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US Antiemetics Market

ID: MRFR/HC/18034-HCR
100 Pages
Garvit Vyas
October 2025

US Antiemetics Market Research Report By Drug Class (Serotonin 5-HT3 Receptor Antagonists, Dopamine Antagonists, Antihistamines, Cannabinoids, Neurokinin-1 Receptor Antagonists), By Route of Administration (Oral, Intravenous, Transdermal, Rectal, Subcutaneous), By Indication (Chemotherapy-Induced Nausea, Postoperative Nausea and Vomiting, Motion Sickness, Pregnancy-Related Nausea, Radiation-Induced Nausea) and By End User (Hospitals, Clinics, Homecare Settings, Pharmacies) - Forecast to 2035

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US Antiemetics Market Summary

As per MRFR analysis, the US antiemetics market Size was estimated at 8.0 USD Billion in 2024. The US antiemetics market is projected to grow from 8.34 USD Billion in 2025 to 12.6 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 4.22% during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The US antiemetics market is experiencing a transformative shift driven by innovation and evolving patient needs.

  • The market is witnessing a rising demand for personalized medicine, particularly in the oncology segment, which is the largest in terms of revenue.
  • Technological advancements in drug delivery systems are enhancing the efficacy and patient compliance of antiemetic therapies.
  • There is an increased focus on chronic illness management, with the gastrointestinal segment emerging as the fastest-growing area.
  • Key market drivers include the growing incidence of nausea-related conditions and regulatory support for antiemetic innovations.

Market Size & Forecast

2024 Market Size 8.0 (USD Billion)
2035 Market Size 12.6 (USD Billion)
CAGR (2025 - 2035) 4.22%

Major Players

Roche (CH), Novartis (CH), GlaxoSmithKline (GB), Bristol-Myers Squibb (US), Merck & Co. (US), AstraZeneca (GB), Teva Pharmaceutical Industries (IL), Sanofi (FR), Eli Lilly and Company (US)

US Antiemetics Market Trends

The antiemetics market is currently experiencing notable developments, driven by a combination of factors including increasing awareness of nausea and vomiting conditions, advancements in pharmaceutical formulations, and a growing emphasis on patient-centric care. The rise in chronic illnesses and the need for effective management of side effects from treatments such as chemotherapy and surgery have led to a heightened demand for antiemetic medications. Furthermore, the integration of technology in drug delivery systems appears to enhance the efficacy and convenience of these treatments, potentially improving patient adherence and outcomes. In addition, regulatory bodies are actively involved in ensuring the safety and efficacy of antiemetic products, which may influence market dynamics. The ongoing research into novel compounds and formulations suggests a promising future for the antiemetics market. As healthcare providers increasingly prioritize personalized medicine, the development of targeted therapies could reshape treatment paradigms, offering tailored solutions for patients suffering from nausea and vomiting. This evolving landscape indicates a robust potential for growth and innovation in the sector.

Rising Demand for Personalized Medicine

There is a growing trend towards personalized medicine within the antiemetics market. Healthcare providers are increasingly focusing on tailoring treatments to individual patient needs, which may enhance therapeutic outcomes. This shift is likely driven by advancements in genetic research and a better understanding of patient-specific responses to medications.

Technological Advancements in Drug Delivery

Innovations in drug delivery systems are transforming the antiemetics market. New technologies, such as smart delivery devices and sustained-release formulations, are being developed to improve the effectiveness of antiemetic therapies. These advancements may lead to better patient compliance and overall treatment success.

Increased Focus on Chronic Illness Management

The antiemetics market is witnessing an increased emphasis on managing chronic illnesses that often result in nausea and vomiting. As the prevalence of conditions requiring long-term treatment rises, there is a corresponding demand for effective antiemetic solutions. This trend highlights the importance of addressing the side effects of various therapies, particularly in oncology and palliative care.

US Antiemetics Market Drivers

Advancements in Drug Formulations

Innovations in drug formulations are playing a crucial role in shaping the antiemetics market. The development of long-acting formulations and combination therapies is enhancing the efficacy and convenience of antiemetic treatments. For instance, the introduction of transdermal patches and orally disintegrating tablets is providing patients with more options for managing nausea. These advancements are likely to improve patient adherence to treatment regimens, which is essential for effective nausea management. As pharmaceutical companies continue to invest in research and development, the antiemetics market is expected to benefit from a wider array of innovative products that cater to diverse patient preferences and needs.

