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Polymer Based Solubility Enhancement Excipients Market Research Report: By Excipient Type (Polymeric Surfactants, Cyclodextrins, Polymers, Phospholipids, Other Excipient Types), By Bioavailability Enhancement Mechanism (Solubilization, Permeation Enhancement, Dissolution Rate Enhancement, Crystal Modification), By Application (Oral, Parenteral, Ophthalmic, Dermal, Other Applications) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2032.


ID: MRFR/HC/25468-HCR | 100 Pages | Author: Rahul Gotadki| October 2024

Polymer Based Solubility Enhancement Excipients Market Overview


As per MRFR analysis, the Polymer Based Solubility Enhancement Excipients Market Size was estimated at 1.5 (USD Billion) in 2022. The Polymer Based Solubility Enhancement Excipients Market Industry is expected to grow from 1.57(USD Billion) in 2023 to 2.4 (USD Billion) by 2032. The Polymer Based Solubility Enhancement Excipients Market CAGR (growth rate) is expected to be around 4.83% during the forecast period (2024 - 2032).


Key Polymer Based Solubility Enhancement Excipients Market Trends Highlighted


The market for polymer-based solubility enhancement excipients is projected to witness substantial growth over the coming years. The increasing prevalence of poorly water-soluble drugs, coupled with the need for improved drug delivery systems, is driving demand for these excipients. Additionally, the growing focus on personalized medicine and targeted drug delivery is expected to further propel market growth.


Key market drivers include advancements in nanotechnology, the development of novel drug delivery systems, and the increasing adoption of oral solid dosage forms. Opportunities for growth lie in the exploration of biodegradable and biocompatible polymers, the development of multi-functional excipients, and the integration of artificial intelligence and machine learning in drug development. Recent trends indicate a shift towards eco-friendly and sustainable excipients, as well as an increasing focus on patient-centric drug delivery systems.


Polymer Based Solubility Enhancement Excipients Market Overview


Source: Primary Research, Secondary Research, MRFR Database and Analyst Review


Polymer Based Solubility Enhancement Excipients Market Drivers


Increasing Demand for Solubility Enhancement in Pharmaceutical Formulations


The need to enhance the solubility of numerous drugs still drives the efforts of the pharmaceutical industry, as it can be low in some cases and adversely affect the bioavailability and effectiveness of formulations. To address this problem, industry specialists focus on the creation and application of solubility enhancement excipients that can interact with a drug molecule to improve its solubility and dissolution rate. The growth of the market for this type of excipient is caused by the rise of poorly soluble drugs in pipelines and the need to develop more efficient and targeted drug delivery systems.The exchange of information that can be observed in the life sciences sector and the growth of SEEs’ technologies are predicted to contribute to the significant expansion in the Polymer Based Solubility Enhancement Excipients Market Industry in the next few years.


Technological Advancements in Polymer-Based SEEs


The technological advancement of polymer-based SEEs is also driving the Polymer Solubility Enhancement Excipients Market Industry. Currently, researchers are looking to develop polymers with properties that are customized so that they can interact with a broad range molecular drugs and enhance the solubility. Polymer-based SEEs will as a result be more effective and versatile and used across different pharmaceutical applications.


Growing Focus on Patient-Centric Drug Development


The increased emphasis on patient-centric drug development is one of the factors that foster the growing of the Polymer Based Solubility Enhancement Excipients Market Industry. Indeed, at present, patients are more adamant about receiving drugs through more effective delivery systems and benefiting from innovative polymers, which makes it possible to improve drug solubility and, therefore, patients’ ability to benefit from the pharmaceuticals mentioned.Thus, the development of SEEs that can be used in the process of creating more patient-centered drug delivery options is identified as an important direction in which pharmaceutical companies are currently investing.


