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Cancer Gene Therapy Market

ID: MRFR/Pharma/40603-HCR
200 Pages
Garvit Vyas
October 2025

Cancer Gene Therapy Market Research Report By Therapeutic Approach (Gene Editing, Gene Transfer, Oncolytic Virus Therapy, Gene Silencing, Immunotherapy), By Target Disease (Breast Cancer, Lung Cancer, Leukemia, Colorectal Cancer, Prostate Cancer), By Type of Therapy (Ex-Vivo Therapy, In-Vivo Therapy, Combination Therapy), By Delivery Method (Viral Vectors, Plasmid DNA, Nanoparticles) andBy Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa)- Forecast to 2035

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Cancer Gene Therapy Market Summary

As per MRFR analysis, the Cancer Gene Therapy Market was estimated at 8.05 USD Billion in 2024. The Cancer Gene Therapy industry is projected to grow from 9.126 USD Billion in 2025 to 32.01 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 13.37 during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The Cancer Gene Therapy Market is poised for substantial growth driven by technological advancements and increasing acceptance of innovative treatments.

  • Technological advancements in gene editing are revolutionizing treatment options in the Cancer Gene Therapy Market.
  • North America remains the largest market, while the Asia-Pacific region is emerging as the fastest-growing area for cancer gene therapies.
  • Immunotherapy continues to dominate the market, whereas gene editing is recognized as the fastest-growing segment.
  • The rising incidence of cancer and increased investment in cancer research are key drivers propelling market expansion.

Market Size & Forecast

2024 Market Size 8.05 (USD Billion)
2035 Market Size 32.01 (USD Billion)
CAGR (2025 - 2035) 13.37%

Major Players

Novartis (CH), Gilead Sciences (US), Bristol-Myers Squibb (US), Amgen (US), Sangamo Therapeutics (US), Bluebird Bio (US), Spark Therapeutics (US), Celyad Oncology (BE), Zymeworks (CA)

Cancer Gene Therapy Market Trends

The Cancer Gene Therapy Market is currently experiencing a transformative phase, characterized by rapid advancements in genetic engineering and personalized medicine. This evolution is largely driven by the increasing understanding of genetic mutations and their roles in cancer progression. As researchers delve deeper into the genetic underpinnings of various malignancies, the potential for targeted therapies appears to expand. Moreover, the integration of innovative technologies, such as CRISPR and viral vectors, is enhancing the efficacy of gene therapies, thereby offering new hope for patients with previously untreatable cancers. Regulatory bodies are also adapting to these changes, streamlining approval processes to facilitate quicker access to novel therapies. In addition to technological advancements, the Cancer Gene Therapy Market is witnessing a growing emphasis on patient-centric approaches. This shift is reflected in the development of therapies tailored to individual genetic profiles, which may lead to improved treatment outcomes. Furthermore, collaborations between academic institutions and biotechnology firms are fostering an environment ripe for innovation. As the market continues to evolve, it is likely that the focus will remain on enhancing the safety and effectiveness of gene therapies, ultimately aiming to provide more comprehensive solutions for cancer treatment.

Technological Advancements in Gene Editing

The Cancer Gene Therapy Market is increasingly influenced by breakthroughs in gene editing technologies. Innovations such as CRISPR and TALENs are revolutionizing the way genetic modifications are performed, allowing for precise alterations in the DNA of cancer cells. This precision may lead to more effective therapies that target specific mutations, potentially improving patient outcomes.

Personalized Medicine Trends

There is a notable shift towards personalized medicine within the Cancer Gene Therapy Market. Therapies are being developed to cater to the unique genetic profiles of individual patients, which may enhance treatment efficacy. This trend suggests a move away from one-size-fits-all approaches, indicating a more tailored strategy in cancer treatment.

Collaborative Research Initiatives

Collaborations between academic institutions and biotechnology companies are becoming increasingly prevalent in the Cancer Gene Therapy Market. These partnerships are fostering innovation and accelerating the development of new therapies. By pooling resources and expertise, stakeholders are likely to enhance the pace of research and bring novel treatments to market more efficiently.

Cancer Gene Therapy Market Drivers

Rising Incidence of Cancer

The increasing prevalence of cancer worldwide is a primary driver for the Cancer Gene Therapy Market. According to recent statistics, cancer cases are projected to rise significantly, with estimates suggesting that by 2040, the number of new cancer cases could reach over 27 million annually. This alarming trend necessitates innovative treatment options, including gene therapy, which aims to target the genetic basis of cancer. As healthcare systems grapple with the growing burden of cancer, the demand for effective therapies is likely to escalate, propelling the Cancer Gene Therapy Market forward. Furthermore, the shift towards more personalized treatment approaches aligns with the capabilities of gene therapy, which can be tailored to individual genetic profiles, thereby enhancing treatment efficacy and patient outcomes.