Increasing Healthcare Expenditure

The rising healthcare expenditure in the US is a significant driver for the antiemetics market. As healthcare spending continues to grow, there is a corresponding increase in the availability of advanced medical treatments, including antiemetic therapies. In 2025, healthcare expenditure in the US is projected to reach approximately $4 trillion, reflecting a commitment to improving patient care. This financial investment is likely to facilitate the development and accessibility of antiemetic medications, ensuring that patients have access to effective treatments for nausea. Furthermore, increased healthcare spending may lead to greater insurance coverage for antiemetic therapies, further driving market growth as more patients seek and receive treatment.

Rising Awareness of Nausea Management

There is a notable increase in awareness regarding the importance of nausea management among both healthcare professionals and patients, which is influencing the antiemetics market. Educational initiatives and campaigns aimed at highlighting the impact of nausea on quality of life are gaining traction. This heightened awareness is likely to lead to more patients seeking treatment for nausea-related conditions, thereby driving demand for antiemetic medications. In the US, healthcare providers are increasingly recognizing the need for effective nausea management strategies, which may result in a shift towards prescribing antiemetics more frequently. Consequently, this trend could contribute to the overall growth of the antiemetics market as more individuals are treated for nausea.

Regulatory Support for Antiemetic Innovations

Regulatory bodies in the US are increasingly supportive of the development and approval of new antiemetic therapies, which serves as a significant driver for the antiemetics market. The FDA has streamlined the approval process for novel antiemetic drugs, particularly those targeting specific patient populations, such as cancer patients. This regulatory environment encourages pharmaceutical companies to invest in research and development, leading to a broader range of treatment options. As a result, the market is likely to witness an influx of innovative antiemetic products, catering to diverse patient needs. The potential for expedited approvals and favorable regulatory pathways may further stimulate market growth, as companies aim to capitalize on emerging opportunities.

Growing Incidence of Nausea-Related Conditions

The rising prevalence of nausea-related conditions, such as motion sickness, chemotherapy-induced nausea, and postoperative nausea, is a key driver for the antiemetics market. In the US, it is estimated that approximately 30% of patients undergoing chemotherapy experience severe nausea, necessitating effective antiemetic therapies. This growing patient population is likely to increase the demand for antiemetic medications, thereby propelling market growth. Furthermore, the increasing awareness of nausea management among healthcare providers and patients contributes to the expansion of the antiemetics market. As more individuals seek treatment options, pharmaceutical companies are incentivized to innovate and develop new antiemetic drugs, enhancing the overall market landscape.

Market Segment Insights

By Drug Class: Serotonin 5-HT3 Receptor Antagonists (Largest) vs. Cannabinoids (Fastest-Growing)

The US antiemetics market is significantly influenced by various drug classes, with Serotonin 5-HT3 Receptor Antagonists leading the market. This class has consistently captured the largest market share, reflecting its effectiveness in treating nausea and vomiting associated with chemotherapy and post-operative care. Dopamine Antagonists and Antihistamines also hold substantial shares, but they face stiff competition from emerging therapies. Cannabinoids, while smaller in share, are gaining traction due to increasing legalization and acceptance, particularly among patients seeking alternative treatments. Growth trends within the drug class segment show a clear shift as Cannabinoids emerge as the fastest-growing option, driven by a rising awareness of their therapeutic benefits. The endorsement by regulatory bodies and a growing patient population are contributing to this trend. Similarly, Serotonin 5-HT3 Receptor Antagonists are expected to maintain their dominance due to ongoing clinical advancements, while Dopamine Antagonists and Neurokinin-1 Receptor Antagonists continue to play critical roles in managing various conditions, adapting to incorporate new evidence and treatment practices.

