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    Endocannabinoid Therapeutics Market

    ID: MRFR/HC/38243-HCR
    100 Pages
    Rahul Gotadki
    October 2025

    Endocannabinoid Therapeutics Market Research Report By Product Type (Cannabinoid-based Medications, Cannabinoid-based Supplements, Cannabinoid-based Topicals), By Application (Pain Management, Neurological Disorders, Mental Health Disorders, Cancer Symptom Management), By Route of Administration (Oral, Topical, Inhalation, Transdermal), By End User (Hospitals, Clinics, Homecare) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2035

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    Endocannabinoid Therapeutics Market Infographic
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    Endocannabinoid Therapeutics Market Summary

    As per MRFR analysis, the Endocannabinoid Therapeutics Market was estimated at 6.401 USD Billion in 2024. The Endocannabinoid Therapeutics industry is projected to grow from 7.983 USD Billion in 2025 to 72.65 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 24.71 during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The Endocannabinoid Therapeutics Market is experiencing robust growth driven by increasing acceptance and advancements in research.

    • The market is witnessing a rising acceptance of cannabinoid therapies, particularly in North America.
    • Advancements in research and development are propelling innovations in cannabinoid-based medications and supplements.
    • Regulatory developments and standardization are shaping the landscape, especially in the Asia-Pacific region.
    • Key market drivers include the increasing prevalence of chronic diseases and growing consumer awareness and acceptance.

    Market Size & Forecast

    2024 Market Size 6.401 (USD Billion)
    2035 Market Size 72.65 (USD Billion)
    CAGR (2025 - 2035) 24.71%

    Major Players

    GW Pharmaceuticals (GB), Canopy Growth Corporation (CA), Aurora Cannabis (CA), Tilray, Inc. (CA), Cronos Group (CA), Aphria Inc. (CA), Zynerba Pharmaceuticals (US), Epidiolex (US), Cura Cannabis Solutions (US)

    Endocannabinoid Therapeutics Market Trends

    The Endocannabinoid Therapeutics Market is currently experiencing a notable evolution, driven by increasing recognition of the therapeutic potential of cannabinoids. This market encompasses a range of products that interact with the endocannabinoid system, which plays a crucial role in regulating various physiological processes. As research continues to unveil the benefits of cannabinoids in treating conditions such as chronic pain, anxiety, and neurological disorders, the demand for these therapeutics is likely to rise. Furthermore, the growing acceptance of cannabis-based treatments among healthcare professionals and patients alike suggests a shift in perception, which may further bolster market growth. In addition to the expanding therapeutic applications, regulatory frameworks surrounding cannabinoid products are gradually becoming more defined. This development could enhance market stability and encourage investment in research and development. Moreover, advancements in extraction and formulation technologies are likely to improve product efficacy and safety, thereby attracting a broader consumer base. As the Endocannabinoid Therapeutics Market continues to mature, it appears poised for sustained growth, driven by innovation and a deeper understanding of the endocannabinoid system's role in health and disease.

    Rising Acceptance of Cannabinoid Therapies

    The growing acceptance of cannabinoid-based therapies among healthcare providers and patients is reshaping the Endocannabinoid Therapeutics Market. This trend indicates a shift in attitudes towards cannabis, as more individuals recognize its potential benefits for various health conditions.

    Advancements in Research and Development

    Ongoing research into the endocannabinoid system and its implications for health is propelling innovation within the market. New findings may lead to the development of novel therapeutics, enhancing treatment options for patients and expanding the market's scope.

    Regulatory Developments and Standardization

    The evolution of regulatory frameworks surrounding cannabinoid products is fostering a more structured market environment. As regulations become clearer, companies may find it easier to navigate compliance, potentially leading to increased investment and market growth.

    The increasing recognition of the therapeutic potential of cannabinoids in managing various health conditions appears to be reshaping the landscape of modern medicine.

