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UK Gene Therapy Market

ID: MRFR/Pharma/51497-HCR
200 Pages
Rahul Gotadki
October 2025

UK Gene Therapy Market Research Report: Size, Share, Trend Analysis By Therapeutic Area (Oncology, Genetic Disorders, Infectious Diseases, Cardiovascular Diseases, Neurological Disorders), By Technology (Viral Vectors, CRISPR, Gene Editing, RNA Therapy, Non-Viral Methods), By Applications (Research, Clinical, Commercial) and By Route of Administration (Intravenous, Intramuscular, Intradermal, Intrathecal, Oral) - Growth Outlook & Industry Forecast 2025 To 2035

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UK Gene Therapy Market Summary

As per Market Research Future analysis, the UK gene therapy market Size was estimated at 306.0 USD Million in 2024. The UK gene therapy market is projected to grow from 364.26 USD Million in 2025 to 2082.0 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 19.0% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The UK gene therapy market is poised for substantial growth driven by regulatory advancements and increased investment.

  • Regulatory advancements are streamlining the approval process for gene therapies, enhancing market accessibility.
  • The largest segment in the UK gene therapy market is oncology, while the fastest-growing segment is rare genetic disorders.
  • Investment in gene therapy research is surging, with collaborative initiatives between academia and industry becoming more prevalent.
  • Key market drivers include the rising prevalence of genetic disorders and supportive government policies and funding.

Market Size & Forecast

2024 Market Size 306.0 (USD Million)
2035 Market Size 2082.0 (USD Million)
CAGR (2025 - 2035) 19.04%

Major Players

Novartis (CH), Gilead Sciences (US), Sangamo Therapeutics (US), Bluebird Bio (US), Spark Therapeutics (US), CRISPR Therapeutics (CH), Bristol-Myers Squibb (US), Roche (CH), AstraZeneca (GB)

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UK Gene Therapy Market Trends

The gene therapy market is currently experiencing a transformative phase, characterized by rapid advancements in technology and an increasing number of clinical applications. Regulatory bodies in the UK are actively working to streamline approval processes, which may facilitate faster access to innovative therapies for patients. This evolving landscape suggests a growing recognition of the potential benefits of gene therapies in treating various genetic disorders and chronic diseases. Furthermore, collaborations between academic institutions and biotechnology firms appear to be fostering a robust pipeline of novel therapies, enhancing the overall research environment. In addition, the gene therapy market is witnessing a surge in investment, driven by both public and private sectors. The UK government has shown commitment to supporting biopharmaceutical innovation, which may lead to increased funding opportunities for research and development. As a result, the market is likely to expand, with more therapies entering the market and addressing unmet medical needs. The convergence of scientific innovation and supportive policy frameworks indicates a promising future for gene therapies, potentially improving patient outcomes and quality of life.

Regulatory Advancements

Regulatory bodies in the UK are enhancing frameworks to expedite the approval of gene therapies. This shift may lead to quicker access for patients, fostering innovation and encouraging investment in the sector.

Increased Investment

There is a notable rise in funding for gene therapy initiatives, driven by both governmental support and private sector interest. This influx of capital is likely to accelerate research and development efforts, resulting in a more dynamic market.

Collaborative Research Initiatives

Partnerships between academic institutions and biotechnology companies are becoming more prevalent. These collaborations may enhance the development of novel therapies, contributing to a more robust pipeline in the gene therapy market.

UK Gene Therapy Market Drivers

Rising Prevalence of Genetic Disorders

The increasing incidence of genetic disorders in the UK is a primary driver for the gene therapy market. Conditions such as cystic fibrosis, hemophilia, and muscular dystrophy are becoming more prevalent, necessitating innovative treatment options. According to recent estimates, approximately 1 in 25 individuals in the UK is affected by a genetic disorder, highlighting the urgent need for effective therapies. This growing patient population is likely to propel demand for gene therapies, as they offer the potential for long-term solutions rather than symptomatic treatments. The gene therapy market is thus positioned to expand significantly, as healthcare providers and patients alike seek advanced therapeutic options that address the root causes of these disorders.

