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    Antidepressant Drugs Market

    ID: MRFR/HC/7450-HCR
    100 Pages
    Rahul Gotadki
    October 2025

    Antidepressant Drug Market Research Report By Drug Class (Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), Tricyclic Antidepressants (TCAs), Monoamine Oxidase Inhibitors (MAOIs), Atypical Antidepressants), By Administration Route (Oral, Injectable), By Therapeutic Application (Major Depressive Disorder, Anxiety Disorders, Bipolar Disorder, Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorder), By Patient Demographics (Adults, Geriatric Patients, Adolescents), By Prescription Stat...

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    Antidepressant Drugs Market Infographic
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    Antidepressant Drugs Market Summary

    The global antidepressant drug market is projected to grow from 16.53 USD billion in 2024 to 23.16 USD billion by 2035.

    Key Market Trends & Highlights

    Antidepressant Drug Key Trends and Highlights

    • The global antidepressant drug market is valued at 16.5 USD billion in 2024.
    • By 2035, the market is expected to reach 23.2 USD billion, indicating robust growth.
    • The compound annual growth rate (CAGR) for the period from 2025 to 2034 is estimated at 3.11 percent.
    • Growing adoption of antidepressant therapies due to increasing awareness of mental health issues is a major market driver.

    Market Size & Forecast

    2024 Market Size 16.53 (USD Billion)
    2035 Market Size 23.16 (USD Billion)
    CAGR (2025-2035) 3.11%

    Major Players

    Takeda, AbbVie, Johnson & Johnson, Eli Lilly, Bristol-Myers Squibb, Otsuka Pharmaceutical, Forest Laboratories, Sanofi, Merck, Pfizer, AstraZeneca, Novartis, H Lundbeck, Actavis, GlaxoSmithKline

    Antidepressant Drugs Market Trends

    The global antidepressant drug market is experiencing significant transformation driven by increasing awareness and a growing prevalence of mental health disorders across populations. The rise in stressors related to urbanization, lifestyle changes, and economic pressures has led to a burgeoning demand for effective antidepressant therapies. Additionally, advancements in pharmaceutical research have paved the way for the development of novel compounds that offer improved efficacy and fewer side effects, enhancing patient adherence to treatment regimens. The increasing acceptance of mental health issues is also prompting healthcare systems to prioritize mental health care, thus driving the market further.

    Opportunities in the global antidepressant drug market are vast and encompass several areas, including the growing demand for personalized medicine approaches and the integration of digital health solutions, such as telepsychiatry and mobile health applications, to support treatment adherence and monitoring. With an expanding demographic of patients seeking relief from mental health disorders, there is a pressing need for innovative drug formulations and delivery systems that cater to diverse population needs. This trend is particularly evident in regions where stigma has started to diminish, enabling more individuals to seek help.

    Recent times have witnessed shifts toward holistic and integrative approaches in treating depression, focusing not only on pharmacological options but also on lifestyle modifications, cognitive-behavioral therapies, and support groups. The market is increasingly attentive to the importance of mental well-being, leading to collaborations among various stakeholders, including pharmaceutical companies, healthcare providers, and policymakers. These trends highlight a collective movement toward creating a more inclusive mental health care environment, ultimately benefitting patients and broadening the scope of therapeutic options available in the global antidepressant drug market.

    The ongoing evolution of treatment modalities in the antidepressant drug market appears to reflect a growing recognition of the multifaceted nature of mental health disorders, suggesting a shift towards more personalized therapeutic approaches.

    U.S. Food and Drug Administration (FDA)

    Antidepressant Drugs Market Drivers

    Market Growth Projections

    The Global Antidepressant Drug Market Industry is poised for substantial growth, with projections indicating a market value of 16.5 USD Billion in 2024 and an anticipated increase to 23.2 USD Billion by 2035. This growth trajectory reflects a compound annual growth rate of 3.11% from 2025 to 2035, driven by various factors including rising prevalence of depression, advancements in pharmaceutical research, and increased awareness of mental health issues. As the market evolves, it is likely to witness the introduction of innovative therapies and a broader acceptance of antidepressant medications, further solidifying its position in the healthcare landscape.

