The chromatography columns market is expected to cross ~USD 16,320 million by 2027 at a CAGR of ~5.8%.
Chromatography columns are analytical instruments used to separate molecules from a mixture based on their properties. The columns hold a stationary phase within them and act as a container through which the mobile phase flows, along with the sample. They play important functions, such as protein purification, sample preparation, and desalting. The market is driven by various factors such as an increase in life science R&D expenditure, a rise in the production of monoclonal antibodies, and the increasing demand for biopharmaceutical products. However, the lack of skilled professionals may hamper the growth of the market.
The present COVID-19 pandemic has impacted people all over the world and forced the closure of operational facilities across the world. During the lockdown, the healthcare business faced extraordinary challenges such as supply chain disruptions, resulting in an increase in warehouse inventories of manufactured goods.The market for chromatography equipment is also experiencing a phase of short-term negative growth due to the same reasons.
However, the COVID-19 pandemic also created growth opportunities for the companies involved in the chromatography columns industry.This is due to the increased R&D efforts to produce treatments for COVID-19, such as monoclonal antibody therapies where column chromatography is used for product purification purposes. For instance, in May 2021, GlaxoSmithKline (UK) got the FDA approved for sotrovimab, a monoclonal antibody therapy for emergency use in mild-to-moderate COVID-19 cases. Furthermore, column chromatography procedures such as protein A affinity chromatography are used in vaccine development, increasing demand.
Column chromatography methods are used extensively in biopharma company R&D departments as well as in research institutes for different purposes such as drug process development. Thus, the increasing R&D expenditure drives the growth of the chromatography columns market.
For instance, according to Statista (Germany), global pharmaceutical R&D spending had increased from USD 136 billion in 2012 to USD 186 billion in 2019. The company estimates the value to increase to USD 233 billion by 2026.
Emerging countries such as India are improving their healthcare infrastructure at a tremendous rate along with initiatives to fund life science companies. China had invested USD 378 billion in R&D in 2020, an increase of 10.3% compared to 2019.
Furthermore, the rise in approval of protein and monoclonal antibody therapies isalso supplementing market growth in the region. For instance, the Drugs Controller General of India (DCGI) approved monoclonal antibody therapy for COVID-19 treatment in June 2021.
Running column chromatography procedures and implementing the results require expertise and skilled professionals. Such professionals should be knowledgeable regarding the different components of the chromatography process, starting from resin selection to the interpretation of the results, along with being updated with the technological advancements and performing complex analytical calculations as well.
The lack of such skilled professionals may hamper the growth of the market as irregularities in the performance of these techniques may result in significant losses to the companies.However, companies are setting up training initiatives to overcome this restraint.
The global chromatography columns market is projected to exhibit significant growth over the forecast period, which can be attributed to an increase in life science R&D expenditure, a rise in the production of monoclonal antibodies, and the increasing demand for biopharmaceutical products. The value chain analysis for the cell banking outsourcing industry comprises five major components, which start with research & product development, followed by the manufacturing of the products, distribution& sales, and ends with post-marketing surveillance.
By Column Type
Normal phase columns have a stationary phase which is polar in nature, and a mobile phase which is less polar. They are used to separate positional isomers based on the polarity of the molecules in the sample. The analysis of solutes that are readily soluble in organic solvents are easily separated using this normal phase chromatography column.
Pre-packed chromatography columns have a stationary phase already pre-filled within the column and can be used directly after attaching to a chromatography system. This removes the extra steps of column cleaning, sterilization, and re-packing. Product innovations and launches are also driving growth for this segment. For instance, in September 2020, Bio-Works Technologies (Sweden) launched two new resins WorkBeadsNiMAC and WorkBeadsDsalt, which are also sold in pre-packed columns. These resins show high resistance to chelating agents like EDTA and reducing agents like DTT.
Automating the various steps of a column chromatographic process necessitates the employment of computerized systems of varying design and complexity, depending on the level of automation required and the chromatograph's architecture.Automated chromatography columns offer fully automated packing, unpacking, and cleaning capabilities which reduces the time required for setting up and removes chances of human error during the process.