Increased Investment in Cancer Research

The Cancer Gene Therapy Market is experiencing a surge in investment from both public and private sectors. Governments and organizations are recognizing the urgent need for innovative cancer treatments, leading to increased funding for research initiatives. For instance, funding for cancer research has seen a substantial rise, with billions allocated annually to support clinical trials and the development of new therapies. This influx of capital is fostering collaboration among researchers, biotech companies, and academic institutions, which is essential for advancing gene therapy technologies. As more resources are dedicated to understanding cancer at the molecular level, the potential for breakthroughs in gene therapy is likely to expand, further propelling the Cancer Gene Therapy Market.

Advancements in Gene Editing Technologies

Recent advancements in gene editing technologies, such as CRISPR and TALEN, are revolutionizing the Cancer Gene Therapy Market. These technologies enable precise modifications to the genetic material of cancer cells, offering new avenues for treatment. The ability to edit genes with high accuracy has led to the development of novel therapies that can potentially cure previously untreatable cancers. Market data indicates that the gene editing market is expected to grow at a compound annual growth rate of over 30% in the coming years, reflecting the increasing investment in research and development. As these technologies continue to evolve, they are likely to enhance the effectiveness and safety of gene therapies, thereby driving growth in the Cancer Gene Therapy Market.

Regulatory Support for Gene Therapy Approvals

Regulatory bodies are increasingly supportive of gene therapy innovations, which is a crucial driver for the Cancer Gene Therapy Market. Recent regulatory frameworks have been established to expedite the approval process for gene therapies, recognizing their potential to address unmet medical needs in oncology. For example, the introduction of breakthrough therapy designations allows for faster review and approval of promising gene therapies. This regulatory support not only encourages pharmaceutical companies to invest in gene therapy research but also instills confidence in investors and stakeholders. As more gene therapies receive regulatory approval, the market is likely to witness a surge in available treatment options, further stimulating growth in the Cancer Gene Therapy Market.

Growing Awareness and Acceptance of Gene Therapies

There is a notable increase in awareness and acceptance of gene therapies among healthcare professionals and patients, which is positively impacting the Cancer Gene Therapy Market. Educational campaigns and successful case studies are helping to demystify gene therapy, showcasing its potential benefits in treating various cancers. As patients become more informed about their treatment options, they are increasingly advocating for advanced therapies, including gene therapy. Market Research Future indicates that patient acceptance of gene therapies is on the rise, with many expressing willingness to consider these innovative treatments. This shift in perception is likely to drive demand for gene therapy solutions, thereby contributing to the growth of the Cancer Gene Therapy Market.

Market Segment Insights

By Therapeutic Approach: Immunotherapy (Largest) vs. Gene Editing (Fastest-Growing)

In the Cancer Gene Therapy Market, Immunotherapy dominates with the largest share, driven by its effectiveness in harnessing the body's immune system to target and destroy cancer cells. It is being adopted widely in treatment protocols, reflecting a shift towards personalized medicine. In contrast, Gene Editing, employing tools like CRISPR, is gaining rapid traction as it offers precise modifications at the genetic level, unlocking new potential for curing previously untreatable cancers. As research progresses, its market share is expected to grow significantly. The growth trends in the Cancer Gene Therapy Market are largely influenced by advancements in technology and increased investment in research and development. Immunotherapy continues to thrive due to its robust clinical results and regulatory approvals, while Gene Editing benefits from breakthroughs in genetic research. The increasing prevalence of cancer and a shift towards targeted therapies are propelling demand for these therapeutic approaches, further expanding their market presence.

Therapeutic Approaches: Immunotherapy (Dominant) vs. Gene Editing (Emerging)

Immunotherapy remains the dominant therapeutic approach in the Cancer Gene Therapy Market, characterized by its ability to leverage the body's immune response to fight tumors effectively. This method includes monoclonal antibodies, checkpoint inhibitors, and CAR T-cell therapy, which have shown promising results in a variety of cancers. In contrast, Gene Editing is emerging as a revolutionary approach, focusing on the precise alteration of genetic material to target cancer at its source. With increasing research and successful trials, this segment is gaining popularity for its potential to provide long-lasting, curative treatments for patients. As technologies evolve, both approaches are expected to co-exist and complement each other, advancing the field of cancer therapy.

