine doses administered as of 20th July 2021. An increasing number of administration of doses and a large number of confirmed cases will increase the demand for chromatography reagents to develop effective vaccines during the forecast period.

Limited availability of rapid antigen tests and reagents required for Reverse Transcription Polymerase Chain reaction (RT-PCR) test is expected to increase the number of alternate modes of diagnostics globally. For example, an article published in The Indian Journal of Medical Research in October 2020 evaluated the performance of a rapid chromatographic immunoassay-based test compared with a clinical reference standard. Similarly, a research paper published in the Journal of Medical Virologyduring November 2020 assessed the diagnostic performance of immunochromatography assay for rapid detection of IgM and IgG in coronavirus disease. The application of chromatography-based diagnostic tests isanticipated to exponentially increase the demand for chromatography reagents during the forecast period.

Many companies ceased their manufacturing and supply operations in the early phase of the pandemic. However, the existing situation of COVID-19 is expected to become normal since the medical professionals and health authorities in various countries are taking the necessary steps to fight against the virus.

Market Drivers

  • Rising applications of chromatography reagents for drug development in oncology

    • Therapeutic drug monitoring and dose adjustment of drugs are beneficial in treating various cancer. For example, a research paper published in 2020 in Therapeutic Drug Monitoring aimed to validate a high-performance liquid chromatography (HPLC) method for routine serum lenvatinib detection in patients with thyroid cancer.A high number of methods are being developed by researchers based on various chromatographic techniques increasing the demand for chromatography reagents

    • Similarly, a clinical study published in Biomedical Chromatography during 2020 assessed various bioanalytical methods used for immuno-oncology drugs in cancer therapy. The most commonly used methods according to this study were HPLC and Liquid Chromatography-Mass Spectrometry (LC-MS).A higher frequency of chromatography-based techniques for quantitative analysis of drugs used for cancer is expected to propel the chromatography reagents market growth. Moreover, an increasing number of cancer patients is expected to support this growth. National Cancer Institute estimated 1,806,590 new cases of cancer in the US for 2020, while an estimated 16.9 million cancer survivors in the US.

  • Increasing number of awards, grants, scholarships, and funding for chromatography research

Market Restraints

  • Shortage of supplies and reagents

    • Helium is widely utilized as the carrier gas for gas chromatography. Its applications include deep-sea diving, airbags, cryogenics, rocket fuel, and MRI machines.It is the gold standard for gas chromatography as it is safe, inert, and provides optimal run times for gas chromatography. The helium shortage, which startedin 2019 globally, can impede the growth of the chromatography reagents market. Owing to this,severalgas chromatography professionals are switching to hydrogen gas using a hydrogen generator as their carrier gas supply.

    • The commonly used organic solvents for mobile phases in reverse chromatography are probably acetonitrile and methanol. The analytical industry experienceda severeacetonitrile shortage during the first half of 2020. Waters Corporation (US) has recommended replacing traditional high-performance HPLC with Waters ACQUITY UltraPerformance LC,which reduces acetonitrile consumption by at least 70%. The shortage of necessary supplies is anticipated to curb the growth of the chromatography reagents market.

Market Opportunities

  • Growing applications of chromatography

Chromatography is one of the most preferred separation techniques in various industries. The suppliers and manufacturers of chromatography reagents can capitalize on the opportunities created by various governmental agencies for environmental testing and petrochemical analysis. Manufacturers can sign long-term contracts with academic & research institutes for steady generation of revenue. Moreover, the development of supplies in shortage provides an opportunity for researchers. Additionally, the application of chromatography for drug development and purification is increasing the lucrativeness of the chromatography reagents market.

  • Value Chain Analysis

The global chromatography reagents market is estimated to exhibit considerable growth during the forecast period, which can be credited to factors such as a rise in the per capita disposable income and rapid technological advancements in chromatography.Moreover, other factors include the availability of research funding, along with an increasing number of researchers developing chromatography reagents-based novel techniques for unit operations. The value chain analysis for the chromatography reagentsindustry comprises four major components,starting with the R&D of product, followed by the product manufacturing, distribution, and ends with post-marketing surveillance.

Segment Overview

By Type

  • Solvents

Solvents was the fastest-growing segment in 2020 dueto its need for research and clinical purpose. They are used to help separate components of a mixture.Acetic acid, methanol, acetone, and ethyl alcoholare some of the most frequently utilized solvents.

  • Buffers

Buffers are solutions formed by combining a weak acid and its conjugate base or a weak base and its conjugate acid. In analytical chemistry, buffers are typically used in reversed-phase high performance liquid chromatography when the sample contains acidic or basic functional groups.Buffers areimportant for their property of maintaining pH and analyzing ionizable analytes.

  • Derivatization Reagents

The derivatization technique is used to reduce the polarity of amines and modify their characteristic. Derivatization reagents are used to modify compounds, which are then analyzed using gas chromatography and HPLC.

