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X-Linked Hypophosphatemia Market Research Report -  Forecast till 2027

X-Linked Hypophosphatemia Market: By Treatment (Medication, Surgical, or Orthopedic Treatment), End User (Hospitals and Clinics, Research Centers) & Region (Americas, Europe, Asia-Pacific & RoW) - Forecast till 2027

ID: MRFR/LS/4806-CR | August 2019 | Region: Global | 73 pages

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X-Linked Hypophosphatemia Market


The X-Linked Hypophosphatemia Market is expected to register a CAGR of 3.6% to reach USD 40,309.1 Thousand by 2025.


X-linked hypophosphatemia (XLH) is an inherited disorder characterized by low levels of phosphate in the blood. The phosphate levels reduce as it is abnormally processed in the kidneys, which leads to the loss of phosphate through urine (phosphate wasting) and leads to soft and weak bones, causing rickets. XLH is usually diagnosed in childhood, and symptoms include bowed or bent legs, short stature, bone pain, and severe dental pain. XLH is caused by mutations in the PHEX gene on the X chromosome, and the inheritance of the X-linked is dominant. The treatment generally involves supplements of phosphate and high-dose calcitriol (an active form of vitamin D) and may also include growth hormones and corrective surgery. The key factors responsible for driving the market are the increasing prevalence rates of XLH, growing awareness about XLH. However, negative psychological and emotional impacts of having X-linked hypophosphatemia, post-operative complications, unfavorable drug price control policies in many countries, increasing penetration of counterfeit drugs, and complex license renewal procedures are hindering the growth of the X-linked hypophosphatemia market.


Market Dynamics


XLH is an inherited phosphate metabolism disorder in which inactivating mutations of the PHEX gene lead to local and systemic effects such as impaired growth, rickets, hearing difficulties, enthesopathy, osteomalacia, bone pain, bone abnormalities, spontaneous dental abscesses, osteoarthritis, and muscular dysfunction. Due to the rising cases of XLH in developing and developed economies, the global XLH market is expected to grow at a steady rate during the forecast period. For instance, according to the European Journal of Endocrinology statistics published in 2016, the incidence of XLH has been estimated to be 3.9 per 100,000 live births and has a prevalence of 4.8 per 100,000 people. Also, according to the study published in May 2016 by NIHR Horizon Scanning Research & Intelligence Centre, XLH affected more than 500 children in the UK.


Similarly, according to the statistics published in 2017 by the Food and Drug Administration (FDA), XLH affected an approximate of 3,000 children and 12,000 adults in the US. And according to a report published in 2017 by the National Institute for Health and Care Excellence, there were approximately 250 children and young people with XLH in England, and up to 2,500 adults, till date. Thus, the overall market growth is projected to rise owing to the rising prevalence rates of XLH, which required adequate drugs and therapies for treatment.


X-Linked Hypophosphatemia Market Revenue, by Treatment, 2018 (USD Thousands)  X-linked Hypophosphatemia Market


Sources: MRFR Analysis


Segmentation


The X-linked hypophosphatemia (XLH) market by treatment has been segmented into medication and Surgical or orthopedic treatment. The X-linked hypophosphatemia market has been categorized by the end user into hospitals and clinics and research centers. The research centers segment is expected to account for the largest market share during the forecast period attributing to the increasing prevalence of XLH, increasing awareness regarding the disease, and growing research activity for its treatment.


The X-linked hypophosphatemia market, by region, is segmented into the Americas, Europe, Asia-Pacific, and RoW. Factors such as the increasing prevalence of XLH and increasing awareness about the disorder are anticipated to propel the growth of the X-Linked hypophosphatemia market.


