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    US Antiemetics Market

    ID: MRFR/HC/18034-HCR
    100 Pages
    Garvit Vyas
    October 2025

    US Antiemetics Market Research Report By Drug Class (Serotonin 5-HT3 Receptor Antagonists, Dopamine Antagonists, Antihistamines, Cannabinoids, Neurokinin-1 Receptor Antagonists), By Route of Administration (Oral, Intravenous, Transdermal, Rectal, Subcutaneous), By Indication (Chemotherapy-Induced Nausea, Postoperative Nausea and Vomiting, Motion Sickness, Pregnancy-Related Nausea, Radiation-Induced Nausea) and By End User (Hospitals, Clinics, Homecare Settings, Pharmacies) - Forecast to 2035

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    US Antiemetics Market Infographic
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    US Antiemetics Market Summary

    The US Antiemetics market is projected to grow from 8.5 USD Billion in 2024 to 14 USD Billion by 2035.

    Key Market Trends & Highlights

    US Antiemetics Key Trends and Highlights

    • The market is expected to exhibit a compound annual growth rate (CAGR) of 4.64 percent from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 14 USD Billion, indicating robust growth potential.
    • In 2024, the market is valued at 8.5 USD Billion, reflecting a strong foundation for future expansion.
    • Growing adoption of innovative treatment options due to increasing prevalence of nausea and vomiting is a major market driver.

    Market Size & Forecast

    2024 Market Size 8.5 (USD Billion)
    2035 Market Size 14 (USD Billion)
    CAGR (2025-2035) 4.64%

    Major Players

    Merck and Co, Bristol Myers Squibb, Novartis, AstraZeneca, GlaxoSmithKline, Gilead Sciences, Eli Lilly and Company, Pfizer, Amgen, Roche, AbbVie, Sanofi, Johnson and Johnson, Mylan, Teva Pharmaceuticals

    US Antiemetics Market Trends

    The US antiemetics market is currently experiencing several key trends driven by a growing demand for effective nausea and vomiting treatment options. The increasing prevalence of conditions that cause emesis, such as chemotherapy-induced nausea and vomiting (CINV) and post-operative nausea, is a significant market driver. Efforts by healthcare providers to improve patient management, especially in oncology and surgery, have led to heightened usage of antiemetics.

    Additionally, there is a shift towards personalized medicine, where treatments are tailored to individual patient responses, optimizing therapeutic outcomes. Opportunities exist in the development of novel drug formulations, including those that can target specific receptors or pathways involved in emesis. The growing interest in non-pharmacological solutions, like acupuncture and behavioral therapies, also highlights avenues for complementary approaches alongside existing drug therapies.

    Furthermore, the US Food and Drug Administration (FDA) is actively reviewing and approving new antiemetic agents, which encourages innovation while addressing market demand. In recent times, the trend towards over-the-counter antiemetic medications has gained traction, providing consumers with greater access to these treatments. This shift reflects an increase in awareness and willingness among individuals to manage mild to moderate nausea independently.

    Additionally, there is a growing focus on education about the side effects of existing medications, prompting patients to seek integrated solutions. The confluence of these factors is shaping the US antiemetics market, aligning it with both clinical needs and patient preferences.

    Market Segment Insights

    Antiemetics Market Drug Class Insights

    The US Antiemetics Market showcases a diverse landscape within the Drug Class segment, which plays a vital role in addressing various types of nausea and vomiting. This segment exhibits a segmented structure, comprising Serotonin 5-HT3 Receptor Antagonists, Dopamine Antagonists, Antihistamines, Cannabinoids, and Neurokinin-1 Receptor Antagonists. Each of these classes addresses specific causes and pathways associated with emesis, making them crucial in clinical treatment practices across various settings.

