Low-Pressure Liquid Chromatography Market: By Component (Instruments, Consumables, and Services), By End User (Pharmaceutical Companies, Biotechnology Companies, Research Laboratories, and Academic Institutions), and by Region (North America, Europe, Asia-Pacific, and Rest of the World)—Forecast to 2027

Low-Pressure Liquid Chromatography Market Forecast

The global low-pressure liquid chromatography market is expected grow at a CAGR of ~3.6% during the forecast period of 2021-2027.  

Market Overview:

Low-pressure liquid chromatography (LPLC) is a system that coerces mobile phase through the column at low pressure. The low-pressure liquid chromatography is used to study the characteristics of biomolecules such as peptides, proteins, and monoclonal antibodies. The low-pressure liquid chromatography technique is one of the ideal biomolecule separation techniques for the segregation of recombinant-tagged proteins. In addition, the process is also used to purify active pharmaceutical ingredients, cleanse small & complex samples and eliminate pesticides from test samples. Moreover, the low-pressure liquid chromatography systems are easy to use and are designed to provide desired results. Furthermore, scientists are innovating the low-pressure liquid chromatography process for paclitaxel recovery and purification from plant tissue culture fluid. The market players are deploying an experienced workforce to innovate new technologies for upgrading low-pressure liquid chromatography products.

Increasing investment in drug development, a growing number of R&D facilities, modernization of lab facilities, and supportive government regulatory guidelines are driving the low-pressure liquid chromatography market. Moreover, the market players are involved in business strategies such as partnerships, product launches, service contracts, and association with public and private research institutions. The low-pressure liquid chromatography market is estimated to grow over time owing to the increasing funding in the research infrastructure by the government authorities. The government authorities in the countries such as the US, India, China, and Japan are focusing on modernization and technological advancement of clinical research and drug development infrastructure. These factors are driving the low-pressure liquid chromatography market and are assessed to grow in the projected timeline.  

COVID-19 Analysis

The COVID-19 outbreak reduced the development and production of products across different sectors. The pharmaceutical sector and R&D facilities faced a backlash in market demand during the pandemic outbreak. The market players faced a downfall in low-pressure liquid chromatography demand during the first quarter of COVID-19. However, the increasing demand for vaccines and supportive drugs has augmented the market demand. The growing urgency of coronavirus vaccines and life-saving drugs propelled the demand for low-pressure liquid chromatography products. In addition, increasing R&D activities to develop diagnostic and treatment products is driving the low-pressure liquid chromatography market. Moreover, an increasing number of government and drug manufacturers invested in installing equipment that specializes in protein and peptide separation, creating opportunities for the industry players.

Low-pressure liquid chromatography has shown pioneering results in therapeutic research. Vaccine development through protein extraction methodology is one of the major and efficient techniques for SARS-CoV-2 drug development. In addition, the private and public authorities have collaborated to accelerate drug development, creating possibilities for the low-pressure liquid chromatography manufacturers. Moreover, the market players manufactured a large number of low-pressure liquid chromatography to meet the growing needs of R&D activities during a pandemic outbreak. The production and transport of the equipment were done under controlled conditions to prevent the spread of the deadly virus. Furthermore, the pandemic outbreak created financial imbalance among the healthcare research units owing to high investment in drug development activities. The companies under financial stress borrowed the equipment or signed an agreement with the low-pressure liquid chromatography service provider to strengthen and accelerate the research activities.

Market Dynamics

• The protein-based vaccines are in early clinical development and show huge potential as therapeutic drugs. The growing interest in the production of peptide-based vaccines is fueling the low-pressure liquid chromatography market. The peptide-based drugs are economical, safe, and effective. In addition, drug manufacturers are developing medicines for hepatitis-B and acellular pertussis using protein subunits. Moreover, during the COVID-19 outbreak, researchers across the globe were keen on developing protein-based subunit vaccines. In November 2020, scientists in the UK had developed a protein-based vaccine to treat Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). These vaccines are destined to be used as an alternative to mRNA-based vaccines.


• Companies such as Sanofi (France) are developing COVID-19 recombinant protein vaccine in partnership with GSK (UK). In May 2021, the company announced the start of the third phase of the clinical trial for their COVID-19 recombinant vaccine. The company is analyzing the results of the recombinant protein vaccine from the earlier clinical trials and is expecting to get the vaccine approved by the fourth quarter of 2021. The development of such an advanced vaccine is projected to accelerate the low-pressure liquid chromatography market growth in the assessed period.

• The peristaltic pumps used in the low-pressure liquid chromatography generate lower pressure and create pressure pulsations. The production of such pulsations adversely affects the segregation of proteins and peptides at lower pressure. Additionally, the bubbles generated can contract and expand with a change in pressure pulsations or conductivity signals. Moreover, a change in volume and concentration of the sample with variation in pressure pulsation results in precipitated protein. The alteration in the physical and chemical composition of the sample distorts the final results, further limiting the extraction of proteins.