By Target Disease: Breast Cancer (Largest) vs. Lung Cancer (Fastest-Growing)

In the Cancer Gene Therapy Market, Breast Cancer represents the largest share among the target diseases, attributed to its high prevalence and considerable research investment. This segment benefits from increased awareness and improved screening technologies, fostering robust growth. Conversely, Lung Cancer has emerged as the fastest-growing segment, driven by heightened incidence rates and the ongoing demand for innovative therapies that address the unique genomic characteristics of this disease.

Target Disease: Breast Cancer (Dominant) vs. Lung Cancer (Emerging)

Breast Cancer gene therapy has dominated the market due to significant advancements in targeted therapies and the increasing number of clinical trials. This segment is characterized by a wide range of treatment options tailored to specific genetic mutations, making it a focal point for researchers and clinicians alike. Meanwhile, Lung Cancer is recognized as an emerging sector within the market, with rapid developments in immunotherapy and personalized medicine leading the way. The rising prevalence of smoking and environmental factors heightens the necessity for innovations in treatment, positioning lung cancer therapies as a vital growing category in the Cancer Gene Therapy Market landscape.

By Type of Therapy: Ex-Vivo Therapy (Largest) vs. In-Vivo Therapy (Fastest-Growing)

In the Cancer Gene Therapy Market, the type of therapy segment is primarily dominated by Ex-Vivo Therapy, which holds the largest share due to its established methods and effectiveness in providing targeted treatments. In-Vivo Therapy, while smaller in current share, is rapidly gaining traction as advancements in technology and delivery systems improve its appeal. Combination Therapy, though significant, serves more of a supplementary role in this landscape, integrating both ex-vivo and in-vivo methods to enhance treatment efficacy. The growth trends within this segment showcase a clear shift toward In-Vivo Therapy as it becomes the focal point of research and development efforts. Factors driving this growth include improved patient outcomes and the ability to deliver treatment directly to affected areas within the body. Additionally, ongoing innovations in genetic engineering and vector technology continue to pave the way for expedited development cycles and increased acceptance within the oncology community.

Therapy Approach: Ex-Vivo Therapy (Dominant) vs. Combination Therapy (Emerging)

Ex-Vivo Therapy stands as the dominant approach within the Cancer Gene Therapy Market, primarily due to its established protocols and success in clinical settings. This therapy entails the modification of a patient's cells outside the body before reintroducing them, allowing for precise targeting and minimal off-target effects. Combination Therapy, emerging in popularity, seeks to integrate multiple therapeutic strategies, including both gene therapies and traditional chemotherapy or immunotherapy. This approach aims to enhance overall treatment efficacy by addressing cancer from various fronts. The combination of ex-vivo techniques with complementary therapies not only demonstrates potential for improved patient outcomes but also reflects a growing trend in personalized medicine, where tailored treatment plans are developed based on individual patient profiles.

By Delivery Method: Viral Vectors (Largest) vs. Nanoparticles (Fastest-Growing)

In the Cancer Gene Therapy Market, the delivery method segment is primarily dominated by viral vectors, which significantly outperform other methods in terms of market share. This is largely attributed to their efficacy in delivering therapeutic genes directly into target cells. Plasmid DNA is also utilized but retains a smaller share, while nanoparticles have emerged recently, capturing attention due to their potential in targeting and minimizing off-target effects, which is crucial in cancer therapy.

Delivery Method: Viral Vectors (Dominant) vs. Nanoparticles (Emerging)

Viral vectors are the dominant delivery method in the Cancer Gene Therapy Market, renowned for their high transfection efficiency and ability to integrate genetic material into host cells, leading to durable therapeutic effects. They include adenoviruses, lentiviruses, and adeno-associated viruses, each offering unique advantages for different types of cancer. On the other hand, nanoparticles present an emerging alternative, characterized by their versatile composition and ability to encapsulate therapeutic agents for controlled release. This method is gaining traction due to advancements in nanotechnology, making it a promising approach for targeted therapy, especially in overcoming challenges associated with traditional delivery methods.

Get more detailed insights about Cancer Gene Therapy Market

Regional Insights

The Regional segmentation of the Global Cancer Gene Therapy Market reveals significant insights into its valuation and growth dynamics among various regions. In 2024, North America is set to dominate the market, valued at 3.5 USD Billion, contributing to the larger market growth driven by advanced healthcare infrastructure and high research investment. Europe follows with a market valuation of 2.5 USD Billion, exemplifying substantial growth due to increased awareness and adoption of gene therapies.