  • Ion-Pair Reagents

The separation of organic ions and partly ionized analytes is aided with ion-pair reagents as mobile phase additives.The addition of ion-pair reagents promotesthe formation of ionpairs with ionic analytes in the sample to modulate the retention of the ionic analytes.

By Technology

  • Gas Chromatography Reagents

Gas chromatography is mostly used when the mixture's chemical components are volatile and thermally stable. GC reagents have applications in various industries from research to manufacturing, including chemical, pharmaceutical, food & beverage, and space research.

  • Liquid Chromatography Reagents

The solvents are in the mobile phasein liquid chromatography. The identification and quantification of food compositions, pharmaceuticals, and other bioactive moleculesare gaining wide application in analytical laboratories. The reagents used for HPLC analysisare most important for increasing and decreasing retention time.

  • Supercritical Fluid Chromatography Reagents

Supercritical fluid chromatography uses a supercritical fluid such as supercritical carbon dioxide as the mobile phase in the food industry.Supercritical fluid chromatography reagent is used in a state above the critical temperature and critical pressure where gases and liquids can coexist.The lower viscosity of supercritical fluids makes SFC a faster method than HPLC.

  • Thin-Layer Chromatography Reagents

Thin-layer chromatography reagents are mostly used in organic chemistry laboratory because it gives quick information about the purity of a sample. These reagents are useful to detect a particular compound present in mixture or monitoring reactions. The analysis is done using a sheet of an inert substrate coated with a thin layer of adsorbent material.

By Separation Mechanism 

  • Adsorption Chromatography

Adsorption is one of the oldest types of chromatography in which separation occurs based on adsorption. It makes use of a mobile phase, either in liquid or gaseous form, which is adsorbed onto the surface of a stationary solid phase.

  • Partition Chromatography

Partition chromatography is based on the differential partitioning of components of a sample mixture between two phases – stationary phase and mobile phase. This technique is mainly used to separate the components present in the mixture into two liquid phases.

  • Ion-Exchange Chromatography

In ion exchange chromatography technique, commonly biomolecule purification is done. In this method, the separation of molecules happens on the basis of their charge. For example, separating proteins with different charges is done using this technique.

  • Size-Exclusion Chromatography

Size-exclusion chromatography is a method in which the analytes are separated by size and/or structure. It is used in the separation of natural as well as synthetic polymers, biopolymers, proteins, and nanoparticles. The smaller the molecules, the later they are eluted from the chromatography column.

  • Affinity Chromatography

Affinity chromatography involves the separation of molecules in solution based on differences in binding interaction with a ligand that is immobilized to a stationary material. It is used to separate and purify biological molecules from a mixture.

By Application

  • Pharmaceutical Testing

Pharmaceutical companies use chromatography to prepare large quantities of extremely pure materials and analyze the purified compounds for trace contaminants. The rising use of chromatography in the pharmaceutical industry is for the separation of chiral compounds.

  • Biopharma-Biotech Applications

Separating a specific amino acid, protein, or other biomolecules from a sample is one of the applications of chromatography reagents to the biotechnology industry. Assessing yield, cost, and purity of products such as inulin, growth hormone, interferons, erythropoietin, and others is important in this industry.

  • Research & Academic Applications

Research & academic institutes mostly consume chromatography reagents for educational purposes or develop new separation techniquesona pilot scale. The growingnumber of research organizations may contribute to the growth of this segment.

  • Food & Beverage Testing

In beverage testing, chromatographic methods are employed to assess the sugar level and separation of caffeine from drinks. Similarly, food companies identify components such as flavors, colorants, additives, and preservatives in food.

  • Clinical Testing

Therapeutic drug monitoring, toxicology, and doping analyses are the major applications of fast chromatography in clinical applications. Diagnostic laboratories use chromatography reagents for the diagnosis of human metabolic disorders.

  • Others

Other applications of chromatography includecosmeceutical applications, forensic testing, environmental testing, petrochemical analysis, and others.

By Region

  • North America:

The North American market accounted for the market largest share in 2020 due to the presence of major key players,favorable government regulations, and increasing research expenditure by the countries in the region. The presence of severalresearch institutes is expected to support the market growth globally.

  • Europe:

The European chromatography reagents market is driven byincreasing government initiatives and the large availability of research grants. The growing advancementsin products, increasing number of research activities, and support for infrastructural development from governmental agencies required for research areprojected to drivethe size of the chromatography reagents market in the region.

  • Asia-Pacific:

The rapid growth of the Asia-Pacific market is due to the rising number of contract research and manufacturing companies, developing infrastructure,and an increase in the number of academic institutes.

  • Rest of the World:

The Rest of the World regionis segmented into the Middle East, Africa, and Latin America. The chromatography reagents marketin the region is driven by technological developmentsand the growing number of research studies.

