Gene Synthesis Market Size

ID: MRFR/HC/10104-HCR

128 Pages

Rahul Gotadki

October 2025

Gene Synthesis Market Research Report By Application (Synthetic Biology, Therapeutics, Vaccines, Genetic Engineering, Agricultural Biotechnology), By Product Type (Gene Libraries, Oligonucleotides, Plasmids, Gene Fragments), By Technology (Polymerase Chain Reaction, Microarray Technology, DNA Sequencing, Automated Synthesis), By End Use (Academic Research, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecas... read more

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Gene Synthesis Size

Gene Synthesis Market Growth Projections and Opportunities

There are several distinct factors that make a fine combination to shape the gene synthesis market on which this is sculpted by intricate operations towards growth and development. A major impetus for the marked improvement is mainly brought about by an intrinsic surge in synthetic genes need inside biotechnology, pharmaceuticals, and scientific homework. With the increasing number of applications for synthetic biology, there becomes a widespread demand for custom made genes to be produced via the services offered and required by gene synthesis. Technological innovations in gene synthesis prove to be very vital when it comes to dictating the market share. Fast and affordable alpha-genes synthesis. The advancements in DNA synthesis, continuous innovation in gene editing technology by CRISPR-Cas9 and high-throughput methods ensure they will continue creating the alpha genes that are well suited for various applications. As productive as these technology breakthroughs are in accelerating gene synthesis, they allow for the fabrication of genetic constructs that realize a variety of objectives. However, the crucial operating environment in genomic and biotechnology research is geared towards regulating the dynamics of this market. These guidelines ensure that gene synthesis technologies are used in an ethical and reasonable manner, especially regarding the development of genes that could potentially be hazardous or controversial. These regulations need to be complied with since non-compliance will mean that you cannot get market approval and neither can clients have trust that he or she is in the hands of a competent professional. Economic regulation and the state of market access to gene synthesis services that are adopted by different regions. In a destination country, funding availability, and research infrastructure as well as the status of economic conditions affect gene synthesis usage and weakening or enforcing need for custom-made DNA constructs. It is also worth noting that there are diverse markets with their specific landscapes, and therefore, market players need to address all these discrepancies in order to provide gene synthesis services that fit unique challenges which different markets may pose. In the gene synthesis market, competitive environment is characterized by great innovation and diversification. Since it is a timely process to develop such approach its desirable and efficient services that companies try to provide the chemical synthesis of gene contains factors like turnaround time, sequence fidelity, cost-effective quality standards. With the occurrence of such a competitive environment this in its own turn spurs an innovative cycle, which encourages market participants to stay on the very edge of technological development and found further advanced capacities for gene synthesis. First, international cooperation and partnerships between the gene synthesis service providers, academic establishments, and biotechnology firms play a vital role in innovation within the market. These partnerships center around projects like the development of symphonic applications, gene entries and improvements in good therapy. The products result from the synergy and; on the other hand, they can as well contribute to the acceleration of progress in the field of gene synthesis because they meet emerging needs defined by biotechnology and life sciences industry. It happened mainly because of the emerging approach to gene synthesis, which is directed towards so-called patient centricity, and gene therapy.

Market Highlights

Author

Rahul Gotadki

Assistant Manager

He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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FAQs

What is the current valuation of the Gene Synthesis Market as of 2024?

The Gene Synthesis Market was valued at 2.615 USD Billion in 2024.

What is the projected market size for the Gene Synthesis Market in 2035?

The market is projected to reach 19.36 USD Billion by 2035.

What is the expected CAGR for the Gene Synthesis Market during the forecast period 2025 - 2035?

The expected CAGR for the Gene Synthesis Market during 2025 - 2035 is 19.96%.

Which application segment is anticipated to have the highest valuation by 2035?

The Therapeutics application segment is expected to reach 4.5 USD Billion by 2035.

What are the projected revenues for Oligonucleotides by 2035?

Oligonucleotides are projected to generate revenues of 6.5 USD Billion by 2035.

Which technology segment is likely to see significant growth by 2035?

DNA Sequencing technology is likely to reach a valuation of 4.0 USD Billion by 2035.

What is the expected market size for Academic Research in 2035?

