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    Knock Out Mice Model Market

    ID: MRFR/HC/30879-HCR
    128 Pages
    Rahul Gotadki
    October 2025

    Knockout Mice Model Market Research Report By Application (Oncology Research, Genetic Research, Pharmaceutical Research, Immunology Research), By Type (Constitutive Knockout Mice, Conditional Knockout Mice, Transgenic Mice), By Key End User (Academic Institutions, Biotechnology Companies, Pharmaceutical Companies, Contract Research Organizations), By Technology (CRISPR-Cas9, Homologous Recombination, Gene Targeting) and By Regional (North America, Europe, South America, Asia-Pacific, Middle East and Africa) - Forecast to 2035

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    Knock Out Mice Model Market Infographic
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    Knock Out Mice Model Market Summary

    As per MRFR analysis, the Knockout Mice Model Market Size was estimated at 2.744 USD Billion in 2024. The Knockout Mice Model industry is projected to grow from 2.945 USD Billion in 2025 to 5.969 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 7.32 during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The Knockout Mice Model Market is experiencing robust growth driven by technological advancements and increasing research initiatives.

    • North America remains the largest market for knockout mice models, driven by extensive biomedical research funding.
    • The Asia-Pacific region is emerging as the fastest-growing market, fueled by rising investments in genetic research.
    • Oncology research continues to dominate the market, while immunology research is witnessing the fastest growth due to evolving therapeutic needs.
    • Advancements in genetic engineering and the rising demand for personalized medicine are key drivers propelling market expansion.

    Market Size & Forecast

    2024 Market Size 2.744 (USD Billion)
    2035 Market Size 5.969 (USD Billion)
    CAGR (2025 - 2035) 7.32%

    Major Players

    Jackson Laboratory (US), Charles River Laboratories (US), Taconic Biosciences (US), Horizon Discovery (GB), GenOway (FR), Crown Bioscience (US), InVivo Biosystems (US), The Jackson Laboratory (US)

    Knock Out Mice Model Market Trends

    The Knockout Mice Model Market is currently experiencing a notable evolution, driven by advancements in genetic engineering and an increasing focus on personalized medicine. Researchers and pharmaceutical companies are increasingly utilizing knockout mice to understand gene functions and disease mechanisms, which appears to enhance drug discovery processes. This model serves as a crucial tool in preclinical studies, allowing for the exploration of genetic contributions to various diseases. As the demand for innovative therapies rises, the relevance of knockout mice in translational research seems to grow, indicating a robust future for this market. Moreover, the ongoing collaboration between academic institutions and biotechnology firms is likely to foster further developments in knockout technology. This synergy may lead to the creation of more sophisticated models that can mimic human diseases more accurately. Additionally, the rising prevalence of genetic disorders and the need for effective treatments could drive the adoption of knockout mice in research settings. As the landscape of biomedical research continues to evolve, the Knockout Mice Model Market appears poised for significant growth, reflecting the increasing importance of genetic models in understanding complex biological systems.

    Advancements in Genetic Engineering

    Recent innovations in genetic engineering techniques, such as CRISPR-Cas9, are enhancing the precision and efficiency of creating knockout mice. This trend suggests that researchers can generate models that more accurately reflect human diseases, thereby improving the relevance of preclinical studies.

    Rising Demand for Personalized Medicine

    The growing emphasis on personalized medicine is likely to drive the use of knockout mice models in research. These models facilitate the exploration of individual genetic variations, which may lead to tailored therapeutic approaches and improved patient outcomes.

    Collaborative Research Initiatives

    Increased collaboration between academic institutions and industry players appears to be fostering advancements in knockout mice technology. Such partnerships may result in the development of novel models that better replicate human pathologies, thereby enhancing the utility of these models in drug discovery.

    The increasing prevalence of genetic disorders and the growing demand for personalized medicine are driving advancements in the development and application of knockout mice models, which are pivotal for understanding gene function and disease mechanisms.