    Growing Geriatric Population

    The aging global population is a significant driver of the Global Antidepressant Drug Market Industry. Older adults are particularly susceptible to depression due to factors such as chronic illness, social isolation, and cognitive decline. As the geriatric population continues to expand, the demand for antidepressant medications is expected to rise correspondingly. By 2035, the number of individuals aged 65 and older is projected to reach 1.5 billion globally, further emphasizing the need for effective mental health interventions. This demographic shift is likely to sustain market growth, contributing to the overall increase in market value.

    Rising Prevalence of Depression

    The increasing prevalence of depression globally is a primary driver of the Global Antidepressant Drug Market Industry. According to estimates, over 264 million individuals suffer from depression worldwide, leading to a heightened demand for effective treatment options. This growing patient population necessitates a robust supply of antidepressant medications, contributing to the market's projected value of 16.5 USD Billion in 2024. As awareness of mental health issues continues to rise, healthcare providers are more likely to prescribe antidepressants, further propelling market growth. The urgency to address mental health concerns is likely to sustain this upward trajectory in the coming years.

    Advancements in Pharmaceutical Research

    Innovations in pharmaceutical research and development are significantly influencing the Global Antidepressant Drug Market Industry. The emergence of novel antidepressant classes, such as fast-acting antidepressants and personalized medicine approaches, enhances treatment efficacy and patient outcomes. For instance, the introduction of ketamine-based therapies has shown promise in treating resistant depression, attracting attention from both clinicians and patients. This ongoing research is expected to drive market growth, with projections indicating a market value of 23.2 USD Billion by 2035. As new therapies enter the market, they may reshape treatment paradigms and expand the overall antidepressant market.

    Regulatory Support for Mental Health Initiatives

    Regulatory bodies worldwide are increasingly recognizing the importance of mental health, leading to supportive policies that bolster the Global Antidepressant Drug Market Industry. Initiatives aimed at improving access to mental health care and funding for research into new treatments are becoming more prevalent. For example, government programs that promote mental health screenings and subsidize antidepressant medications enhance patient access to necessary treatments. Such regulatory support is likely to foster market growth, as it encourages pharmaceutical companies to invest in research and development. This environment of support may contribute to the anticipated market value of 23.2 USD Billion by 2035.

    Increased Awareness and Acceptance of Mental Health

    The growing awareness and acceptance of mental health issues play a crucial role in shaping the Global Antidepressant Drug Market Industry. Public campaigns and educational initiatives have contributed to a reduction in stigma associated with mental health disorders, encouraging individuals to seek treatment. This cultural shift is reflected in the rising number of prescriptions for antidepressants, as more patients are willing to discuss their mental health concerns with healthcare providers. As a result, the market is likely to experience sustained growth, with a projected compound annual growth rate of 3.11% from 2025 to 2035, indicating a robust future for antidepressant medications.

    Market Segment Insights

    Antidepressant Drug Market Drug Class Insights

    The Global Antidepressant Drug Market is witnessing significant growth, particularly concerning the Drug Class segment, which is anticipated to play a vital role in shaping market dynamics over the coming years. In 2023, the overall market is expected to be valued at approximately 15.55 USD billion, with projections indicating a rise to around 20.48 USD billion by 2032. Within this broad category, the market is segmented into various sub-classes, including Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), Tricyclic Antidepressants (TCAs), Monoamine Oxidase Inhibitors (MAOIs), and Atypical Antidepressants, each contributing differently to the overall market landscape.

    The SSRI segment, valued at 6.0 USD billion in 2023, is expected to grow to approximately 7.8 USD billion by 2032, making it a dominant player in the Global Antidepressant Drug Market revenue. This growth can be attributed to the increasing prevalence of depression and anxiety disorders, as well as growing awareness regarding mental health, which is driving demand for SSRIs due to their well-established efficacy and favorable side effect profiles.