By Chromatography Type
Charged biomolecules are separated using Ion Exchange (IEX) chromatography. The liquid phase is made up of a crude sample containing charged molecules to be separated. Molecules bind to oppositely charged sites in the stationary phase as they move through the chromatographic column. A solution of changing ionic strength is used to elute the molecules segregated based on their charge.They are of two types, anion and cation exchange chromatography.
Affinity chromatography works on the principle of specific binding that happens between a ligand in the stationary phase and its binding partner. These bindings may happen between enzyme/substrate, antibody/antigen, or enzyme/inhibitor. Affinity chromatography is the first step if nor the only step in the purification process of moleculesthat boosts the demand for this segment.
In gas chromatography, the boiling points of molecules and their interactions with the stationary phase are leveraged to separate the molecules. The temperature of the mixtures to be separated is raised above the boiling point of the least volatile component. Then the components are carried with the help of an inert gas (such as helium) through the chromatography column.
Gel filtration chromatography is also known as size exclusion chromatography. Here an organic solvent is used as the mobile phase and used to either fractionate molecules and complexes in a sample into fractions with a specific size range, or eliminate all molecules larger than a certain size from the sample, or do both. Its applications includethe separation of tiny molecules, polysaccharides,proteins, protein complexes, and nucleic acids.
The other types of chromatography where columns are used are High-Performance Liquid Chromatography (HPLC) and multimodal chromatography.
IEX chromatography is of two types, anion, and cation exchange chromatography. Each type contains different types of raisins filled in the columns. Those resins used for exchanging positively charged ions are called cation resins, and those exchanging negative ions are called anion resins. Anion and cation exchange chromatography columns are used to separate charged molecules such as DNA, proteins, peptides, nucleotides, and enzymes.
Sample preparation is an important process done before the analysis of the sample. This is because the raw sampleis generally not responsive to the analytical techniques or may have interfering species that would give ambiguous results. Therefore, sample preparation specific to the analytical method, such as the different chromatography techniques,is required for proper sample analysis. Solid-phase extractions and liquid chromatography are two major sample preparation methods where columns are utilized.
Using a stationary phase, chromatography resins are used to capture and polish monoclonal antibodies (mAbs), antibody fragments, vaccinations, and other biomolecules. For both analytical and purifying uses, there are a variety of resin types employed. Therefore, it is necessary to screen different resins out of the available ones to test which would fit the molecule of interest based on factors like reproducibility and scalability from lab scale to mass production.
Column chromatography is one of the most common techniques used for protein purification. The increasing R&D initiatives into protein research and funding is boosting the market growth. Furthermore, recombinant protein-based vaccines are being tested against the Coronavirus, further boosting this segment's growth.
Desalting is the process of removal of salts, phenols, and excess unrequired proteins from the target molecules. Size exclusion chromatography is generally used here. The size exclusion limit is chosen to be smaller than the target molecules' size. As a result, the target molecules remain in the mobile phase and are excluded from the pores and eluted first. The desalting column slows down salts and other tiny molecules, separating them from the target molecules.
By End User
The improving healthcare infrastructure of developing countries and increases funding for R&D is driving growth for this segment, especially after witnessing the effects of the COVID-19 pandemic. For instance, funding for the National Institutes of Health (NIH) of the US is expected to increase by 15% for the fiscal year 2022, according to a report bythe American Association for the Advancement of Science (AAAS) in July 2021.
Biopharmaceutical companies in search of new drug innovation and the production and distribution of existing therapeutics where column chromatography is utilized are driving the market growth. Furthermore, the players in this market are involved in collaboration and product launches, further helping the market grow. For instance, in February 0201,Waters (US) had launched the Waters ACQUITY PREMIER Solution, a next-gen liquid chromatography system aimed to make R&D faster and even more efficient.
Column chromatography is extensively used in the food & beverage industry for food testing purposes. Some of the applications of chromatography in the food & beverage industry include quality control, separation of food additives and preservatives, vitamins, proteins, and amino acids. Liquid chromatography and gas chromatography are two common column chromatography techniques used for this in this industry.
The other end users that utilize column chromatography are nutraceutical companies, Environmental testing labs, cosmeceutical companies, and hospitals & clinics.
