The Global Preparative and Process Chromatography Market size is projected to be worth ~USD 9,904 million and registering a CAGR of ~6.8% during the forecast period 2021 - 2027
Preparative and Process Chromatography Market Forecast
The global preparative and process chromatography market size is projected to be worth ~USD 9,904 million by 2027, registering a CAGR of ~6.8% during the forecast period (2021 - 2027)
Chromatography is a process that involves the separation of a mixture into its components, carried by a mobile phase through a stationary phase.The separation between the components takes place based on their interaction with the two phases. Preparative and process chromatography are two applications of chromatography used at different stages of downstream processing of products. The preparative and process chromatography market has been segmented based on type, product, chromatography type, and end user. The market is driven by factors like the wide applications of chromatography and rising R&D initiatives for novel therapeutics. However, the high costs of chromatography instruments could hamper the growth of thepreparative and process chromatography market.
Due to the COVID-19 pandemic, drug discovery and research efforts have intensified, adding pressure on the healthcare industry. Although the initial impact of the pandemic was negative due to its impact on supply chains and workforces, the increase in demand for novel therapeutics has overall positively impacted the demand of the preparative and process chromatography market.
The pandemic has also increased the collaboration rate among players and government initiatives to support the development of treatments and vaccines for COVID-19.The market is expected to show additional growth due to the increasing use of chromatography techniques in the R&D and production of drugs and vaccines. For instance, Immunoaffinity Chromatography (IAC), a type of process chromatography, is used to filter and purify vaccines. Therefore, the COVID-19 impact has been positive for the preparative and process chromatography market.
Value Chain Analysis
The global preparative and process chromatography market is projected to exhibit significant growth over the forecast period, which can be attributed to factors such as the various applications of chromatography and increasing R&D initiatives. The value chain analysis for the market comprises five major components, which start with research & product development, followed by the manufacturing of the products, distribution & sales, and ends with post-marketing surveillance.
Process chromatography is a scalable Good Manufacturing Practice (GMP) compliant manufacturing approach for producing biotherapeutics by separating biomolecules from feedstock or slurry. Biosimilars,gene therapies, bio-betters, vaccinations, and other molecules are processed and benefit from this purification method. It is a cost-effective and efficient purification method that allows for high purity and yield. Furthermore, process chromatography can be modified tomeet the customer needs such as automation, scalability, and availabilityin single and batch modes, further increasing demand for the segment.
Process chromatography held the largest share in the market in 2020 due to its wide applications in product purification and process scale-up capabilities for large-scale product manufacturing purposes.
Preparative or purification chromatography is described as the process of isolating a chemical in sufficient amount and purity for additional tests or procedures employing chromatography.The use of preparative methods for the purification of highly valuable substances and APIs has acquired widespread popularity, with major drivers being increased throughput, cost-effectiveness, and purity. These methods provide users with enough material volume at the appropriate quality to begin clinical and preclinical studies at purity levels of 95% or higher. These methods are known to be highly precise and give accurate results.
Chemicals and reagents play a very important role in the preparative and process chromatography methods, as chemicals and reagents create the environment required to achieve the desired purification and results. Chemicals and reagents are used for various purposes in chromatography, including visualization of components, establishing polarity of the mobile phase, adjusting pH, system cleaning, and calibration.
Chromatography resins are major components of chromatographic techniques. They aid in the isolation of the target components from the mixture sample. Additionally, resins have a variety of end uses in different types of chromatography, including size exclusion, affinity, hydrophobic interaction, ionexchange, and multi-mode chromatography techniques. Furthermore, they are utilized in different industrial applications such as food testing, environmental testing, biomolecule separation, and diagnostic testing, which increases their demand.
Resins are further segmented into affinity resins, ion-exchange resins, size-exclusion resins, reversed-phase, protein A resins, hydrophobic interaction resins, and mixed-mode/multi-mode resins.