X-linked Hypophosphatemia Market Share, by Region, 2018 (%)      X-linked Hypophosphatemia Market           


Sources: MRFR Analysis


Regional Analysis


The XLH market in the Americas is expected to hold a major market share owing to the growing prevalence of XLH in the US and Canada and the presence of a well-established healthcare sector. The rising research funding towards rare diseases such as XLH and the high healthcare expenditure is also expected to fuel the growth of the market during the forecast period. For instance, Genome Canada and the Canadian Institutes for Health Research entered into a partnership to study rare genetic diseases by using Next-Generation Sequencing (NGS) technology. Similarly, the International Rare Diseases Research Consortium (IRDiRC) is a Scientific Secretariat that works in collaboration with Orphanet. Since 2010, IRDiRC financed over 3,000 projects. Moreover, according to the statistics published in 2017 by the Food and Drug Administration (FDA), XLH affected an approximate of 3,000 children and 12,000 adults in the US. Moreover, the rising government funding for the healthcare sector, the increasing prevalence rate of rare diseases, and research funding are expected to propel the growth of the market in this region.


Key Players


The prominent players in the X-linked hypophosphatemia market are Ultragenyx Pharmaceutical, Validus Pharmaceuticals LLC, Prospec-Tany Technogene Ltd, Merck KGaA, Zeria Pharmaceutical Co., Ltd, Smith & Nephew, Narang Medical Limited, Eli Lilly and Company, F. Hoffmann-La Roche Ltd, and Others.


The players operating in the global X-linked hypophosphatemia (XLH) market are focusing on product launches, along with expanding their global footprints by entering untapped markets.


Market Segmentation


X-Linked Hypophosphatemia Market, by Treatment



  • Medication

  • Surgical or Orthopedic Treatment


X-Linked Hypophosphatemia Market, by End User



  • Hospitals and Clinics

  • Research Centers


X-Linked Hypophosphatemia Market, by Region



  • Americas

    • North America

      • US

      • Canada

      • South America







  • Europe

    • Germany

    • UK

    • France

    • Spain

    • Italy

    • Rest of Europe





  • Asia-Pacific

    • China

    • India

    • Japan

    • Australia & New Zealand

    • Southeast Asia

    • Rest of Asia-Pacific





  • Rest of the World

    • Middle East

    • Africa




Available Additional Customizations


Company Profiles of Key Regional Players



  • Kyowa Hakko Kirin

  •  Smith & Nephew

  • Nestle

  • Pfizer

  • Koninklijke DSM

  • ADM Alliance Nutrition


Intended Audience



  • Drug Suppliers

  • Research and Development (R&D) Companies

  • Government Research Laboratories

  • Independent Research Laboratories

  • Government and Independent Regulatory Authorities

  • Market Research and Consulting Service Providers

  • Medical Research Laboratories

  • Academic Medical Institutes and Universities



Report Scope:
Report Attribute/Metric Details
  Market Size   USD 40,309.1 Thousand
  CAGR   3.6% (2019-2025)
  Base Year   2019
  Forecast Period   2020-2027
  Historical Data   2018
  Forecast Units   Value (USD Thousands)
  Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Treatment and End User
  Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
  Key Vendors   Ultragenyx Pharmaceutical, Validus Pharmaceuticals LLC, Prospec-Tany Technogene Ltd, Merck KGaA, Zeria Pharmaceutical Co., Ltd, Smith & Nephew, Narang Medical Limited, Eli Lilly and Company, F. Hoffmann-La Roche Ltd
  Key Market Opportunities   A recent drug approval by regulatory authorities are likely to offer lucrative opportunities for the growth of the market
  Key Market Drivers

  • Rising cases of X-linked hypophosphatemia.
  • Increasing awareness about XLH and the severity of the disease


  • Speak to Analyst Ask for Customization

    Frequently Asked Questions (FAQ) :

    X-Linked Hypophosphatemia Market CAGR would be 3.6% during the forecast period.

    X-Linked Hypophosphatemia Market valuation would be USD 40309.1 thousand by 2025.

    The research centers segment would X-Linked Hypophosphatemia Market.

    The Americas would dominate X-Linked Hypophosphatemia Market

    Players involved in X-Linked Hypophosphatemia Market are Validus Pharmaceuticals LLC, Ultragenyx Pharmaceutical, Merck KGaA, Prospec-Tany Technogene Ltd, Narang Medical Limited, Zeria Pharmaceutical Co., Ltd, Smith & Nephew, F. Hoffmann-La Roche Ltd, Eli Lilly and Company, and Others.