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    Acute Agitation Aggression Treatment Market

    ID: MRFR/Pharma/7365-CR
    128 Pages
    Kinjoll Dey
    October 2023

    Acute Agitation and Aggression Treatment Market Research Report Information by Drug Class (First-Generation Anti-Psychotics, Second-Generation Anti-Psychotics, Benzodiazepines, and Others), by Route of Administration (Oral, Intramuscular, and Others), by Indication (Schizophrenia, Dementia, Bipolar Disorder, Depression, Drug-induced Agitation and Aggression, Alcohol Withdrawal, and Others), by End User (Hospitals & Clinics, Psychiatric Care Facilities, and Others), and Region (North America, Europe, Asia-Pacific, and Rest of the World)—F...

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    Acute Agitation Aggression Treatment Market Summary

    The Global Acute Agitation and Aggression Treatment Market is projected to grow significantly from 6.22 USD Billion in 2024 to 13.0 USD Billion by 2035.

    Key Market Trends & Highlights

    Acute Agitation and Aggression Treatment Key Trends and Highlights

    • The market is expected to witness a compound annual growth rate (CAGR) of 6.96% from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 13.0 USD Billion, indicating robust growth potential.
    • In 2024, the market is valued at 6.22 USD Billion, reflecting the increasing demand for effective treatment options.
    • Growing adoption of innovative treatment modalities due to rising awareness of mental health issues is a major market driver.

    Market Size & Forecast

    2024 Market Size 6.22 (USD Billion)
    2035 Market Size 13.0 (USD Billion)
    CAGR (2025-2035) 6.96%

    Major Players

    Eli Lilly and Company, Pfizer Inc, GlaxoSmithKline plc, Teva Pharmaceutical Industries Ltd, Otsuka Holdings Co., Ltd, VIATRIS INC, Johnson & Johnson Services, Inc, Novartis AG, Lundbeck A/S, Amneal Pharmaceuticals LLC

    Acute Agitation Aggression Treatment Market Trends

    The rising prevalence of acute agitation and aggression boosts the market growth.

    Acute agitation is a state of high anxiety, intense arousal, and high motor activity that can arise from several psychiatric and medical conditions such as anxiety, dementia, and insomnia. The rising prevalence of acute agitation and aggression demands the discovery of newer and more effective drugs for their treatment. Moreover, the growing incidence of schizophrenia, dementia, depression, bipolar disorder, drug-induced agitation, and other mental illnesses is anticipated to fuel the market growth during the forecast period.

    For instance, according to the National Institute of Mental Health (US), in 2020, serious mental illness (SM)I was expected to affect 14.2 million adults in the US aged 18 and above. Females had a higher prevalence of SMI (7.0%) than males (4.2%). Stress, workplace stress, depression, endocrine disorders, electrolyte imbalance, and other factors are the major causes of acute agitation and aggression.

    Furthermore, according to the World Health Organization (WHO), dementia currently affects approximately 10 million people in Europe, with the prevalence expected to double by 2030. Hence, the increasing prevalence of acute agitation and rising burden of psychological illness & mortality will drive the market growth during the forecast period.

    The increasing recognition of acute agitation and aggression as critical components of mental health care is driving the demand for innovative treatment strategies and interventions.

    National Institute of Mental Health

    Acute Agitation Aggression Treatment Market Drivers

    Rising Prevalence of Mental Health Disorders

    The increasing incidence of mental health disorders globally is a primary driver of the Global Acute Agitation and Aggression Treatment Market Industry. Conditions such as schizophrenia, bipolar disorder, and severe depression contribute significantly to acute agitation and aggression. According to the World Health Organization, mental health disorders affect approximately 1 in 4 individuals at some point in their lives. This growing prevalence necessitates effective treatment options, thereby expanding the market. As awareness of mental health issues rises, the demand for innovative treatment solutions is likely to increase, further propelling market growth.

    Market Segment Insights

    Acute Agitation and Aggression Treatment Drug Class Insights

    The Acute Agitation and Aggression Treatment Market segmentation, based on drug class, includes first-generation anti-psychotics, second-generation anti-psychotics, benzodiazepines, and others. The second-generation antipsychotics (SGA) segment is to hold the majority share in 2022 in the Acute Agitation and Aggression Treatment Market revenue. This is due to the effective medication giving the best results for patients suffering from agitation and aggression, and other related disorders. Moreover, second-generation antipsychotics (SGA), also called atypical antipsychotics, are commonly used in the acute setting. Furthermore, SGAs are also used in children with severe autism exhibiting behavioral disturbances though repeatedly giving antipsychotics is not preferred.