    National Institutes of Health (NIH)

    Endocannabinoid Therapeutics Market Drivers

    Innovations in Delivery Systems

    Advancements in delivery systems for cannabinoid therapies are poised to enhance the efficacy and appeal of products within the Endocannabinoid Therapeutics Market. Innovative formulations, such as transdermal patches, inhalers, and sublingual sprays, are being developed to improve bioavailability and patient compliance. These novel delivery methods may allow for more precise dosing and faster onset of effects, addressing some of the limitations associated with traditional consumption methods. As these innovations gain traction, they could potentially attract a wider range of consumers, thereby expanding the market. The Endocannabinoid Therapeutics Market stands to benefit from these technological advancements, which may lead to increased sales and market penetration.

    Rising Investment in Cannabis Research

    The increasing investment in cannabis research and development is expected to significantly impact the Endocannabinoid Therapeutics Market. Both public and private sectors are allocating substantial resources to explore the therapeutic applications of cannabinoids, leading to a surge in clinical trials and scientific studies. This influx of funding may accelerate the discovery of new cannabinoid-based treatments, potentially addressing a variety of medical conditions. As research continues to validate the efficacy of these therapies, the Endocannabinoid Therapeutics Market could experience substantial growth, driven by a pipeline of innovative products that meet the evolving needs of patients.

    Growing Consumer Awareness and Acceptance

    Consumer awareness regarding the therapeutic benefits of cannabinoids is on the rise, which may significantly influence the Endocannabinoid Therapeutics Market. As educational initiatives and advocacy efforts proliferate, more individuals are becoming informed about the potential health benefits of cannabinoid therapies. Surveys indicate that a substantial percentage of the population is open to using cannabis-derived products for medicinal purposes. This shift in perception is likely to drive demand for cannabinoid-based treatments, as patients seek alternatives to traditional pharmaceuticals. Consequently, the Endocannabinoid Therapeutics Market may experience robust growth as acceptance continues to broaden across various demographics.

    Increasing Prevalence of Chronic Diseases

    The rising incidence of chronic diseases such as arthritis, multiple sclerosis, and epilepsy appears to be a significant driver for the Endocannabinoid Therapeutics Market. As these conditions become more prevalent, the demand for effective treatment options intensifies. Research indicates that cannabinoids may provide relief for symptoms associated with these ailments, leading to a growing interest in their therapeutic potential. In fact, studies have shown that approximately 50 million adults in the United States alone suffer from chronic pain, which could potentially be alleviated through cannabinoid-based therapies. This trend suggests that the Endocannabinoid Therapeutics Market is likely to expand as healthcare providers increasingly consider cannabinoid therapies as viable treatment alternatives.

    Regulatory Support and Evolving Legislation

    The evolving regulatory landscape surrounding cannabinoid therapies is likely to play a crucial role in shaping the Endocannabinoid Therapeutics Market. As governments and regulatory bodies begin to recognize the therapeutic potential of cannabinoids, there is a growing trend towards the establishment of clear guidelines and frameworks for their use. This regulatory support may facilitate research and development efforts, encouraging pharmaceutical companies to invest in cannabinoid-based products. Furthermore, as legislation becomes more favorable, the market could witness an influx of new entrants and innovative therapies, ultimately enhancing competition and consumer choice within the Endocannabinoid Therapeutics Market.

    Market Segment Insights

    By Type: Cannabinoid-based Medications (Largest) vs. Cannabinoid-based Supplements (Fastest-Growing)

    The Endocannabinoid Therapeutics Market showcases a diverse landscape characterized by three primary segments: Cannabinoid-based Medications, Cannabinoid-based Supplements, and Cannabinoid-based Topicals. Cannabinoid-based Medications hold the largest share in this market, driven by the increasing acceptance and recognition of cannabinoids in therapeutic applications. In contrast, Cannabinoid-based Supplements are witnessing rapid growth, appealing to a health-conscious demographic attractive to natural and holistic approaches to wellness, positioning themselves as an essential player in the market. The growth trajectory of these segments is influenced by several factors, including the rising prevalence of chronic diseases, increased patient awareness, and expanding clinical research supporting the medicinal benefits of cannabinoids. Notably, Cannabinoid-based Supplements are becoming popular among consumers seeking alternative therapies for various health conditions, thereby adjusting the overall dynamics of the Endocannabinoid Therapeutics Market and prompting manufacturers to innovate to meet rising demand.