    Serotonin 5-HT3 Receptor Antagonists are particularly significant, primarily used in managing chemotherapy-induced nausea and postoperative vomiting, highlighting their importance in oncological therapies and surgical recovery. These drugs act by blocking serotonin receptors in the central nervous system and gastrointestinal tract, providing effective relief for patients undergoing intense treatment regimens. Additionally, Dopamine Antagonists are valued for their broad-spectrum efficacy against different types of nausea, including that experienced in motion sickness and due to gastrointestinal disturbances.

    Their mechanism involves inhibiting dopamine receptors in the brain, which helps mitigate symptoms effectively. Antihistamines have long been a staple in the treatment of motion sickness and allergies, reflecting their longstanding presence in the market. Their action primarily centers on blocking histamine receptors, which can provide relief from symptoms associated with travel and allergic reactions. Cannabinoids have emerged as a novel class of agents in recent years, particularly in the context of chronic conditions such as cancer and HIV/AIDS.

    By interacting with the endocannabinoid system, they offer alternative solutions for patients who may not find relief from traditional treatments. Neurokinin-1 Receptor Antagonists are gaining traction due to their effectiveness in preventing acute and delayed nausea in patients undergoing chemotherapy. Their unique action on the neurokinin-1 receptor within the central nervous system makes them invaluable in comprehensive antiemetic therapy. The combination of these various drug classes indicates a robust and continually evolving market aimed at improving patient outcomes and addressing unmet medical needs in the realm of nausea and vomiting management.

    The continuous innovation in drug development, along with rising healthcare expenditures and an aging population in the US, will likely further propel the growth within this critical Drug Class segment of the US Antiemetics Market. As healthcare providers seek effective management strategies for nausea and vomiting, the importance of each drug class will remain a focal point for ongoing research and development efforts in the industry, signifying the dynamic nature of the US Antiemetics Market overall.

    Antiemetics Market Route of Administration Insights

    The Route of Administration segment within the US Antiemetics Market plays a crucial role in addressing the varying needs of patients requiring antiemetic therapies. Different administration methods cater to diverse patient populations and clinical situations. Oral administration, being the most common route, ensures ease of use and accessibility for patients, making it a primary choice for managing nausea and vomiting. Intravenous administration is significant for acute situations, allowing for rapid onset of action, especially in hospitalized settings.

    Transdermal patches provide a convenient alternative, offering sustained drug release and higher compliance rates among patients who may struggle with oral intake. Rectal administration, while less commonly discussed, presents an important option for patients unable to take medications orally due to nausea or vomiting, particularly in pediatrics. Subcutaneous routes facilitate self-administration and can be effective in settings where intravenous access is challenging. The choice of route significantly impacts treatment effectiveness, patient adherence, and overall therapeutic outcomes, making the Route of Administration a vital component of the US Antiemetics Market landscape.

    With ongoing advancements in drug delivery systems and patient-centered approaches, this segment continues to evolve, presenting both challenges and opportunities in the competitive market.

    Antiemetics Market Indication Insights

    The US Antiemetics Market segmentation under the Indication category addresses various conditions requiring antiemetic treatment, reflecting significant healthcare needs within the population. Chemotherapy-Induced Nausea is a key area, driven by the rising incidence of cancer and subsequent treatments, requiring effective nausea management to enhance patient quality of life. Postoperative Nausea and Vomiting is also a critical segment, often affecting surgical patients, necessitating efficient solutions to improve recovery experiences.

    Motion Sickness remains prevalent among travelers, creating demand for effective treatments to alleviate symptoms during transit. Pregnancy-Related Nausea presents a unique challenge, as it is a common condition among expectant mothers, requiring safe and effective remedies to support maternal well-being. Lastly, Radiation-Induced Nausea constitutes an important area of focus due to the ongoing use of radiation therapy in cancer treatment. The diverse landscape of indications indicates a broad necessity for innovative antiemetic therapies tailored to specific patient circumstances, driving advancements in the US Antiemetics Market.

    Furthermore, ongoing research and development efforts aim to enhance treatment efficacy, responding to the nuanced needs of affected individuals across these various conditions.