Preparative and process chromatography columns are the containers that hold the stationary phase and through which the mobile phase containing the mixture flows. The proper selection, packing, and validation of columns are essential for the proper purification of the analytes. New product launches in this segment are also driving growth for the segment. For instance, in March 2019, KNAUER WissenschaftlicheGeräte GmbH (Germany) had launched new protein purification liquid chromatography columns for efficient affinity, size-exclusion, and ion-exchange (IEX) chromatography.
Columns are further segmented into pre-packed columns and empty columns.The columns segment held the highest share in 2020 due to its dynamic use in different applications of chromatography and as itforms a crucial component for the majority of chromatography processes.
Chromatography systems are all-inclusive systems that possess all the equipment required for sample separationsoftware and are automated in nature.Chromatography systems provide several benefits such as automation, higher result accuracy, efficient data analysis, and faster turnaround times. However,they are generally more expensive and are mostly utilized by mid- and large-sized organizations.Different types of chromatography systems are available to cater to the needs of researchers and specific purposes.
Systems are further segmented into single-use batch chromatography systems, multi-use batch chromatography systems, continuous chromatography systems, and others.
By Chromatography Type
Liquid chromatography (LC) uses a solid stationary phase to separate molecules in a liquid mobile phase. Liquid chromatography is a technique that can be used for both analytical and preparative purposes. This segment is driven by new product launches made by the key players in the market. For instance, in February 2021, Thermo Fisher Scientific (US) launched its new Vanquish Online 2D-Liquid Chromatography (LC) system, which offers multidimensional chromatography.
The liquid chromatography segment has been sub-segmented into HPLC, flash chromatography, ion-exchange chromatography, size-exclusion chromatography, and affinity chromatography. This segment also held the largest market share in 2020, owing to its varied applications and high demandfor analytical processes.
Gas chromatography (GC) is a method for analyzing gas, liquid, and solid sample mixture containing the analyte. The major difference between LC and GC is that here the mobile phase is in the gaseous state called the carrier gas, while in LC, the mobile phase is a liquid. GC has several applications in the food, pharmaceutical, and forensics industries.
Other chromatography types include hydrophobic interaction chromatography, paper chromatography, thin-layer chromatography, and size-exclusion chromatography.
By End User
The biotechnology and pharmaceutical industries segment held the highest market share in 2020 due to factors like increasing R&D activities and funding. According to a report published bythe International Federation of Pharmaceutical Manufacturers & Associations (IFPMA), in 2021, global biopharmaceutical R&D Spending is expected to reach USD 213 billion by 2024 with a CAGR of 3%. This will, in turn, supplement the growth of the market.
Chromatography is utilized in the food and beverage businesses to separate and analyze additives, preservatives, vitamins, proteins, and amino acids and for the6 quality control of food &beverageproducts. For instance, Aflatoxin, a cancer-causing chemical generated by a mold on peanuts, may also be separated and detected through chromatography. The demand for chromatography methods is further supplemented by growing food safety concerns driving growth for this segment.
Preparative and process chromatography techniques are used extensively in academic research laboratories for various research purposes that require the separation or purification of products. In recent years, the use of chromatography for studying metabolomics has increased in demand in research labs, propelling growth for the market.
Other end users include forensics, nutraceutical industry, cosmetics industry, oil and gas industry, and environmental biotechnology industry. In forensics,gas chromatography is used to determine if a deceased individual had taken any alcohol or not, and liquid chromatography is used to detect and quantify different drugs.
The preparative and process chromatography market based on the region has been segmented into North America, Europe, Asia-Pacific, and the Rest of the World.
The presence of key players, rising prevalence of NCDs, and increasing R&D initiativesfor novel therapeutics arefueling the growth ofthe North Americapreparative and process chromatography market.
The North American region, comprisingthe US and Canada, held the largest market share in 2020. This is due to factors such as developed healthcare infrastructure and key players in the region driving growth through new product launches, expansion, and acquisitions. For instance, in June 2019, Agilent Technologies (US) launched its intelligent LC/MS system that has a specialized mass selective detector.Furthermore, the rising cases of non-communicable diseases (NCDs) in the region are increasing demand for more effective therapeutics that supplement growth for the preparative and process chromatography market. According to the American Cancer Society, in 2020, an estimated 1.8 million new cases of cancer were diagnosed and 606,520 cancer deaths were recorded.