    Cannabinoid-based Medications (Dominant) vs. Cannabinoid-based Topicals (Emerging)

    Cannabinoid-based Medications are currently the dominant force within the Endocannabinoid Therapeutics Market, primarily due to their established efficacy in treating serious health conditions such as chronic pain, epilepsy, and inflammation-related disorders. They benefit from a strong regulatory framework which allows for their widespread availability and application in clinical settings. Conversely, Cannabinoid-based Topicals are emerging as a popular alternative, particularly for consumers seeking localized relief without systemic effects. This segment is gaining traction, especially in the skincare and wellness markets, where consumers are increasingly opting for natural solutions. The juxtaposition of these two segments illustrates the broader trend within the market, where consumer awareness and preference for cannabinoid-based solutions are rapidly evolving.

    By Application: Pain Management (Largest) vs. Neurological Disorders (Fastest-Growing)

    The Endocannabinoid Therapeutics Market is witnessing distinct dynamics in its application segments, with Pain Management leading in market share. This segment is widely recognized for its effectiveness in addressing chronic pain conditions, driving substantial demand. Neurological Disorders, while smaller in share, exhibit rapid growth as the understanding of endocannabinoid systems and their role in conditions like epilepsy and multiple sclerosis expands, drawing increased interest in therapeutic applications. Analysis of growth trends shows that Pain Management remains the dominant application due to its established therapeutic benefits and broad acceptance among healthcare providers and patients. Conversely, Neurological Disorders are gaining momentum, driven by increasing research and clinical trials. The rising prevalence of neurological conditions and supportive regulatory environments catalyze this segment's growth, making it an area of significant investment and innovation.

    Pain Management (Dominant) vs. Cancer Symptom Management (Emerging)

    Pain Management is firmly established as the dominant application in the Endocannabinoid Therapeutics Market. This segment benefits from a robust foundation of clinical evidence supporting the efficacy of cannabinoids in alleviating various forms of pain. Its widespread acceptance among medical practitioners and patients alike positions it favorably against competitors. On the other hand, Cancer Symptom Management is emerging as a vital application, appealing to patients seeking relief from treatment-induced symptoms like nausea and lack of appetite. This segment's growth is fueled by increasing research into cannabinoids' efficacy in improving quality of life for cancer patients, highlighting the necessity for integrated therapeutic approaches within oncological care.

    By Route of Administration: Oral (Largest) vs. Inhalation (Fastest-Growing)

    In the Endocannabinoid Therapeutics Market, the Route of Administration segment showcases a diverse landscape, with Oral administration holding the largest share. This method has gained significant traction due to its convenience and ease of use for patients seeking therapeutic benefits. Following closely is Transdermal delivery, which has also carved out a substantial niche, appealing particularly to patients desiring localized effects. In contrast, Inhalation methods, while currently smaller in market share, are surging in popularity due to their rapid onset and effectiveness, indicating a dynamic shift in consumer preferences. Growth trends within this segment are driven by evolving consumer acceptance of cannabis-derived products, alongside advancements in formulation technologies. The rise of Inhalation methods signals a strong push towards immediacy in therapeutic effects, catering to individuals seeking fast relief. Meanwhile, the Oral route’s sustained dominance underscores a foundational shift in treatment paradigms, embracing natural alternatives that harmonize with patient-centric care. This evolving landscape is shaping the future of the Endocannabinoid Therapeutics Market as it adapts to changing patient needs and regulatory landscapes.

    Oral (Dominant) vs. Inhalation (Emerging)

    The Oral route is the dominant method of administration in the Endocannabinoid Therapeutics Market. It is favored for its user-friendliness, allowing patients to easily consume cannabinoid-infused products like oils and capsules. This method offers a steady release of cannabinoids into the system, providing a gradual and sustained therapeutic effect, which is particularly appealing for chronic conditions. On the other hand, Inhalation techniques, including vaporizing and smoking, represent an emerging approach, gaining ground due to their quick absorption and efficiency. Frequently preferred by patients seeking immediate relief, Inhalation methods are increasingly becoming popular among younger demographics who prioritize rapid therapeutic response. The contrasting characteristics of these two segments highlight the diverse preferences of patients and underline the complexities of the market.