The Academic Research segment is expected to reach 3.5 USD Billion by 2035.

Who are the key players in the Gene Synthesis Market?

Key players include Thermo Fisher Scientific, Integrated DNA Technologies, and GenScript, among others.

What is the projected valuation for Gene Libraries by 2035?

Gene Libraries are projected to reach a valuation of 2.5 USD Billion by 2035.

How does the Gene Synthesis Market's growth compare across different end-use segments?

Pharmaceutical Companies are expected to lead with a valuation of 5.0 USD Billion by 2035, followed by Biotechnology Companies at 4.0 USD Billion.

1. Market Overview

2. Market Trends

3. Market Segment Insights

4. Key Players and Competitive Insights

5. Industry Developments

6. Market Segmentation

7. Report Scope

8. Market Highlights

9. FAQs

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Market Summary

As per MRFR analysis, the Gene Synthesis Market Size was estimated at 2.615 USD Billion in 2024. The Gene Synthesis industry is projected to grow from 3.137 in 2025 to 19.36 by 2035, exhibiting a compound annual growth rate (CAGR) of 19.96 during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The Gene Synthesis Market is experiencing robust growth driven by technological advancements and increasing demand for customized solutions.

Technological advancements are propelling the Gene Synthesis Market, particularly in North America, which remains the largest market. The rising demand for custom solutions is evident in the Synthetic Biology segment, which holds the largest market share. Collaborative research initiatives are gaining traction, especially in the Asia-Pacific region, recognized as the fastest-growing market. Key market drivers include increasing applications in synthetic biology and rising investment in genomic research, fueling growth in both the Therapeutics and Oligonucleotides segments.

Gene Synthesis Market

CAGR

19.96%

Market Size & Forecast

2024 Market Size	2.615 (USD Billion)
2035 Market Size	19.36 (USD Billion)
CAGR (2025 - 2035)	19.96%
Largest Regional Market Share in 2024	North America

Major Players

<a href="https://www.thermofisher.com/in/en/home/life-science/cloning/gene-synthesis/geneart-gene-synthesis.html">Thermo Fisher Scientific </a>(US), Integrated DNA Technologies (US), GenScript (CN)<a href="https://www.eurofins.com/genomic-services/our-services/gene-synthesis-molecular-biology/">, Eurofins Genomics (</a>DE), Twist Bioscience (US), Synthetic Genomics (US), DNA2.0 (US), LGC Biosearch Technologies (GB), Bioneer (KR)

Market Trends

The Gene Synthesis Market is currently experiencing a transformative phase, driven by advancements in biotechnology and increasing demand for synthetic genes across various applications. This market encompasses the design and synthesis of DNA sequences, which are essential for research, therapeutic development, and agricultural improvements. As the scientific community continues to explore the potential of synthetic biology, the Gene Synthesis Market is likely to expand, fueled by innovations in sequencing technologies and automation. Furthermore, the growing emphasis on personalized medicine and genetic engineering is propelling the need for customized gene synthesis solutions, thereby enhancing the market's growth prospects. In addition to technological advancements, the Gene Synthesis Market is influenced by collaborations between academic institutions and industry players. These partnerships facilitate knowledge exchange and accelerate the development of novel applications. Moreover, the increasing investment in genomics research and the rising prevalence of genetic disorders are expected to further stimulate market demand. As stakeholders navigate this evolving landscape, they may encounter challenges related to regulatory frameworks and ethical considerations, which could impact the pace of innovation. Overall, the Gene Synthesis Market appears poised for substantial growth, driven by a confluence of scientific progress and market dynamics.

Technological Advancements

Recent innovations in sequencing and synthesis technologies are reshaping the Gene Synthesis Market. Enhanced precision and efficiency in gene synthesis processes are enabling researchers to create more complex genetic constructs, which may lead to breakthroughs in various fields, including medicine and agriculture.

Rising Demand for Custom Solutions

There is a growing trend towards personalized and tailored gene synthesis solutions. As researchers and companies seek specific genetic sequences for unique applications, the demand for customized services is likely to increase, reflecting a shift towards more individualized approaches in biotechnology.