    September 2021:Otsuka Holdings Co., Ltd (Japan) announced a worldwide collaboration and license agreement with Sumitomo Dainippon Pharma (Japan) for four psychiatry and neurology compounds development codes, including SEP-363856(ulotaront), SEP-4199, SEP-378614, and SEP-380135, which is further augmenting the market growth.

    Acute Agitation and Aggression Treatment Route of Administration Insights

    The Acute Agitation and Aggression Treatment Market segmentation is based on a route of administration, that includes oral, intramuscular, and others. The oral segment has dominated the market in 2022 and the others segment is projected to be the fastest-growing segment during the forecast period, 2023-2032. This is due to the rising use of agitation treatment drugs in oral form. In addition, orally administered medication are easier route of administration for patients and is preferred as it offers a greater sense of control to patients.

    Figure 2: ACUTE AGITATION AND AGGRESSION TREATMENT MARKET, BY ROUTE OF ADMINISTRATION, 2022 & 2032 (USD Billion)

    Source: Secondary Research, Primary Research, Market Research Future Database, and Analyst Review

    Acute Agitation and Aggression Treatment Indication Insights

    The Acute Agitation and Aggression Treatment Market segmentation, based on indication, includes schizophrenia, dementia, bipolar disorder, depression, drug-induced agitation and aggression, alcohol withdrawal, and others. The dementia segment is to hold the majority share in 2022 in the Acute Agitation and Aggression Treatment Market revenue. This is due to the increase in the incidences of dementia among the geriatric population, the rise in the burden of mental illness, a surge in agitation in patients, and a rise in prescriptions of anti-psychotics.

    According to the Centers for Disease Control and Prevention, dementia is not a particular disease but is rather a general term for the reduced ability to remember, think, or make choices that interfere with everyday activities. Moreover, it only affects older adults over the age of 65.

    Acute Agitation and Aggression Treatment End User Insights

    The Acute Agitation and Aggression Treatment Market segmentation is based on the end user that includes hospitals & clinics, psychiatric care facilities, and others. The hospitals & clinics segment has dominated the market in 2022 and psychiatric care facilities is projected to be the fastest-growing segment during the forecast period, 2023-2032. This is due to the rise in the geriatric population, and the increasing number of hospitals. Today most large general hospitals have a psychiatric unit. Most hospitals have adult mental health, old age, and learning disability link psychiatry teams. If needed, they are ready to attend to crises immediately.

    The hospital stay of many persons with chronic mental illness has been shortened by modern medication and better understanding on the part of the public.

    February 2021:Sapravato (Esketamine Nasal Spray) received Johnson & Johnson Services, Inc’s (US) authorization in Europe for the rapid reduction of depressive symptoms in a psychiatric emergency for patients with major depressive disorder.

    Get more detailed insights about Acute Agitation and Aggression Treatment Market Research Report - Global Forecast till 2034

    Regional Insights

    By Region, the study segments the market into North America, Europe, Asia-Pacific, and the Rest of the World. The North American acute agitation and aggression treatment market accounted for the largest market share in 2022. This is attributed to the growing focus on spreading awareness among people regarding treatment associated with agitation and aggression, well-established healthcare infrastructure, the rise in the economic burden of mental illness, presence of leading market players in the region.

    Additionally, the rise in the focus of players on research and development in the region is also expected to increase demand for acute agitation and aggression treatment across North America.

    Further, the major countries studied are the U.S., Canada, Germany, France, the UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil

    Figure 3: ACUTE AGITATION AND AGGRESSION TREATMENT MARKET BY REGION 2022 & 2032

    ACUTE AGITATION AND AGGRESSION TREATMENT MARKET BY REGION 2022 & 2032

    Source: Secondary Research, Primary Research, Market Research Future Database, and Analyst Review

    Europe acute agitation and aggression treatment market is expected to account for the second-largest market share due to the increasing prevalence of various health disorders such as dementia, alcohol dependence, depression, and bipolar disorders in the region. Further, the Germany acute agitation and aggression treatment market was attributed to holding the largest market share, and the UK acute agitation and aggression treatment market is expected to fastest-growing market in the European region.

    The Asia-Pacific acute agitation and aggression treatment market is expected to grow at the fastest rate from 2023 to 2032. This is due to the rise in the geriatric population and increase in agitation in patients, and ongoing research on the development of novel treatments for agitation in the region. Moreover, China’s acute agitation and aggression treatment market is expected to hold the largest market share, and India acute agitation and aggression treatment market is expected fastest-growing market in the Asia-Pacific region.