    Antiemetics Market End User Insights

    The US Antiemetics Market has shown notable segmentation based on end users, primarily encompassing Hospitals, Clinics, Homecare Settings, and Pharmacies, each playing a vital role in the distribution and utilization of antiemetic drugs. Hospitals serve as a central hub, dealing with complex cases requiring acute management of nausea and vomiting, thereby significantly driving demand for effective antiemetics. Clinics, on the other hand, offer treatment options for outpatients, catering to those with less severe ailments and providing essential support for chronic conditions.

    Homecare Settings are increasingly recognized for their importance due to the rising trend of personalized care, allowing patients to manage their symptoms in a comfortable environment, which enhances adherence to treatment protocols. Pharmacies remain a critical access point for patients seeking over-the-counter options, supporting widespread availability and education on antiemetic use. Collectively, these end users contribute to a comprehensive network ensuring that patients receive necessary care, reflecting broad market penetration and varying consumer needs across the healthcare continuum.

    The growing emphasis on patient-centered care and advancements in therapeutic options will likely further influence the evolution and dynamics of these segments within the US Antiemetics Market.

    Get more detailed insights about US Antiemetics Market

    Key Players and Competitive Insights

    The US Antiemetics Market is characterized by a dynamic landscape, driven by an increasing demand for effective treatment options to combat nausea and vomiting associated with various medical conditions, including chemotherapy, surgery, and motion sickness. This market is witnessing substantial growth due to rising healthcare expenditures, more advanced drug formulations, and heightened awareness about the availability of antiemetic therapies. Competitive dynamics are shaped by the constant evolution of product offerings, the emphasis on clinical effectiveness, and the strategic maneuvering of key players within the sector.

    Innovation plays a pivotal role, with companies striving to expand their portfolios and improve patient outcomes by developing new drugs and therapies tailored to specific needs. Merck and Co has established a significant presence in the US Antiemetics Market, capitalizing on its robust research and development capabilities to deliver effective solutions. The company boasts a strong pipeline of antiemetic drugs, which are backed by extensive clinical trials demonstrating their efficacy in alleviating nausea and vomiting. Merck's strength lies in its ability to leverage its wide-reaching distribution network and partnerships with healthcare professionals to enhance patient accessibility to its antiemetic medications.

    Additionally, its commitment to innovation ensures that the company remains competitive by continuously updating its product offerings and integrating the latest scientific advancements to optimize treatment outcomes. Bristol Myers Squibb has a notable market presence in the US Antiemetics Market, primarily through its focus on providing high-quality therapies aimed at managing nausea and vomiting in patients undergoing cancer treatments. The company is recognized for its key products that are designed to effectively address these symptoms, ensuring patient adherence to cancer regimens.

    Bristol Myers Squibb has invested significantly in research and development, which has enhanced its portfolio with innovative solutions tailored for specific patient populations. The company’s strategic mergers and acquisitions have further solidified its competitive stance, allowing for the integration of complementary products and widening its market reach. Bristol Myers Squibb’s dedication to advancing antiemetic care is evident through its collaboration with healthcare providers, which helps to improve treatment processes and patient outcomes across the United States.

    Key Companies in the US Antiemetics Market market include

    Industry Developments

    Recent developments in the US Antiemetics Market indicate a growing focus on innovative therapies and expanded accessibility. Companies like Merck and Co., Bristol Myers Squibb, Novartis, AstraZeneca, GlaxoSmithKline, and Gilead Sciences are actively engaging in Research and Development initiatives to enhance their product portfolios. Notably, in April 2023, Eli Lilly and Company launched an advanced antiemetic drug, which has positively impacted patient outcomes and market acceptance.

    In terms of mergers and acquisitions, AbbVie’s acquisition of a biotechnology firm in March 2022, aimed at enhancing antiemetic therapies, has drawn attention, reflecting a strategic shift towards consolidating strengths in this domain. Market valuations have continued to rise, with Pfizer and Amgen reporting increased revenues due to the growing demand for innovative antiemetic treatments following the surge in chemotherapy use. Furthermore, regulatory changes and increased awareness regarding nausea treatment options have accelerated market growth, encouraging pharmaceutical firms to invest heavily in this segment.These dynamics are expected to shape the US Antiemetics Market landscape significantly in the coming years.

