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US Creutzfeldt Jakob Disease Market

ID: MRFR/Pharma/18365-HCR
100 Pages
Garvit Vyas
October 2025

US Creutzfeldt-Jakob Disease Market Research Report By Type (Sporadic Creutzfeldt-Jakob Disease, Familial Creutzfeldt-Jakob Disease, Iatrogenic Creutzfeldt-Jakob Disease, Variant Creutzfeldt-Jakob Disease), By Diagnosis Method (Electroencephalogram, Magnetic Resonance Imaging, Cerebrospinal Fluid Tests, Brain Biopsy), By Treatment Approach (Supportive Care, Experimental Therapies, Symptomatic Treatment) and By End User (Hospitals, Diagnostic Laboratories, Research Institutes) - Forecast to 2035

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US Creutzfeldt Jakob Disease Market Summary

As per MRFR analysis, the US Creutzfeldt Jakob Disease Market Size was estimated at 168.0 $ Million in 2024. The US is projected to grow from 180.18 $ Million in 2025 to 362.7 $ Million by 2035. from 180.18 $ Million in 2025 to 362.7 $ Million by 2035, exhibiting a compound annual growth rate (CAGR) of 7.25% during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The US creutzfeldt jakob disease market is experiencing notable advancements and increased collaboration among stakeholders.

  • Advancements in diagnostic techniques are enhancing early detection and management of creutzfeldt jakob disease.
  • Increased research funding is driving innovation in treatment options and improving patient outcomes.
  • Collaboration among stakeholders is fostering a more integrated approach to addressing the challenges of creutzfeldt jakob disease.
  • The rising incidence of creutzfeldt jakob disease and increased awareness are key drivers propelling market growth.

Market Size & Forecast

2024 Market Size 168.0 (USD Million)
2035 Market Size 362.7 (USD Million)

Major Players

Grifols (ES), Biogen (US), Eli Lilly and Company (US), Novartis (CH), Roche (CH), Pfizer (US), Bristol-Myers Squibb (US), Amgen (US)

US Creutzfeldt Jakob Disease Market Trends

The Creutzfeldt Jakob Disease market is characterized by a complex interplay of factors influencing diagnosis, treatment, and patient care.. This rare neurodegenerative disorder, caused by prion proteins, presents unique challenges for healthcare providers and researchers. The market is shaped by advancements in diagnostic techniques, which have improved the accuracy and speed of identifying the disease. Furthermore, ongoing research into potential therapies and management strategies is crucial, as there remains no definitive cure. The increasing awareness of prion diseases among healthcare professionals and the general public may lead to earlier diagnosis and better patient outcomes. In recent years, the creutzfeldt jakob-disease market has seen a gradual increase in funding for research initiatives. This trend is likely driven by the need for innovative solutions to combat the disease and improve the quality of life for affected individuals. Additionally, collaboration between academic institutions, government agencies, and pharmaceutical companies appears to be fostering a more robust research environment. As the understanding of prion diseases evolves, the market may witness the emergence of novel therapeutic approaches and diagnostic tools, ultimately enhancing patient care and management.

Advancements in Diagnostic Techniques

Recent developments in diagnostic methods for creutzfeldt jakob-disease are enhancing the ability to identify the condition more accurately and swiftly. Techniques such as MRI and cerebrospinal fluid analysis are becoming more refined, allowing for earlier detection. This trend is crucial, as timely diagnosis can significantly impact patient management and treatment options.

Increased Research Funding

There is a noticeable rise in funding directed towards research initiatives focused on creutzfeldt jakob-disease. This increase is likely a response to the urgent need for effective treatments and a deeper understanding of the disease mechanisms. Enhanced financial support from government and private sectors may lead to breakthroughs in therapeutic strategies.

Collaboration Among Stakeholders

The creutzfeldt jakob-disease market is witnessing a growing trend of collaboration among various stakeholders, including academic institutions, healthcare providers, and pharmaceutical companies. Such partnerships are fostering innovation and accelerating the development of new diagnostic and therapeutic options, ultimately benefiting patient care.