    Furthermore, rise in the prevalence of mental illnesses such as schizophrenia and bipolar disorder, and the focus of market players on India and Japan to exploit opportunities in these emerging markets. will accelerate growth in the acute agitation and aggression treatment market.

    The Rest of the World includes the Middle East, Africa, and Latin America. The main factors influencing the growth of acute agitation and aggression treatment in the Middle East and Africa are the increase in agitation in patients, an increase in focus on creating awareness about agitation and aggression, and ongoing research on the development that boost the market growth in the Middle East. On the other hand, the growth opportunities in developing countries such as South Africa, UAE, and Saudi Arabia are estimated to provide lucrative growth opportunities to the market players.

    Key Players and Competitive Insights

    The Acute Agitation and Aggression Treatment Market is characterized by the presence of many global, regional, and local vendors catering to the demand created by research scientists and pharmaceutical and biotechnology companies operating in the industry. The market comprises tier-1, tier-2, and local players. The tier-1 and tier-2 players have reach across the globe with diverse product portfolios. Companies such as Eli Lilly and Company (US), Pfizer Inc (US), GlaxoSmithKline plc (UK), and Teva Pharmaceutical Industries Ltd (Israel) dominate the Acute Agitation and Aggression Treatment Market due to product differentiation, financial stability, strategic developments, and diversified regional presence.

    The players are focused on investing in extensive research and development as well. Furthermore, they adopt strategic growth initiatives, such as expansion, product launches, joint ventures, and partnerships, to strengthen their market position and capture a large customer base.

    One of the primary business strategies adopted by manufacturers in the global acute agitation and aggression treatment industry to benefit clients and expand the acute agitation and aggression treatment market sector is to manufacture locally to reduce operating costs.

    GlaxoSmithKline is engaged in R&D and manufacturing innovative pharmaceutical medicine, vaccines, and consumer healthcare products across the globe. It operates through four segments, namely, pharmaceuticals, pharmaceuticals R&D, vaccines, and consumer healthcare. Its pharmaceutical segment offers innovative and well-established medicines in respiratory, human immunodeficiency virus (HIV), including lupus, psychiatry, neurology, urology, & anti-infectives, immunoinflamation, and oncology. Its vaccine segment includes pneumococcal disease, meningitis, hepatitis, rotavirus, whooping, cough, and influenza. The company has a significant global presence in more than 150 countries, including 87 manufacturing sites in 36 countries and large R&D centers in the UK, US, Spain, Belgium, and China.

    For instance, in July 2021, GlaxoSmithKline plc (UK) collaborated with Alector (US) to co-develop progranulin-elevating monoclonal antibodies, AL001, and AL101, to treat neurodegenerative disorders. This helped the company to retain exclusive commercialization rights outside the US.

    Also, Teva Pharmaceutical Industries Ltd (Israel) is one of the leaders in pharmaceutical industries engaged in developing and providing services in generic medicines. The company has more than 1,800 molecules used to create an extensive variety of generic products in almost every therapeutic area. It is specialized in generic medicines, the central nervous system (CNS), brand and specialty medicines, oncology, active pharmaceutical ingredients, respiratory, women’s health, and biologics. It operates in the following regions–North America, Latin America, Europe, Japan, and South Korea. It has 26 FDA-approved plants, and 31 European Medicines Agency (EMA) approved plants worldwide.

    Key Companies in the Acute Agitation Aggression Treatment Market market include

    Industry Developments

    In July 2022, Impel Pharmaceuticals commenced a Phase 2a proof-of-concept study for INP105, a nasal formulation of olanzapine, aimed at addressing acute agitation in individuals diagnosed with autism spectrum disorder (ASD). This investigation utilizes Impel's unique Precision Olfactory Delivery (POD) technology, designed to administer drugs to the upper nasal cavity, providing a non-invasive approach with a swift onset of action.

    Otsuka Pharmaceutical Co., Ltd. has established itself as a significant contributor in the market for treating acute agitation and aggression. In June 2022, the company, in partnership with H. Lundbeck A/S, reported favorable outcomes from a Phase III clinical trial of brexpiprazole aimed at addressing agitation in individuals with Alzheimer's dementia.

    In December 2024, Axsome Therapeutics revealed its intention to pursue marketing approval for its oral medication, AXS-05, aimed at addressing agitation in individuals diagnosed with Alzheimer's disease. The medication showed considerable delays in relapse time and provided symptom relief in the majority of the four late-stage studies carried out.

    Future Outlook

    Acute Agitation Aggression Treatment Market Future Outlook

    The Acute Agitation and Aggression Treatment Market is projected to grow at a 6.96% CAGR from 2024 to 2035, driven by increasing mental health awareness and advancements in treatment methodologies.

