Preparative and Process Chromatography Market Research Report: Information by Type (Process and Preparative Chromatography), by Product (Chemicals & Reagents, Resins [Affinity Resins, Ion-Exchange Resins, Size-exclusion Resins, Reversed Phase, Protein A Resins, Hydrophobic Interaction Resins, Mixed-Mode/Multimode Resins], Columns [Pre-packed and Empty Columns], Systems [Single-use Batch Chromatography Systems, Multi-use Batch Chromatography Systems, Continuous Chromatography Systems]), by Chromatography Type (Liquid andGas Chromatography),

Preparative and Process Chromatography Market Forecast

The global preparative and process chromatography market size is projected to be worth ~USD 9,904 million by 2027, registering a CAGR of ~6.8% during the forecast period (2021 - 2027)

Chromatography is a process that involves the separation of a mixture into its components, carried by a mobile phase through a stationary phase.The separation between the components takes place based on their interaction with the two phases. Preparative and process chromatography are two applications of chromatography used at different stages of downstream processing of products. The preparative and process chromatography market has been segmented based on type, product, chromatography type, and end user. The market is driven by factors like the wide applications of chromatography and rising R&D initiatives for novel therapeutics. However, the high costs of chromatography instruments could hamper the growth of thepreparative and process chromatography market.

COVID-19 Analysis

Due to the COVID-19 pandemic, drug discovery and research efforts have intensified, adding pressure on the healthcare industry. Although the initial impact of the pandemic was negative due to its impact on supply chains and workforces, the increase in demand for novel therapeutics has overall positively impacted the demand of the preparative and process chromatography market.

The pandemic has also increased the collaboration rate among players and government initiatives to support the development of treatments and vaccines for COVID-19.The market is expected to show additional growth due to the increasing use of chromatography techniques in the R&D and production of drugs and vaccines. For instance, Immunoaffinity Chromatography (IAC), a type of process chromatography, is used to filter and purify vaccines. Therefore, the COVID-19 impact has been positive for the preparative and process chromatography market.

Market Dynamics

Drivers

• 
  Usage of chromatography in various applications
  
  
  
  • The variety of applications of chromatography is the major growth driver for the preparative and process chromatography market. Chromatography is used for several purposes including, product separations, purification, forensics, food & beverage testing, and environmental testing, across different industries, which boosts the demand for the market.
  
  
  • Additionally, technological advancements enable the use of chromatographic techniques in more applications, further driving growth for the market. Some developments in recent times include the development of ultrahigh performance/pressure liquid chromatography (UHPLC) and its use in pharmaceuticals and forensics. Moreover, the application of Liquid Chromatography-mass Spectrometry (LC-MS) and Gas Chromatography-mass Spectrometry (GC-MS) in proteomics and metabolomics studies is also driving demand for the market.
  
  
  
  

• Rising R&D initiatives for novel therapeutics


• Growing food safety concerns

Market Opportunities

• 
  Rise in demand for monoclonal antibodies
  
  
  
  • The rising incidence of cancer, demand for personalized medicine, and increasing product approvals are driving demand for monoclonal antibodies. Furthermore, the recent COVID-19 pandemic has led to the approval of several monoclonal antibody therapies. For instance, in February 2021, FDA gave emergency use authorization for the combination of bamlanivimab and etesevimab made by Eli Lilly and Company (US) for COVID-19 treatment.
  
  
  • Different preparative and process chromatography steps are utilized during the purification of monoclonal antibodies. Chromatography plays an important role in the separation of target monoclonal antibodies and Host Cell Proteins (HCP) impurities present in the sample. Hence, the increase in their demand will propel growth for the preparative and process chromatography market in the future.
  
  
  
  

• Emerging markets for chromatography

Market Restraints

• 
  High cost of instruments
  
  
  
  • The high costs of chromatography systems and their components may hamper the growth of the preparative and process chromatography market as purchasing them might be difficult for small- and medium-sized organizations as well as academic institutes. Furthermore, companies generally need to obtain several chromatography setupsto achieve efficient throughput and productivity, which further adds to the costs.
  
  
  • The cost of maintaining the systems to function as intended further adds to the costs. Apart from this, the organizations must invest in hiring skilled professionals who can operate the systems efficiently. Lack of such skilled labor in the market can thwart market growth.
  
