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Vanishing Bone Disease Market Research Report Information Diagnosis (X-Rays, CT Scans, MRIs, Ultrasound, Nuclear Medicine, Others), Treatment (Medicine Therapy, Radiation Therapy), End-User (Hospitals, Diagnostic Centers, Others) ‚Äď Forecast Till 2030

ID: MRFR/MED/4689-HCR | 100 Pages | Author: Rahul Gotadki| April 2024

Vanishing Bone Disease Market Scenario:

The vanishing bone disease market size is expected to gain prominence over the forecast period (2022-2030). It is estimated that the global vanishing bone disease industry is expected to register a CAGR 6.40% during the forecast period of 2022-2030

Vanishing bone disease or Gorham-stout syndrome is a rare skeletal disease characterized by progressive osteolysis and the proliferation of lymphatic vessels within the bone which leads to the destruction and absorption of bone. Additionally, the bones affected by the disease are more prone to osteopenia and fracture. Furthermore, the exact cause of the disease is unknown. However, it is considered to be caused due to the improper development of the lymphatic system.

According to the National Center for Advancing Translational Sciences (NIH), in 2016, the number of cases of vanishing bone disease reported ranged from 64 to 200 cases globally. The growing occurrence of the disease is the key driver for the growth of the market. Furthermore, current research for the development of an effective therapeutic intervention for disease treatment is expected to contribute to the growth of the market.

However, lack of awareness of the disease in developing economies, high treatment cost restrains the market growth. Furthermore, challenges in diagnosis of the disease in the patient pool may hamper the growth of the market.


The global vanishing bone disease market is segmented on the basis of the diagnosis, treatment, and end-user.

On the basis of diagnosis, the market is classified as X-rays, CT scans, MRIs, ultrasound, nuclear medicine, and others.

On the basis of treatment, the market is segmented as medical therapy and radiation therapy. The medicine therapy is segmented into bisphosphonates, vitamin D, interferon, a-2b interferon, calcium, adrenal extracts, androgen, bleomycin, and others. The radiation therapy is further segmented into chest drainage, thoracic duct ligation, pleurodesis, pleurectomy, and others.

On the basis of end-user, the global market is segmented as hospitals & clinics, diagnostic centers, ambulatory surgical centers, and others.

Geographically, the market has been segmented into America, Europe, Asia Pacific, and the Middle East and Africa. The American market is further segmented into North America and South America. North America is further classified as the U.S. and Canada.

The European market is segmented into Western Europe and Eastern Europe. Western Europe is further classified as Germany, France, the U.K., Italy, Spain, and the rest of Western Europe.

The Asia Pacific market is segmented into Japan, China, India, Republic of Korea, Australia, and the rest of Asia Pacific.

The Middle Eastern and African market is segmented into the Middle East and Africa.

Regional Market Summary

Global Vanishing Bone Disease Market, by Region Market Share, 2017 (%)

 Vanishing Bone Disease Market

Source: MRFR Analysis

The global vanishing bone disease market consists of four regions: Americas, Europe, Asia Pacific and the Middle East & Africa. The North American region dominates the global vanishing bone market due to the existing well-established healthcare system, increasing occurrences of rare diseases. For instance, according to the National Institute of Health, rare disorders that affect approximately 30 million people in the United States.  Furthermore, according to the U.S. FDA, rare diseases or disorder affects an approximate 200,000 people in the United States.

Europe holds the second market share in the vanishing bone disease market. It is expected that the government support towards research & development expenditure and rising incidences of rare diseases is likely to drive the European market. For instance, according to the European Commission, rare diseases comprises 5000 to 8000 life-threatening or chronically debilitating diseases which together affect from 27 and 36 million people in the European Union.

The Asia Pacific, vanishing bone disease market, consists of countries namely China, Japan, Republic of Korea, India, Australia and Rest of Asia Pacific. The vanishing bone disease market growth in this region is driven by rising healthcare expenditure, rising occurrences of rare diseases, and growing bone disorders, technological advancements in interventional radiology segment. For instance, in February 2018, Elekta AB received clearance from China Food and Drug Administration (CFDA) for its Leksell Gamma Knife Icon radiosurgery system.

The Middle East & Africa holds the lowest share of the global vanishing bone disease market due to lack of awareness of rare diseases, the low incidence rate of the disease and poor medical facilities, especially in the African region.