    Similarly, the SNRI segment is projected to rise from 3.5 USD billion in 2023 to about 4.7 USD billion by 2032, driven by the rising diagnosis of major depressive disorder and the broadening of treatment options for patients who do not respond to traditional SSRIs. The TCAs segment, although smaller, shows a steady increase from 1.8 USD billion in 2023 to 2.2 USD billion in 2032, owing to their effectiveness in treatment-resistant depression, albeit often overshadowed by newer classes of medications.

    On a more niche scale, MAOIs generated revenue from approximately 0.9 USD billion in 2023, projecting growth to 1.1 USD billion by 2032, reflecting their specificity for atypical depression despite the challenge posed by dietary restrictions and potential side effects that accompany their use. On the other side, Atypical Antidepressants are valued at 3.35 USD billion in 2023, with expectations of growing to around 4.68 USD billion by 2032, attributed to their flexible mechanisms of action that appeal to a diverse patient population.

    The segmentation of the Global Antidepressant Drug Market provides not only a structure but also insights into drug development and innovation opportunities as pharmaceutical companies aim to enhance efficacy and reduce adverse effects. The market trends signal a shift towards personalized medicine, where treatment protocols are increasingly tailored to the individual's biological and psychological profiles. Growth drivers include an aging population, greater access to healthcare services, expanding drug formularies, and more favorable regulatory policies promoting new therapies' introduction. However, challenges such as rising healthcare costs, medication adherence issues, and the stigma surrounding mental health disorders may hinder growth.

    Opportunities abound through advanced clinical research that focuses on developing next-generation antidepressant agents with improved therapeutic indices, thus positioning the Global Antidepressant Drug Market industry in a robust framework for innovation and accessibility. The overall Global Antidepressant Drug Market statistics reflect a continued and growing emphasis on mental health care, reinforcing the essential role that various Drug Classes play in addressing the global burden of depression and related disorders.

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Antidepressant Drug Market Administration Route Insights

    The Global Antidepressant Drug Market, projected to reach a valuation of 20.48 USD Billion by 2032, demonstrates significant growth stemming from various administration routes, with the oral route being the predominant choice among patients. As of 2024, the oral administration segment is expected to contribute substantially to the Global Antidepressant Drug Market revenue due to its convenience and ease of use. Injectable antidepressants, while accounting for a smaller market share, are gaining traction, particularly for patients who prefer or require this method of administration.

    Trends in this segment highlight an increased emphasis on patient adherence and the effectiveness of treatment, further influencing the demand for these drugs. In 2023, oral antidepressants, led by sub-segments such as Selective Serotonin Reuptake Inhibitors (SSRIs) and Atypical Antidepressants, are expected to collectively generate a significant portion of the market value at approximately 9.35 USD Billion. Meanwhile, injectable options, although still emerging, are anticipated to play a crucial role in future market dynamics with growing acceptance in clinical settings.

    This outlook reflects the broader Global Antidepressant Drug Market statistics, emphasizing the diverse administration routes that cater to varying patient needs and preferences, ultimately driving the overall market growth through innovative delivery methods.

    Antidepressant Drug Market Therapeutic Application Insights

    The Global Antidepressant Drug Market is on track for substantial growth, with a total market valuation expected to reach 20.48 USD Billion by 2032, reflecting a steady CAGR of 3.11% from 2024. Within this expanding market, the Therapeutic Application segment plays a crucial role, encompassing various mental health disorders. Major Depressive Disorder, which remains one of the most prevalent conditions, is predicted to significantly contribute to market revenue.

    Additionally, Anxiety Disorders are increasingly recognized for their escalating incidence, driving demand for effective antidepressant interventions.  bipolar disorder, though less common, presents a compelling case for targeted antidepressant therapies, while obsessive-compulsive disorder and Post-Traumatic Stress Disorder are garnering more attention as they affect a substantial segment of the population. Different classes of antidepressants serve these disorders specifically; for instance, Selective Serotonin Reuptake Inhibitors (SSRIs) generated a market value of 7.8 USD Billion in 2032, while Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) are projected to reach 4.7 USD Billion in the same year.