    By End User: Hospitals (Largest) vs. Clinics (Fastest-Growing)

    In the Endocannabinoid Therapeutics Market, the distribution of market share among end users reveals that hospitals hold the largest portion, benefitting from their comprehensive healthcare services that incorporate advanced therapies. Clinics, while smaller in terms of current market share, are emerging as a pivotal segment due to their increasing adoption of cannabinoid-based treatments tailored for outpatient care. This shift in therapy alignment supports a rising trend towards more personalized medicine in clinics for managing conditions like chronic pain and anxiety.

    Hospitals: Dominant vs. Clinics: Emerging

    Hospitals as the dominant end user in the Endocannabinoid Therapeutics Market are equipped to deliver multifaceted treatment plans and have the infrastructure necessary for extensive patient management. They typically integrate these therapies within their protocols for pain management and palliative care. On the emerging side, clinics are carving out their niche by offering specialized cannabinoid therapies, catering to patients who prefer outpatient settings. This growth is propelled by increasing patient awareness and acceptance of medical cannabis, as well as favorable regulatory changes. Clinics are becoming vital access points for patients seeking effective alternatives to traditional pharmaceuticals.

    Get more detailed insights about Endocannabinoid Therapeutics Market

    Regional Insights

    North America : Leading Market for Innovation

    North America is the largest market for endocannabinoid therapeutics, holding approximately 60% of the global market share. The region's growth is driven by increasing acceptance of cannabis for medical use, supportive regulatory frameworks, and rising consumer demand for alternative therapies. The U.S. leads this market, followed closely by Canada, which contributes around 20% to the overall market. Regulatory catalysts, such as the legalization of cannabis in various states, further enhance market dynamics. The competitive landscape in North America is robust, featuring key players like GW Pharmaceuticals, Canopy Growth Corporation, and Tilray, Inc. The presence of established companies and innovative startups fosters a dynamic environment for research and development. The U.S. market is characterized by a diverse range of products, including oils, capsules, and edibles, catering to various consumer needs. This competitive edge positions North America as a leader in the endocannabinoid therapeutics sector.

    Europe : Emerging Market with Potential

    Europe is rapidly emerging as a significant player in the endocannabinoid therapeutics market, currently holding about 25% of the global share. The growth is fueled by increasing legalization of medical cannabis across various countries, alongside rising awareness of its therapeutic benefits. Germany and the UK are the largest markets in Europe, contributing approximately 10% and 8% respectively. Regulatory frameworks are evolving, with governments actively supporting research and development in this sector. Leading countries in Europe are Germany, the UK, and Italy, with a competitive landscape that includes both established pharmaceutical companies and new entrants. The presence of key players like Aurora Cannabis and Tilray enhances market dynamics. The European market is characterized by a growing demand for cannabis-based medicines, with a focus on patient-centric solutions. This trend is expected to drive further investment and innovation in the region.

    Asia-Pacific : Emerging Powerhouse in Cannabis

    Asia-Pacific is an emerging powerhouse in the endocannabinoid therapeutics market, currently holding around 10% of the global market share. The region's growth is driven by increasing interest in cannabis for medicinal purposes, particularly in countries like Australia and New Zealand, where regulations are becoming more favorable. The demand for alternative therapies is rising, and governments are beginning to recognize the potential benefits of cannabis-based treatments, which is expected to catalyze market expansion. Key players in the Asia-Pacific region include local companies and international firms looking to enter this burgeoning market. Australia is leading the charge with its progressive regulatory framework, while countries like Japan and South Korea are also exploring cannabis for medical use. The competitive landscape is evolving, with a focus on research and development to create innovative therapeutic solutions tailored to regional needs. This positions Asia-Pacific as a promising market for future growth in endocannabinoid therapeutics.