  
  
  

• Preparative liquid chromatography associated challenges

Value Chain Analysis

The global preparative and process chromatography market is projected to exhibit significant growth over the forecast period, which can be attributed to factors such as the various applications of chromatography and increasing R&D initiatives. The value chain analysis for the market comprises five major components, which start with research & product development, followed by the manufacturing of the products, distribution & sales, and ends with post-marketing surveillance.

Segment Overview

By Type

• Process Chromatography

Process chromatography is a scalable Good Manufacturing Practice (GMP) compliant manufacturing approach for producing biotherapeutics by separating biomolecules from feedstock or slurry. Biosimilars,gene therapies, bio-betters, vaccinations, and other molecules are processed and benefit from this purification method. It is a cost-effective and efficient purification method that allows for high purity and yield. Furthermore, process chromatography can be modified tomeet the customer needs such as automation, scalability, and availabilityin single and batch modes, further increasing demand for the segment.

Process chromatography held the largest share in the market in 2020 due to its wide applications in product purification and process scale-up capabilities for large-scale product manufacturing purposes.

• Preparative Chromatography

Preparative or purification chromatography is described as the process of isolating a chemical in sufficient amount and purity for additional tests or procedures employing chromatography.The use of preparative methods for the purification of highly valuable substances and APIs has acquired widespread popularity, with major drivers being increased throughput, cost-effectiveness, and purity. These methods provide users with enough material volume at the appropriate quality to begin clinical and preclinical studies at purity levels of 95% or higher.  These methods are known to be highly precise and give accurate results.

By Product

• Chemicals & Reagents

Chemicals and reagents play a very important role in the preparative and process chromatography methods, as chemicals and reagents create the environment required to achieve the desired purification and results. Chemicals and reagents are used for various purposes in chromatography, including visualization of components, establishing polarity of the mobile phase, adjusting pH, system cleaning, and calibration.

• Resins

Chromatography resins are major components of chromatographic techniques. They aid in the isolation of the target components from the mixture sample. Additionally, resins have a variety of end uses in different types of chromatography, including size exclusion, affinity, hydrophobic interaction, ionexchange, and multi-mode chromatography techniques. Furthermore, they are utilized in different industrial applications such as food testing, environmental testing, biomolecule separation, and diagnostic testing, which increases their demand.

Resins are further segmented into affinity resins, ion-exchange resins, size-exclusion resins, reversed-phase, protein A resins, hydrophobic interaction resins, and mixed-mode/multi-mode resins.

• Columns

Preparative and process chromatography columns are the containers that hold the stationary phase and through which the mobile phase containing the mixture flows. The proper selection, packing, and validation of columns are essential for the proper purification of the analytes. New product launches in this segment are also driving growth for the segment. For instance, in March 2019, KNAUER WissenschaftlicheGeräte GmbH (Germany) had launched new protein purification liquid chromatography columns for efficient affinity, size-exclusion, and ion-exchange (IEX) chromatography.

Columns are further segmented into pre-packed columns and empty columns.The columns segment held the highest share in 2020 due to its dynamic use in different applications of chromatography and as itforms a crucial component for the majority of chromatography processes.

• Systems

Chromatography systems are all-inclusive systems that possess all the equipment required for sample separationsoftware and are automated in nature.Chromatography systems provide several benefits such as automation, higher result accuracy, efficient data analysis, and faster turnaround times. However,they are generally more expensive and are mostly utilized by mid- and large-sized organizations.Different types of chromatography systems are available to cater to the needs of researchers and specific purposes.

Systems are further segmented into single-use batch chromatography systems, multi-use batch chromatography systems, continuous chromatography systems, and others.

By Chromatography Type

• Liquid Chromatography

Liquid chromatography (LC) uses a solid stationary phase to separate molecules in a liquid mobile phase. Liquid chromatography is a technique that can be used for both analytical and preparative purposes. This segment is driven by new product launches made by the key players in the market. For instance, in February 2021, Thermo Fisher Scientific (US) launched its new Vanquish Online 2D-Liquid Chromatography (LC) system, which offers multidimensional chromatography.  

The liquid chromatography segment has been sub-segmented into HPLC, flash chromatography, ion-exchange chromatography, size-exclusion chromatography, and affinity chromatography. This segment also held the largest market share in 2020, owing to its varied applications and high demandfor analytical processes.

• Gas Chromatography

Gas chromatography (GC) is a method for analyzing gas, liquid, and solid sample mixture containing the analyte. The major difference between LC and GC is that here the mobile phase is in the gaseous state called the carrier gas, while in LC, the mobile phase is a liquid. GC has several applications in the food, pharmaceutical, and forensics industries.

