ID: MRFR/HC/0689-CR | August 2021 | Region: Global | 126 pages
The bone graft substitute market is expected to cross USD 4,408.50 million by 2027 at a CAGR of 6.29%.
Bone grafting is a surgical procedure used to operate on severely complicated bone fractures. Bone grafts are implantable materials used during themedical process to aid in bone formation, bone healing, and osseous reconstruction. A bone substitute is a synthetic, inorganic, or biologically organic combination that can be used to treat a bone defect instead of autogenous or allogenous bone.The rising incidents of road injuries and joint disorders, the development of biocompatible synthetic bone grafts, and increased demand for dental bone graft procedures are some major factors leading to the market growth. However, the high costs of surgery and risks and complications arising from bone graft procedures are some factors negatively affecting the market growth.
COVID-19 will have a short-term impact on market growth, but the market will remain largely unaffected by the pandemic since the demand for orthopedic procedures, including bone graft substitute devices, is rapidly increasing due to the subsequent growth in the requirement of bone-related treatments. Several countries have also started lifting lockdowns and other COVID-19-related precautions, enabling orthopedic procedures to be carried out again.
The rate of road injuries is on the rise. For instance, according to the WHO, about 20 to 50 million people suffer non-fatal injuries, and approximately 1.35 million people die due to road accidents every year. Moreover, according to the National Trauma Institute, 2014, the economic burden due to trauma cases has increased to USD 671 billion, including healthcare costs and lost productivity costs. Bone grafting has numerous applications in fixing injuries and diseases. It may be used in the case of multiple or complex fractures or those that do not heal well after initial treatment. It is also used for fusion which helps two bones heal ina diseased joint. Fusion is most often done on the spine.
The cost of a bone graft varies widely depending on the situation and the condition of the patient. For example, simple bone grafting for dental purposes using synthetic bone will cost anywhere from USD 300 to USD 800 for a single implant region. When a patient's bone material is sourced from different parts of the body for a bone graft operation, hospitalization is needed, which increases the cost. This form of graft also necessitates the services of an orthopedic surgeon and an anesthesiologist, resulting in a dental bone graft cost of USD 2,500 to USD 3,500.
Comprehensive and comparable estimates of health spending in each country are a key input for health policy and planning. They are necessary to support the achievements of national and international health goals. On February 20, 2019, the WHO released a new report on global health expenditure, according to which the global spending on health in low- and middle-income countries increased by 6%and in high-income countries by 4 percent. Governments account for less than 40%of primary health care spending. Many companies are joining the sector because of the high market opportunity. Existing players are spending a lot of money on research & development to add advanced technologies to their portfolios and maintain their market share.
Global Bone Graft Substitute market Share (%), by Product Type, 2020
Source: MRFR Analysis
Value Chain Analysis
The global bone graft substitute market is multiplying and is expected to continue growing steadily during the study period. This is due to the growing contribution of existing players to make the product more effective. The supply chain analysis for the bone graft substitute market comprises five major components, which start with the research and product development followed by manufacturing the products, distribution, sales, and ends with post-sales services.
The key market players focus on incorporating innovations in their current techniques to keep any discrepancies at bay. For instance, in July 2020, Baxter International Inc. announced the US Food and Drug Administration (FDA) clearance of Altapore Shape Bioactive Bone Graft to its next-generation bone graft substitute product line.
The global bone graft substitute market has been divided based on product type and application.
By Product Type
Allografts are the logical replacement for autografts. Allografts are taken from individuals other than the one receiving the graft. It is mostly taken from cadavers that have donated their bone so that it can be used for people who are alive and in need; it is typically sourced from a bone bank.However, there is a high risk of disease transmission while using these allografts for bone grafting as the body from which it is taken may be carrying the disease. Hence, these bones are highly processed and sterilized to reduce the chances of disease transmission. Allografts are segmented into machine allografts and Demineralized Bone Matrix (DBM).
The bone graft substitute is a synthetic inorganic or biologically organic combination, which stimulates bone healing and fills bone defects. It is further classified into Bone Morphogenic Proteins (BMP) and synthetic bone grafts.BMP are naturally occurring proteins found in the human body. These proteins stimulate the growth of the bones naturally in the human body. Different types of BMPs are found in the body. However, researchers have been focusing mainly on the BMP-2 & BMP-7. These BMPs are majorly used in spinal fusion treatment and are said to have a better result than the other bone substitutes.