Supportive Government Policies and Funding

The UK government has been actively promoting the development of the gene therapy market through supportive policies and funding initiatives. Programs aimed at fostering innovation in biotechnology and healthcare are encouraging research and development in gene therapies. For instance, the UK government allocated £1.5 billion to support life sciences research, which includes gene therapy projects. This financial backing is likely to stimulate growth in the gene therapy market, as it provides the necessary resources for companies to advance their research and bring new therapies to market. The collaboration between public and private sectors is expected to enhance the overall ecosystem for gene therapy development.

Technological Advancements in Gene Editing

Technological innovations in gene editing techniques, such as CRISPR-Cas9 and TALENs, are transforming the landscape of the gene therapy market. These advancements enable precise modifications to genetic material, enhancing the efficacy and safety of gene therapies. In the UK, research institutions and biotech companies are increasingly adopting these technologies, leading to a surge in clinical trials and product development. The gene therapy market is witnessing a shift towards more targeted therapies, which could potentially reduce treatment costs and improve patient outcomes. As these technologies continue to evolve, they are expected to drive further investment and interest in gene therapy solutions.

Growing Awareness and Acceptance of Gene Therapies

There is a notable increase in public awareness and acceptance of gene therapies in the UK, which is positively influencing the gene therapy market. Educational campaigns and success stories from clinical trials are helping to demystify these advanced treatments. As patients and healthcare professionals become more informed about the potential benefits of gene therapies, the demand for these innovative solutions is likely to rise. The gene therapy market is benefiting from this shift in perception, as more individuals seek out these therapies for conditions previously deemed untreatable. This growing acceptance may lead to increased investment and research in the field.

Expansion of Clinical Trials and Research Collaborations

The expansion of clinical trials and research collaborations in the UK is a significant driver for the gene therapy market. Numerous academic institutions and biotech companies are partnering to explore new gene therapy applications, resulting in a robust pipeline of potential treatments. The UK has become a hub for clinical research, with over 200 ongoing gene therapy trials reported in recent years. This collaborative environment fosters innovation and accelerates the development of new therapies, thereby enhancing the gene therapy market. As more successful trials emerge, they are likely to attract further investment and interest from stakeholders, contributing to the overall growth of the market.

Market Segment Insights

By Vector Type: Viral Vector (Largest) vs. Non-Viral Vector (Fastest-Growing)

In the UK gene therapy market, the distribution of market share between viral and non-viral vectors shows a clear dominance of viral vectors, which are widely recognized for their efficiency in delivering genetic material into target cells. This segment holds a significant share owing to established methodologies and successful product launches. Conversely, non-viral vectors, while currently holding a smaller share, have garnered interest due to their safety profile and ease of manufacture, contributing to their growing presence in the market. Growth trends indicate that while viral vectors remain the cornerstone of gene therapy applications, non-viral vectors are poised for rapid advancement, attributed to rising research and development initiatives and increasing investments focused on novel delivery systems. The demand for safer therapeutic options without the risks associated with viral vectors has driven interest and innovation in the non-viral segment, marking it as an emerging leader in future gene therapy solutions.

Viral Vector (Dominant) vs. Non-Viral Vector (Emerging)

Viral vectors are characterized by their ability to efficiently deliver genetic material into cells, leveraging naturally occurring viral mechanisms for effective gene transfer. This dominance in the UK gene therapy market is fueled by a robust pipeline of viral vector-based therapies that have shown promise in clinical applications. In contrast, non-viral vectors, which include plasmid DNA, liposomes, and nanoparticles, are emerging as viable alternatives due to their favorable safety profile and scalability in manufacturing processes. The shift towards non-viral approaches is being driven by advancements in technology and a growing body of research emphasizing their potential to treat a wider range of genetic disorders with reduced immunogenicity.