Collaborative Research Initiatives

Collaborations between academic institutions and industry are becoming more prevalent in the Gene Synthesis Market. These partnerships foster innovation and expedite the development of new technologies, potentially leading to novel applications and enhanced market growth.

Gene Synthesis Market Market Drivers

Rising Investment in Genomic Research

Investment in genomic research is a key driver for the Gene Synthesis Market. As governments and private entities allocate substantial funding towards genomics, the demand for gene synthesis services is likely to increase. Recent reports indicate that funding for genomic research has reached unprecedented levels, with billions of dollars being invested annually. This influx of capital supports various projects, including personalized medicine and genetic engineering, which rely heavily on gene synthesis technologies. The Gene Synthesis Market stands to benefit from this trend, as researchers require high-quality synthesized genes to facilitate their studies and applications.

Growing Demand for Personalized Medicine

The Gene Synthesis Market is significantly influenced by the rising demand for personalized medicine. As healthcare shifts towards more individualized treatment approaches, the need for tailored genetic solutions becomes increasingly apparent. Personalized medicine relies on understanding the genetic makeup of patients, which necessitates the synthesis of specific genes for therapeutic purposes. The market for personalized medicine is expected to expand rapidly, with projections indicating a growth rate of approximately 15% annually. This trend underscores the importance of the Gene Synthesis Market in providing the necessary tools and technologies to support the development of customized therapies.

Advancements in Gene Editing Technologies

Recent advancements in gene editing technologies, such as CRISPR and TALEN, are propelling the Gene Synthesis Market forward. These technologies require precise gene synthesis to create the necessary components for effective editing. As researchers and companies adopt these innovative methods, the demand for high-quality synthesized genes is likely to increase. The market is witnessing a shift towards more efficient and cost-effective gene synthesis solutions, which are essential for the successful application of gene editing techniques. This trend indicates a robust growth trajectory for the Gene Synthesis Market as it adapts to the evolving needs of the scientific community.

Increasing Applications in Synthetic Biology

The Gene Synthesis Market is experiencing a surge in demand due to the expanding applications in synthetic biology. This field encompasses a variety of sectors, including agriculture, pharmaceuticals, and biofuels. As researchers and companies seek to engineer organisms for specific purposes, the need for precise gene synthesis becomes paramount. The market is projected to grow significantly, with estimates suggesting a compound annual growth rate of over 20% in the coming years. This growth is driven by the increasing focus on developing sustainable solutions and innovative products that can address global challenges. Consequently, the Gene Synthesis Market is poised to play a crucial role in advancing synthetic biology initiatives.

Expansion of Biotechnology and Pharmaceutical Industries

The expansion of the biotechnology and pharmaceutical industries is a significant driver for the Gene Synthesis Market. As these sectors continue to grow, the demand for gene synthesis services is expected to rise correspondingly. The biotechnology industry alone has seen substantial growth, with revenues projected to reach hundreds of billions in the next few years. This growth is fueled by the increasing need for novel therapeutics, vaccines, and diagnostic tools, all of which rely on gene synthesis technologies. Consequently, the Gene Synthesis Market is well-positioned to capitalize on the burgeoning opportunities presented by these expanding industries.

Market Segment Insights

By Application: Synthetic Biology (Largest) vs. Therapeutics (Fastest-Growing)

In the Gene Synthesis Market, the application segment is primarily driven by Synthetic Biology, which has emerged as the largest player, leveraging advancements in genomic technologies. This segment encompasses a diverse range of applications, contributing significantly to the overall market landscape. In contrast, Therapeutics stands out as the fastest-growing category, fueled by increasing investment in personalized medicine solutions and the expansion of gene editing technologies that cater to a range of health conditions.

Synthetic Biology (Dominant) vs. Therapeutics (Emerging)

Synthetic Biology is a dominant force within the Gene Synthesis Market, characterized by its broad applicability across various industries, including healthcare and agriculture. This segment enables the design and construction of new biological parts, devices, and systems, thus driving innovation and efficiency. Conversely, the Therapeutics segment is emerging dynamically, focusing on gene therapies and personalized treatments. It is characterized by rapid advancements, responding swiftly to the needs of modern medicine and offering solutions to long-standing medical challenges. Both segments are integral to the market's growth trajectory.