    National Institutes of Health (NIH)

    Knock Out Mice Model Market Drivers

    Collaborative Research Initiatives

    The Knockout Mice Model Market benefits from collaborative research initiatives among academic institutions, pharmaceutical companies, and biotechnology firms. These partnerships often focus on the development of novel therapeutic strategies and the validation of new drug targets using knockout mice. Such collaborations enhance resource sharing and knowledge exchange, which can lead to more efficient research outcomes. As of 2025, numerous initiatives are underway that leverage knockout mice to study complex diseases, including cancer and neurodegenerative disorders. The increasing number of joint research projects is likely to propel the demand for knockout mice models, as they provide a reliable platform for testing hypotheses and validating findings across various research domains.

    Advancements in Genetic Engineering

    The Knockout Mice Model Market is experiencing a surge due to advancements in genetic engineering techniques. Innovations such as CRISPR-Cas9 and TALENs have revolutionized the ability to create precise genetic modifications in mice. This precision allows researchers to develop models that closely mimic human diseases, thereby enhancing the relevance of preclinical studies. As of 2025, the market for genetic engineering tools is projected to reach substantial figures, indicating a robust growth trajectory. The ability to generate knockout mice with specific gene deletions facilitates the exploration of gene functions and disease mechanisms, which is crucial for drug discovery and development. Consequently, the demand for knockout mice models is likely to increase as researchers seek to leverage these advanced techniques to accelerate their studies.

    Rising Demand for Personalized Medicine

    The Knockout Mice Model Market is significantly influenced by the rising demand for personalized medicine. As healthcare shifts towards tailored treatments, the need for animal models that can accurately represent human genetic diversity becomes paramount. Knockout mice serve as essential tools in understanding the genetic basis of diseases, which is critical for developing personalized therapies. The market for personalized medicine is expected to grow at a compound annual growth rate (CAGR) of over 10% in the coming years, reflecting the increasing investment in research and development. This trend underscores the importance of knockout mice models in identifying patient-specific responses to therapies, thereby driving their adoption in both academic and pharmaceutical research settings.

    Growing Investment in Biomedical Research

    The Knockout Mice Model Market is poised for growth due to the increasing investment in biomedical research. Governments and private entities are allocating substantial funds to support research initiatives aimed at understanding genetic disorders and developing new therapies. This financial backing is crucial for the creation and maintenance of knockout mice colonies, which are essential for experimental studies. In recent years, funding for biomedical research has seen a notable increase, with billions of dollars being invested annually. This trend suggests a sustained commitment to advancing scientific knowledge, which in turn drives the demand for knockout mice models as researchers seek to explore the genetic underpinnings of diseases and test potential treatments.

    Technological Innovations in Animal Research

    The Knockout Mice Model Market is being propelled by technological innovations in animal research methodologies. Advances in imaging techniques, data analysis, and bioinformatics are enhancing the capabilities of researchers to utilize knockout mice models effectively. These technologies allow for more detailed phenotypic characterization and better understanding of the biological implications of gene modifications. As of 2025, the integration of artificial intelligence and machine learning in research is expected to further streamline the analysis of data derived from knockout mice studies. This evolution in research technology not only improves the efficiency of experiments but also increases the accuracy of results, thereby fostering greater reliance on knockout mice models in various fields of biomedical research.

    Market Segment Insights

    By Application: Oncology Research (Largest) vs. Immunology Research (Fastest-Growing)

    The Knockout Mice Model Market exhibits a diverse distribution of applications, with oncology research holding the largest market share. This segment is bolstered by an escalating prevalence of cancer globally, driving significant investments in oncology research to develop novel therapies. Following closely are genetic and pharmaceutical research, which also contribute substantially to the market, while immunology research is emerging strongly as a critical area, reflecting a significant evolution in therapeutic approaches aimed at autoimmune and infectious diseases. Furthermore, the growth trends within the Knockout Mice Model Market are heavily influenced by advancements in genetic engineering and biopharmaceutical technologies. As research aims to unlock complex biological pathways and mechanisms, the demand for innovative models like knockout mice is intensifying. The immunology research segment, in particular, is gaining momentum due to increased awareness of immune system disorders and ongoing clinical trials, highlighting its status as the fastest-growing domain in this market.

