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Italy Plasma Fractionation Market

ID: MRFR/HC/47868-HCR
200 Pages
Rahul Gotadki
October 2025

Italy Plasma Fractionation Market Research Report: Size, Share, Trend Analysis By Product Type (Immunoglobulin, Albumin, Coagulation Factors, Protease Inhibitors), By Applications (Neurology, Hematology, General Medicine, Immunology), By End Users (Hospitals, Ambulatory Surgical Centers, Blood Banks, Pharmaceutical Companies) and By Technology (Centrifugation, Chromatography, Precipitation, Filtration) - Growth Outlook & Industry Forecast 2025 To 2035

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Italy Plasma Fractionation Market Summary

As per Market Research Future analysis, the Italy plasma fractionation market Size was estimated at 1113.7 USD Million in 2024. The Italy plasma fractionation market is projected to grow from 1187.09 USD Million in 2025 to 2247.4 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 6.5% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The Italy plasma fractionation market is poised for growth driven by increasing demand for therapies and technological advancements.

  • Rising demand for plasma-derived therapies is evident, particularly in the immunoglobulin segment, which remains the largest.
  • Technological advancements in fractionation processes are enhancing efficiency and product yield, contributing to market expansion.
  • Sustainable practices are gaining traction, reflecting a broader industry trend towards environmental responsibility.
  • The increasing prevalence of chronic diseases and government initiatives are key drivers propelling market growth.

Market Size & Forecast

2024 Market Size 1113.7 (USD Million)
2035 Market Size 2247.4 (USD Million)
CAGR (2025 - 2035) 6.59%

Major Players

Grifols (ES), CSL Behring (AU), Takeda Pharmaceutical Company (JP), Octapharma (CH), Kedrion (IT), Biotest AG (DE), LFB Group (FR), Sangamo Therapeutics (US), Emergent BioSolutions (US)

Italy Plasma Fractionation Market Trends

The plasma fractionation market is experiencing notable growth, driven by increasing demand for immunoglobulins and clotting factors. This demand is largely attributed to the rising prevalence of chronic diseases and the growing awareness of the therapeutic benefits of plasma-derived products. Additionally, advancements in technology and manufacturing processes are enhancing the efficiency and safety of plasma collection and fractionation. Regulatory frameworks in Italy are also evolving, which may facilitate smoother operations for manufacturers and suppliers in this sector. Moreover, the market is witnessing a shift towards more sustainable practices, with companies exploring eco-friendly methods for plasma processing. This trend aligns with broader environmental goals and reflects a commitment to reducing the carbon footprint associated with healthcare production. As the plasma fractionation market continues to expand, stakeholders are likely to focus on innovation and collaboration to meet the increasing needs of patients and healthcare providers. In summary, the plasma fractionation market is poised for growth, driven by technological advancements, regulatory support, and a commitment to sustainability. The landscape appears dynamic, with opportunities for new entrants and established players alike to contribute to this vital sector of healthcare.

Rising Demand for Plasma-Derived Therapies

The demand for therapies derived from plasma is increasing, particularly for immunoglobulins and clotting factors. This trend is influenced by the growing incidence of chronic diseases and the recognition of the therapeutic potential of these products. As healthcare providers seek effective treatments, the plasma fractionation market is likely to benefit from this heightened interest.

Technological Advancements in Fractionation Processes

Innovations in technology are transforming the plasma fractionation market. Enhanced manufacturing processes and improved safety measures are making plasma collection and processing more efficient. These advancements not only streamline operations but also ensure higher quality and safety standards for end products, which is crucial for patient care.

Focus on Sustainable Practices

There is a noticeable shift towards sustainability within the plasma fractionation market. Companies are increasingly adopting eco-friendly practices in their operations, reflecting a broader commitment to environmental responsibility. This trend may lead to the development of greener technologies and processes, aligning with global sustainability goals.

Italy Plasma Fractionation Market Drivers

Government Initiatives and Funding

Government support plays a pivotal role in the advancement of the plasma fractionation market. In Italy, various initiatives aimed at improving healthcare infrastructure and funding for research in biopharmaceuticals are evident. The Italian government has allocated substantial budgets to enhance blood donation programs and support plasma collection centers. This funding is likely to facilitate the development of new fractionation technologies and improve the overall efficiency of plasma processing. As a result, the plasma fractionation market may experience accelerated growth, with increased availability of plasma-derived therapies for patients in need.

