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Vitamin K2 Market Research Report—Global Forecast till 2027

Vitamin K2 Market: Information by Product Type (MK-7, MK-4 and Combination Drugs), by Source (Natural and Synthetic), by Form (Capsules & Tablets, Powder, Oil), by Application (Nutraceutical & Food and Pharmaceutical) and by Region (Americas, Europe, Asia-Pacific, and Middle East & Africa)—Forecast till 2027

ID: MRFR/HC/6026-CR | November 2021 | Region: Global | 117 pages

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Vitamin K2 Market Forecast


vitamin K2 market is expected to cross USD 703.82 million by 2027 at a CAGR of 31.08%.


Market Overview:


The cases of vitamin K2 deficiency are increasing due to changing lifestyle and food-related habits. Vitamin K2 is naturally produced in human guts by bacteria. Vitamin K2 is rare in the western diet, and it is necessary to involve vitamin K2 through supplementary diet and pharmaceutical products. The key factors attributing to the market growth include increasing patient pool suffering from vitamin deficiency, rising demand for nutraceutical products containing vitamin K2, and increasing cases of osteoporosis and arthritis. However, the stringent regulations for nutraceuticals may hamper the market growth in the forecast period. On the contrary, the multifunctional ingredients offer opportunities for market players to develop advanced products.


COVID-19 Analysis:


The rising prevalence of COVID-19 is projected to influence market growth over the forecast period. The COVID-19 crisis has generated a direct and huge impact on the healthcare sector. During the initial stage of the coronavirus outbreak, most pharmaceutical and nutraceutical companies experienced a slight loss in the first few quarters, owing to sudden impact on the supply chain and restrictions implemented on manufacturing and supply operations. However, COVID-19 has led to an increased demand for nutraceuticals, including vitamin K2, and several key players have witnessed positive growth in sales owing to the growth in demand.


Market Dynamics:


Market Drivers


  • Increasing patient pool suffering from vitamin deficiency


In recent years the number of cases of vitamin deficiency is constantly increasing. The increasing vitamin deficiency disorders are responsible for the increasing demand for nutraceuticals containing vitamins. Furthermore, Vitamin K Deficiency Bleeding (VKDB) is a condition when babies cannot stop bleeding because their blood does not have enough Vitamin K to form a clot. According to the Centers for Disease Control and Prevention (CDC), healthcare providers divide VKDB into three types: early, classical, and late. Early and classical VKDB are more common and occur in 1 in 60 to 1 in 250 newborns, and Late VKDB is rarer, occurring in 1 in 14,000 to 1 in 25,000 infants. Moreover, according to the report published by the Food and Agriculture Organization of the United Nations (FAO), Vitamin K deficiency bleeding (VKDB) in infants is a serious concern, and the prevalence rate of VKDB in Thailand is 72 per 100,000 births.



  • Growing demand for nutraceutical products containing vitamin K2

  • Rising cases of osteoporosis and arthritis


Market Restraints


  • Stringent regulations for nutraceuticals


Key players in the nutraceuticals market are required to fulfill the rules and regulations set by governments to meet the standards set by them. The concerned authorities are responsible for controlling permits, setting regulations for the entry of new players, residual management issues, and inspection of expiry dates for certain products such as dietary supplements. FDA is responsible for regulating the manufacturing and distribution of functional food and nutraceuticals in the US.


Market Opportunities


  • Multifunctional ingredients


In recent years, technological advancements in the market have led to the development of multifunctional nutritional ingredients, which synergistically lead to the increased functional performance of various complex nutraceutical and pharmaceutical formulations. Moreover, it is estimated that such ingredients reduce the need for the binder, lubricant, glidant, and others. Thus, multifunctionality of these ingredients results in significant savings in production costs when compared with other techniques.


Global Vitamin K2 Market Share (%), by Product Type, 2020
Vitamin K2 Market Share by Product Type 2020
Source: MRFR Analysis


Segment Overview


The global vitamin K2 market has been divided based on product type, source, form, and application.


By Product Type



  • MK-7


Vitamin K2 MK-7 (menaquinone-7) is derived from the bacterial fermentation of soy and is created and processed in a manufacturing facility. It is used in dietary supplements. MK-7 is an enhanced bioactive form of vitamin K2 found naturally occurring in natto and is responsible for the carboxylation of specific bone proteins needed for building bones.