    Market Segmentation

    Antiemetics Market End User Outlook

    • Hospitals
    • Clinics
    • Homecare Settings
    • Pharmacies

    Antiemetics Market Drug Class Outlook

    • Serotonin 5-HT3 Receptor Antagonists
    • Dopamine Antagonists
    • Antihistamines
    • Cannabinoids
    • Neurokinin-1 Receptor Antagonists

    Antiemetics Market Indication Outlook

    • Chemotherapy-Induced Nausea
    • Postoperative Nausea and Vomiting
    • Motion Sickness
    • Pregnancy-Related Nausea
    • Radiation-Induced Nausea

    Antiemetics Market Route of Administration Outlook

    • Oral
    • Intravenous
    • Transdermal
    • Rectal
    • Subcutaneous

    Report Scope

    Report Attribute/Metric Source: Details
    MARKET SIZE 2018 7.56(USD Billion)
    MARKET SIZE 2024 8.5(USD Billion)
    MARKET SIZE 2035 14.0(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 4.641% (2025 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    MARKET FORECAST PERIOD 2025 - 2035
    HISTORICAL DATA 2019 - 2024
    MARKET FORECAST UNITS USD Billion
    KEY COMPANIES PROFILED Merck and Co, Bristol Myers Squibb, Novartis, AstraZeneca, GlaxoSmithKline, Gilead Sciences, Eli Lilly and Company, Pfizer, Amgen, Roche, AbbVie, Sanofi, Johnson and Johnson, Mylan, Teva Pharmaceuticals
    SEGMENTS COVERED Drug Class, Route of Administration, Indication, End User
    KEY MARKET OPPORTUNITIES Growing demand for nausea relief, Expansion of preventive therapies, Increased use in oncology treatments, Development of innovative formulations, Rising awareness on medication options
    KEY MARKET DYNAMICS rising incidence of nausea disorders, increasing preference for oral medications, advancements in drug formulations, growing acceptance of preventive therapies, expanding geriatric population
    COUNTRIES COVERED US

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    FAQs

    What is the expected market size of the US Antiemetics Market in 2024?

    The US Antiemetics Market is expected to be valued at 8.5 USD Billion in 2024.

    What will be the market size of the US Antiemetics Market by 2035?

    By 2035, the US Antiemetics Market is projected to reach a value of 14.0 USD Billion.

    What is the expected CAGR for the US Antiemetics Market from 2025 to 2035?

    The US Antiemetics Market is expected to grow at a CAGR of 4.641 % from 2025 to 2035.

    Which drug class will generate the highest revenue in the US Antiemetics Market by 2035?

    By 2035, Serotonin 5-HT3 Receptor Antagonists is expected to generate the highest revenue with a value of 4.0 USD Billion.

    What is the revenue forecast for Dopamine Antagonists in 2035?

    The revenue for Dopamine Antagonists is projected to be 2.9 USD Billion by 2035.

    Who are the major players in the US Antiemetics Market?

    Key competitors in the US Antiemetics Market include Merck and Co, Bristol Myers Squibb, and Novartis among others.

    What is the projected market size for Antihistamines in 2035?

    The Antihistamines segment is anticipated to reach a market size of 2.7 USD Billion by 2035.

    What opportunities are driving growth in the US Antiemetics Market?

    The growth in the US Antiemetics Market is driven by advancements in drug formulations and increased prevalence of nausea-related conditions.

    How much is the Cannabinoids segment expected to be valued in 2035?

    The Cannabinoids segment is expected to be valued at 1.6 USD Billion by 2035.

    What challenges does the US Antiemetics Market currently face?

    The US Antiemetics Market faces challenges like regulatory hurdles and competition from alternative therapies.

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