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Bone Graft Substitutes Market Share

ID: MRFR//0689-CR | 126 Pages | Author: Rahul Gotadki| August 2021

The Bone Graft Substitutes market is witnessing a surge in competition, prompting companies to adopt strategic positioning to capture market share. Several tactics are used to achieve a keen position within this rapidly evolving market.
The competition is fierce in the market of bone graft substitutes, so companies are looking into ways to develop more unique and advanced products. Firms would accomplish product differentiation in three different ways - by composition, effectiveness and application methods so as to appeal for a wider scope range of surgeons and patients.
Market leaders should invest in research and development. Constant innovations in bone graft substitute technologies keep a competitive advantage as products with better performance, faster recovery times and improved patients’ outcomes are launched.
The company can also take advantage by collaborating with key stakeholders such as hospitals, research institutions and orthopedic surgeons to help it penetrate new markets. Strategic alliances allow companies to tap into their current networks and earn the respect of doctors.
Market leaders tend to embrace a global orientation by going beyond their home markets. As emerging economies with an increasing need for orthopedic procedures present opportunities to address uncovered niches and develop a broader market share.
Cost leadership can be achieved if an organization achieves economies of scale and optimizes its production processes. High-quality bone graft substitutes offered at competitive prices attract price sensitive customers and enable companies to have wider market penetration.
In the healthcare sector, it is necessary to adhere to very strict regulatory standards. Companies positioning themselves as leaders focus more on quality assurance and compliance with the regulatory requirements, thus gaining trust of healthcare professionals and end users.
It is necessary to highlight the importance of educating healthcare professionals and patients about the use benefits bone graft substitutes as a part market positioning. Companies advertise and use marketing and educational campaigns to create awareness, making sure that their products come into consideration whenever there is decision being made.
Recognizing the varying needs of patients and surgeons, companies are coming up with adjustable solutions. Personalization of bone graft substitutes to individual patient needs and different clinical conditions makes the products more attractive, allowing securing a stronger market position for the company.
Promoting bone graft substitutes through different outlets, such as the digital platforms, conferences and medical journals is also beneficial for gaining market share. Aggressive marketing strategies place the target audience adequately informed about a specific product’s unique features and advantages.
By providing comprehensive post-sales services such as training programs for surgeons, bone graft substitutes are likely to succeed in the market. When companies emphasize continuous training and support, loyalty develops among healthcare professionals resulting in a higher market share.
Continuous monitoring of competitors' activities allows companies to adapt quickly to changing market dynamics. Staying informed about new product launches, pricing strategies, and market trends enables firms to make informed decisions and maintain a competitive edge.

Bone Graft Substitute Market Overview

Bone Graft Substitute Market Size was valued at USD 2.83 Billion in 2022. The Bone Graft Substitute industry is projected to grow from USD 3.02 Billion in 2023 to USD 5.41 Billion by 2032, exhibiting a compound annual growth rate (CAGR) of 6.70% during the forecast period (2023 - 2032). Bone grafting is a medical procedure used to repair severe bone fractures. Bone grafts are implantable materials that are used in the surgical process to help with bone healing, bone formation, and osseous reconstruction. A bone substitute is a synthetic, artificial, or biologically organic fusion that can be used instead of autogenous or allogenous bone to treat a bone defect

March 2022

Molecular Matrix, Inc. (MMI), a leader in regenerative medicine polymer technology, is proud to announce the full launch of its Osteo-P® Synthetic Bone Graft Substitute (BGS) for use in the musculoskeletal system. Osteo-P® BGS is made using MMI’s hyper-crosslinked carbohydrate polymer (HCCP) technology platform which has been engineered to optimize the microenvironment for bone repair and regeneration.

Osteo-P® BGS’s natural matrix does not require the addition of a collagen xenograft or other binder to improve handling.

COVID-19 Impact Analysis

Although COVID-19 will have a short-term effect on market growth, the market will largely be unaffected by the pandemic because orthopedic procedures, including bone graft substitute devices, are in high demand due to the subsequent rise in the demand for bone-related treatments. Additionally, many nations have begun easing lockdowns and other COVID-19-related precautions, allowing for the resumed performance of orthopedic procedures.

The situation following the COVID-19 outbreak has improved tremendously since governments worldwide have started to relax norms, giving way to business activities operating once again. Movement restrictions are no longer an issue, which is encouraging companies to now expand their presence in other regions, other than their own.