    Oncology Research: Dominant vs. Immunology Research: Emerging

    Oncology research is the dominant segment within the Knockout Mice Model Market, characterized by its pivotal role in cancer studies and drug discovery processes. This segment benefits from substantial public and private funding, alongside a pressing global need for effective cancer therapies. In contrast, immunology research is emerging as a noteworthy area of focus, leveraging knockout mice models to investigate the underpinnings of immune responses and the development of vaccines. The rapid evolution in immunology aligns with heightened research initiatives targeting autoimmune disorders and infectious diseases, fostering a burgeoning market landscape. As both segments continue to progress, their interdependence may lead to innovative approaches in therapeutic development and a more holistic understanding of disease mechanisms.

    By Type: Constitutive Knockout Mice (Largest) vs. Conditional Knockout Mice (Fastest-Growing)

    In the Knockout Mice Model Market, the distribution of market share among various types is predominant with Constitutive Knockout Mice leading the pack. This segment captures the largest share due to its extensive application in genetic research and disease modeling. In contrast, Conditional Knockout Mice, despite currently holding a smaller market share, are gaining traction rapidly as researchers increasingly adopt advanced techniques for targeted gene expression.

    Knockout Mice: Constitutive (Dominant) vs. Conditional (Emerging)

    Constitutive Knockout Mice represent a dominant segment in the market, characterized by total gene inactivation, effectively rendering the gene inactive throughout the organism's life. This established type is primarily used in studies requiring a complete loss of gene function. Meanwhile, Conditional Knockout Mice are emerging, offering flexibility through targeted gene editing that allows researchers to activate or deactivate genes in specific tissues or at specific developmental stages. As technology advances, the ability to control gene expression will likely accelerate the growth of this segment, meeting the evolving demands of the scientific community.

    By Key End User: Pharmaceutical Companies (Largest) vs. Biotechnology Companies (Fastest-Growing)

    The Knockout Mice Model Market exhibits a diverse distribution of market share among various key end users, with pharmaceutical companies securing the largest share due to their extensive research and development initiatives focusing on drug discovery and testing. Academic institutions closely follow, relying heavily on knockout mice for fundamental research and teaching purposes. Contract Research Organizations (CROs) play a vital enabling role, providing essential services to both pharmaceutical and biotechnology firms, thus influencing their market dynamics significantly.

    Academic Institutions (Dominant) vs. Contract Research Organizations (Emerging)

    In the Knockout Mice Model Market, academic institutions dominate by utilizing these models for pioneering research and educational purposes. Their infrastructure and funding support robust research programs, making them critical players in advancing genetic studies. On the other hand, Contract Research Organizations (CROs) represent an emerging segment that is becoming increasingly important. They offer outsourcing solutions for preclinical and clinical development, allowing pharmaceutical and biotech firms to focus on innovation. As drug development accelerates, CROs are expected to grow rapidly, providing tailored services that cater to the complex needs of their clients.

    By Technology: CRISPR-Cas9 (Largest) vs. Homologous Recombination (Fastest-Growing)

    In the Knockout Mice Model Market, CRISPR-Cas9 holds the largest market share, reflecting its dominance due to its efficiency and precision in gene editing. This technique has become the go-to choice for researchers and scientists, allowing for faster, more cost-effective generation of knockout models compared to traditional methods. Meanwhile, Homologous Recombination, while maintaining a smaller share, is noted for its critical role in generating precise genetic modifications, particularly for specific applications in gene therapy.

    Technology: CRISPR-Cas9 (Dominant) vs. Homologous Recombination (Emerging)

    CRISPR-Cas9 stands out as the dominant technology in the Knockout Mice Model Market due to its user-friendly nature and versatility, quickly transforming research paradigms. It allows for targeted modifications with relatively low off-target effects, making it highly favored in both academic and industrial settings. On the other hand, Homologous Recombination is emerging as a key player for specific applications that demand high precision, such as generating specific models for complex diseases. Despite being overshadowed by CRISPR-Cas9, its relevance in specialized research ensures it attracts continuous investment and research interest, positioning it for potential growth.

