Nanobody Market

The increasing prevalence of chronic diseases boosts market growth.

Nanobodies are small antibody fragments that have several advantages over traditional antibodies, such as greater stability, better tissue penetration, and reduced immunogenicity. The rising prevalence of autoimmune diseases and other chronic disorders demands the discovery of newer and more effective nanobody-based drugs for their treatment. For instance, in February 2019, the United States Food and Drug Administration (FDA) approved Cablivi (caplacizumab-yhdp), the first nanobody-based medicine of Sanofi S.A. (France), for adults with acquired thrombotic thrombocytopenic purpura (aTTP).

According to the World Health Organization (WHO), chronic diseases such as cancer, cardiovascular disease, and diabetes are responsible for 74% of all deaths globally. The incidence and prevalence of these diseases are expected to continue to rise, driven by factors such as aging populations, changing lifestyles, and increasing urbanization. Hence, the increasing prevalence of chronic diseases, combined with the unique advantages of nanobodies drives the market growth.

The Global Nanobody Market Industry experiences a notable surge in demand for targeted therapies, driven by the increasing prevalence of chronic diseases and cancer. Nanobodies, due to their unique properties, offer advantages such as high specificity and low immunogenicity, making them suitable for therapeutic applications. In 2024, the market is valued at 0.72 USD Billion, reflecting a growing interest from pharmaceutical companies in developing nanobody-based treatments. This trend is expected to continue, as the industry anticipates a market growth to 4.82 USD Billion by 2035, indicating a robust CAGR of 18.86% from 2025 to 2035.

By Region, the study segments the market into North America, Europe, Asia-Pacific, and the Rest of the World. The North America nanobody market accounted for the largest market share in 2022. This is due to the high awareness associated with nanobodies technology in drug discovery and development to reduce the cost of production in the North American region. Companies such as Proteintech Group, Inc. (US), and Genscript Biotech Corporation (US) are actively working on improving nanobodies and fulfilling the demands of customers.

The Genscript Biotech Corporation (US) offers comprehensive research and therapeutic nanobodies application services, and in several research studies, the company has provided lucrative growth opportunities.

Further, the major countries studied are the U.S., Canada, Germany, France, the UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.

Source: Secondary Research, Primary Research, Market Research Future Database, and Analyst Review

Europe nanobody market accounts for the second-largest market share due to the presence of active market players, growing nanobodies startups, and increasing prevalence of diseases such as infectious, neurological, and cancer. further, Germany nanobody market was attributed to hold the largest market share, and the France nanobody market is expected to fastest-growing market in the European region.

The Asia-Pacific nanobody market is expected to grow at a significant share from 2025 to 2035. This is due to the growing geriatric population, increasing prevalence of cancer and infectious diseases, and improving research capabilities in the Asia-Pacific region. Moreover, China nanobody market is expected to hold the largest market share, and India nanobody market is expected fastest-growing market in the Asia-Pacific region.

Furthermore, as per the National AIDS Control organization (NACO), approximately 62.97 thousand people were diagnosed with HIV infection, and 41.97 thousand deaths in India in 2021. According to the Integrated Health Information Platform, there were 3,038 influenza cases, including H3N2, in India till March 2023, and influenza is rapidly spreading in India. Thus, these factors are likely to have considerable growth for nanobody market.

The Rest of the World is segmented into the Middle East, Africa, and Latin America. The nanobody market in the above-mentioned regions is likely to witness growth due to the increasing prevalence of infectious diseases and the rising prevalence of non-communicable diseases. Moreover, the lack of knowledge associated with nanobody applications is also affecting the market's growth to some extent in these regions.

The Nanobody Market is characterized by the presence of many global, regional, and local vendors. Developments in the healthcare industry and growing research and development make the nanobody market lucrative. To expand their reach and optimize their operational costs, the major players focus on obtaining regulatory authorizations from government agencies for their products and emphasize acquisitions and product launches to gain a substantial market share. The market comprises tier-1, tier-2, and local players. The tier-1 and tier-2 players have reach across the globe with diverse product portfolios.

Companies such as Sanofi (France), Merck KGaA (Germany), BIOCYTOGEN (US), and Proteintech Group, Inc (US) dominate the Nanobody Market due to product differentiation, financial stability, strategic developments, and diversified regional presence. The players are focused on investing in research and development. Furthermore, they adopt strategic growth initiatives, such as expansion, product launches, joint ventures, and partnerships, to strengthen their market position and capture a large customer base.

One of the primary business strategies adopted by manufacturers in the global nanobody industry to benefit clients and expand the nanobody market sector is to manufacture locally to reduce operating costs.

Merck KGaA (Germany) is a pharmaceutical company that offers a varied range of products subgrouped into three segments—healthcare, life sciences, and electronics. The company researches drugs in the areas of oncology and neurodegenerative as well as autoimmune and inflammatory diseases. The company is distributing its products in the following countries: China, India, Japan, Australia, Israel, United Arab Emirates, South Korea, Denmark, Italy, Netherlands, Spain, United Kingdom, Switzerland, Sweden, Argentina, Brazil, Canada, US, and New Zealand.

For instance, in October 2020, Merck KGaA (Germany) announced that it has entered into an out-licensing agreement with Novartis AG (Switzerland), for the development of M6495, an anti-ADAMTS5 Nanobody for the

potential treatment of Osteoarthritis (OA).

Also, Sanofi (France) is a multinational pharmaceutical company that manufactures pharmaceutical products. The company offers drugs, generic drugs, and food supplements and provides medical devices for cancer, cardiology, gynecology, and diabetes. Sanofi's research and development efforts are concentrated on developing combination drugs to improve the efficacy of treatments and on developing novel biologic formulations to create precision medicines. Sanofi serves customers in more than 100 countries worldwide and more than 75 manufacturing sites in 70 countries. The company has about 20 R&D facilities across Europe, Asia, and North America.