• Others

Other chromatography types include hydrophobic interaction chromatography, paper chromatography, thin-layer chromatography, and size-exclusion chromatography.

By End User

• Biotechnology and Pharmaceutical Industries

The biotechnology and pharmaceutical industries segment held the highest market share in 2020 due to factors like increasing R&D activities and funding. According to a report published bythe International Federation of Pharmaceutical Manufacturers & Associations (IFPMA), in 2021, global biopharmaceutical R&D Spending is expected to reach USD 213 billion by 2024 with a CAGR of 3%. This will, in turn, supplement the growth of the market.

• Food & Beverage Industries

Chromatography is utilized in the food and beverage businesses to separate and analyze additives, preservatives, vitamins, proteins, and amino acids and for the6 quality control of food &beverageproducts. For instance, Aflatoxin, a cancer-causing chemical generated by a mold on peanuts, may also be separated and detected through chromatography. The demand for chromatography methods is further supplemented by growing food safety concerns driving growth for this segment.

• Academic Research Laboratories

Preparative and process chromatography techniques are used extensively in academic research laboratories for various research purposes that require the separation or purification of products. In recent years, the use of chromatography for studying metabolomics has increased in demand in research labs, propelling growth for the market.

• Others

Other end users include forensics, nutraceutical industry, cosmetics industry, oil and gas industry, and environmental biotechnology industry. In forensics,gas chromatography is used to determine if a deceased individual had taken any alcohol or not, and liquid chromatography is used to detect and quantify different drugs.

Regional Analysis

The preparative and process chromatography market based on the region has been segmented into North America, Europe, Asia-Pacific, and the Rest of the World.

• North America

The presence of key players, rising prevalence of NCDs, and increasing R&D initiativesfor novel therapeutics arefueling the growth ofthe North Americapreparative and process chromatography market.

The North American region, comprisingthe US and Canada, held the largest market share in 2020. This is due to factors such as developed healthcare infrastructure and key players in the region driving growth through new product launches, expansion, and acquisitions. For instance, in June 2019, Agilent Technologies (US) launched its intelligent LC/MS system that has a specialized mass selective detector.Furthermore, the rising cases of non-communicable diseases (NCDs) in the region are increasing demand for more effective therapeutics that supplement growth for the preparative and process chromatography market. According to the American Cancer Society, in 2020, an estimated 1.8 million new cases of cancer were diagnosed and 606,520 cancer deaths were recorded.

• Asia-Pacific

Improving healthcare infrastructure, high prevalence of chronic diseases, and rising R&D expenditure are anticipated to drive the market growth in the region.

The Asia-Pacific region is expected to show the highest CAGR during the forecast period. This is due to factors like the presence of emerging economies and improving healthcare infrastructure, making the utilization of chromatography processes more feasible and accessible. Moreover, this is supplemented by the increasing R&D expenditure in the region. For instance, according to the American Association for the Advancement of Science (AAAS),in March 2021, China is expected to cross the US and become the global leader in R&D spending, with its R&D spending increasing by 13% compared to 8% of US in 2019. Additionally, key players are expanding operations in this region, further providing growth for the market. For instance, in January 2018, Danaher (US) announced that it would invest USD 100 million over three years to expand its operations in India, primarily through acquisitions.

Competitive Landscape

The industry players are adopting several business strategies to increase their market presence. They are significantly investing in R&D activities to expand their product portfolio, further driving the preparative and process chromatography market. In addition, the market players are adopting several strategic initiatives such as new product launches,contractual agreements,mergers and acquisitions, increasing investments, and partnering with other players to expand their global footprint.

Thermo Fisher Scientific (US) is one of the key market players, founded in 1956. The company specializes in various biotechnology products such as analytical instruments, laboratory equipment, lab services, specialty diagnostics, and others. They possess a diverse product portfolio of chromatography instruments and consumables, including HPLC, GC systems, UHPLC, and ion chromatography columns. In August 2021, the company collaborated with ChromSword (Latvia) to launch its new automated HPCL and UHPLC system called the Vanquish Method Development HPLC and UHPLC system.