    New opportunities lie in:

    • Develop digital therapeutics for real-time monitoring and intervention.
    • Invest in personalized medicine approaches to enhance treatment efficacy.
    • Expand telehealth services to improve access to care for patients globally.

    By 2035, the market is expected to exhibit robust growth, reflecting enhanced treatment options and increased demand.

    Market Segmentation

    Acute Agitation and Aggression Treatment End User Outlook

    • Hospitals & Clinics
    • Psychiatric Care Facilities
    • Others

    Acute Agitation and Aggression Treatment Regional Outlook

    • US
    • Canada
    • Germany
    • France
    • UK
    • Italy
    • Spain
    • Rest of Europe
    • China
    • Japan
    • India
    • Australia
    • South Korea
    • Rest of Asia-Pacific
    • Middle East
    • Africa
    • Latin America

    Acute Agitation and Aggression Treatment Drug Class Outlook

    • First-Generation Anti-Psychotics
    • Second-Generation Anti-Psychotics
    • Benzodiazepines
    • Others

    Acute Agitation and Aggression Treatment Indication Outlook

    • Schizophrenia
    • Dementia
    • Bipolar Disorder
    • Depression
    • Drug-induced Agitation and Aggression
    • Alcohol Withdrawal
    • Others

    Acute Agitation and Aggression Treatment Route of Administration Outlook

    • Oral
    • Intramuscular
    • Others

    Report Scope

    Report Attribute/Metric Details
    Market Size 2024    6.22 (USD Billion)
    Market Size 2025    6.66 (USD Billion)
    Market Size 2034   12.19 (USD Billion)
    Compound Annual Growth Rate (CAGR)    6.95 % (2025 - 2034)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2024
    Market Forecast Period 2025 - 2034
    Historical Data 2020 - 2024
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Segments Covered Drug Class, Route of Administration, Indication, End User, and Region
    Geographies Covered North America, Europe, Asia Pacific, and the Rest of the World
    Countries Covered The US, Canada, Germany, France, the UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil
    Key Companies Profiled Eli Lilly and Company (US), Pfizer Inc (US), GlaxoSmithKline plc (UK), Teva Pharmaceutical Industries Ltd (Israel), Otsuka Holdings Co., Ltd (Japan), VIATRIS INC (US), Johnson & Johnson Services, Inc (US), Novartis AG (Switzerland), H. Lundbeck A/S (Denmark), and Amneal Pharmaceuticals LLC (US)
    Key Market Opportunities ·       Ongoing research on the development of novel treatment for agitation
    Key Market Dynamics ·       Rising prevalence of acute agitation and aggression·       Increase in focus on creating awareness about agitation and aggression

    Market Highlights

    Author
    Kinjoll Dey
    Research Analyst Level I

    He is an extremely curious individual currently working in Healthcare and Medical Devices Domain. Kinjoll is comfortably versed in data centric research backed by healthcare educational background. He leverages extensive data mining and analytics tools such as Primary and Secondary Research, Statistical Analysis, Machine Learning, Data Modelling. His key role also involves Technical Sales Support, Client Interaction and Project management within the Healthcare team. Lastly, he showcases extensive affinity towards learning new skills and remain fascinated in implementing them.

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    FAQs

    How much is the acute agitation and aggression treatment market?

    How much is the acute agitation and aggression treatment market?

    How big is the US acute agitation and aggression treatment market?

    The US is expected to hold a 70-80% share of the North American market for the acute agitation and aggression treatment market during the forecast period of 2023-2032.

    What is the growth rate of the acute agitation and aggression treatment market?

    The acute agitation and aggression treatment market is expected to grow at a 6.95% CAGR during the forecast period from 2025 to 2034

    Which region held the largest market share in the acute agitation and aggression treatment market?

    The North America region market held the largest market share in the acute agitation and aggression treatment market.

    Who are the key players in the acute agitation and aggression treatment market?

    The key players include Eli Lilly and Company (US), Pfizer Inc (US), GlaxoSmithKline plc (UK), Teva Pharmaceutical Industries Ltd (Israel), Otsuka Holdings Co., Ltd (Japan), VIATRIS INC (US), Johnson & Johnson Services, Inc (US), Novartis AG (Switzerland), H. Lundbeck A/S (Denmark), and Amneal Pharmaceuticals LLC (US).

    Which type of indication led the acute agitation and aggression treatment market?

    The dementia segment was estimated to lead the acute agitation and aggression treatment market.

    Which end user had the largest market share in the acute agitation and aggression treatment market?

    The hospitals & clinics segment is attributed to having the largest market share based on end user.

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