By Gene Type: Antigen (Largest) vs. Cytokine (Fastest-Growing)

In the UK gene therapy market, the gene type segment reveals a diversified landscape with Antigen holding a significant market share due to its extensive application in immunotherapy. Cytokine follows closely, showcasing promising growth potential driven by increasing research and development in regenerative medicine. Other noteworthy segments include Tumor Suppressor and Growth Factors, which also contribute to the overall market dynamics, albeit with smaller shares. Growth trends in the gene type segment are largely influenced by advancements in technology and a deeper understanding of genetic diseases. The rapid development of personalized medicine and an increased focus on treating previously untreatable conditions are key drivers. Emerging therapies targeting Cytokines are particularly noteworthy, as they offer innovative solutions in the treatment landscape, enhancing patient outcomes and attracting substantial investment in R&D.

Antigen (Dominant) vs. Cytokine (Emerging)

Antigen represents a dominant force in the UK gene therapy market, primarily due to its central role in immunotherapeutic applications. It benefits from a well-established infrastructure and extensive clinical research that supports its efficacy in treating various diseases. Conversely, Cytokine is emerging as a new frontier in this market, leveraging cutting-edge technologies to harness the immune system's potential. The increasing prevalence of chronic diseases is propelling interest in Cytokine therapies, allowing for breakthrough developments. Both segments are crucial, with Antigen providing stability while Cytokine captures the innovative edge of the market, leading to a dynamic interplay between established methods and novel solutions.

By Application: Oncological Disorders (Largest) vs. Rare Diseases (Fastest-Growing)

In the UK gene therapy market, the application segments display a varied distribution of market share. Oncological disorders have emerged as the largest segment, capturing a significant portion of the market due to the increasing prevalence of cancer and the heightened focus on developing targeted therapies. Rare diseases also represent a crucial segment, driven by advancements in gene editing technologies and growing recognition of the need for specialized treatments. The growth trends within this sector showcase a robust trajectory, especially for rare diseases, which are regarded as the fastest-growing segment. The increasing investment in research and development for gene therapies targeting rare genetic disorders is a key driver, alongside regulatory incentives aimed at expediting the approval process for these innovative treatments. As a result, the competition among companies in the UK gene therapy market intensifies, with a focus on harnessing unique technologies to address unmet medical needs.

Oncological Disorders (Dominant) vs. Infectious Diseases (Emerging)

Oncological disorders dominate the UK gene therapy market, supported by extensive research and advancements in treatment protocols. This segment attracts significant investments due to its established therapeutic frameworks and a strong pipeline of innovative products. In contrast, infectious diseases represent an emerging area within the market, gaining traction as researchers explore gene therapies to combat viral and bacterial pathogens. The growing need for efficient treatments against persistent infections amplifies interest in this segment. While oncological therapies benefit from robust infrastructure and historical precedence, the exploration of gene therapy applications in infectious diseases is fueled by continuous innovations in delivery systems and genetic modifications. Both segments are pivotal, yet their developmental trajectories differ substantially, reflecting the diverse applications of gene therapy.

By Delivery Method: In Vivo Gene Therapy (Largest) vs. Ex Vivo Gene Therapy (Fastest-Growing)

In the UK gene therapy market, In Vivo Gene Therapy holds the largest market share among delivery methods, demonstrating considerable traction as gene therapy technologies advance. This segment's dominance can be attributed to its ability to deliver therapeutic genes directly into the patient's cells, leading to increased adoption rates and rising interest from both providers and recipients alike. Conversely, Ex Vivo Gene Therapy is emerging as the fastest-growing segment, driven by innovations in cell processing and gene editing technologies. Factors such as personalized medicine trends, coupled with advancements in regulatory pathways, are propelling this segment forward, making it increasingly attractive for research and clinical applications in the UK gene therapy domain.