By Product Type: Oligonucleotides (Largest) vs. Gene Fragments (Fastest-Growing)

The Gene Synthesis Market exhibits a diverse distribution across its product types, with oligonucleotides holding the largest market share due to their extensive applications in research and development. This segment benefits from a variety of uses, including synthetic biology, therapeutic applications, and diagnostics, making it a critical component of the market. In contrast, gene fragments are gaining traction and are recognized as the fastest-growing segment, attributed to their increasing utility in genetic engineering and CRISPR technologies, positioning this segment for rapid expansion in the forthcoming years.

Oligonucleotides (Dominant) vs. Gene Fragments (Emerging)

Oligonucleotides dominate the Gene Synthesis Market owing to their versatility and established role across numerous applications, including DNA sequencing, molecular diagnostics, and as therapeutic agents. Their demand is continuously heightened by advancements in synthetic biology, where precise and customizable sequences are essential. On the other hand, gene fragments represent an emerging opportunity within the market, reflecting a surge in demand for modular gene constructs in genome editing. These segments are increasingly utilized in synthetic and metabolic engineering, unlocking new potential in biopharmaceutical development and personalized medicine, thus driving innovation and market dynamics favorably.

By Technology: DNA Sequencing (Largest) vs. Automated Synthesis (Fastest-Growing)

The gene synthesis market is segmented into key technologies: Polymerase Chain Reaction, Microarray Technology, DNA Sequencing, and Automated Synthesis. Among these, DNA Sequencing holds the largest market share, driven by its wide applications in genomics, diagnostics, and personalized medicine. Automated Synthesis, on the other hand, is rapidly gaining traction, making it the fastest-growing segment as laboratories increasingly adopt automation for efficiency in genome assembly and synthesis processes.

Technology: DNA Sequencing (Dominant) vs. Automated Synthesis (Emerging)

DNA Sequencing has established itself as the dominant technology in the gene synthesis market due to its critical role in advancing genetic research and applications. Its precision and ability to analyze vast amounts of genetic data make it indispensable for various fields, including clinical diagnostics and therapeutic development. Conversely, Automated Synthesis is an emerging player, characterized by its innovative advancements in streamlining gene synthesis processes. By enabling faster and more accurate synthesis of genes, it caters to the growing demand for rapid and cost-effective genetic material production. This technological shift is pivotal for research institutions and biotechnology companies aiming to stay competitive in the evolving landscape of genetic research.

By End Use: Pharmaceutical Companies (Largest) vs. Academic Research (Fastest-Growing)

In the Gene Synthesis Market, the distribution of market share among end-use segments is significantly weighted towards pharmaceutical companies, which dominate the landscape due to their robust R&D activities and the growing demand for personalized medicine. Following closely, biotechnology companies play a crucial role in utilizing synthesized genes for innovative healthcare solutions. Academic research institutions, while smaller in market share, are gaining momentum as they increasingly adopt gene synthesis technologies for advanced studies in molecular biology and genetics. The growth trends within the Gene Synthesis Market are primarily driven by the increasing applications of synthetic genes in drug development, diagnostics, and therapeutic research. Pharmaceutical companies are leveraging these advancements to expedite the discovery of novel drugs, while academic institutions are experiencing rapid growth as they expand their research capabilities. This dynamic interplay showcases a promising trajectory for both dominant and emerging segments, highlighting the potential for collaboration and innovation in the years to come.

Academic Research (Emerging) vs. Contract Research Organizations (Dominant)

The Academic Research segment in the Gene Synthesis Market represents an emerging force, characterized by a surge in research activities focused on genetics and synthetic biology. Universities and research institutions are increasingly integrating gene synthesis into their studies, driven by funding initiatives and the need for advanced analytical techniques. This segment is likely to witness growth as more academic institutions invest in gene synthesis tools to enhance their research capabilities. On the other hand, Contract Research Organizations (CROs) serve as a dominant force in this market, offering outsourced research services to pharmaceutical and biotechnology companies. They play a pivotal role in facilitating gene synthesis processes, providing specialized expertise and accelerating project timelines, thus securing their position as essential partners in the gene synthesis landscape.