Rising Awareness of Plasma Donation

Public awareness regarding the importance of plasma donation is steadily increasing in Italy. Campaigns aimed at educating citizens about the benefits of donating plasma have gained traction, leading to a higher number of donations. This increase in plasma availability is crucial for the plasma fractionation market, as it ensures a steady supply of raw material for fractionation processes. The plasma fractionation market could potentially benefit from this trend, as more donations may lead to enhanced production capabilities and a wider range of therapeutic products available for patients. This shift in public perception is likely to contribute positively to the market's growth trajectory.

Advancements in Research and Development

Ongoing research and development efforts in Italy are significantly influencing the plasma fractionation market. Innovations in fractionation techniques and the development of new plasma-derived therapies are at the forefront of this industry. Italian research institutions and universities are collaborating with pharmaceutical companies to explore novel applications of plasma proteins. This collaborative approach is likely to yield breakthroughs that enhance the efficacy and safety of plasma-derived products. The plasma fractionation market stands to gain from these advancements, as they may lead to the introduction of new therapies that address unmet medical needs, thereby expanding the market.

Increasing Prevalence of Chronic Diseases

The rising incidence of chronic diseases in Italy is a crucial driver for the plasma fractionation market. Conditions such as hemophilia, immune deficiencies, and other blood-related disorders necessitate the use of plasma-derived therapies. According to recent health statistics, approximately 1 in 10 individuals in Italy suffers from a chronic illness, which underscores the growing need for effective treatment options. This trend is likely to propel the demand for plasma-derived products, thereby enhancing the market's growth. The plasma fractionation market is expected to see a surge in investments aimed at developing innovative therapies that cater to these health challenges, potentially leading to a more robust healthcare system in Italy.

Growing Demand for Immunoglobulin Products

The demand for immunoglobulin products is on the rise in Italy, driven by their critical role in treating various immune disorders. Immunoglobulins, derived from plasma, are essential for patients with immunodeficiencies and autoimmune diseases. The plasma fractionation market is likely to experience growth as healthcare providers increasingly recognize the therapeutic benefits of these products. Market data indicates that the consumption of immunoglobulin therapies has increased by approximately 15% annually in recent years. This trend suggests a robust market potential for plasma-derived immunoglobulins, further solidifying the importance of the plasma fractionation market in the Italian healthcare landscape.

Market Segment Insights

Italy Plasma Fractionation Market Segment Insights

Italy Plasma Fractionation Market Segment Insights

Plasma Fractionation Market Product Type Insights

Plasma Fractionation Market Product Type Insights

The Italy Plasma Fractionation Market encompasses various product types, with Immunoglobulin, Albumin, Coagulation Factors, and Protease Inhibitors being key segments contributing to the market's growth. Immunoglobulin plays a critical role in treating immunodeficiencies and autoimmune diseases, thus showcasing its importance in the healthcare landscape of Italy, where advancements in treatment protocols are continuously being made. Albumin is another essential product, primarily utilized in therapeutic and clinical settings, serving functions ranging from volume replacement to maintaining oncotic pressure, making it significant for patient care, particularly in surgical and critical care environments.

Coagulation Factors are vital in managing bleeding disorders such as hemophilia, highlighting their importance in enhancing patient outcomes and improving the quality of life for individuals with these conditions. Meanwhile, Protease Inhibitors are crucial in the management of viral infections and to treatment protocols in various clinical scenarios. The growing elderly population in Italy coupled with the rising prevalence of chronic diseases, forms a strong backdrop for the increasing demand for these products.

Plasma Fractionation Market Application Insights

Plasma Fractionation Market Application Insights

The Application segment of the Italy Plasma Fractionation Market is characterized by diverse fields, each contributing significantly to the healthcare landscape. Neurology, with its increasing prevalence of neurodegenerative disorders, underscores the critical role of plasma-derived therapies in managing conditions like multiple sclerosis and Guillain-Barre syndrome. In Hematology, the demand for immunoglobulins and clotting factors is prominent, aiding in the treatment of blood disorders and supporting patients with hemophilia. 

General Medicine encapsulates a range of therapeutic applications, highlighting how various plasma products are utilized in surgeries and emergency care.Immunology stands out due to the rising focus on immune deficiencies and autoimmune diseases, where plasma-derived products are essential in bolstering patient health. The Italy Plasma Fractionation Market is poised for growth, driven by advancements in biotechnology and increasing healthcare needs, which collectively enhance the importance and application of these therapeutic areas in the region. As such, the segmentation reflects a strong interplay between medical necessity and innovative therapies in addressing complex health challenges.