Polymer Based Solubility Enhancement Excipients Market Segment Insights


Polymer Based Solubility Enhancement Excipients Market Excipient Type Insights


The Polymer Based Solubility Enhancement Excipients Market is segmented by Excipient Type into Polymeric Surfactants, Cyclodextrins, Polymers, Phospholipids, and Other Excipient Types. Among these segments, Polymeric Surfactants held the largest market share in 2023, accounting for around 35% of the Polymer Based Solubility Enhancement Excipients Market revenue. The dominance of Polymeric Surfactants can be attributed to their ability to effectively solubilize poorly water-soluble drugs and improve their bioavailability. Cyclodextrins are another important segment of the Polymer Based Solubility Enhancement Excipients Market, with a market share of approximately 25% in 2023.Cyclodextrins are cyclic oligosaccharides that can form inclusion complexes with poorly water-soluble drugs, thereby increasing their solubility and stability. Polymers are also widely used as solubility enhancement excipients, with a market share of around 20% in 2023. Polymers can act as solubilizers, stabilizers, and controlled-release agents for poorly water-soluble drugs. Phospholipids are another important class of solubility enhancement excipients, with a market share of approximately 15% in 2023. Phospholipids can form micelles or liposomes that can encapsulate poorly water-soluble drugs and improve their solubility and bioavailability.The remaining market share is accounted for by Other Excipient Types, which include various other excipients such as surfactants, co-solvents, and complexing agents. These excipients play a crucial role in enhancing the solubility and bioavailability of poorly water-soluble drugs. The Polymer Based Solubility Enhancement Excipients Market is expected to witness steady growth in the coming years, driven by the increasing demand for poorly water-soluble drugs and the development of new and innovative excipients.


Polymer Based Solubility Enhancement Excipients Market Insights


Source: Primary Research, Secondary Research, MRFR Database and Analyst Review


Polymer Based Solubility Enhancement Excipients Market Bioavailability Enhancement Mechanism Insights


Bioavailability Enhancement Mechanism Segment Insight and Overview The bioavailability enhancement mechanism segment plays a crucial role in the Polymer Based Solubility Enhancement Excipients Market. It encompasses various techniques used to improve the solubility and bioavailability of poorly water-soluble drugs. Key mechanisms include Solubilization: This involves increasing the solubility of drugs in aqueous solutions by using surfactants or other solubilizing agents. Permeation Enhancement: Enhancing drug permeation across biological membranes is achieved through the use of penetration enhancers or absorption promoters.Dissolution Rate Enhancement: This mechanism focuses on increasing the dissolution rate of drugs, thereby improving their bioavailability. Crystal Modification: Modifying the crystal structure of drugs can alter their solubility and bioavailability characteristics. In 2023, the polymer-based Solubility Enhancement Excipients Market revenue for this segment is estimated to be around USD 550 million, with a projected CAGR of 5.2% over the forecast period. The growing demand for improved drug solubility and bioavailability, coupled with advancements in polymer-based excipient technology, is driving the market growth.


Polymer Based Solubility Enhancement Excipients Market Application Insights


The Polymer Based Solubility Enhancement Excipients Market is segmented on the basis of application into oral, parenteral, ophthalmic, dermal, and other applications. The oral segment is expected to hold the largest share of the market in 2023, owing to the increasing demand for oral drug delivery systems due to their ease of administration and cost-effectiveness. The parenteral segment is also expected to grow at a significant CAGR during the forecast period due to the increasing use of injectable drugs for the treatment of various diseases.The ophthalmic segment is expected to witness a steady growth rate, driven by the rising prevalence of eye diseases and the increasing demand for ophthalmic drug delivery systems. The dermal segment is also expected to grow at a moderate CAGR, owing to the increasing use of topical drug delivery systems for the treatment of various skin conditions. The other applications segment includes applications such as pulmonary, nasal, and rectal drug delivery systems, which are expected to grow at a moderate CAGR during the forecast period.