For instance, in October 2022, CGBio, a South Korean healthcare provider, has procured a firm hold on the sale of its advanced synthetic bone graft material that has clinical uses in spine, orthopedic, trauma and dental applications across North America via a license-out and product supply contract with a U.S. medical device company, Orthofix.

CGBio's material called Novosis, has been approved in South Korea, Mexico, India, and Southeast Asia, and can be described as a recombinant human bone morphogenetic protein-2 bone growth material that is used as a scaffold for the development of a new bone while offering moldable handling.  

Market Dynamics

The growth of biocompatible synthetic bone grafts, an increase in demand for dental bone graft processes, and an increase in road injury and joint disorder incidences are some of the key factors driving market expansion. Bone graft substitutes market growth is being hindered by factors like high surgical costs, risks associated with bone graft procedures, and complications.

THERAVET has developed a new line of calcium-phosphate and biological bone substitutes, BIOCERA-VET. BIOCERA-VET® is a full range of innovative, easy-to-use, efficient & cost-effective bone substitutes indicated in bone surgeries where a bone graft is required and as a palliative alternative in the management of canine osteosarcoma.


  • Rising incidence of road injuries and joint disorders

The frequency of traffic accidents is increasing. For instance, the WHO estimates that every year, 1.35 million people die in road accidents and 20 to 50 million people suffer non-fatal injuries. Additionally, the National Trauma Institute estimates that the economic toll of trauma cases in 2014 increased to USD 671 billion, including lost productivity and healthcare costs. There are many ways to treat diseases and injuries with bone grafting. If a fracture has multiple, complex, or poor healing after initial treatment, it may be used. In a diseased joint, it is also used for fusion, which aids in the healing of two bones. Fusion is typically carried out on the spine.


  • Surgery fees are very expensive

The price of a bone graft varies greatly depending on the circumstance and the patient's health. For instance, a single implant region will cost anywhere between USD 300 and USD 800 for simple bone grafting for dental purposes using synthetic bone. Hospitalization is required and adds to the cost of a bone graft operation when a patient's bone material is obtained from various body locations.


  • The orthopedic care sector has received a lot of investmen

A crucial component of health policy and planning is accurate and comparable estimates of each nation's health spending. They are essential to advancing regional, global, and national health objectives. The WHO published a new report on global health spending on February 20, 2019, which showed that high-income countries saw an increase in health spending of 4% and low- and middle-income countries saw an increase of 6% globally. Less than 40% of primary health care spending is covered by the government. Due to the significant market opportunity for bone graft substitutes, many businesses are entering the space.

Segment Overview

By Product Type

Based on the Product Type, the global Bone Graft Substitute market has been divided into Allograft, {Machine allografts, Demineralized Bone Matrix (DBM)}, Bone Graft Substitute {Synthetic Bone Grafts, Bone Morphogenic Proteins}, Cell-based Matrices. The spinal fusion segment holds the largest share of bone graft substitute market. Allografts come from people other than the recipient of the graft. It is typically sourced from a bone bank and is mainly taken from cadavers who have donated their bone so that it can be used for people who are alive and in need.

By Application

Based on the Application, the global Bone Graft Substitute market is divided into Spinal Fusion, Joint Reconstruction, Long Bone, Dental, Foot & Ankle. The spinal fusion segment will grow the fastest. It's crucial to realize that bone grafts do not perform the spinal fusion or heal the distress in the spine. However, a bone graft creates a setting in which a strong bridge can develop. The spine is supported by a bone graft, which also enables the body to regenerate the bone and fuse the affected section of the spine.

February 2022

Orthofix Medical Inc. (NASDAQ:OFIX), a global medical device company with a spine and orthopedics focus, today announced the full market launch of Opus™ BA, a synthetic bioactive bone graft solution for cervical and lumbar spine fusion procedures.

Opus BA can be used to fill bone voids or gaps in the skeletal system that are not intrinsic to the stability of bony structure. Opus BA acts as a scaffold allowing bone growth across the surface that is reabsorbed and replaced with natural bone during the healing process.

Global Bone Graft Substitute Market Share, by Region, 2021 (%)Global Bone Graft Substitute Market Share, by Region, 2021 (%)

Regional Analysis

By region, the global market has been divided into North America, Europe, Asia-Pacific, and the Rest of the World. Europe accounted for the largest market share. Asia-Pacific is projected to exhibit the highest CAGR during the review period.