Advances in the field of stem cell technology have stimulated the development and increased the use of allogeneic bone grafts containing live Mesenchymal Stem Cells (MSCs), also known as Cellular Bone Matrices (CBMs). Bone marrow and adipose tissue are two of the main sources of these cells. It is estimated that CBMs comprise morethan 17% of all bone grafts and bone graft substitutes used.
The global bone graft substitute market, by application, is segmented into dental, foot & ankle, joint reconstruction, long bone, and spinal fusion. The spinal fusion segment dominated the market in 2020. The spinal fusion segment is projected to be the fastest-growing segment during the study period.
Spinal fusion is an extremely important procedure wherein a solid bridge is formed between two vertebral of the spines to stop the movement in that section. It is very important to understand that bone grafts do not directly heal the spinal distress or carry out the spinal fusion. However, bone graft creates an environment for that solid bridge to form. Bone graft provides a foundation for the spine and allows the body to regenerate the bone and fuse the section of the spine.
Joint reconstruction is a surgical procedure used to repair and restore full function to a given joint. It is another orthopedic area where the use of bone graft substitutes is excessively done. With the increasing age, the human joints tend to become weak and are damaged even during the smallest of accidents or injuries. Moreover, there are certain scenarios, such as sports injuriesand vehicular accidents, where the joints are dislodged or damaged.
Long bones are mainly damaged due to severe injuries, accidents, trauma, or diseases. They are meant to be strong and stable to cope with the weight of the body. Synthetic bone substitutes are not used for the reconstruction of long bones as they lack growth factors and other osteogenic properties. Autogenous grafts or allografts are mainly used for long bone reconstruction.
Bone grafting is mainly used in dental implants to repair damaged or missing teeth. Advanced function and enhanced esthetic value are some of the basic needs for patients in today’s world. Bone grafts are used in dental restorations as there is a requirement of enough bone volume and superior biologic properties for the correct placement of the dental implants and the desired outcomes. Dental science has been increasingly using bone grafts as substitutes for restorative procedures.
Bone grafting is a common procedure for foot and ankle-related surgeries. Foot & ankle surgeries are extremely important as the patients leading a normal life are dependent on whether they will be able to walk again without any pain or defect. Historically, autografts were the preferred choice, but due to disadvantages such as site morbidity, interest is rising in using bone graft substitutes instead. Synthetic bone grafts such as calcium sulfate allow complex shapes to be sculpted and even percutaneous injections to be performed.Calcium sulfate is a synthetic bone graft that allows complex shapes to be sculpted and even facilitates percutaneous injections.
Apart from the above-mentioned application areas, bone graft substitutes are used in the treatment of maxillofacial injuries, oral surgeries, cranial defects, bone void fillers, and reconstruction of other parts of our body.
Global Bone Graft Substitute Market Share (%), by Region, 2020
Source: MRFR Analysis
The global bone graft substitute market, based on region, has been divided into the Americas, Europe, Asia-Pacific, and the Middle East & Africa.
The Americas is further segmented into North America and Latin America. The North American market is further divided into the US and Canada. The largest market share of North America is due to several factors, such as high volumes of orthopedic surgeries, adoption of bone graft substitutes, and the presence of prominent key players. According to a published article by Wolters Kluwer Health Inc., the number of elective lumbar fusions has increased by 62.3%, from 122,679 cases in 2004 to 199,140 cases in 2019 in the US.
Europe accounted for a substantial share in the global bone graft substitute market.Europe has evolved as a prominent market with the growing awareness about bone graft substitutes and surging healthcare expenses. The region has considerable growth potentials that would help in the expansion of the global market in the coming years. Countries such as the UK and Germany are expected to make significant contributions in developing the regional market that can benefit the industry.
Asia-Pacific is expected to be the fastest-growing market in the bone graft substitute market. The region represents lucrative opportunities for players operating in the bone graft substitute market, owing to the presence of evolving economies, such as India, China, and South Korea, and the increasing potential patient population. In addition, the growing geriatric population and increasing expenditure on healthcare expenses are anticipated to fuel the market growth during the review timeframe.Rapid research &development efforts are boosting the bone graft market growth in the Asia-Pacific region.