Serotonin 5-HT3 Receptor Antagonists (Dominant) vs. Cannabinoids (Emerging)

Serotonin 5-HT3 Receptor Antagonists are recognized for their pivotal role in managing acute nausea and vomiting, particularly linked to cancer treatments. They dominate the US antiemetics market due to their long-standing efficacy and safety profile, making them the first-line treatment in various protocols. Meanwhile, Cannabinoids are emerging as a notable alternative, driven by trends favoring natural products and their use in chronic pain and nausea management. As regulatory landscapes evolve, Cannabinoids are positioned to capture a broader patient base, especially among those hesitant to use traditional medications. The dynamic between these two classes illustrates a robust market landscape, adapting to both clinical needs and patient preferences.

By Route of Administration: Oral (Largest) vs. Intravenous (Fastest-Growing)

In the US antiemetics market, the route of administration segment showcases a diverse distribution, with oral medications taking the largest share due to their convenience and patient preference. Intravenous administration follows, but its growth is remarkable as it caters to severe cases where rapid action is essential. Other routes like transdermal, rectal, and subcutaneous are less prominent yet play crucial roles depending on specific patient needs and clinical scenarios. Growth trends in this segment are largely driven by the rising prevalence of nausea and vomiting related to various medical conditions and treatments, particularly chemotherapy. The increasing development of advanced formulations and delivery systems further propels the intravenous route, making it the fastest-growing segment. Innovations aimed at enhancing patient compliance and efficacy are also contributing to the expanded use of oral and other routes.

Route of Administration: Oral (Dominant) vs. Intravenous (Emerging)

The oral route remains the dominant method of administration in the US antiemetics market due to its ease of use and favorable patient compliance. This method is widely preferred for outpatient settings and routine nausea management. On the other hand, the intravenous route is emerging vigorously, particularly in hospital settings, where rapid onset of action is critical. This route is often utilized for patients undergoing chemotherapy or those experiencing severe nausea. The differences in application highlight the oral route's stability and consistency against the intravenous method's responsiveness and adaptability to urgent medical needs, making both crucial in comprehensive antiemetic therapies.

By Indication: Chemotherapy-Induced Nausea (Largest) vs. Postoperative Nausea and Vomiting (Fastest-Growing)

In the US antiemetics market, the indication segment is predominantly characterized by Chemotherapy-Induced Nausea, which commands the largest share among the various indications. This segment is significantly driven by the increasing incidence of cancer cases and the consequent rise in chemotherapy treatments. Other notable indications include Postoperative Nausea and Vomiting, which is gaining relevance due to the rising number of surgical procedures performed, indicating a changing competitive landscape in terms of market share distribution. Growth trends within the indication segment are showcased by the rapid expansion of Postoperative Nausea and Vomiting, which stands out as the fastest-growing category. Factors propelling this growth include advancements in surgical techniques and increased awareness of patient care, contributing to higher utilization of antiemetics in postoperative settings. Additionally, the rise in preventive healthcare measures and improved clinical guidelines regarding nausea management post-surgery are further projected to enhance market dynamics for this indication.

Chemotherapy-Induced Nausea (Dominant) vs. Motion Sickness (Emerging)

Chemotherapy-Induced Nausea remains the dominant segment within the US antiemetics market, primarily due to the well-established protocols for managing nausea associated with cancer therapies. This segment benefits from a wide range of drug options and continual research devoted to improving treatment outcomes. In contrast, Motion Sickness is emerging as a noteworthy segment, gradually gaining traction as awareness around various non-pharmaceutical interventions, such as lifestyle modifications and behavioral techniques, expands. As public interest in holistic and alternative approaches rises, Motion Sickness is projected to witness enhanced growth, driven by consumer demand for effective solutions in travel-related nausea management.

By End User: Hospitals (Largest) vs. Homecare Settings (Fastest-Growing)

In the US antiemetics market, the distribution of the market share among end-user segments reveals that hospitals maintain the largest share, driven by high patient volumes and the critical need for effective antiemetic therapies. Followed by clinics, pharmacies, and homecare settings, the latter shows a noteworthy rise in demand as more patients opt for at-home treatments, reflecting a shift in patient care models. The growth trends in this segment are influenced by several factors, including an increasing prevalence of conditions inducing nausea, such as chemotherapy for cancer patients. Moreover, the shift towards outpatient care has propelled the use of antiemetics in homecare settings, making this segment the fastest-growing in the market, catering to the rising preference for integrated home health solutions and personalized care options.