    Middle East and Africa : Untapped Market Opportunities

    The Middle East and Africa region is currently an untapped market for endocannabinoid therapeutics, holding approximately 5% of the global market share. The growth potential is significant, driven by increasing interest in cannabis for medical applications and evolving regulatory landscapes. Countries like South Africa are leading the way in legalization efforts, which could pave the path for broader acceptance and market growth. The region's diverse healthcare needs present unique opportunities for cannabis-based therapies. Leading countries in this region include South Africa and Israel, known for their progressive stances on medical cannabis. The competitive landscape is still developing, with a mix of local startups and international companies exploring opportunities. As regulations continue to evolve, the market is expected to attract investment and innovation, positioning the Middle East and Africa as a future player in the endocannabinoid therapeutics market.

    Key Players and Competitive Insights

    The Endocannabinoid Therapeutics Market is currently characterized by a dynamic competitive landscape, driven by increasing consumer demand for cannabinoid-based therapies and a growing body of research supporting their efficacy. Key players such as GW Pharmaceuticals (GB), Canopy Growth Corporation (CA), and Tilray, Inc. (CA) are strategically positioning themselves through innovation and partnerships. GW Pharmaceuticals (GB) has focused on expanding its product portfolio, particularly in the area of epilepsy treatments, while Canopy Growth Corporation (CA) has been investing heavily in research and development to enhance its therapeutic offerings. Tilray, Inc. (CA) is also pursuing strategic collaborations to broaden its market reach, indicating a collective emphasis on innovation and strategic partnerships that shape the competitive environment.

    In terms of business tactics, companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and reduce costs. The Endocannabinoid Therapeutics Market appears moderately fragmented, with several players vying for market share. The collective influence of these key players is significant, as they not only drive innovation but also set industry standards that smaller companies may follow, thereby influencing the overall market structure.

    In August 2025, GW Pharmaceuticals (GB) announced a collaboration with a leading research institution to develop new cannabinoid-based therapies for chronic pain management. This strategic move underscores the company's commitment to expanding its therapeutic applications and enhancing its competitive edge in a rapidly evolving market. By leveraging academic expertise, GW Pharmaceuticals (GB) aims to accelerate the development of innovative treatments, potentially positioning itself as a leader in pain management solutions.

    In September 2025, Canopy Growth Corporation (CA) launched a new line of cannabinoid-infused products aimed at the wellness sector, targeting consumers seeking natural alternatives for health management. This initiative reflects Canopy's strategy to diversify its product offerings and tap into the growing wellness trend, which is increasingly popular among health-conscious consumers. The launch not only enhances Canopy's market presence but also aligns with broader consumer preferences for holistic health solutions.

    In October 2025, Tilray, Inc. (CA) completed the acquisition of a smaller biotech firm specializing in cannabinoid research, which is expected to bolster its R&D capabilities significantly. This acquisition is indicative of Tilray's aggressive growth strategy and its focus on enhancing its product pipeline. By integrating specialized knowledge and technology, Tilray aims to accelerate the development of innovative therapies, thereby strengthening its competitive position in the market.

    As of October 2025, current trends in the Endocannabinoid Therapeutics Market include a pronounced shift towards digitalization, sustainability, and the integration of artificial intelligence in research and development processes. Strategic alliances are increasingly shaping the competitive landscape, as companies recognize the value of collaboration in driving innovation. Looking ahead, competitive differentiation is likely to evolve from traditional price-based competition to a focus on technological advancements, innovative product development, and reliable supply chain management, suggesting a more sophisticated and resilient market environment.

    Key Companies in the Endocannabinoid Therapeutics Market market include

    Industry Developments

    Recent developments in the Endocannabinoid Therapeutics Market have seen companies like Curaleaf Holdings Inc. and Cresco Labs Inc. expanding their operations through strategic partnerships and product launches aimed at enhancing their market presence. The increasing acceptance of cannabis-based therapies, particularly in the treatment of chronic pain and neurological disorders, continues to drive demand. Meanwhile, Planet 13 Holdings Inc. has reported significant revenue growth due to its innovative retail strategies, while Aurora Cannabis Inc. has focused on enhancing its research capabilities to support product development.

    Ascend Wellness Holdings Inc. has been actively expanding its footprint in the U.S. market, recognizing the potential for growth amid changing regulations. Notably, GW Pharmaceuticals plc recently made headlines after the acquisition of new research facilities, reinforcing its commitment to advancing cannabinoid-based medicines. Mergers and acquisitions within the sector are also noteworthy, with Trulieve Cannabis Corp and Tilray Inc engaging in transactions that aim to consolidate their market positions.