• Low-pressure chromatography systems are the output of advanced scientific innovations. Low-pressure liquid chromatography consists of low-pressure pumps, simple detectors, fraction collectors, and sampling systems. It uses acetonitrile, methanol, and water as common mobile phases. When inserted in the column, these mobile phases move at different rates owing to the interactive properties of the components. Low-pressure liquid chromatography functions at a pressure below 300 psi that activate the movement of mobile components through 63-200 um particle columns. It is used to study biomolecules such as monoclonal antibodies and protein. In addition, due to the fragile property of biomolecules, it is treated using low-pressure liquid chromatography due to its non-destructive and preparative technique. Moreover, it also permits the preservation of samples for advanced studies.

• Instruments: It is a type of tool that is specially used for precision work. These instruments are used to perform chromatographic separations. The instruments include products such as pumps, detectors, columns, and flow cells.


• Consumables: It is a commodity that is used for performing liquid chromatography procedures. The consumables for low-pressure liquid chromatography include solvent extraction dispersant, filters, and clean-up cartridges.


• Services: It is an action and does not require transferring of physical goods. The services for low-pressure liquid chromatography products include installation, training, maintenance, and repair works.

• Pharmaceutical Companies: It is a type of organization involved in designing, researching, and producing generic and brand medications. Pharmaceutical companies utilize low-pressure liquid chromatography devices to innovate generic and customized drugs.


• Biotechnology Companies: It is a type of organization involved in manufacturing drugs using live organisms such as bacteria or enzymes. Biotechnology organizations are utilizing low-pressure liquid chromatography devices to extract complex molecules from microbes.


• Research Laboratories: It is a type of workplace that carries out scientific research, experiments, and measurement under controlled conditions. Research laboratories use low-pressure liquid chromatography devices to conduct clinical trials on molecular components.


• Academic Institution: It is a type of educational institution that is specialized in training and research activities. These institutions also provide academic degrees to practitioners. Academic institutions use low-pressure liquid chromatography devices for educational learning and research activities on an institutional level.

• Increasing prevalence of gene therapy across the region is driving the North American low-pressure liquid chromatography market
  
  
  
  • North America held the largest low-pressure liquid chromatography market share in 2020, owing to the rising investment in the development of adeno-associated viral therapy, rising deployment of effective and accurate liquid chromatography, increasing capitalization in the development of new gene-therapy-based products. In addition, the growing geriatric population and increasing demand for diagnostic tests across the region is accelerating the demand for low-pressure liquid chromatography products across the region. These factors are estimated to drive the North American low-pressure liquid chromatography market.
  
  
  
  

• Advancements in healthcare infrastructure are fueling the Asia-Pacific low-pressure liquid chromatography market
  
  
  
  • The Asia-Pacific low-pressure liquid chromatography market is driven by the emergence of different types of diseases, the increasing geriatric population, rising investments in research centers, and supportive government policies. These factors are expected to drive the low-pressure liquid chromatography market demand in the assessed timeline. Moreover, increasing investment to augment the ongoing clinical trials and development of drugs are accounted to accelerate the low-pressure liquid chromatography sales throughout the region.
  
  
  
  

• Increasing demand for low-pressure liquid chromatography system for biomolecule purification
  
  
  
  • Bio-Rad Laboratories, Inc. (US) is one of the leading manufacturers and suppliers of low-pressure liquid chromatography products and accessories. BioLogic LP low-pressure chromatography system, an low-pressure liquid chromatography product by Bio-Rad Laboratories, Inc. (US), is particularly used for biomolecule purification. The product is compact in design and hence requires minimum space for installation. The system is integrated with 254 and 280 nm filters for protein and nucleic acid detection. In addition, the system is equipped with a conductivity cell to monitor gradient progress. Moreover, the low-pressure liquid chromatography system is integrated with a dual-channel peristaltic pump that produces a back pressure of 30 psi. The accessories offered by the company include BioFrac Fraction Collector, Econo Gradient Pump, Biologic LP Data View Software, Biologic LP Valves, and Model 2110 Fraction Collector.
  
  
  • The equipment providers are consistently evolving with the progressing R&D needs. Increasing investment for product development is driving the low-pressure liquid chromatography market. Moreover, the market competitors are adopting various business approaches to augment their market growth. The companies are capitalizing on developing efficient technologies advancing their R&D facilities to enhance the manufacturing capabilities, further strengthening the low-pressure liquid chromatography market. In addition, the market players are focusing on various business strategies such as contractual agreements, acquisitions and mergers, product innovations, increasing investments, and partnering with other regional or local players to expand their global footprint.
  
  
  
  

• Novasep (France)


• LEWA GmbH (Germany)


• GALAK Chromatography Technology Co., Ltd (China)


• Biolinx Labsystems (India)


• Bio-Rad Laboratories, Inc. (US)


• Danaher Corporation (US)


• Nilsan Nishotech Systems Pvt. Ltd (India)

• In December 2019, Danaher Corporation (US) acquired General Electric's Healthcare Life Sciences Biopharma Business expanding its expertise in low-pressure liquid chromatography technology. GE's ÄKTAprocess, a low-pressure liquid chromatography system, offers purification in downstream processing. The acquisition extended the company's product portfolio in the low-pressure liquid chromatography market.

• The study covers the existing short-term and long-term market effects and helps decision-makers draft short-term and long-term plans for businesses by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's Five Forces, value chain, and impact of COVID-19 on the market.

• Instruments


• Consumables


• Services

• Pharmaceutical Companies


• Biotechnology Companies


• Research Laboratories


• Academic Institution