Key Players

  • Varian Medical Systems, Inc

  • Elekta AB

  • C. R. Bard, Inc

  • Teleflex Incorporated

  • Vygon S.A

  • Medtronic plc

  • Cook Medical

  • Smiths Medical

  • ATMOS MedizinTechnik GmbH & Co. KG

  • Merck & Co

  • Sanofi-Aventis

  • F. Hoffmann-La Roche AG

  • Novartis International AG¬†

Research Methodology

Market Research Future research is conducted by industry experts who offer insight into industry structure, market segmentation, Treatment assessment, competitive landscape (CL), penetration, as well as on emerging trends. Besides primary interviews (~ 80%) and secondary research (~ 20%), their analysis is based on their years of professional expertise in respective industries. Our analysts also predict where the market will be headed in the next five to ten years, by analyzing historical trends and current market positions. Furthermore, the varying trends of segments & categories geographically presented are studied and are estimated based on primary & secondary research.

  • Primary Research

Extensive primary research was conducted to gain a deeper insight into the market and the industry performance. In this particular report, we have conducted primary surveys (interviews) with the key level executives (VPs, CEOs, Marketing Directors, Business Development Managers, and many more) of the major players who are active in the market. In addition to analyzing the current and historical trends, our analysts predict where the market is headed, over the next five to ten years.

  • Secondary Research

Secondary research was mainly used to collect and identify information useful for an extensive, technical, market-oriented, and commercial study of the vanishing bone disease market. It was also used to obtain key information about major players, market classification and segmentation according to the industry trends, geographical markets, & developments related to the market and Treatment Perspectives. For this study, analysts have gathered information from various credible sources, such as annual reports, SEC filings, journals, white papers, corporate presentations, company websites, the international organization of chemical manufacturers, some paid databases and many others.

Global Vanishing Bone Disease Market, by Diagnosis

  • X-rays

  • CT Scans

  • MRIs

  • Ultrasound

  • Nuclear Medicine

  • Others

Global Vanishing Bone Disease Market, by Treatment

  • Medicine Therapy

  • Bisphosphonates

  • Vitamin D

  • Interferon

  • a-2b Interferon

  • Calcium

  • Adrenal extracts

  • Androgens

  • Bleomycin

  • Others

  • Radiation Therapy

  • Chest drainage

  • Thoracic Duct Ligation

  • Pleurodesis

  • Pleurectomy

  • Others

Global Vanishing Bone Disease Market, by End-User

  • Hospitals and clinics

  • Diagnostic centers

  • Ambulatory surgical centers

Global Vanishing Bone Disease Market, by Region

  • Americas

  • North America

  • U.S.

  • Canada

  • South America

  • Europe

  • Western Europe

  • Germany

  • France

  • Italy

  • Spain

  • U.K.

  • Rest of Western Europe

  • Eastern Europe

  • Asia Pacific

  • Japan

  • China

  • India

  • Australia

  • Republic of Korea

  • Rest of Asia Pacific

  • The Middle East & Africa

  • Middle East

  • Africa

Intended Audience

  • Pharmaceutical Companies

  • Research and Development (R&D) Companies

  • Government Research Institutes

Report Attribute/Metric Details
  Market Size   Significant Value
  CAGR   6.40%
  Base Year   2021
  Forecast Period   2022-2030
  Historical Data   2020
  Forecast Units   Value (USD Million)
  Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Diagnosis, Treatment, and End-user
  Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
  Key Vendors   Varian Medical Systems, Inc., Elekta AB, C. R. Bard, Inc., Teleflex Incorporated, Vygon S.A. Medtronic plc., Cook Medical, Smiths Medical, ATMOS MedizinTechnik GmbH & Co. KG, Merck & Co., Sanofi-Aventis, F. Hoffmann-La Roche AG, and Novartis International AG
  Key Market Opportunities   Research for the development of the effective therapeutic intervention for the disease treatment
¬†¬†Key Market Drivers Ôā∑¬† Number of cases of vanishing bone disease Ôā∑¬† Growing occurrence of the disease

Frequently Asked Questions (FAQ) :

VANISHING BONE DISEASE or Gorham-stout syndrome is a rare skeletal disease characterized by progressive osteolysis and proliferation of lymphatic vessels within the bone, which leads to the destruction and absorption of bone.

Global Vanishing Bone Disease Market is expected to exhibit a strong 6.40% CAGR over the forecast period from 2022-2030.

The growing prevalence of vanishing bone disease is the major driver for the market.

North America dominates the Global Vanishing Bone Disease Market.

Leading players in the Vanishing Bone Disease Market include Elekta AB, Varian Medical Systems, and Teleflex Inc., among others.

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