Hospitals (Dominant) vs. Clinics (Emerging)

In the US antiemetics market, hospitals play a dominant role due to their comprehensive facilities and the necessity of managing acute conditions effectively. Their established protocols ensure optimal medication utilization, particularly during high-stakes treatments like chemotherapy. Conversely, clinics represent an emerging segment, gradually gaining traction as they provide accessible healthcare solutions for antiemetic treatments, especially for patients in outpatient settings. This trend reflects the broader movement towards decentralized healthcare, where clinics are becoming increasingly integrated into patient care pathways. The convenience and targeted services offered by clinics attract patients seeking alternatives beyond traditional hospital visits.

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Key Players and Competitive Insights

The antiemetics market exhibits a dynamic competitive landscape characterized by innovation and strategic maneuvering among key players. Companies such as Roche (CH), Merck & Co. (US), and Bristol-Myers Squibb (US) are at the forefront, leveraging their extensive research capabilities and established market presence to drive growth. Roche (CH) focuses on developing novel therapies that address unmet medical needs, while Merck & Co. (US) emphasizes partnerships to enhance its product pipeline. Bristol-Myers Squibb (US) is strategically positioned through its commitment to oncology-related antiemetics, reflecting a targeted operational focus that aligns with current treatment trends. Collectively, these strategies contribute to a competitive environment that is increasingly shaped by innovation and therapeutic advancements.

Key business tactics within the antiemetics market include localized manufacturing and supply chain optimization, which are essential for meeting regional demands and ensuring product availability. The market structure appears moderately fragmented, with several players vying for market share. However, the influence of major companies is pronounced, as they often set the pace for innovation and pricing strategies, thereby shaping the overall market dynamics.

In October 2025, Roche (CH) announced the successful completion of a Phase III clinical trial for its new antiemetic drug, which targets chemotherapy-induced nausea and vomiting. This development is significant as it not only reinforces Roche's commitment to oncology but also positions the company to capture a larger share of the antiemetics market. The successful trial results may lead to expedited regulatory approval, enhancing Roche's competitive edge.

In September 2025, Merck & Co. (US) entered into a strategic partnership with a biotechnology firm to co-develop a next-generation antiemetic. This collaboration is indicative of Merck's strategy to bolster its product offerings through innovative partnerships. By leveraging the biotechnology firm's expertise, Merck aims to accelerate the development of more effective treatments, thereby enhancing its market position.

In August 2025, Bristol-Myers Squibb (US) expanded its portfolio by acquiring a smaller pharmaceutical company specializing in antiemetic therapies. This acquisition is likely to enhance Bristol-Myers Squibb's capabilities in the antiemetics segment, allowing for a broader range of treatment options. The integration of new technologies and products from the acquired company could provide a competitive advantage in a market that increasingly values comprehensive treatment solutions.

As of November 2025, current trends in the antiemetics market are heavily influenced by digitalization, sustainability, and the integration of artificial intelligence (AI) in drug development. Strategic alliances are becoming more prevalent, as companies recognize the need for collaboration to drive innovation and efficiency. Looking ahead, competitive differentiation is expected to evolve, with a shift from price-based competition to a focus on technological advancements and supply chain reliability. This transition underscores the importance of innovation as a key driver of market success.

Key Companies in the US Antiemetics Market market include

Industry Developments

Recent developments in the US Antiemetics Market indicate a growing focus on innovative therapies and expanded accessibility. Companies like Merck and Co., Bristol Myers Squibb, Novartis, AstraZeneca, GlaxoSmithKline, and Gilead Sciences are actively engaging in Research and Development initiatives to enhance their product portfolios. Notably, in April 2023, Eli Lilly and Company launched an advanced antiemetic drug, which has positively impacted patient outcomes and market acceptance.

