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Pouchitis is a kind of inflammation that happens in the ileal pouch reservoir. This condition is not specific and typically occurs in individuals who already have ulcerative colitis (UC). It is quite rare in people with Familial adenomatous polyposis (FAP). Those who have UC or FAP may choose to undergo a surgery called ileal pouch-anal anastomosis (IPAA) as a treatment, and pouchitis can sometimes occur after this surgery. Doctors usually recommend a procedure called pouch endoscopy to diagnose this condition. This procedure provides important information about the severity of mucosal inflammation, Crohn's disease (CD) of the pouch or cuffitis, the presence or absence of concurrent backwash ileitis, and the presence or absence of structural abnormalities.
The growth of the pouchitis market is being driven by several factors. Firstly, there is an increasing prevalence of ulcerative colitis, a need for Ileal Pouch–Anal Anastomosis procedures, prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), and a growing elderly population. The global incidence of ulcerative colitis, leading to pouchitis, is on the rise, especially among the aging population. A study published in the World Journal of Gastroenterology in 2015 suggests that the underlying causes of ulcerative colitis may significantly contribute to the development of pouchitis.
However, despite these positive factors, there are certain challenges that could impact the growth of the market. The available treatment options for pouchitis may have side effects, and there are strict regulations from the Food and Drug Administration (FDA) that need to be adhered to. These challenges might pose obstacles to the market's expansion.
Covered Aspects:
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America Pouchitis Treatment Market Highlights:
America Pouchitis Treatment Market Scenario
The America pouchitis treatment market is expected to reach USD 14.40 Million by 2030 at 4.8% CAGR during the forecast period 2022-2030. Pouchitis is a nonspecific inflammatory condition in the ileal pouch reservoir. The condition exclusively occurs in patients with underlying ulcerative colitis (UC) and is rarely seen in patients with Familial adenomatous polyposis (FAP). Patients with UC or FAP opt for ileal pouch-anal anastomosis (IPAA) surgery as a treatment, and pouchitis appears as an outcome of this surgery in some cases. Pouch endoscopy is usually recommended by the physicians for diagnosis as the procedure yields valuable information on the severity of mucosal inflammation, CD of the pouch or cuffitis, presence or absence of concurrent backwash ileitis, and the presence or absence of structural abnormalities.
Notably, rising prevalence of Ulcerative Colitis (UC) is the key factors driving the pouchitis treatment market. According to the Centres for Disease Control and Prevention, in 2015, around 1.3% of the U.S. adults were diagnosed with inflammatory bowel disease (IBD). The prevalence of ulcerative colitis is reported to be 37 to 246 cases per 100,000 individuals whereas, the incidence rate is found to be 2.2 to 14.3 cases per 100,000 people.
Increasing need for ileal pouch-anal anastomosis procedure, long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), and rising geriatric population are fuelling the market growth.
According to the American Society of Colon and Rectal Surgeons, chronological age should not be an exclusion criterion for ileal pouch-anal anastomosis surgery. Patients with IBD are mostly recommended to opt IPAA surgery for the treatment. Around 89% of elderly ulcerative colitis patients undergo this surgery, suggested by the World Journal of Gastrointestinal Pharmacology and Therapeutics in 2016.
However, the side effects of the available treatment options and stringent FDA regulations may hinder the growth of the pouchitis treatment market over the forecast period. Till now not even a single drug is approved by the FDA for the treatment of pouchitis. However, few are in clinical trials waiting for approval such as Alicaforsen by Atlantic Healthcare plc
Intended Audience
- Hospitals & Clinics
- Diagnostic Centers
- Research and Development (R&D) Companies
- Government Research Institute
- Academic Institutes and Universities
Figure: America Pouchitis Treatment Market by Treatment Market Share, 2016 (%) 
Sources: Annual reports, Press release, White paper, Company presentation
Segmentation
The America pouchitis treatment market is segmented on the basis of treatment and end user.
On the basis of the treatment, the America pouchitis treatment market is segmented into antibiotics, probiotics, and others. The antibiotic segment is further sub-segmented into ciprofloxacin, metronidazole, rifaximin, and others.
On the basis of the end -users, the pouchitis treatment market is segmented into hospitals & clinics, research institutes, and others.
Key Findings
- The America pouchitis treatment market is expected to reach USD 18.8 million by 2023 at a CAGR of 8.34%.
- On the basis of the treatment, the antibiotics segment commanded the largest market share of 91.2% and is also expected to grow at a healthy CAGR of 8.65% during the forecast period 2017 to 2023.
- On the basis of the end user, the hospitals & clinics segment commanded the largest market share of 67.3% in 2016, and this segment is also expected to grow at a healthy CAGR of 8.54% during the forecast period, 2017 to 2023.
- North America holds the largest share of the Americas pouchitis treatment market and is expected to reach USD 15.06 million by 2023
Regional Analysis
On the basis of region, the America pouchitis treatment market is segmented into North America, and South America. North America accounts for a major share owing to the rising cases of pouchitis, and high healthcare expenditure. People in this region are more inclined towards quality healthcare that leads to increase in the healthcare spending. Due to rising prevalence of pouchitis, various companies, private organizations, and government associations are also actively participating to improve the treatment options.
The Americas pouchitis market is driven by ongoing extensive research in the inflammatory bowel disease (IBD). The American Gastroenterological Association (AGA) has introduced several new research grants to support investigators studying inflammatory bowel disease (IBD) such as Takeda Pharmaceuticals research scholar awards in IBD, and Pfizer pilot research award in IBD.
Around 30% of patients with ulcerative colitis (UC) undergo colectomy with ileal pouch-anal anastomosis (IPAA) surgery and up to 50% of patients develop at least one episode of pouchitis. So, rising prevalence of ulcerative colitis is boosting the Americas pouchitis treatment market. According to the Centres for Disease Control and Prevention, in 2015, around 1.3% of the U.S. adults were diagnosed with inflammatory bowel disease (IBD). The prevalence of ulcerative colitis is reported to be 37 to 246 cases per 100,000 individuals whereas, the incidence rate is found to be 2.2 to 14.3 cases per 100,000 person-years.
Key Players
Some of key the players in the pouchitis treatment market are Pfizer, Abbott, Allergan Plc, Bayer, Takeda Pharmaceutical Company Limited, Alfa sigma, Atlantic Healthcare, Tillotts Pharma AG, AstraZeneca, Novartis AG, Teva Pharmaceutical Industries Ltd., Sanofi, B. Braun Medical Inc., Valeant Pharmaceuticals, Sucampo Pharmaceuticals, Ironwood Pharmaceuticals, Inc., Astellas Pharma Inc., Synergy Pharmaceuticals, Inc., Ardelyx, Inc., Sebela Pharmaceuticals, Probi, and others
Research Methodology
Sources: Annual reports, Press release, White paper, and Company presentation
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