    Overall, the segment presents significant opportunities for innovation and investment in the Global Antidepressant Drug Market industry.

    Antidepressant Drug Market Patient Demographics Insights

    The Global Antidepressant Drug Market, valued at approximately 15.55 USD Billion in 2023, is projected to grow steadily, reaching an estimated 20.48 USD Billion by 2032, marking a CAGR of 3.11 from 2024 to 2032. This upward trajectory is underscored by the increasing prevalence of depression across various patient demographics, including Adults, Geriatric Patients, and Adolescents. Among these segments, Adults account for a substantial portion of the market. Notably, the sub-segment of Selective Serotonin Reuptake Inhibitors (SSRIs) leads the way, with a valuation of 6.0 USD Billion in 2023 and expected growth to 7.8 USD Billion in 2032.

    The Global Antidepressant Drug Market data further indicates a diversification within these demographics, presenting opportunities for industry players to innovate and address specific needs in therapy.

    Antidepressant Drug Market Prescription Status Insights

    Get more detailed insights about Antidepressant Drugs Market

    Regional Insights

    The comprehensive market segmentation reveals significant insights into various regional markets, including North America, Europe, APAC, South America, and the Middle East  Africa (MEA). North America remains a dominant market, largely due to the rising prevalence of depressive disorders and increased awareness regarding mental health treatment options. Europe also presents lucrative opportunities driven by a growing emphasis on mental health care and advancements in antidepressant formulations. The APAC region is emerging as a significant player, with increasing investments in healthcare infrastructure and rising disposable incomes leading to greater access to antidepressant medications.

    South America is expected to experience moderate growth as awareness of mental health issues rises, although challenges related to healthcare access may impede rapid advancements. In the MEA region, the market is anticipated to develop gradually, mostly encouraged by improving healthcare systems. The sub-segment analysis indicates that Selective Serotonin Reuptake Inhibitors (SSRIs) are expected to grow from 6.0 USD Billion in 2023 to 7.8 USD Billion in 2032, while Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) will expand from 3.5 USD Billion to 4.7 USD Billion during the same period.

    Antidepressant Drug Market Regional

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    The Global Antidepressant Drug Market is characterized by a diverse landscape where numerous players compete to offer a range of therapeutic options. This market is driven by an increasing prevalence of depression and related disorders, which has prompted significant investments in research and development by pharmaceutical companies. Competitive dynamics are influenced by various factors, such as the efficacy of drugs, sales strategies, partnerships, and advancements in marketing techniques. Additionally, regulatory environments and patent expirations play a crucial role in shaping the competition as new entrants emerge and generic products enter the market.

    Companies are focusing on innovative formulations and personalized medicine approaches to address the unmet needs of patients. As a result, the competition in this sector is not only about maintaining market share but also about improving patient outcomes through effective treatment options. Takeda has established a strong foothold in the Global Antidepressant Drug Market, showcasing its commitment to enhancing patient care through innovative therapeutic solutions.

    The company’s extensive research capabilities, backed by a robust pipeline of products targeting various aspects of mental health, illustrate its strategic focus on addressing the complex needs of patients suffering from depression. Takeda’s established reputation in the biopharmaceutical space aids in building trust with healthcare providers and consumers alike, facilitating the widespread adoption of their medications. Collaborations and strategic partnerships with other organizations enhance Takeda's ability to remain competitive, enabling the company to leverage the latest scientific findings and technologies to improve its antidepressant offerings. Its comprehensive approach toward mental health treatment positions Takeda favorably within this growing market.

    AbbVie is another key player in the Global Antidepressant Drug Market, recognized for its innovative approach and significant contributions to mental health therapies. The company's extensive portfolio includes leading antidepressant drugs that target various underlying mechanisms of depression, reflecting its depth of expertise and commitment to research. AbbVie places a strong emphasis on clinical trials and evidence-based research, ensuring that its products are effective and meet the patients' needs. The company’s global reach allows it to penetrate multiple markets effectively, providing a sustainable advantage against competitors.