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Regional Insights

North America : Innovation and Leadership Hub

North America leads the gene synthesis market, holding approximately 45% of the global share, driven by advanced research facilities, significant investments in biotechnology, and a robust regulatory framework. The demand for synthetic genes is propelled by applications in pharmaceuticals, agriculture, and synthetic biology. The U.S. is the largest market, followed closely by Canada, which contributes around 15% to the regional market share. The competitive landscape is characterized by major players such as Thermo Fisher Scientific, Integrated DNA Technologies, and Twist Bioscience, which are at the forefront of innovation. The presence of numerous biotech startups and established companies fosters a dynamic environment for growth. Regulatory support from agencies like the FDA further enhances market stability and encourages research and development initiatives.

Europe : Emerging Market with Regulations

Europe is witnessing significant growth in the gene synthesis market, accounting for approximately 30% of the global share. The region benefits from stringent regulatory frameworks that ensure quality and safety in biotechnology applications. Countries like Germany and the UK are leading the market, with Germany holding about 12% of the share, driven by strong research institutions and funding initiatives. The competitive landscape includes key players such as Eurofins Genomics and LGC Biosearch Technologies, which are expanding their capabilities to meet rising demand. The European market is also characterized by collaborations between academia and industry, fostering innovation. The European Medicines Agency emphasizes the importance of regulatory compliance in biotechnology, which further supports market growth.

Asia-Pacific : Rapid Growth and Innovation

Asia-Pacific is rapidly emerging as a significant player in the gene synthesis market, holding around 20% of the global share. The region's growth is driven by increasing investments in biotechnology, rising healthcare needs, and a growing number of research institutions. China is the largest market in the region, contributing approximately 12%, followed by Japan and South Korea, which are also expanding their biotech sectors. The competitive landscape is evolving, with companies like GenScript and Bioneer leading the charge. The region is witnessing a surge in collaborations between local firms and international players, enhancing technological advancements. Government initiatives aimed at boosting research and development in biotechnology further support the market's growth trajectory, positioning Asia-Pacific as a key player in the global landscape.

Middle East and Africa : Untapped Potential and Growth

The Middle East and Africa region is gradually emerging in the gene synthesis market, currently holding about 5% of the global share. The growth is primarily driven by increasing investments in healthcare and biotechnology, alongside a rising demand for genetic research. Countries like South Africa and the UAE are leading the market, with initiatives aimed at enhancing research capabilities and fostering innovation in biotechnology. The competitive landscape is still developing, with a few key players beginning to establish their presence. Local firms are increasingly collaborating with international companies to leverage expertise and technology. Government support for biotechnology initiatives is crucial for market growth, as it encourages investment and research in the region, paving the way for future advancements.

Key Players and Competitive Insights

The Gene Synthesis Market is currently characterized by a dynamic competitive landscape, driven by advancements in biotechnology and increasing demand for synthetic genes across various applications, including pharmaceuticals, agriculture, and industrial biotechnology. Key players such as Thermo Fisher Scientific (US), Integrated DNA Technologies (US), and GenScript (CN) are strategically positioned to leverage their technological capabilities and extensive product portfolios. These companies focus on innovation and partnerships to enhance their market presence, thereby shaping a competitive environment that is both collaborative and competitive.

In terms of business tactics, companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and reduce lead times. The market appears moderately fragmented, with several players vying for market share. However, the collective influence of major companies like Twist Bioscience (US) and Synthetic Genomics (US) suggests a trend towards consolidation, as these firms seek to expand their operational capabilities and geographic reach.

In August 2025, Thermo Fisher Scientific (US) announced a strategic partnership with a leading academic institution to develop next-generation gene synthesis technologies. This collaboration is expected to accelerate innovation in gene editing and synthetic biology, positioning Thermo Fisher at the forefront of emerging biotechnological advancements. The partnership underscores the importance of academic-industry collaborations in driving research and development in the gene synthesis sector.

In September 2025, Integrated DNA Technologies (US) launched a new line of high-fidelity gene synthesis products aimed at enhancing the accuracy and efficiency of synthetic gene construction. This product launch not only reflects the company's commitment to innovation but also addresses the growing demand for precision in genetic engineering applications. By expanding its product offerings, Integrated DNA Technologies strengthens its competitive position in a rapidly evolving market.