The market is growing significantly in the Middle East & Africa due to the increasing number of research companies and subsidiaries involved in R&D, increasing initiatives taken by the Middle East countries to develop their healthcare infrastructure. Moreover, the growing awareness and demand from the general population for effective orthopedic treatments are likely to favor the market growth.As a result of their economic stability, Middle East countries such as the UAE and Kuwait are expected to make a significant contribution to the regional market.. However, Africa is expected to obstruct the expansion of the regional market due to poor economic conditions.
The global bone graft substitute market is expected to grow significantly in the coming years due to the rising incidence of road injuries and joint disorders, the development of biocompatible synthetic bone grafts, and the increase in demand for dental bone grafts. The global bone graft substitute market is characterized by the presence of several global and regional vendors. The market is highly competitive, with all the players trying to gain maximum market share. Frequent changes in government policies, intense competition, and FDA regulations are the key factors that impact global market growth. The vendors compete based on cost, product quality, reliability, and aftermarket services. It is crucial for the players to offer cost-efficient and high-quality bone graft substitutes to succeed in an intensely competitive market environment.
The leading players such as Medtronic plc (Ireland), Zimmer Biomet Holdings Inc. (US), Baxter International Inc. (US), and Stryker (US) are dominating the market due to their advanced product offerings, high industry experience, and regional reach. These players may establish their presence worldwide through strategic partnerships and acquisitions during the forecast period. Players with access to better technologies can develop unique and innovative products, which could render the competitors' offerings obsolete. The competitive environment in the market is likely to intensify further due to the rising number of contracts and expansions. For instance, Baxter International Inc. (US)announced the US Food and Drug Administration (FDA) clearance of Altapore Shape Bioactive Bone Graft to its next-generation bone graft substitute product line. In February 2019, Medtronic Plc (US) announced approval and launch of Japan's first Grafton(TM) Demineralized Bone Matrix (DBM) bone grafting product for spine and orthopedic procedures.
List of Key Companies Covered in this report:
The study covers the existing short-term and long-term market effects, helping decision-makers draft short-term and long-term plans for businesses by region. The report covers major regions in the Americas, Europe, Asia-Pacific, and the Middle East & Africa. The report analyzes market drivers, restraints, opportunities, challenges, Porter's Five Forces, Value Chain, and impact of COVID-19 on the market.
Scope of the Report & Segmentation
Global Bone graft substitute market, by Product Type
Global Bone graft substitute Market, by Application
Global Bone graft substitute Market, by Region
|Market Size||USD 4,408.50 million|
|CAGR||CAGR of 6.29%|
|Forecast Units||Value (USD Million)|
|Report Coverage||Revenue Forecast, Competitive Landscape, Growth Factors, and Trends|
|Segments Covered||Type, Application|
|Geographies Covered||North America, Europe, Asia-Pacific, and Rest of the World (RoW)|
|Key Vendors||ACE Surgical Supply Company, Inc. (US), BioHorizons (US), Dentium (South Korea), Dentsply Sirona (US), Institut Straumann AG (Switzerland), Medtronic (Ireland), Stryker (US), Zimmer Biomet (US)|
|Key Market Opportunities||Introduction of Biocompatible Synthetic Bone Grafts to Offer Significant Opportunities for Market Growth|
|Key Market Drivers||Rising Incidences of Bones & Joint Disorders to Boost the Market Growth during the Projection Period|
Frequently Asked Questions (FAQ) :
The global bone graft substitute market is predicted to touch USD 5,031.0 million by 2027.
The bone graft substitute market is predicted to grow at a 6.52% CAGR between 2014-2027.
The Americas is projected to spearhead the bone graft substitute market during the forecast period.
Key competitors in the bone graft substitute market include Zimmer Biomet (US), Stryker (US), Medtronic (Ireland), Institut Straumann AG (Switzerland), Dentsply Sirona (US), Dentium (South Korea), BioHorizons (US), and ACE Surgical Supply Company, Inc. (US).
High treatment cost and complications & risks may limit market growth.
This table of content is tentative and subject to change as the research progresses.
Please Note: Financial details of company cannot be provided if the information of the company is not available in public domain and or reliable source.