    Get more detailed insights about Knock Out Mice Model Market

    Regional Insights

    The Global Knockout Mice Model Market revenue is witnessing consistent growth across various regions, with North America taking a significant lead in market valuation. In 2023, North America was valued at 1.05 USD Billion and is projected to reach 2.1 USD Billion by 2032, demonstrating its majority holding in the market. Europe follows as another key player, registering a market value of 0.8 USD Billion in 2023 and advancing to 1.4 USD Billion by 2032, highlighting its important role in research and development.

    The APAC region, valued at 0.41 USD Billion in 2023, shows potential for growth, reaching 0.9 USD Billion by 2032, driven by increasing investments in biotechnology.

    South America and MEA represent smaller yet developing segments, with valuations of 0.07 USD Billion and 0.06 USD Billion in 2023, respectively, expected to grow modestly to 0.15 USD Billion each by 2032. The market faces challenges such as stringent regulations and high costs, but opportunities arise from improved research capabilities and technological advancements, enhancing overall market growth and Global Knockout Mice Model Market statistics.

    Knockout Mice Model Market Regional

    Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

    Key Players and Competitive Insights

    The competitive landscape of the Global Knockout Mice Model Market is characterized by a diverse array of players, each contributing to the advancement of genetic research and pharmaceutical development through innovative approaches. This market has seen significant growth due to the increasing demand for personalized medicine and the rising prevalence of genetic disorders.

    As research institutions and pharmaceutical companies strive to overcome challenges in drug development and understanding complex diseases, the need for precise and reliable animal models becomes paramount. Knockout mice, which are genetically modified to lack specific genes, serve as critical tools in this endeavor. Thus, companies involved in the production and development of knockout mice are continuously enhancing their technologies, methodologies, and service offerings, creating a dynamic competitive environment that drives innovation and collaboration across the industry.

    genOway stands out in the Global Knockout Mice Model Market due to its strong focus on customized genetic models and its commitment to high-quality service. The company leverages advanced genetic engineering techniques to develop tailored knockout models that meet specific client requirements, thereby addressing unique research questions. This adaptability gives genOway a competitive advantage, as researchers are increasingly seeking models that closely mimic human diseases for more effective drug testing and therapeutic development.

    With a robust portfolio of knockout mice that are effectively validated for various applications, genOway enjoys a solid reputation among academic and biotech organizations. The company's emphasis on customer support, scientific expertise, and reliability further solidifies its market presence, allowing it to build long-term partnerships with clients in need of sophisticated genetic models.

    Charles River Laboratories holds a prominent position in the Global Knockout Mice Model Market, recognized for its comprehensive portfolio of research models and in-depth expertise in genetic engineering. The company has established a reputation for delivering high-quality knockout models that accelerate drug discovery and preclinical development.

    Charles River Laboratories distinguishes itself through its extensive breeding and production capabilities, ensuring a consistent supply of genetically modified mice that meet stringent quality standards. Furthermore, the company emphasizes innovation through ongoing investment in cutting-edge technology and research collaborations, enabling it to stay at the forefront of genetic research. The combination of a wide-ranging product offering and a focus on advancing genetic models makes Charles River Laboratories a key player in the knockout mice market, catering to diverse needs across the pharmaceutical and academic sectors.

    Key Companies in the Knock Out Mice Model Market market include

    Industry Developments

    In the Global Knockout Mice Model Market, significant recent developments have been noted, particularly among leading companies like genOway, Charles River Laboratories, and Horizon Discovery. These organizations have been increasingly focusing on expanding their product portfolios and enhancing their technological capabilities to meet growing research demands.

    The Jackson Laboratory and Envigo have also made strides in improving the genetic engineering techniques used for creating knockout mice, which contribute to advancements in biomedical research. Additionally, Biocytogen has gained attention for its innovative models catering to specific therapeutic areas.

    On the merger and acquisition front, notable transactions have involved key players such as Thermo Fisher Scientific and Crown Bioscience, with activities aimed at consolidating capabilities and expanding market reach.

    The financial health of companies involved in this market has been bolstered by a rising demand for genetic disease modeling, significantly impacting overall market growth. This evolution reflects a dynamic landscape where collaboration, technological innovation, and strategic partnerships are paramount for driving the success of knockout mice models in various research applications.