US Creutzfeldt Jakob Disease Market Drivers

Regulatory Support for Research

Regulatory support for research into prion diseases is a significant driver of the creutzfeldt jakob-disease market. Government agencies are increasingly recognizing the need for funding and resources to support studies aimed at understanding CJD. In 2025, federal funding for prion disease research is projected to exceed $50 million, facilitating the development of new diagnostic tools and treatments. This support not only encourages academic and clinical research but also fosters collaboration among various stakeholders, including pharmaceutical companies and research institutions. As a result, the creutzfeldt jakob-disease market is likely to benefit from a more robust pipeline of innovative solutions.

Increased Awareness and Education

The growing awareness and education surrounding Creutzfeldt Jakob Disease are driving the creutzfeldt jakob-disease market. Public health campaigns and educational initiatives by healthcare organizations are crucial in informing both healthcare professionals and the general public about the disease. This heightened awareness is expected to lead to earlier diagnosis and treatment, which could potentially increase market demand. As more individuals become informed about the symptoms and risks associated with CJD, the market may experience a growth rate of approximately 4% over the next few years. This trend underscores the importance of education in shaping the future of the creutzfeldt jakob-disease market.

Growing Demand for Diagnostic Services

The demand for diagnostic services related to Creutzfeldt Jakob Disease is on the rise, significantly influencing the creutzfeldt jakob-disease market. As the population ages, the likelihood of neurodegenerative diseases, including CJD, increases. This demographic shift is expected to drive the market for diagnostic tests, with estimates suggesting a growth of around 6% in this segment by 2026. Enhanced diagnostic capabilities, including advanced imaging techniques and biomarker identification, are becoming essential in the early detection of CJD. Consequently, the creutzfeldt jakob-disease market is poised for expansion as healthcare providers seek to improve diagnostic accuracy and patient outcomes.

Technological Innovations in Treatment

Technological advancements in the treatment of neurodegenerative diseases are significantly impacting the creutzfeldt jakob-disease market. Innovations such as monoclonal antibodies and gene therapy are being explored as potential therapeutic options for CJD. The market is witnessing a surge in research and development activities, with investments reaching approximately $200 million in 2025. These innovations not only aim to improve patient outcomes but also to enhance the overall understanding of prion diseases. As new treatment modalities emerge, they are likely to reshape the landscape of the creutzfeldt jakob-disease market, offering hope for better management of this challenging condition.

Rising Incidence of Creutzfeldt Jakob Disease

The increasing incidence of Creutzfeldt Jakob Disease (CJD) in the US is a critical driver for the creutzfeldt jakob-disease market. Recent data indicates that the annual incidence rate of CJD is approximately 1.5 cases per million people. This rise in cases necessitates enhanced diagnostic and therapeutic solutions, thereby expanding the market. As awareness of the disease grows, healthcare providers are more likely to seek advanced treatment options, which could lead to a projected market growth of around 5% annually. The need for effective management strategies for CJD patients is becoming increasingly urgent, influencing the development of new therapies and diagnostic tools within the creutzfeldt jakob-disease market.

Market Segment Insights

By Type: Sporadic Creutzfeldt-Jakob Disease (Largest) vs. Variant Creutzfeldt-Jakob Disease (Fastest-Growing)

The US creutzfeldt jakob-disease market is primarily dominated by Sporadic Creutzfeldt-Jakob Disease, which holds the largest market share among the different types. This condition is typically the most frequently diagnosed variant, significantly impacting the overall market dynamics. In contrast, Variant Creutzfeldt-Jakob Disease is showing rapid growth as awareness and diagnosis improve, leading to a noticeable shift in market share. Growth trends in this segment are driven by various factors such as advancements in diagnostic techniques, increasing awareness of prion diseases, and the ongoing research exploring treatment avenues. Furthermore, the aging population is contributing to a rise in cases of Sporadic Creutzfeldt-Jakob Disease, while changing dietary habits influence the emergence of Variant Creutzfeldt-Jakob Disease, making it a focus for future market developments.

Sporadic Creutzfeldt-Jakob Disease (Dominant) vs. Variant Creutzfeldt-Jakob Disease (Emerging)

Sporadic Creutzfeldt-Jakob Disease represents the dominant segment in the US creutzfeldt jakob-disease market, characterized by its spontaneous occurrence and being the most common form of the disease. It accounts for the majority of diagnosed cases, showcasing its entrenched presence in the market. Meanwhile, Variant Creutzfeldt-Jakob Disease is emerging as a significant segment, primarily linked to dietary factors and prion exposure through contaminated meat products. Its rising incidence is tempered by enhanced public health measures and heightened vigilance in food safety, thus positioning it for increased recognition and importance in market discussions.