The presence of key players and increasing R&D spendingare driving the growth of the North America Chromatography columns market
North Americaheld the largest market share in chromatography columns in 2020 due to factors like the presence of key players like Thermo Fisher Scientific Inc. (US), Agilent Technologies, Inc. (US), and Bio-Rad Laboratories, Inc. (US). Furthermore, the increasing R&D investment drives the chromatography columns market in the region, for instance, according to the American Association for the Advancement of Science (AAAS), the funding for the National Institutes of Health (NIH) for the fiscal year 2022 was increased by 15% compared to the fiscal year 2021.
Product innovations and increased research funding arefueling the Europechromatography columns market
The Europe Chromatography columns market is accounted to hold a significant market share in 2020. Europe also houses several key players in the region, such as Merck KGaA (Germany), Biotage (Sweden), and KNAUER WissenschaftlicheGeräte GmbH (Germany). These key players are also launching new products, further driving the market growth. For instance, in March 2019, KNAUER WissenschaftlicheGeräte GmbH (Germany) launched new protein purification liquid chromatography columns and media that can be utilized for different chromatography techniques like affinity, size-exclusion, and IEX chromatography.
Improving healthcare infrastructure, increasing diseases burden, and rising R&D investments are supplementing growth for the chromatography columns market in the region
Countries like Japan in this region have well-developed healthcare infrastructure along with the presence of key company headquarters like Daicel Corporation (Japan), and Shimadzu Corporation (Japan). In contrast, countries like India are rapidly developing in the healthcare R&D space. China had spent the highest R&D expenditure up till 2020, which had increased by 10.3% to USD 378 billion in 2020. These factors enable the Asia-Pacific region to grow at the highest CAGR duringthe forecast period.
Government initiatives and expansion of analytical lab space in the region are fueling the market growth
The Rest of the World region includes the Middle East & Africa and Latin America. Government initiatives to bring technological advancements in the region and global players expanding R&D capabilities in the region, drive growth for the market here. For instance, global players like Himalaya Drug Company (India), Jotun Group (Norway), and Global BioTherapeutics (GBT) (US) have all established R&D centers in Dubai between 2018 and 2019 with more companies in the process.
Industry players are coming up with various business strategies to increase their market presence. The companies are significantly investing in R&D activities to expand their product portfolio, further driving the Chromatography columns market. In addition, the market players are engaged in several strategic initiatives, such as mergers and acquisitions, contractual agreements, new product launches, increasing investments, and partnering with other players to expand their global footprint.
For instance, in February 2021, Waters (US) had launched a next-gen liquid chromatography solution called the Waters ACQUITY PREMIER Solution with MaxPeakHigh-Performance Surface (HPS) technology which improves analyte recovery, reproducibility, and the analyte/metal surface interaction issues. Waters offers a wide range of column portfolios, from Ultra-Performance Liquid Chromatography (UPLC) columns toHPLC columns to size exclusion chromatography columns. The company was founded in 1958 in Massachusetts, US, and made a revenue of USD 1,497 million in 2020.
List of companies with HQ
The study covers the existing short-term and long-term market effects. It helps decision-makers to draught short-term and long-term business plans by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's five forces, value chain, and impact of COVID-19 on the market.
Global Chromatography Columns Market,By Column Type
Global Chromatography Columns Market, By Chromatography Type
Global Chromatography Columns Market, By Application
Global Chromatography Columns Market, By End User
Global Chromatography Columns Market, By Region
|Market Size||2027:~USD 16,320Million|
|Historical Data||2018 & 2019|
|Forecast Units||Value (USD Million)|
|Report Coverage||Revenue Forecast, Competitive Landscape, Growth Factors, and Trends|
|Segments Covered||Column Type, Chromatography Type,Application, and End User|
|Geographies Covered||North America, Europe, Asia-Pacific, and Rest of the World (RoW)|
|Key Vendors||• Merck KGaA (Germany) • Thermo Fisher Scientific Inc. (US) • Agilent Technologies, Inc. (US) • Daicel Corporation (Japan) • Shimadzu Corporation (Kyoto) • PerkinElmer Inc. (US) • Bio-Rad Laboratories, Inc. (US) • Biotage (Sweden) • Waters (US) • KNAUER WissenschaftlicheGeräte GmbH (Germany) • Others|
|Key Market Opportunities||• Increase in adoption of chromatography techniques in emerging countries|
|Key Market Drivers||• Increase in life science R&D expenditure • Rise in production of monoclonal antibodies • Increasing demand for biopharmaceutical products|