October 2022

LifeNet Health is showcasing the most advanced allograft biologics for fusion during the North American Spine Society (NASS) 2022 Annual Meeting in Chicago Oct. 12-14 (Booth #3216). The global leader in allograft solutions and processing technology will feature the growing body of evidence supporting LifeNet Health's solutions for thoracic, cervical, and lumbar fusions — including ViviGen® Cellular Bone Matrix, PliaFX® Prime moldable demineralized fibers, and VertiGraft® structural allografts.

Europe Market

Europe held a large share of the global bone graft substitute market. With increased awareness of bone graft substitutes and rising healthcare costs, Europe has emerged as a significant market. The region has significant growth potential, which will aid in the global market's expansion in the coming years. Countries such as the UK and Germany are expected to make major contributions to the growth of the regional market, which will benefit the industry.

Asia-Pacific Market

The bone graft substitute market is predicted to grow fastest in Asia-Pacific. Due to the presence of developing economies such as India, China, and South Korea as well as the growing potential patient population, the region offers lucrative opportunities for players in the bone graft substitute market. Additionally, it is anticipated that the market will expand during the review period due to the growing geriatric population and rising healthcare spending. The bone graft market is expanding quickly in the Asia-Pacific region owing to research and development initiatives.

Competitive Landscape

The market comprises tier-1, tier-2, and local players. The tier-1 and tier-2 players have reach across the globe with diverse product portfolios. Companies such as Johnson & Johnson Services Inc, Geistlich Pharma, AlloSource, Smith & Nephew, and Integra Lifesciences Holdings Corporation dominate the global Bone Graft Substitute market due to product differentiation, financial stability, strategic developments, and diversified regional presence. The players are focused on investing in research and development. Furthermore, they adopt strategic growth initiatives, such as expansion, product launches, joint ventures, and partnerships, to strengthen their market position and capture a large customer base.

Prominent players in the global Bone Graft Substitute market include Medtronic, AlloSource, Zimmer Biomet Holdings Inc, Stryker, Smith & Nephew, Johnson & Johnson Services Inc, Baxter International Inc, Integra Lifesciences Holdings Corporation, Orthofix Holdings Inc, Geistlich Pharma, SeaSpine.

Scope of the Report

Global Bone Graft Substitute Market, By Product Type

  • Allograft

    • Machine allografts

    • Demineralized Bone Matrix (DBM)

  • Bone Graft Substitute

    • Synthetic Bone Grafts

    • Bone Morphogenic Proteins

  • Cell-based Matrices

Global Bone Graft Substitute Market, By Application

  • Spinal Fusion

  • Joint Reconstruction

  • Long Bone

  • Dental

  • Foot & Ankle

  • Others

Global Bone Graft Substitute Market, By Region

  • North America

    • US

    • Canada

    • Mexico

  • Europe

    • UK

    • Germany

    • France

    • Italy

    • Spain

    • Rest of Europe

  • Asia-Pacific

    • China

    • India

    • Japan

    • Australia and New Zealand

    • Rest of Asia-Pacific

  • Rest of the World

    • South America

    • Middle East

    • Africa

Objectives of the Study

The objectives of the study are summarized in 5 stages. They are as mentioned below:

Market Size and Forecast:

To identify and estimate the market size for the global Bone Graft Substitute market segmented by Hardware, Types, and Applications, by value (in US dollars). Also, to understand the consumption/ demand created by consumers of Bone Graft Substitute during the period of 2020-2030

Market Landscape and Trends:

To identify and infer, the drivers, restraints, opportunities, and challenges for the global Bone Graft Substitute market

Market Influencing Factors:

To find out the factors which are affecting the sales of Bone Graft Substitute among consumers

Impact of COVID-19:

To identify and understand the various factors involved in the global Bone Graft Substitute market affected by the pandemic

Company Profiling:

To provide a detailed insight into the major companies operating in the market. The profiling will include the financial health of the company past 2-3 years with segmental and regional revenue breakup, product offering, recent developments, SWOT analysis, and key strategies.

Intended Audience

  • Bone Graft Substitute producers

  • Raw Material Suppliers

  • Retailers, Wholesalers, and Distributors

  • Governments, Associations, and Industrial Bodies

  • Investors and Trade Experts

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