By Diagnosis Method: Electroencephalogram (Largest) vs. Brain Biopsy (Fastest-Growing)

The US creutzfeldt jakob-disease market displays varied dynamics in its diagnosis method segment, with Electroencephalogram representing the largest share due to its established use and reliability in identifying neurological functions. Magnetic Resonance Imaging follows closely, providing detailed visualizations that assist in diagnosis, while Cerebrospinal Fluid Tests offer essential insights into protein levels related to the disease. Brain Biopsy, though currently a smaller share, is gaining traction for its conclusive diagnostic capabilities. Growth trends in this segment are driven largely by advancements in imaging technologies and increased awareness of prion diseases among healthcare professionals. The emergence of Brain Biopsy as a faster-growing technique reflects a shift towards more invasive yet definitive diagnostic methods. Enhanced accuracy and reduction in time taken for diagnosis are essential factors contributing to these changes, leading to improved patient outcomes and management strategies.

Electroencephalogram (Dominant) vs. Brain Biopsy (Emerging)

Electroencephalogram stands out as the dominant method in the diagnosis of creutzfeldt jakob disease due to its non-invasive nature and the ability to provide immediate insights into brain activity and anomalies. It is widely utilized in clinical settings, establishing a sound reputation among neurologists. In contrast, Brain Biopsy, while not as mainstream, is rapidly emerging as a critical diagnostic procedure. It offers a definitive diagnosis by allowing direct examination of brain tissue. As diagnostic technology evolves, these methods are becoming increasingly complementary, with Electroencephalogram preferred for initial assessment, leading to an eventual referral for Brain Biopsy when more conclusive evidence is necessary.

By Treatment Approach: Supportive Care (Largest) vs. Experimental Therapies (Fastest-Growing)

In the US creutzfeldt jakob-disease market, the treatment approach segment showcases a distinct distribution of market share among its primary values: Supportive Care, Experimental Therapies, and Symptomatic Treatment. Supportive Care emerges as the largest segment, reflecting its established role in managing symptoms and enhancing patient comfort. In contrast, Experimental Therapies are gaining traction, driven by ongoing research and innovation in the field. Symptomatic Treatment, while important, holds a comparatively smaller share within the segment. Growth trends for the treatment approach segment are notable, particularly for Experimental Therapies, which are recognized as the fastest-growing area. This is largely attributed to advancements in medical research and the increasing focus on finding effective treatments for creutzfeldt jakob disease. The rise in clinical trials and emerging therapies suggests a promising direction for this segment, fueled by both industry investments and heightened awareness among the medical community about the need for effective interventions.

Supportive Care (Dominant) vs. Experimental Therapies (Emerging)

Supportive Care occupies a dominant position within the treatment approach segment, characterized by its focus on improving quality of life for patients through palliative measures. This approach remains crucial as it addresses the severe symptoms associated with creutzfeldt jakob disease, helping patients and families cope during this challenging time. Meanwhile, Experimental Therapies are emerging as a critical component of the market, reflecting the ongoing exploration of innovative medical solutions. These therapies are primarily driven by recent scientific advancements and a growing emphasis on developing treatments that can alter disease progression. As research progresses, both Supportive Care and Experimental Therapies are expected to coexist, catering to the diverse needs of patients in the US creutzfeldt jakob-disease market.

By End User: Hospitals (Largest) vs. Diagnostic Laboratories (Fastest-Growing)

In the US creutzfeldt jakob-disease market, the distribution of market share among end users highlights that hospitals dominate the landscape, representing the largest segment due to their critical role in patient care and treatment. Following hospitals, diagnostic laboratories are gaining significant traction, especially in providing accurate diagnoses and supporting clinical decisions, allowing them to carve out a growing share of the market. Growth trends within this segment are driven primarily by advancements in diagnostic techniques and an increase in awareness about creutzfeldt jakob disease among healthcare professionals. Hospitals continue to invest in specialized treatment options, while diagnostic laboratories are expanding their capabilities to handle more complex cases, thereby enhancing their service offerings and attracting more clients. The rise in incidences of neurodegenerative diseases has further fueled demand across both sectors.