Polymer Based Solubility Enhancement Excipients Market Regional Insights


The regional segmentation of the Polymer Based Solubility Enhancement Excipients Market provides insights into the market's geographical distribution and growth potential. North America held the largest market share in 2023, owing to the presence of major pharmaceutical and biotechnology companies, advanced healthcare infrastructure, and high demand for novel drug delivery systems. Europe is another significant region, with a strong focus on research and development of innovative excipients. The APAC region is expected to witness the highest growth rate during the forecast period, driven by the increasing demand for pharmaceuticals and the growing healthcare industry in countries such as China and India.South America and MEA are emerging markets with potential for growth due to the increasing adoption of advanced drug delivery technologies.


Polymer Based Solubility Enhancement Excipients Market Regional Insights


Source: Primary Research, Secondary Research, MRFR Database and Analyst Review


Polymer Based Solubility Enhancement Excipients Market Key Players And Competitive Insights


Major players in Polymer Based Solubility Enhancement Excipients Market industry are constantly striving to gain a competitive edge by investing in research and development, expanding their product portfolios, and forming strategic partnerships. Leading polymer-based Solubility Enhancement Excipients Market players are focusing on developing innovative products that meet the evolving needs of the pharmaceutical industry.


The Polymer-Based Solubility Enhancement Excipients Market development landscape is characterized by the emergence of advanced technologies, such as nanotechnology and microfluidics, which are being used to develop novel excipients with enhanced solubility and bioavailability. Additionally, companies are exploring the use of artificial intelligence and machine learning to optimize excipient design and formulation processes. The Polymer-Based Solubility Enhancement Excipients Market Competitive Landscape is expected to remain highly competitive in the coming years, with key players continuing to invest in research and development to maintain their market share and drive innovation.BASF, a leading polymer-based Solubility Enhancement Excipients Market player, offers a wide range of excipients, including Soluplus, Kollidon, and Eudragit. Soluplus is a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol copolymer that is used to enhance the solubility of poorly water-soluble drugs. Kollidon is a polyvinylpyrrolidone that is used as a binder, disintegrant, and solubilizer. Eudragit is a methacrylic acid copolymer that is used as a film-forming agent and release modifier. BASF is committed to providing innovative excipients that meet the needs of the pharmaceutical industry and is continuously investing in research and development to expand its product portfolio.Evonik, another key polymer-based Solubility Enhancement Excipients Market player, offers a range of excipients, including Eudragit, Resomer, and Tego. Eudragit is a methacrylic acid copolymer that is used as a film-forming agent and release modifier. Resomer is a poly(lactic-co-glycolic acid) that is used as a bioresorbable polymer for drug delivery applications. Tego is a series of excipients that are used as emulsifiers, dispersants, and wetting agents. Evonik is focused on developing innovative excipients that improve the performance of drug products and is committed to providing high-quality excipients that meet the regulatory requirements of the pharmaceutical industry.


Key Companies in the Polymer Based Solubility Enhancement Excipients Market Include




  • Ashland Holdings Inc.




  • Eastman Chemical Company




  • Dow Chemical Company




  • Clariant AG




  • Mitsubishi Chemical Corporation




  • Lubrizol Corporation




  • Teijin Limited




  • ShinEtsu Chemical Co., Ltd.




  • INEOS Group Limited




  • Solvay SA




  • BASF SE




  • Croda International Plc.




  • Sumitomo Chemical Co., Ltd.




  • Evonik Industries AG




Polymer Based Solubility Enhancement Excipients Market Industry Developments


The Polymer-Based Solubility Enhancement Excipients market is projected to reach USD 2.4 billion by 2032, exhibiting a CAGR of 4.83% during the forecast period (2024-2032). Rising demand for poorly water-soluble drugs and increasing prevalence of chronic diseases are key factors driving market growth.Technological advancements, such as the development of novel excipients with improved solubility-enhancing capabilities, are further expected to drive market expansion. Strategic collaborations and partnerships among market players are likely to accelerate innovation and strengthen industry growth.Notable recent developments include:In 2022, BASF launched Kolliphor RH 40, a new excipient designed to enhance the solubility of poorly water-soluble drugs.In 2023, Evonik expanded its portfolio with the introduction of EUDRAGIT L 100-55, an excipient specifically tailored for low-dosage formulations.These developments underscore the ongoing efforts within the industry to meet the evolving needs of the pharmaceutical sector and contribute to the overall growth of the Polymer-Based Solubility Enhancement Excipients market.