Meanwhile, the APAC region stands at 1.8 USD Billion in 2024, showcasing its potential driven by a rising patient population and improved healthcare facilities.In South America, the market is valued at 0.8 USD Billion, which reflects emerging opportunities despite challenges such as regulatory barriers. Lastly, the MEA region is estimated at 0.45 USD Billion, indicating a nascent yet developing landscape with significant growth potential as investments in healthcare increase. Collectively, these regions offer an insightful overview of the Global Cancer Gene Therapy Market revenue, revealing distinct factors contributing to their growth and the overall dynamic of the market.

Cancer Gene Therapy Market Regional Image

Key Players and Competitive Insights

The Global Cancer Gene Therapy Market is an evolving and highly competitive landscape that is characterized by rapid advancements in technology and treatment methodologies. This market has garnered significant attention from pharmaceutical companies, biotech firms, and research institutions worldwide, as the innovative approach of utilizing gene therapy to treat cancer presents a transformative opportunity to enhance patient outcomes. Various players are actively engaging in research and development, leveraging collaborations and partnerships to accelerate product development and clinical trials.

As therapies are developed, regulatory considerations, patient accessibility, and pricing strategies also play crucial roles in shaping competitive dynamics within the market.Celgene, a prominent player in the Global Cancer Gene Therapy Market, has established itself through a strong commitment to oncology research and development.

The company has cultivated a robust pipeline of innovative therapies aimed at targeting different cancer types, leveraging its experience in the field of hematology and oncology. Celgene's strengths lie in its extensive research capabilities and a well-established network of collaborations that enhance its ability to bring novel therapies to market more efficiently.

Additionally, its focus on precision medicine and personalized treatment approaches has positioned Celgene favorably in a market that increasingly prioritizes tailored therapies, demonstrating strength in aligning with current medical trends and patient needs.Sangamo Therapeutics presents another noteworthy competitor in the Global Cancer Gene Therapy Market, known for its pioneering work in gene editing technologies, particularly ZFP-TFs (zinc finger protein transcription factors).

This innovative approach allows for precise modifications to genes, which can significantly improve therapeutic efficacy in cancer treatment. Sangamo Therapeutics has a solid emphasis on advancing its proprietary technology, positioning itself as a leader in the development of targeted gene therapies. The company's strength lies in its strong intellectual property portfolio and strategic partnerships that enhance its research capabilities. Furthermore, Sangamo's dedication to addressing unmet medical needs through gene therapy positions it strategically within the market, making it a strong contender amidst the ongoing evolution of cancer treatment paradigms.

Key Companies in the Cancer Gene Therapy Market market include

Industry Developments

  • Q1 2024: Tecelra® (afamitresgene autoleucel) becomes first TCR-T therapy ever approved by the FDA Tecelra® (afamitresgene autoleucel), developed by Adaptimmune, received FDA approval as the first TCR-T cell therapy for metastatic or unresectable synovial sarcoma, marking a major milestone in cancer gene therapy.
  • Q1 2024: Amtgavi™ (lifileucel) receives FDA approval as first TIL therapy for advanced melanoma Amtgavi™ (lifileucel), developed by Iovance Biotherapeutics, was approved by the FDA as the first tumor-infiltrating lymphocyte (TIL) therapy for advanced melanoma, and is the first one-time individualized and unmodified T cell therapy approved for a solid tumor cancer.
  • Q1 2025: AUCATZYL (obecabtagene autoleucel) approved by FDA AUCATZYL (obecabtagene autoleucel), developed by Autolus Limited, received FDA approval in 2025, expanding the portfolio of gene therapies available for cancer treatment.
  • Q1 2025: BEQVEZ (fidanacogene elaparvovec-dzkt) receives FDA approval BEQVEZ (fidanacogene elaparvovec-dzkt), developed by Pfizer, was approved by the FDA in 2025, representing a new gene therapy option in the oncology space.
  • Q1 2025: CARVYKTI (ciltacabtagene autoleucel) receives FDA approval CARVYKTI (ciltacabtagene autoleucel), developed by Janssen Biotech, Inc., was approved by the FDA in 2025, further advancing gene therapy options for cancer patients.
  • Q1 2025: ABECMA (idecabtagene vicleucel) receives FDA approval ABECMA (idecabtagene vicleucel), developed by Celgene Corporation, a Bristol-Myers Squibb Company, was approved by the FDA in 2025, adding to the growing list of gene therapies for cancer.
  • Q1 2025: ADSTILADRIN (nadofaragene firadenovec-vcng) receives FDA approval ADSTILADRIN (nadofaragene firadenovec-vcng), developed by Ferring Pharmaceuticals A/S, was approved by the FDA in 2025, contributing to the expansion of gene therapy treatments for cancer.
  • Q1 2025: ALLOCORD (HPC, Cord Blood) receives FDA approval ALLOCORD (HPC, Cord Blood), developed by SSM Cardinal Glennon Children's Medical Center, was approved by the FDA in 2025, supporting the use of gene therapy in oncology.
  • Q2 2025: Highlights from ACGT Summit 2025: Cell and Gene Therapy The ACGT Summit 2025 brought together 90 researchers and leaders from 51 institutions and companies to discuss recent FDA approvals and major breakthroughs in cancer gene therapy, including the first TCR-T and TIL therapies for solid tumors.