    Furthermore, AbbVie’s dedication to continuous improvement and its investment in emerging therapies position it as a strong contender in the field, allowing it to expand its influence and address the diverse needs of individuals suffering from depression and related disorders. Through adaptive strategies and a focus on innovation, AbbVie maintains a competitive edge in the antidepressant drug sector.

    Key Companies in the Antidepressant Drugs Market market include

    Industry Developments

    • Q2 2024: Axsome Therapeutics Announces FDA Approval of Auvelity for Major Depressive Disorder Axsome Therapeutics received FDA approval for Auvelity, a novel oral NMDA receptor antagonist, for the treatment of major depressive disorder in adults.
    • Q2 2024: Johnson & Johnson completes acquisition of Momenta Pharmaceuticals Johnson & Johnson finalized its acquisition of Momenta Pharmaceuticals, expanding its neuroscience portfolio with new antidepressant drug candidates.
    • Q3 2024: Biogen and Sage Therapeutics Announce Launch of Zuranolone for Postpartum Depression Biogen and Sage Therapeutics launched Zuranolone, a new oral antidepressant, for the treatment of postpartum depression in the United States.
    • Q3 2024: Lundbeck and Otsuka Announce FDA Approval of Rexulti for Agitation Associated with Alzheimer’s Dementia Lundbeck and Otsuka received FDA approval for Rexulti, expanding its indications to include agitation associated with Alzheimer’s dementia, complementing its use in major depressive disorder.
    • Q4 2024: Pfizer announces $150 million investment in new antidepressant manufacturing facility in Ireland Pfizer committed $150 million to build a new facility in Ireland dedicated to the production of next-generation antidepressant drugs.
    • Q4 2024: Alto Neuroscience raises $60M Series B to advance precision antidepressant therapies Alto Neuroscience secured $60 million in Series B funding to accelerate clinical trials of its precision medicine approach for antidepressant drug development.
    • Q1 2025: Eli Lilly receives FDA Fast Track designation for new oral antidepressant candidate Eli Lilly was granted Fast Track designation by the FDA for its investigational oral antidepressant, expediting the review process for the drug.
    • Q1 2025: Sun Pharma launches generic version of vortioxetine in US market Sun Pharma introduced a generic version of vortioxetine, an antidepressant, in the United States, expanding access to treatment for major depressive disorder.
    • Q2 2025: AbbVie and Calico Life Sciences announce partnership to develop novel antidepressant therapies AbbVie and Calico Life Sciences entered a strategic partnership to co-develop new antidepressant drugs targeting treatment-resistant depression.
    • Q2 2025: GSK appoints new Head of Neuroscience Division to lead antidepressant drug pipeline GSK named a new Head of Neuroscience Division to oversee its expanding pipeline of antidepressant drug candidates and related research initiatives.
    • Q3 2025: Takeda wins contract to supply antidepressant drugs to UK National Health Service Takeda secured a multi-year contract to supply its antidepressant medications to the UK National Health Service, strengthening its presence in the European market.
    • Q3 2025: Janssen Pharmaceuticals receives EMA approval for esketamine nasal spray for treatment-resistant depression Janssen Pharmaceuticals obtained European Medicines Agency approval for its esketamine nasal spray, expanding its availability for patients with treatment-resistant depression in Europe.

    Future Outlook

    Antidepressant Drugs Market Future Outlook

    The Global Antidepressant Drug Market is projected to grow at a 3.11% CAGR from 2024 to 2034, driven by rising mental health awareness, innovative drug development, and increasing healthcare access.

    New opportunities lie in:

    • Invest in digital therapeutics to enhance patient engagement and treatment adherence.
    • Develop personalized medicine approaches to improve treatment efficacy and patient outcomes.
    • Expand into emerging markets with tailored marketing strategies and localized formulations.

    By 2035, the market is poised for robust growth, reflecting evolving treatment paradigms and heightened global mental health initiatives.