Plasma Fractionation Market End User Insights

Plasma Fractionation Market End User Insights

The Italy Plasma Fractionation Market is characterized by a diverse range of End Users, including Hospitals, Ambulatory Surgical Centers, Blood Banks, and Pharmaceutical Companies, each playing a critical role in the healthcare ecosystem. Hospitals are essential for administering plasma-derived therapies and managing complex cases, leading to a significant demand for plasma products.

Ambulatory Surgical Centers, with their focus on outpatient procedures, are increasingly utilizing plasma fractionation products for various surgical applications, enhancing patient care and reducing hospital stays.Blood Banks remain vital as they ensure a steady supply of plasma and its derivatives for transfusions and therapies, contributing to public health initiatives. 

Plasma Fractionation Market Technology Insights

Plasma Fractionation Market Technology Insights

The Technology segment of the Italy Plasma Fractionation Market plays a crucial role in the overall industry with techniques such as Centrifugation, Chromatography, Precipitation, and Filtration being prominent methods of plasma processing. Centrifugation is widely recognized for its efficiency in separating plasma components based on density, making it an essential process in the production of immunoglobulins and clotting factors. Chromatography stands out for its capability to purify proteins and other bioactive substances, ensuring high-quality end products.Precipitation offers a cost-effective approach for concentrating proteins and facilitating downstream processing. 

Filtration methods are increasingly significant in maintaining product integrity by effectively removing impurities. The combination of these technologies fosters enhanced product yields and operational efficiency, aligning with the growing demand for therapeutic products derived from human plasma in Italy. The Italy Plasma Fractionation Market continues to evolve, driven by technological advancements, regulatory frameworks, and the ongoing emphasis on innovative treatment options for various medical conditions.

Get more detailed insights about Italy Plasma Fractionation Market

Key Players and Competitive Insights

The plasma fractionation market in Italy is characterized by a competitive landscape that is increasingly shaped by innovation, strategic partnerships, and regional expansion. Key players such as Grifols (ES), CSL Behring (AU), and Takeda Pharmaceutical Company (JP) are at the forefront, each employing distinct strategies to enhance their market presence. Grifols (ES) focuses on expanding its product portfolio through research and development, while CSL Behring (AU) emphasizes strategic acquisitions to bolster its capabilities. Takeda Pharmaceutical Company (JP) appears to be leveraging its global footprint to enhance distribution networks, thereby increasing accessibility to its plasma-derived therapies. Collectively, these strategies contribute to a dynamic competitive environment, where innovation and operational efficiency are paramount.In terms of business tactics, companies are increasingly localizing manufacturing to reduce supply chain vulnerabilities and enhance responsiveness to market demands. The market structure is moderately fragmented, with several players vying for market share, yet a few dominant firms hold significant influence. This competitive structure allows for a diverse range of products and services, catering to various therapeutic needs while fostering a climate of innovation.

In October Grifols (ES) announced the opening of a new state-of-the-art manufacturing facility in Italy, aimed at increasing its production capacity for immunoglobulin therapies. This strategic move is likely to enhance Grifols' ability to meet the growing demand for plasma-derived products in the region, positioning the company favorably against its competitors. The investment in local manufacturing not only signifies a commitment to the Italian market but also reflects a broader trend towards supply chain optimization.

In September CSL Behring (AU) entered into a partnership with a local biotech firm to co-develop novel therapies derived from human plasma. This collaboration is indicative of CSL Behring's strategy to innovate and diversify its product offerings, potentially leading to breakthroughs in treatment options for rare diseases. Such partnerships may enhance the company's research capabilities and accelerate the development of new therapies, thereby strengthening its competitive edge.

In August Takeda Pharmaceutical Company (JP) launched a digital platform aimed at improving patient access to its plasma-derived therapies. This initiative underscores the growing importance of digital transformation in the healthcare sector, as companies seek to enhance patient engagement and streamline distribution processes. By integrating technology into its operations, Takeda is likely to improve its service delivery and maintain a competitive advantage in an increasingly digital marketplace.

As of November current trends in the plasma fractionation market are heavily influenced by digitalization, sustainability, and the integration of artificial intelligence (AI) into operational processes. Strategic alliances are becoming more prevalent, as companies recognize the value of collaboration in driving innovation and expanding market reach. Looking ahead, competitive differentiation is expected to evolve, with a shift from traditional price-based competition towards a focus on technological advancements, innovative solutions, and reliable supply chains. This transition may redefine the competitive landscape, compelling companies to prioritize R&D and operational excellence to maintain their market positions.