Future Outlook

Cancer Gene Therapy Market Future Outlook

The Cancer Gene Therapy Market is projected to grow at a 13.37% CAGR from 2024 to 2035, driven by advancements in technology, increasing prevalence of cancer, and rising investments in research.

New opportunities lie in:

  • Development of personalized gene therapies targeting specific cancer mutations.
  • Expansion of telehealth services for remote patient monitoring and consultations.
  • Strategic partnerships with biotech firms for innovative product development.

By 2035, the Cancer Gene Therapy Market is expected to be robust, reflecting substantial growth and innovation.

Market Segmentation

Cancer Gene Therapy Market Target Disease Outlook

  • Breast Cancer
  • Lung Cancer
  • Leukemia
  • Colorectal Cancer
  • Prostate Cancer

Cancer Gene Therapy Market Delivery Method Outlook

  • Viral Vectors
  • Plasmid DNA
  • Nanoparticles

Cancer Gene Therapy Market Type of Therapy Outlook

  • Ex-Vivo Therapy
  • In-Vivo Therapy
  • Combination Therapy

Cancer Gene Therapy Market Therapeutic Approach Outlook

  • Gene Editing
  • Gene Transfer
  • Oncolytic Virus Therapy
  • Gene Silencing
  • Immunotherapy

Report Scope

MARKET SIZE 20248.05(USD Billion)
MARKET SIZE 20259.126(USD Billion)
MARKET SIZE 203532.01(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR)13.37% (2024 - 2035)
REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR2024
Market Forecast Period2025 - 2035
Historical Data2019 - 2024
Market Forecast UnitsUSD Billion
Key Companies ProfiledMarket analysis in progress
Segments CoveredMarket segmentation analysis in progress
Key Market OpportunitiesAdvancements in personalized medicine and regulatory support enhance prospects in the Cancer Gene Therapy Market.
Key Market DynamicsRising demand for personalized medicine drives innovation and competition in the Cancer Gene Therapy Market.
Countries CoveredNorth America, Europe, APAC, South America, MEA

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FAQs

What is the current valuation of the Cancer Gene Therapy Market as of 2024?

The Cancer Gene Therapy Market was valued at 8.05 USD Billion in 2024.

What is the projected market size for the Cancer Gene Therapy Market by 2035?

The market is projected to reach 32.01 USD Billion by 2035.

What is the expected CAGR for the Cancer Gene Therapy Market during the forecast period 2025 - 2035?

The expected CAGR for the Cancer Gene Therapy Market during 2025 - 2035 is 13.37%.

Which therapeutic approach segments are expected to show significant growth?

The Gene Transfer segment is projected to grow from 2.0 USD Billion to 8.0 USD Billion by 2035.

What are the leading types of therapy in the Cancer Gene Therapy Market?

In-Vivo Therapy is anticipated to expand from 3.0 USD Billion to 12.0 USD Billion by 2035.

Which delivery method is expected to dominate the market?

Viral Vectors are likely to lead the market, growing from 3.22 USD Billion to 12.8 USD Billion by 2035.

What are the key diseases targeted by cancer gene therapies?

Lung Cancer is projected to grow from 1.8 USD Billion to 7.2 USD Billion by 2035.

Who are the major players in the Cancer Gene Therapy Market?

Key players include Novartis, Gilead Sciences, and Bristol-Myers Squibb.

What is the growth potential for immunotherapy in the Cancer Gene Therapy Market?

Immunotherapy is expected to increase from 2.55 USD Billion to 10.01 USD Billion by 2035.

How does the market for leukemia treatments compare to other cancers?

Leukemia treatments are projected to grow from 1.2 USD Billion to 4.8 USD Billion by 2035, indicating a robust market presence.

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