    Market Segmentation

    Antidepressant Drug Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Antidepressant Drug Market Drug Class Outlook

    • Selective Serotonin Reuptake Inhibitors (SSRIs)
    • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
    • Tricyclic Antidepressants (TCAs)
    • Monoamine Oxidase Inhibitors (MAOIs)
    • Atypical Antidepressants

    Antidepressant Drug Market Prescription Status Outlook

    • Prescription-only
    • Over-the-Counter (OTC)

    Antidepressant Drug Market Administration Route Outlook

    • Oral
    • Injectable

    Antidepressant Drug Market Patient Demographics Outlook

    • Adults
    • Geriatric Patients
    • Adolescents

    Antidepressant Drug Market Therapeutic Application Outlook

    • Major Depressive Disorder
    • Anxiety Disorders
    • Bipolar Disorder
    • Obsessive-Compulsive Disorder
    • Post-Traumatic Stress Disorder

    Report Scope

    Report Attribute/Metric Details
    Market Size 2024   16.53 (USD Billion)
    Market Size 2025   17.05 (USD Billion)
    Market Size 2035 23.16 (USD Billion)
    Compound Annual Growth Rate (CAGR) 3.11% (2025 - 2035)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2024
    Market Forecast Period 2025 - 2035
    Historical Data 2020 - 2024
    Market Forecast Units USD Billion
    Key Companies Profiled Takeda, AbbVie, Johnson  Johnson, Eli Lilly, BristolMyers Squibb, Otsuka Pharmaceutical, Forest Laboratories, Sanofi, Merck, Pfizer, AstraZeneca, Novartis, H Lundbeck, Actavis, GlaxoSmithKline
    Segments Covered Drug Class, Administration Route, Therapeutic Application, Patient Demographics, Prescription Status, Regional
    Key Market Opportunities Increasing prevalence of depression cases Growing demand for personalized medicine Rising investment in mental health research Expanding online telemedicine services Development of novel drug delivery systems
    Key Market Dynamics Rising mental health awareness Increasing prevalence of depression Growing geriatric population Advancements in drug formulations Emerging market expansion
    Countries Covered North America, Europe, APAC, South America, MEA

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    FAQs

    What is the projected growth of the Antidepressant Drug market?

    The Antidepressant Drug market is the expected increase in total market value of 23.16 USD billion over a defined forecast period 2025–2035. It is driven by factors such as demand trends, technological advances, regulatory changes, and geographic expansion.

    What is the size of the Antidepressant Drug market?

    Antidepressant Drug market size was valued at approximately 16.53 billion USD in 2024. This figure will reach 23.16 billion USD covering all regions (America, Europe, Asia, MEA and ROW), focusing its segments / services / distribution channels till 2035.

    What is the CAGR of the Antidepressant Drug market?

    Antidepressant Drug market is expected to grow at a CAGR of 3.11% between 2025 and 2035.

    How much will the Antidepressant Drug market be worth by 2035?

    Antidepressant Drug market is expected to be worth of 23.16 billion USD, reflecting growth driven by usage, technology and global demands by the end of 2035.

    How will the Antidepressant Drug market perform over the next 10 years?

    Over the next 10 years the Antidepressant Drug market is expected to shift from usd billion 16.53 to 23.16 billion USD, led by adoption of advanced tech, demographic trends, regulatory approvals, with potential headwinds from 2025 to 2035.

    What is the forecasted market size of the Global Antidepressant Drug Market by 2035?

    The Global Antidepressant Drug Market is expected to be valued at 20.48 USD Billion by 2035.

    Which region is projected to hold the largest market share of the Global Antidepressant Drug Market by 2035?

    North America is projected to hold the largest market share, valued at 8.12 USD Billion by 2035.

    Which key players are significant in the Global Antidepressant Drug Market?

    Major players in the Global Antidepressant Drug Market include Takeda, AbbVie, Johnson Johnson, and Pfizer, among others.

    What is the anticipated market size for Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) by 2035?

    The market size for Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) is expected to reach 4.7 USD Billion by 2035.

    Which region is expected to experience the highest growth in the Global Antidepressant Drug Market during the forecast period?

    The APAC region is anticipated to experience significant growth with a projected market value of 3.88 USD Billion by 2035.

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