Key Companies in the Italy Plasma Fractionation Market include

Industry Developments

In recent months, the Italy Plasma Fractionation Market has seen notable developments, particularly with companies such as Octapharma and Grifols continuing to invest in product innovations and expansions. In September 2023, Octapharma announced a significant increase in their production capacities in Italy, aiming to enhance the availability of their plasma-derived products amidst rising demand. Meanwhile, Grifols has engaged in strategic partnerships to strengthen its distribution channels across Europe, further solidifying its presence in the Italian market.Current affairs highlight a favorable regulatory environment which has been reinforced by the Italian government’s efforts to promote healthcare advancements. 

In terms of mergers and acquisitions, in June 2023, Takeda Pharmaceutical completed their acquisition of a smaller biotech firm focused on plasma therapies, reinforcing their portfolio in Italy. The cumulative effect of these activities has positively impacted the market valuation of companies engaged in plasma fractionation, showcasing intensified competition and innovation. Over the last two to three years, the market witnessed substantial growth driven by rising healthcare needs and advancements in plasma therapies, positioning Italy as a crucial player within the European plasma fractionation landscape.

 

Future Outlook

Italy Plasma Fractionation Market Future Outlook

The Plasma Fractionation Market is projected to grow at a 6.59% CAGR from 2024 to 2035, driven by increasing demand for immunoglobulins and advancements in fractionation technologies.

New opportunities lie in:

  • Expansion of contract manufacturing services for biopharmaceutical companies.
  • Development of innovative plasma-derived therapies targeting rare diseases.
  • Investment in automated plasma collection and processing technologies.

By 2035, the market is expected to achieve robust growth, driven by strategic innovations and increased demand.

Market Segmentation

Italy Plasma Fractionation Market End User Outlook

  • Hospitals
  • Ambulatory Surgical Centers
  • Blood Banks
  • Pharmaceutical Companies

Italy Plasma Fractionation Market Technology Outlook

  • Centrifugation
  • Chromatography
  • Precipitation
  • Filtration

Italy Plasma Fractionation Market Application Outlook

  • Neurology
  • Hematology
  • General Medicine
  • Immunology

Italy Plasma Fractionation Market Product Type Outlook

  • Immunoglobulin
  • Albumin
  • Coagulation Factors
  • Protease Inhibitors

Report Scope

MARKET SIZE 2024 1113.7(USD Million)
MARKET SIZE 2025 1187.09(USD Million)
MARKET SIZE 2035 2247.4(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 6.59% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Grifols (ES), CSL Behring (AU), Takeda Pharmaceutical Company (JP), Octapharma (CH), Kedrion (IT), Biotest AG (DE), LFB Group (FR), Sangamo Therapeutics (US), Emergent BioSolutions (US)
Segments Covered Application, Product Type, End User, Technology
Key Market Opportunities Advancements in plasma-derived therapies drive growth in the plasma fractionation market.
Key Market Dynamics Rising demand for immunoglobulins drives innovation and competition in the plasma fractionation market.
Countries Covered Italy
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FAQs

What is the expected market size of the Italy Plasma Fractionation Market in 2024?

The Italy Plasma Fractionation Market is expected to be valued at 709.8 USD Million in 2024.

What is the forecasted market size for the Italy Plasma Fractionation Market by 2035?

By 2035, the Italy Plasma Fractionation Market is expected to grow to 1120.0 USD Million.

What is the expected compound annual growth rate (CAGR) for the Italy Plasma Fractionation Market from 2025 to 2035?

The CAGR for the Italy Plasma Fractionation Market from 2025 to 2035 is expected to be 4.234 %.

Which product type is projected to have the highest market value in 2035 within the Italy Plasma Fractionation Market?

Immunoglobulin is projected to have the highest market value, reaching 550.0 USD Million by 2035.

Who are the major players in the Italy Plasma Fractionation Market?

Key players in the market include Octapharma, Grifols, and CSL Behring, among others.

What is the market value of Albumin in the Italy Plasma Fractionation Market for 2024?

The market value of Albumin in 2024 is expected to be 180.0 USD Million.

What is the expected market size for Coagulation Factors by 2035?

The expected market size for Coagulation Factors in 2035 is projected to be 200.0 USD Million.

What opportunities for growth exist in the Italy Plasma Fractionation Market?

Emerging trends and increased demand for therapeutic proteins present significant opportunities for growth.

What challenges does the Italy Plasma Fractionation Market currently face?

Regulatory hurdles and competition among major players are current challenges in the market.

How does regionality impact the growth rate of the Italy Plasma Fractionation Market?

The growth rate in the Italy Plasma Fractionation Market is influenced by regional healthcare policies and demand for plasma-derived therapies.

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