In Vivo Gene Therapy (Dominant) vs. Ex Vivo Gene Therapy (Emerging)

In Vivo Gene Therapy is recognized as the dominant delivery method, providing direct interventions in the body that enhance therapeutic effectiveness. It allows for targeted delivery and the potential for robust outcomes in treating genetic disorders. On the other hand, Ex Vivo Gene Therapy is an emerging method characterized by its innovative approach of modifying cells outside the body before reintroducing them. This technique offers higher precision and customization, making it appealing for patient-specific therapies. Together, these delivery methods are reshaping the landscape of gene therapy, each playing a crucial role in therapeutic advancements and market diversification.

Get more detailed insights about UK Gene Therapy Market

Key Players and Competitive Insights

The gene therapy market in the UK is currently characterized by a dynamic competitive landscape, driven by rapid advancements in technology and increasing investment in research and development. Key players such as Novartis (CH), Gilead Sciences (US), and AstraZeneca (GB) are strategically positioning themselves through innovation and partnerships. Novartis (CH) has focused on expanding its gene therapy portfolio, particularly in rare diseases, while Gilead Sciences (US) emphasizes its commitment to developing transformative therapies for serious conditions. AstraZeneca (GB) is leveraging its strong pipeline and collaborations to enhance its market presence, indicating a collective strategy among these companies to foster innovation and address unmet medical needs.The market structure appears moderately fragmented, with several players vying for dominance. Companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and reduce costs. This trend is likely to intensify as firms seek to improve their competitive edge. The influence of major players is significant, as their strategic initiatives shape the overall market dynamics, fostering a competitive environment that encourages innovation and collaboration.

In October Novartis (CH) announced a partnership with a leading UK research institution to develop next-generation gene therapies targeting genetic disorders. This collaboration is expected to accelerate the development of innovative treatments, showcasing Novartis's commitment to advancing gene therapy solutions. Such strategic alliances are crucial for enhancing research capabilities and expediting the delivery of therapies to patients.

In September Gilead Sciences (US) launched a new gene therapy aimed at treating a rare genetic condition, marking a significant milestone in its product pipeline. This launch not only reinforces Gilead's position in the market but also highlights its focus on addressing niche therapeutic areas. The introduction of this therapy is anticipated to enhance patient outcomes and solidify Gilead's reputation as a leader in gene therapy innovation.

In August AstraZeneca (GB) expanded its gene therapy research initiatives by acquiring a biotech firm specializing in CRISPR technology. This acquisition is likely to bolster AstraZeneca's capabilities in gene editing, positioning the company to leverage cutting-edge technologies in its therapeutic offerings. The integration of CRISPR technology could potentially lead to breakthroughs in treating genetic disorders, further enhancing AstraZeneca's competitive standing.

As of November the gene therapy market is witnessing trends such as digitalization and AI integration, which are reshaping competitive strategies. Companies are increasingly forming strategic alliances to enhance their research and development capabilities, indicating a shift towards collaboration over competition. The focus is moving from price-based competition to innovation, technology, and supply chain reliability, suggesting that future differentiation will hinge on the ability to deliver advanced therapies efficiently and effectively.

Key Companies in the UK Gene Therapy Market include

Industry Developments

The UK Gene Therapy Market is experiencing significant advancements, underscored by recent developments in various companies. Finite Resources, Amgen, and GSK are exploring innovative gene therapies to treat genetic disorders, while Bluebird Bio is progressing with trials for its gene editing technologies. In August 2023, Pfizer announced a strategic collaboration with uniQure, aimed at developing gene therapies targeting rare diseases, enhancing their position in the UK market. Furthermore, AstraZeneca remains committed to its gene therapy initiatives, with plans to expand Research and Development efforts in the UK. 

The gene therapy sector is projected to see substantial valuation growth, influenced by advancements in technology and increased government support for biotechnology initiatives, reflecting the UK's strategic prioritization of healthcare innovation. Notably, in 2022, Roche completed its acquisition of Spark Therapeutics, further consolidating the gene therapy landscape in the UK. The last two to three years have seen a surge in investment and research activities, with financial backing from both private and public sectors bolstering major players like Bristol Myers Squibb, Novartis, and Celgene in their gene therapy endeavors.