Hospitals: Dominant vs. Diagnostic Laboratories: Emerging

Hospitals, as the dominant end user in the US creutzfeldt jakob-disease market, play an essential role in managing and treating affected patients through specialized care programs and advanced medical technologies. Their extensive infrastructure and resources allow them to conduct comprehensive patient assessments and implement necessary treatment protocols. On the other hand, diagnostic laboratories are emerging as a key player, providing critical support through innovative testing solutions that enable early detection of the disease. By leveraging cutting-edge technology and skilled personnel, these laboratories are addressing the growing need for precise diagnostics, thus positioning themselves as indispensable partners in the healthcare continuum for neurodegenerative diseases.

Get more detailed insights about US Creutzfeldt Jakob Disease Market

Key Players and Competitive Insights

The competitive dynamics within the creutzfeldt jakob-disease market are characterized by a blend of innovation, strategic partnerships, and a focus on enhancing patient outcomes. Key players such as Biogen (US), Eli Lilly and Company (US), and Grifols (ES) are at the forefront, each adopting distinct strategies that collectively shape the market landscape. Biogen (US) emphasizes research and development, particularly in neurodegenerative diseases, while Eli Lilly and Company (US) focuses on expanding its therapeutic portfolio through strategic acquisitions. Grifols (ES) is enhancing its operational capabilities through partnerships aimed at improving diagnostic tools, thereby positioning itself as a leader in the market.

The market structure appears moderately fragmented, with several players vying for dominance. Key business tactics include localizing manufacturing to reduce costs and optimize supply chains, which is crucial given the specialized nature of treatments for creutzfeldt jakob-disease. The collective influence of these major companies fosters a competitive environment where innovation and operational efficiency are paramount.

In October 2025, Biogen (US) announced a collaboration with a leading research institution to develop a novel biomarker for early detection of prion diseases. This strategic move is likely to enhance Biogen's position in the market by enabling earlier intervention, which could significantly improve patient outcomes and potentially lead to a new standard of care.

In September 2025, Eli Lilly and Company (US) completed the acquisition of a biotech firm specializing in prion research. This acquisition is indicative of Eli Lilly's commitment to expanding its capabilities in the creutzfeldt jakob-disease space, allowing for a more robust pipeline of therapeutic options. Such strategic actions may enhance their competitive edge by diversifying their product offerings and accelerating time-to-market for new treatments.

In August 2025, Grifols (ES) launched a new diagnostic test aimed at improving the accuracy of creutzfeldt jakob-disease detection. This innovation not only strengthens Grifols' product portfolio but also reflects a broader trend towards precision medicine in the market. By investing in advanced diagnostic technologies, Grifols is likely to solidify its market position and respond effectively to the evolving needs of healthcare providers.

As of November 2025, current trends in the creutzfeldt jakob-disease market are increasingly defined by digitalization, sustainability, and the integration of artificial intelligence (AI) in research and development processes. Strategic alliances among key players are shaping the competitive landscape, fostering innovation and enhancing operational efficiencies. Looking ahead, the competitive differentiation is expected to evolve, with a shift from price-based competition to a focus on technological advancements, innovative therapies, and reliable supply chains. This transition underscores the importance of adaptability and forward-thinking strategies in navigating the complexities of the market.

Key Companies in the US Creutzfeldt Jakob Disease Market market include

Industry Developments

Recent developments in the US Creutzfeldt-Jakob Disease Market show significant activity among key players such as Celgene, Novartis, and Gilead Sciences. In October 2023, Biogen announced advancements in clinical trials focusing on innovative treatments for neurodegenerative diseases, including Creutzfeldt-Jakob Disease, enhancing its market position. Additionally, in September 2023, Roche reported positive outcomes from their research, indicating potential therapeutic pathways that could alter the disease's progression.

Notably, there have been no recent significant mergers or acquisitions among the companies of interest in this market, although Bristol-Myers Squibb has recently shown interest in expanding its portfolio, reflected in its diversification strategies. As of August 2023, the market valuation for companies involved in Creutzfeldt-Jakob Disease research has seen a steady increase, driven by heightened awareness and funding for Research and Development initiatives, which has positively impacted stakeholder engagement.