Competitive Landscape

The global chromatography reagents market is characterized by the presence of many global, regional, and local vendors catering to the demand created by research scientists and pharmaceutical and biotechnology companies operating in the industry.The growing demand from researchers and manufacturers is propelling the chromatography reagents market growth. The market is highly competitive, with players competing and partnering to gain a substantial market share. For instance, in January 2021, Sartorius (France) acquiredNovasep's(France) chromatography process equipment division.The prominent players are involved in strategic agreements and joint ventures to sustain their market positions.

Key Players

  • Agilent Technologies, Inc. (US)

  • Avantor (US)

  • Bio-Rad Laboratories, Inc. (US)

  • Chiron AS (Norway)

  • Cytiva (US)

  • GFS Chemicals Inc (US)

  • Kanto Chemical (Japan)

  • Loba Chemie Pvt. Ltd (India)

  • Merck KGaA (Germany)

  • Regis Technologies, Inc. (US)

  • Restek (US)

  • Santa Cruz Biotechnology (US)

  • Spectrum Chemical Mfg. Corp. (US)

  • Thermo Fisher Scientific (US)

  • Tosoh Bioscience (Japan)

  • Waters Corporation (US)

Recent Developments

  • In 2019, CARLO ERBA Reagents (Italy), a producer of solvents for chromatography,extended its range of solvents for GC to meet the increasing demand from researchers for detection methods. CARLO ERBA Reagents offers a specific range of products dedicated to the GC-MS application with very high purity.

Report Overview:

The study covers the existing short-term and long-term market effects, as well as helping decision-makers to draught short-term and long-term plans for businesses by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's Five Forces, Value Chain, and impact of COVID-19 on the market.

The scope of the global chromatography reagents market study includes market size analysis and a detailed analysis of the manufacturer's products and strategies. The market has been segmented based on bank type, cell type, application, and region.

Market Segmentation

Global Chromatography Reagents Market, by Type

  • Solvents

  • Buffers

  • Derivatization Reagents

  • Ion-Pair Reagents

  • Other

Global Chromatography Reagents Market, by Technology

  • Gas Chromatography Reagents

  • Liquid Chromatography Reagents

  • Supercritical Fluid Chromatography Reagents

  • Thin Layer Chromatography Reagents

  • Others

Global Chromatography Reagents Market, by Separation Mechanism

  • Adsorption Chromatography

  • Partition Chromatography

  • Ion-Exchange Chromatography

  • Size-Exclusion Chromatography

  • Affinity Chromatography

  • Others

Global Chromatography Reagents Market, by Application

  • Pharmaceutical Testing

  • Biopharma-Biotech Applications

  • Research & Academic Applications

  • Food & Beverage Testing

  • Clinical Testing

  • Others

Global Chromatography Reagents Market, by Region

  • North America

    • US

    • Canada

  • Europe

    • Germany

    • France

    • UK

    • Italy

    • Spain

    • Rest of Europe

  • Asia-Pacific

    • China

    • Japan

    • India

    • Australia

    • South Korea

    • Rest of Asia-Pacific

  • Rest of the World

    • Middle East

    • Africa

    • Latin America

Report Scope:

Report Attribute/Metric Details
  Market Size   2027: ~USD 10,494 Million
  CAGR   ~6.8%
  Base Year   2020
  Forecast Period   2021-2027
  Historical Data   2018 & 2019
  Forecast Units   Value (USD Million)
  Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Type, Technology, Separation Mechanism, Application
  Geographies Covered   North America, Europe, AsNorth America, Europe, Asia-Pacific, Rest of the Worldia-Pacific, Rest of the World
  Key Vendors   • Agilent Technologies, Inc. (US) • Avantor (US) • Bio-Rad Laboratories, Inc. (US) • Chiron AS (Norway) • Cytiva (US) • GFS Chemicals Inc (US) • Kanto Chemical (Japan) • Loba Chemie Pvt. Ltd. (India) • Merck KGaA (Germany) • Regis Technologies, Inc. (US) • Restek (US) • Santa Cruz Biotechnology (US) • Spectrum Chemical Mfg. Corp. (US) • Thermo Fisher Scientific (US) • Tosoh Bioscience (Japan) • Waters Corporation (US)
  Key Market Opportunities   Development of cell banks in developing countries
  Key Market Drivers   • Growing utilization of chromatography in drug development • Rising number of strategic decisions by manufacturers

Key Questions Answered

  • ✅ Global Market Outlook
  • ✅ In-depth analysis of global and regional trends
  • ✅ Analyze and identify the major players in the market, their market share, key developments, etc.
  • ✅ To understand the capability of the major players based on products offered, financials, and strategies.
  • ✅ Identify disrupting products, companies, and trends.
  • ✅ To identify opportunities in the market.
  • ✅ Analyze the key challenges in the market.
  • ✅ Analyze the regional penetration of players, products, and services in the market.
  • ✅ Comparison of major players’ financial performance.
  • ✅ Evaluate strategies adopted by major players.
  • ✅ Recommendations
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