Improving healthcare infrastructure, high prevalence of chronic diseases, and rising R&D expenditure are anticipated to drive the market growth in the region.
The Asia-Pacific region is expected to show the highest CAGR during the forecast period. This is due to factors like the presence of emerging economies and improving healthcare infrastructure, making the utilization of chromatography processes more feasible and accessible. Moreover, this is supplemented by the increasing R&D expenditure in the region. For instance, according to the American Association for the Advancement of Science (AAAS),in March 2021, China is expected to cross the US and become the global leader in R&D spending, with its R&D spending increasing by 13% compared to 8% of US in 2019. Additionally, key players are expanding operations in this region, further providing growth for the market. For instance, in January 2018, Danaher (US) announced that it would invest USD 100 million over three years to expand its operations in India, primarily through acquisitions.
The industry players are adopting several business strategies to increase their market presence. They are significantly investing in R&D activities to expand their product portfolio, further driving the preparative and process chromatography market. In addition, the market players are adopting several strategic initiatives such as new product launches,contractual agreements,mergers and acquisitions, increasing investments, and partnering with other players to expand their global footprint.
Thermo Fisher Scientific (US) is one of the key market players, founded in 1956. The company specializes in various biotechnology products such as analytical instruments, laboratory equipment, lab services, specialty diagnostics, and others. They possess a diverse product portfolio of chromatography instruments and consumables, including HPLC, GC systems, UHPLC, and ion chromatography columns. In August 2021, the company collaborated with ChromSword (Latvia) to launch its new automated HPCL and UHPLC system called the Vanquish Method Development HPLC and UHPLC system.
List of companies covered in this report:
The study covers the existing short-term and long-term market effects. It helps decision-makers to draught short-term and long-term business plans by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's five forces, value chain, and impact of COVID-19 on the market.
Global Preparative and Process Chromatography Market, By Type
Global Preparative and Process Chromatography Market, By Product
Global Preparative and Process Chromatography Market, By Chromatography Type
Global Preparative and Process Chromatography Market, By End User
Global Preparative and Process Chromatography Market, By Region
|Market Size||2027:~USD 9,904 Million|
|Forecast Units||Value (USD Million)|
|Report Coverage||Revenue Forecast, Competitive Landscape, Growth Factors, and Trends|
|Segments Covered||Type,Product, Chromatography Type, and End User|
|Geographies Covered||North America, Europe, Asia-Pacific, and Rest of the World|
|Key Vendors||Merck KGaA (Germany), Danaher Corporation (US), Bio-Rad Laboratories (US), Thermo Fisher Scientific (US), Shimadzu Corporation (Japan), Daicel Corporation (Japan), Waters Corporation (US), Agilent Technologies (US), Novasep Holding S.A.S (France), and PerkinElmer Inc. (US)|
|Key Market Opportunities||• Rise in demand for monoclonal antibodies • Emerging markets for chromatography|
|Key Market Drivers||• Variety in the application of chromatography • Rising R&D initiativesfor novel therapeutics • Growing food safety concerns|
preparative and process chromatography market size is projected to be worth ~USD 9,904 million by 2027, registering a CAGR of ~6.8% during the forecast period (2021 - 2027)
Merck KGaA (Germany), Danaher Corporation (US), Bio-Rad Laboratories (US), Thermo Fisher Scientific (US), Shimadzu Corporation (Japan), Daicel Corporation (Japan), Waters Corporation (US), Agilent Technologies (US), Novasep Holding S.A.S (France), and PerkinElmer Inc. (US) are the key players in the market of preparative and process chromatography
North America is predicted to lead the market of preparative and process chromatography
Variety in the application of chromatography and Rising R&D initiativesfor novel therapeutics are the major market driver of preparative and process chromatography
High cost of instruments and Preparative liquid chromatography associated challenges may limit the market growth of preparative and process chromatography