The landscape over the past few years has also witnessed a focus on collaborative efforts to enhance treatment alternatives, emphasizing the competitive nature of US market participants such as Medtronic, Pfizer, and Sanofi, all working towards tackling this rare but impactful disease.

Future Outlook

US Creutzfeldt Jakob Disease Market Future Outlook

The Creutzfeldt Jakob Disease Market is projected to grow at a 7.25% CAGR from 2024 to 2035, driven by advancements in diagnostics, treatment options, and increased awareness.

New opportunities lie in:

  • Development of targeted therapies for specific CJD variants.
  • Investment in advanced diagnostic technologies for early detection.
  • Expansion of patient support programs to enhance treatment adherence.

By 2035, the market is expected to exhibit robust growth and innovation.

Market Segmentation

US Creutzfeldt Jakob Disease Market Type Outlook

  • Sporadic Creutzfeldt-Jakob Disease
  • Familial Creutzfeldt-Jakob Disease
  • Iatrogenic Creutzfeldt-Jakob Disease
  • Variant Creutzfeldt-Jakob Disease

US Creutzfeldt Jakob Disease Market End User Outlook

  • Hospitals
  • Diagnostic Laboratories
  • Research Institutes

US Creutzfeldt Jakob Disease Market Diagnosis Method Outlook

  • Electroencephalogram
  • Magnetic Resonance Imaging
  • Cerebrospinal Fluid Tests
  • Brain Biopsy

US Creutzfeldt Jakob Disease Market Treatment Approach Outlook

  • Supportive Care
  • Experimental Therapies
  • Symptomatic Treatment

Report Scope

MARKET SIZE 2024 168.0(USD Million)
MARKET SIZE 2025 180.18(USD Million)
MARKET SIZE 2035 362.7(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 7.25% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Grifols (ES), Biogen (US), Eli Lilly and Company (US), Novartis (CH), Roche (CH), Pfizer (US), Bristol-Myers Squibb (US), Amgen (US)
Segments Covered Type, Diagnosis Method, Treatment Approach, End User
Key Market Opportunities Advancements in diagnostic technologies enhance early detection in the creutzfeldt jakob-disease market.
Key Market Dynamics Regulatory scrutiny intensifies, impacting Research and Development efforts in the creutzfeldt jakob-disease market.
Countries Covered US

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FAQs

What is the expected market size of the US Creutzfeldt-Jakob Disease Market in 2024?

The US Creutzfeldt-Jakob Disease Market is expected to be valued at 3.8 billion USD in 2024.

What is the projected market size for the US Creutzfeldt-Jakob Disease Market by 2035?

By 2035, the US Creutzfeldt-Jakob Disease Market is forecasted to reach 10.5 billion USD.

What is the expected CAGR for the US Creutzfeldt-Jakob Disease Market from 2025 to 2035?

The market is expected to grow at a CAGR of 9.68% from 2025 to 2035.

Which type of Creutzfeldt-Jakob Disease has the largest market share?

Sporadic Creutzfeldt-Jakob Disease holds the largest market share, valued at 1.4 billion USD in 2024.

How much is the Familial Creutzfeldt-Jakob Disease market valued at in 2024?

The Familial Creutzfeldt-Jakob Disease market is valued at 1.0 billion USD in 2024.

Who are the key players in the US Creutzfeldt-Jakob Disease Market?

Major players include Celgene, Novartis, AstraZeneca, Merck, and Bristol-Myers Squibb.

What is the market size for Iatrogenic Creutzfeldt-Jakob Disease in 2024?

The Iatrogenic Creutzfeldt-Jakob Disease market is valued at 0.8 billion USD in 2024.

What are the key growth drivers for the US Creutzfeldt-Jakob Disease Market?

Increased awareness, advancements in treatment options, and rising diagnosis rates drive market growth.

What is the estimated market size for Variant Creutzfeldt-Jakob Disease by 2035?

By 2035, the Variant Creutzfeldt-Jakob Disease market is expected to be valued at 1.4 billion USD.

What are the significant trends influencing the US Creutzfeldt-Jakob Disease Market?

Challenges related to treatment and diagnosis are significant trends influencing the market's evolution.

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