Future Outlook

UK Gene Therapy Market Future Outlook

The Gene Therapy Market is projected to grow at a 19.04% CAGR from 2025 to 2035, driven by advancements in technology, regulatory support, and increasing disease prevalence.

New opportunities lie in:

  • Development of personalized gene therapies for rare diseases
  • Expansion of telehealth platforms for remote patient monitoring
  • Investment in scalable manufacturing technologies for cost reduction

By 2035, the gene therapy market is expected to achieve substantial growth and innovation.

Market Segmentation

UK Gene Therapy Market Gene Type Outlook

  • Antigen
  • Cytokine
  • Tumor Suppressor
  • Suicide
  • Deficiency
  • Growth Factors
  • Receptors
  • Others

UK Gene Therapy Market Application Outlook

  • Oncological Disorders
  • Rare Diseases
  • Cardiovascular Diseases
  • Neurological Disorders
  • Infectious Diseases
  • Others

UK Gene Therapy Market Vector Type Outlook

  • Viral Vector
  • Non-Viral Vector

UK Gene Therapy Market Delivery Method Outlook

  • In Vivo Gene Therapy
  • Ex Vivo Gene Therapy

Report Scope

MARKET SIZE 2024 306.0(USD Million)
MARKET SIZE 2025 364.26(USD Million)
MARKET SIZE 2035 2082.0(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 19.04% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Novartis (CH), Gilead Sciences (US), Sangamo Therapeutics (US), Bluebird Bio (US), Spark Therapeutics (US), CRISPR Therapeutics (CH), Bristol-Myers Squibb (US), Roche (CH), AstraZeneca (GB)
Segments Covered Vector Type, Gene Type, Application, Delivery Method
Key Market Opportunities Advancements in gene editing technologies enhance treatment options in the gene therapy market.
Key Market Dynamics Regulatory advancements and technological innovations drive growth in the gene therapy market, enhancing treatment accessibility and efficacy.
Countries Covered UK
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FAQs

What is the expected market size of the UK Gene Therapy Market in 2024?

The UK Gene Therapy Market is expected to be valued at 363.5 USD Million in 2024.

What is the projected market size for the UK Gene Therapy Market by 2035?

By 2035, the UK Gene Therapy Market is anticipated to reach a value of 1820.0 USD Million.

What is the expected compound annual growth rate (CAGR) for the UK Gene Therapy Market from 2025 to 2035?

The expected CAGR for the UK Gene Therapy Market is 15.77 % for the period from 2025 to 2035.

Which therapeutic area holds the largest market share in the UK Gene Therapy Market?

The oncology segment is projected to have a market value of 100.0 USD Million in 2024, making it the highest within the UK Gene Therapy Market.

What will be the market value for the genetic disorders segment in the UK Gene Therapy Market by 2035?

The genetic disorders segment is expected to reach a market value of 450.0 USD Million by 2035.

Who are the major players in the UK Gene Therapy Market?

Key players in the UK Gene Therapy Market include Amgen, Pfizer, and Roche among others.

What is the expected market size for the infectious diseases segment in the UK Gene Therapy Market by 2035?

The infectious diseases segment is anticipated to grow to a market size of 400.0 USD Million by 2035.

What is the projected market value for cardiovascular diseases in the UK Gene Therapy Market in 2024?

The cardiovascular diseases segment is expected to be valued at 50.0 USD Million in 2024.

What is the expected market size for neurological disorders in the UK Gene Therapy Market in 2035?

The neurological disorders segment is projected to reach a value of 220.0 USD Million by 2035.

What growth opportunities exist in the UK Gene Therapy Market?

Emerging trends such as increased research funding and advancements in technology present significant growth opportunities in the UK Gene Therapy Market.

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