In July 2025, GenScript (CN) expanded its global footprint by establishing a new manufacturing facility in Europe. This strategic move is likely to enhance GenScript's ability to meet the increasing demand for gene synthesis services in the region, while also reducing shipping times and costs. The establishment of this facility indicates a proactive approach to regional expansion, which is crucial for maintaining competitiveness in the global market.

As of October 2025, the Gene Synthesis Market is witnessing significant trends such as digitalization, sustainability, and the integration of artificial intelligence in research and development processes. Strategic alliances are increasingly shaping the competitive landscape, as companies recognize the value of collaboration in driving innovation. Looking ahead, it appears that competitive differentiation will evolve from traditional price-based competition to a focus on technological innovation, supply chain reliability, and sustainable practices, thereby redefining the parameters of success in the gene synthesis arena.

Key Companies in the Gene Synthesis Market market include

Industry Developments

Recent developments in the Global Gene Synthesis Market highlight a notable surge in investments and technological advancements. Companies such as Molecular Assemblies and Genscript continue to innovate, with a focus on improving the efficiency and accuracy of gene synthesis. In September 2023, Thermo Fisher Scientific announced a strategic collaboration with Illumina to enhance genomic solutions, demonstrating a push towards integrated service offerings. Additionally, Codex Biotechnology reported growth in demand for its custom DNA synthesis, pointing to a broader trend in personalized medicine.

Recent mergers and acquisitions include the acquisition of DNA2.0 by Twist Bioscience in July 2022, which enhanced Twist’s capabilities in gene synthesis and market reach. Eurofins Genomics has also gained significant traction, marking its footprint in the synthetic biology landscape with recent investments. The market saw a valuation increase driven by the rising demand in the biotechnology and pharmaceutical sectors, reflected by increased production capacities by companies like Integrated DNA Technologies and Synlogic.

Over the past few years, the overall market has benefited from heightened interest in genetic engineering, particularly in 2021 and 2022, with increasing funding directed towards Research and Development initiatives across the globe.

Future Outlook

Gene Synthesis Market Future Outlook

The Gene Synthesis Market is projected to grow at a 19.96% CAGR from 2024 to 2035, driven by advancements in biotechnology, increasing demand for synthetic genes, and rising applications in therapeutics.

New opportunities lie in:

Development of customized gene synthesis platforms for <a href="https://www.marketresearchfuture.com/reports/personalized-medicine-market-2937">personalized medicine.</a>
Expansion into emerging markets with tailored gene synthesis solutions.
Partnerships with biotech firms for co-development of novel gene therapies.

By 2035, the Gene Synthesis Market is expected to be robust, reflecting substantial growth and innovation.

Market Segmentation

Gene Synthesis Market End Use Outlook

Academic Research
Pharmaceutical Companies
Biotechnology Companies
Contract Research Organizations

Gene Synthesis Market Technology Outlook

Polymerase Chain Reaction
Microarray Technology
DNA Sequencing
Automated Synthesis

Gene Synthesis Market Application Outlook

Synthetic Biology
Therapeutics
Vaccines
Genetic Engineering
Agricultural Biotechnology

Gene Synthesis Market Product Type Outlook

Gene Libraries
Oligonucleotides
Plasmids
Gene Fragments

Report Scope

MARKET SIZE 2024	2.615(USD Billion)
MARKET SIZE 2025	3.137(USD Billion)
MARKET SIZE 2035	19.36(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR)	19.96% (2024 - 2035)
REPORT COVERAGE	Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR	2024
Market Forecast Period	2025 - 2035
Historical Data	2019 - 2024
Market Forecast Units	USD Billion
Key Companies Profiled	Market analysis in progress
Segments Covered	Market segmentation analysis in progress
Key Market Opportunities	Advancements in synthetic biology drive demand for customized gene synthesis solutions in diverse applications.
Key Market Dynamics	Rising demand for personalized medicine drives innovation and competition in the gene synthesis market.
Countries Covered	North America, Europe, APAC, South America, MEA