    The overall market valuation of companies such as Green Thumb Industries Inc. and Harvest Health and Recreation Inc. has seen measurable increases, reflecting growing investor confidence and the potential for continued expansion in the sector.

    Future Outlook

    Endocannabinoid Therapeutics Market Future Outlook

    The Endocannabinoid Therapeutics Market is projected to grow at a 24.71% CAGR from 2024 to 2035, driven by increasing legalization, rising consumer awareness, and advancements in research.

    New opportunities lie in:

    • Development of personalized cannabinoid therapies for chronic pain management.
    • Expansion of telehealth platforms for cannabinoid consultations.
    • Investment in clinical trials for novel cannabinoid-based medications.

    By 2035, the market is expected to be robust, reflecting substantial growth and innovation.

    Market Segmentation

    Endocannabinoid Therapeutics Market Type Outlook

    • Cannabinoid-based Medications
    • Cannabinoid-based Supplements
    • Cannabinoid-based Topicals

    Endocannabinoid Therapeutics Market End User Outlook

    • Hospitals
    • Clinics
    • Homecare

    Endocannabinoid Therapeutics Market Application Outlook

    • Pain Management
    • Neurological Disorders
    • Mental Health Disorders
    • Cancer Symptom Management

    Endocannabinoid Therapeutics Market Route of Administration Outlook

    • Oral
    • Topical
    • Inhalation
    • Transdermal

    Report Scope

    MARKET SIZE 20246.401(USD Billion)
    MARKET SIZE 20257.983(USD Billion)
    MARKET SIZE 203572.65(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR)24.71% (2024 - 2035)
    REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR2024
    Market Forecast Period2025 - 2035
    Historical Data2019 - 2024
    Market Forecast UnitsUSD Billion
    Key Companies ProfiledMarket analysis in progress
    Segments CoveredMarket segmentation analysis in progress
    Key Market OpportunitiesEmerging research on cannabinoid receptors indicates potential for novel therapeutic applications in the Endocannabinoid Therapeutics Market.
    Key Market DynamicsRising consumer demand for natural remedies drives innovation and competition in the Endocannabinoid Therapeutics Market.
    Countries CoveredNorth America, Europe, APAC, South America, MEA

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    FAQs

    What is the current valuation of the Endocannabinoid Therapeutics Market?

    The Endocannabinoid Therapeutics Market was valued at 6.401 USD Billion in 2024.

    What is the projected market size for the Endocannabinoid Therapeutics Market by 2035?

    The market is projected to reach 72.65 USD Billion by 2035.

    What is the expected CAGR for the Endocannabinoid Therapeutics Market during the forecast period 2025 - 2035?

    The expected CAGR for the market during 2025 - 2035 is 24.71%.

    Which segment of the Endocannabinoid Therapeutics Market had the highest valuation in 2024?

    In 2024, the Cannabinoid-based Medications segment had the highest valuation at 2.56 USD Billion.

    What applications are driving growth in the Endocannabinoid Therapeutics Market?

    Pain Management, with a valuation of 2.56 USD Billion in 2024, is a key application driving market growth.

    How do cannabinoid-based supplements compare to other segments in terms of market size?

    Cannabinoid-based Supplements were valued at 2.4 USD Billion in 2024, indicating strong market presence.

    What routes of administration are most prevalent in the Endocannabinoid Therapeutics Market?

    Oral administration, valued at 1.92 USD Billion in 2024, is currently the most prevalent route.

    Which end user segment is expected to dominate the Endocannabinoid Therapeutics Market?

    The Homecare segment, with a valuation of 2.93 USD Billion in 2024, is expected to dominate the market.

    Who are the key players in the Endocannabinoid Therapeutics Market?

    Key players include GW Pharmaceuticals, Canopy Growth Corporation, and Tilray, Inc.

    What is the projected growth trend for cannabinoid-based topicals in the coming years?

    Cannabinoid-based Topicals, valued at 1.45 USD Billion in 2024, may experience substantial growth through 2035.

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