List of companies covered in this report:

• Merck KGaA (Germany)


• Danaher Corporation (US)


• Bio-Rad Laboratories (US)


• Thermo Fisher Scientific (US)


• Shimadzu Corporation (Japan)


• Daicel Corporation(Japan)


• Waters Corporation (US)


• Agilent Technologies (US)


• Novasep Holding S.A.S.(France)


• PerkinElmer Inc. (US)


• Others

Recent Developments

• In August 2021, Thermo Fisher Scientific Inc. (US) collaborated with ChromSword (Latvia) to launch its new automated HPCL and UHPLC system called the Vanquish Method Development HPLC and UHPLC system.


• In July 2021, Cytiva (US) and Pall (US), part of Danaher Corporation (US),had invested USD 1.5 billion in the expansion of their manufacturing capacity and services, which includes new facilities and acquisitions.


• In February 2021, Thermo Fisher Scientific Inc. (US) launched its new Vanquish Online 2D-Liquid Chromatography (LC) system, which offers multidimensional chromatography.


• In November 2020, Shimadzu Corporation (Japan) launched its Advanced i-SeriesHPLC system. This was an improved liquid chromatography system that supported remote work.


• In March 2020, Danaher Corporation (US) acquired the biopharma business of General Electric Life Sciences (US), now called Cytiva, for USD 21.4 billion. This move will boost the company's position in the life sciences industry

Report Overview

The study covers the existing short-term and long-term market effects. It helps decision-makers to draught short-term and long-term business plans by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's five forces, value chain, and impact of COVID-19 on the market.

Study Objectives

• To provide a detailed analysis of the market structure and forecast for the next sevenyears of the various segments and sub-segments of the preparative and process chromatography market


• To provide insights about factors affecting the market growth


• To analyze the preparative and process chromatography market based on various factors- price analysis, supply chain analysis, Porter's five force analysis,etc


• To provide historical and forecast revenues of the market segments and sub-segments with respect to four main geographies and their countries- North America, Europe, Asia-Pacific, and the Rest of the World


• To provide country-level analysis of the market with respect to the current market size and future prospective


• To provide country-level analysis of the market for segments by type, product, and end user


• To provide strategic profiling of key players in the market, comprehensively analyze their core competencies, and draw a competitive market landscape


• To track and analyze competitive developments such as joint ventures, strategic alliances, mergers & acquisitions, new product developments, and R&D in the preparative and process chromatography market

Market Segmentation:

Global Preparative and Process Chromatography Market, By Type

• Process Chromatography


• Preparative Chromatography

Global Preparative and Process Chromatography Market, By Product

• Chemicals & Reagents


• 
  Resins
  
  
  
  • Affinity Resins
  
  
  • Ion-Exchange Resins
  
  
  • Size-exclusion Resins
  
  
  • Reversed-Phase
  
  
  • Protein A Resins
  
  
  • Hydrophobic Interaction Resins
  
  
  • Mixed-Mode/Multimode Resins
  
  
  
  


• 
  Columns
  
  
  
  • Pre-packed Columns
  
  
  • Empty Columns
  
  
  
  


• 
  Systems
  
  
  
  • Single-use Batch Chromatography Systems
  
  
  • Multi-use Batch Chromatography Systems
  
  
  • Continuous Chromatography Systems
  
  
  • Others
  
  
  
  

Global Preparative and Process Chromatography Market, By Chromatography Type

• 
  Liquid Chromatography
  
  
  
  • HPLC
  
  
  • Flash/Column Chromatography
  
  
  • Ion-exchange chromatography
  
  
  • Size-exclusion chromatography
  
  
  • Affinity chromatography
  
  
  
  


• Gas Chromatography


• Others

Global Preparative and Process Chromatography Market, By End User

• Biotechnology and Pharmaceutical Industries


• Food and Nutraceutical Industries


• Academic Research Laboratories


• Others

Global Preparative and Process Chromatography Market, By Region

• 
  North America
  
  
  
  • US
  
  
  • Canada
  
  
  
  


• Europe


• 
  Germany
  
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• 
  Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • Australia
  
  
  • South Korea
  
  
  • Rest of Asia-Pacific
  
  
  
  


• 
  Rest of the World
  
  
  
  • Middle East
  
  
  • Africa
  
  
  • Latin America
  
  
  
  

• Chromatography product manufacturers and suppliers


• Contract Research Organizations (CROs)


• Research and Development (R&D) Companies


• Biopharmaceutical Companies


• Government & Independent Research Laboratories


• Government and Independent Regulatory Authorities


• Market Research and Consulting Service Providers


• Academic Institutes and Universities