In terms of mergers and acquisitions, AbbVie’s acquisition of a biotechnology firm in March 2022, aimed at enhancing antiemetic therapies, has drawn attention, reflecting a strategic shift towards consolidating strengths in this domain. Market valuations have continued to rise, with Pfizer and Amgen reporting increased revenues due to the growing demand for innovative antiemetic treatments following the surge in chemotherapy use. Furthermore, regulatory changes and increased awareness regarding nausea treatment options have accelerated market growth, encouraging pharmaceutical firms to invest heavily in this segment.These dynamics are expected to shape the US Antiemetics Market landscape significantly in the coming years.

Future Outlook

US Antiemetics Market Future Outlook

The Antiemetics Market is projected to grow at a 4.22% CAGR from 2024 to 2035, driven by increasing demand for effective nausea management and advancements in drug formulations.

New opportunities lie in:

  • Development of personalized antiemetic therapies for specific patient demographics.
  • Expansion of telehealth services for remote antiemetic consultations.
  • Investment in AI-driven drug discovery for novel antiemetic compounds.

By 2035, the antiemetics market is expected to achieve robust growth, reflecting evolving healthcare needs.

Market Segmentation

US Antiemetics Market End User Outlook

  • Hospitals
  • Clinics
  • Homecare Settings
  • Pharmacies

US Antiemetics Market Drug Class Outlook

  • Serotonin 5-HT3 Receptor Antagonists
  • Dopamine Antagonists
  • Antihistamines
  • Cannabinoids
  • Neurokinin-1 Receptor Antagonists

US Antiemetics Market Indication Outlook

  • Chemotherapy-Induced Nausea
  • Postoperative Nausea and Vomiting
  • Motion Sickness
  • Pregnancy-Related Nausea
  • Radiation-Induced Nausea

US Antiemetics Market Route of Administration Outlook

  • Oral
  • Intravenous
  • Transdermal
  • Rectal
  • Subcutaneous

Report Scope

MARKET SIZE 2024 8.0(USD Billion)
MARKET SIZE 2025 8.34(USD Billion)
MARKET SIZE 2035 12.6(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR) 4.22% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Billion
Key Companies Profiled Roche (CH), Novartis (CH), GlaxoSmithKline (GB), Bristol-Myers Squibb (US), Merck & Co. (US), AstraZeneca (GB), Teva Pharmaceutical Industries (IL), Sanofi (FR), Eli Lilly and Company (US)
Segments Covered Drug Class, Route of Administration, Indication, End User
Key Market Opportunities Emerging therapies targeting specific nausea causes present growth potential in the antiemetics market.
Key Market Dynamics Rising demand for innovative antiemetics drives competition and regulatory scrutiny in the evolving healthcare landscape.
Countries Covered US

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FAQs

What is the expected market size of the US Antiemetics Market in 2024?

The US Antiemetics Market is expected to be valued at 8.5 USD Billion in 2024.

What will be the market size of the US Antiemetics Market by 2035?

By 2035, the US Antiemetics Market is projected to reach a value of 14.0 USD Billion.

What is the expected CAGR for the US Antiemetics Market from 2025 to 2035?

The US Antiemetics Market is expected to grow at a CAGR of 4.641 % from 2025 to 2035.

Which drug class will generate the highest revenue in the US Antiemetics Market by 2035?

By 2035, Serotonin 5-HT3 Receptor Antagonists is expected to generate the highest revenue with a value of 4.0 USD Billion.

What is the revenue forecast for Dopamine Antagonists in 2035?

The revenue for Dopamine Antagonists is projected to be 2.9 USD Billion by 2035.

Who are the major players in the US Antiemetics Market?

Key competitors in the US Antiemetics Market include Merck and Co, Bristol Myers Squibb, and Novartis among others.

What is the projected market size for Antihistamines in 2035?

The Antihistamines segment is anticipated to reach a market size of 2.7 USD Billion by 2035.

What opportunities are driving growth in the US Antiemetics Market?

The growth in the US Antiemetics Market is driven by advancements in drug formulations and increased prevalence of nausea-related conditions.

How much is the Cannabinoids segment expected to be valued in 2035?

The Cannabinoids segment is expected to be valued at 1.6 USD Billion by 2035.

What challenges does the US Antiemetics Market currently face?

The US Antiemetics Market faces challenges like regulatory hurdles and competition from alternative therapies.

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