Polymer Based Solubility Enhancement Excipients Market Segmentation Insights




  • Polymer Based Solubility Enhancement Excipients Market Excipient Type Outlook





    • Polymeric Surfactants




    • Cyclodextrins




    • Polymers




    • Phospholipids




    • Other Excipient Types







  • Polymer Based Solubility Enhancement Excipients Market Bioavailability Enhancement Mechanism Outlook





    • Solubilization




    • Permeation Enhancement




    • Dissolution Rate Enhancement




    • Crystal Modification







  • Polymer Based Solubility Enhancement Excipients Market Application Outlook





    • Oral




    • Parenteral




    • Ophthalmic




    • Dermal




    • Other Applications







  • Polymer Based Solubility Enhancement Excipients Market Regional Outlook





    • North America




    • Europe




    • South America




    • Asia Pacific




    • Middle East and Africa




Report Attribute/Metric Details
Market Size 2022 1.5(USD Billion)
Market Size 2023 1.57(USD Billion)
Market Size 2032 2.4(USD Billion)
Compound Annual Growth Rate (CAGR) 4.83% (2024 - 2032)
Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
Base Year 2023
Market Forecast Period 2024 - 2032
Historical Data 2019 - 2023
Market Forecast Units USD Billion
Key Companies Profiled Ashland Holdings Inc., Eastman Chemical Company, Dow Chemical Company, Clariant AG, Mitsubishi Chemical Corporation, Lubrizol Corporation, Teijin Limited, ShinEtsu Chemical Co., Ltd., INEOS Group Limited, Solvay SA, BASF SE, Croda International Plc., Sumitomo Chemical Co., Ltd., Evonik Industries AG
Segments Covered Excipient Type, Bioavailability Enhancement Mechanism, Application, Regional
Key Market Opportunities Increasing demand for poorly soluble drugs Technological advancements Growing pharmaceutical industry Rising prevalence of chronic diseases Government initiatives for drug development
Key Market Dynamics Growing demand for oral drug delivery Increasing prevalence of poorly water-soluble drugs Technological advancements in polymer-based excipients Regulatory support for solubility enhancement technologies Rising number of drug approvals for poorly soluble drugs.
Countries Covered North America, Europe, APAC, South America, MEA


Frequently Asked Questions (FAQ) :

The Polymer Based Solubility Enhancement Excipients Market is projected to reach USD 1.57 billion in 2023.

The Polymer Based Solubility Enhancement Excipients Market is projected to grow at a CAGR of 4.83% from 2023 to 2032.

North America is expected to hold the largest market share in the Polymer Based Solubility Enhancement Excipients Market in 2023.

The oral drug delivery segment is expected to hold the largest market share in the Polymer Based Solubility Enhancement Excipients Market in 2023.

Key competitors in the Polymer Based Solubility Enhancement Excipients Market include BASF, Dow, Evonik, Ashland, and Croda.

Key factors driving the growth of the Polymer Based Solubility Enhancement Excipients Market include increasing demand for oral drug delivery systems, rising prevalence of chronic diseases, and growing adoption of personalized medicine.

Challenges faced by the Polymer Based Solubility Enhancement Excipients Market include regulatory hurdles, high cost of development, and competition from alternative technologies.

Opportunities for growth in the Polymer Based Solubility Enhancement Excipients Market include expanding applications in emerging markets, technological advancements, and strategic collaborations.

Key trends in the Polymer Based Solubility Enhancement Excipients Market include the development of novel polymers, increasing use of bio-based polymers, and growing adoption of nanotechnology.

The Polymer Based Solubility Enhancement Excipients Market is expected to reach USD 2.4 billion by 2032.

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