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    Future Outlook

    Knock Out Mice Model Market Future Outlook

    The Knockout Mice Model Market is projected to grow at a 7.32% CAGR from 2024 to 2035, driven by advancements in genetic research, increasing demand for personalized medicine, and rising investments in biotechnology.

    New opportunities lie in:

    • Development of custom gene-editing services for research institutions.
    • Expansion into emerging markets with tailored knockout models.
    • Partnerships with pharmaceutical companies for drug discovery applications.

    By 2035, the market is expected to solidify its position as a cornerstone of biomedical research.

    Market Segmentation

    Knock Out Mice Model Market Type Outlook

    • Constitutive Knockout Mice
    • Conditional Knockout Mice
    • Transgenic Mice

    Knock Out Mice Model Market Technology Outlook

    • CRISPR-Cas9
    • Homologous Recombination
    • Gene Targeting

    Knock Out Mice Model Market Application Outlook

    • Oncology Research
    • Genetic Research
    • Pharmaceutical Research
    • Immunology Research

    Knock Out Mice Model Market Key End User Outlook

    • Academic Institutions
    • Biotechnology Companies
    • Pharmaceutical Companies
    • Contract Research Organizations

    Report Scope

    MARKET SIZE 20242.744(USD Billion)
    MARKET SIZE 20252.945(USD Billion)
    MARKET SIZE 20355.969(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR)7.32% (2024 - 2035)
    REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR2024
    Market Forecast Period2025 - 2035
    Historical Data2019 - 2024
    Market Forecast UnitsUSD Billion
    Key Companies ProfiledMarket analysis in progress
    Segments CoveredMarket segmentation analysis in progress
    Key Market OpportunitiesAdvancements in gene editing technologies enhance precision in the Knockout Mice Model Market.
    Key Market DynamicsRising demand for personalized medicine drives innovation and competition in the Knockout Mice Model Market.
    Countries CoveredNorth America, Europe, APAC, South America, MEA

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    FAQs

    What is the projected growth of the Knock Out Mice Model market?

    The Knock Out Mice Model market is the expected increase in total market value of 5.97 USD billion over a defined forecast period 2025–2035. It is driven by factors such as demand trends, technological advances, regulatory changes, and geographic expansion.

    What is the size of the Knock Out Mice Model market?

    Knock Out Mice Model market size was valued at approximately 2.74 billion USD in 2024. This figure will reach 5.97 billion USD covering all regions (America, Europe, Asia, MEA and ROW), focusing its segments / services / distribution channels till 2035.

    What is the CAGR of the Knock Out Mice Model market?

    Knock Out Mice Model market is expected to grow at a CAGR of 7.32% between 2025 and 2035.

    How much will the Knock Out Mice Model market be worth by 2035?

    Knock Out Mice Model market is expected to be worth of 5.97 billion USD, reflecting growth driven by usage, technology and global demands by the end of 2035.

    How will the Knock Out Mice Model market perform over the next 10 years?

    Over the next 10 years the Knock Out Mice Model market is expected to shift from usd billion 2.74 to 5.97 billion USD, led by adoption of advanced tech, demographic trends, regulatory approvals, with potential headwinds from 2025 to 2035.

    Which region held the largest market share in the Global Knockout Mice Model Market in 2024?

    North America held the largest market share in the Global Knockout Mice Model Market, valued at 1.05 USD Billion in 2024.

    How much is the Oncology Research application segment valued in 2035?

    The Oncology Research application segment is expected to be valued at 1.8 USD Billion in 2035.

    What are the projected values for the Genetic Research application segment by 2035?

    The Genetic Research application segment is projected to be valued at 1.2 USD Billion by 2035.

    What is the expected market value of the Pharmaceutical Research application segment in 2035?

    The Pharmaceutical Research application segment is expected to be valued at 1.1 USD Billion in 2035.

    Which emerging players are key competitors in the Global Knockout Mice Model Market?

    Key competitors in the Global Knockout Mice Model Market include genOway, Charles River Laboratories, and Horizon Discovery.

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