  • MK-4


Vitamin K2 MK-4 (menaquinone-4) is found in supplements and functional foods as synthetic MK-4 to promote bone health and support blood coagulation and the formation of prothrombin. MK-4 is a short-chain form of K2 found in eggs, butter, cheese, and animal products. It is a synthetic vitamin K2 compound with a short half-life as compared to MK-7. It stops and reverses bone loss, leads to strong bones, and reduces the chance of fractures.



  • Combination Drugs


The combination drugs segment included combination drugs such as MK7+MK4, K2+D3, MK4 to MK7 Plus MK8/9/10, D3+MK7+MK4, and others. Combining vitamin D3 and vitamin K2 ensures that calcium is absorbed easily and reaches the bone mass while preventing arterial calcification.


 By Source


On the basis of source, the global vitamin K2 market is divided into natural and synthetic.



  • Natural


Natural vitamin K is found in dark leafy greens and is crucial for normal blood coagulation and metabolic pathways. Foods rich in vitamin K2 include fermented soy, natto, goose liver, cheese, egg yolks, dark chicken meat/salami, sauerkraut, and butter. Natural vitamin K2 is a part of the family of vitamin K, a group of fat-soluble compounds having hemostatic, anti-osteoporotic, and antioxidant properties.



  • Synthetic


Synthetic vitamin K2 is derived from the flower extracts of geraniol and farnesol and is an alternative to the natural soy-based MK-7. In August 2010, the Norwegian ingredient supplier Kappa Bioscience AS developed a synthetic form of vitamin K2 that has similar bioavailability to existing forms in the market and is available at lower prices than the natural forms (soy-based ingredients) of vitamin K2.


By Form


On the basis of form, the market is divided into capsules & tablets, powder, oil, and others such as tablets, capsules, and soft gels..



  • Capsules & Tablets


Vitamin K2 products are widely consumed in the form of capsules, tablets, or softgels. Several key companies manufacture vitamin K2 supplements in the capsule and tablet forms due to the high preference and easy accessibility. Key companies are strongly focused on improving the techniques involved in encapsulation to strengthen their product portfolio. There is a wide product portfolio available for these forms in the vitamin K2 market.



  • Powder


Vitamin K2 products in the powder form are absorbed more quickly and efficiently in the body than capsules and tablets when taken with water. Gnosis SPA (Italy) offers the VitaMK7 powder as dried natural biomass or as blended bulk with maltodextrin.



  • Oils


Vitamin K2 oil drops are more effective than tablets and capsules with the same vitamin K2 dosage, thereby offering a quick and easy alternative. MenaQ7 is provided as an oil solution (M-1500 µg K2/g) by NattoPharma (Norway). VitaMK7 is available in oil formulations, particularly suitable for soft gel and liquid drop dosage forms. Menaquinone-7 is highly soluble in oil that works as a delivery system.



  • Others


Others include other forms of vitamin K2 products, including gel, pastille, liquid, and chewing gum. The key players are expanding their product portfolio with innovative forms of vitamin K2 supplements to reach a larger consumer base.


By Application


On the basis of application, the market is divided into nutraceuticals & food and pharmacuetical.



  • Nutraceuticals & food


Vitamin K2 is added for nutritional purposes in food supplements and foods intended for the general population. Vitamin K2 has traditionally been available in functional foods as synthetic MK-4 and natural MK-7. In the US, MenaQ7 vitamin K2 is also sold as a medical food (food specially adapted for precise nutritional needs). Currently, NattoPharma (Norway) is selling MenaQ7 in Europe and North America in food supplements and fortified foods.



  • Pharmaceutical


Pharma-grade vitamin K2 ingredients are witnessing significant growth in the vitamin K2 market. The pharmaceuticals segment is expected to spearhead the market during the forecast period owing to rising applications of vitamin K2 in the pharmaceutical industry focusing on improved bone, dental, and cardiovascular health to manage osteoporosis and cardiovascular diseases.


Global Vitamin K2 Market Share (%), by Region, 2020
Vitamin K2 Market Share by Region 2020
Source: MRFR Analysis


Regional Analysis


The global vitamin K2 market, based on region, has been divided into the Americas, Europe, Asia-Pacific, and the Middle East & Africa.



  • Americas:


The market in the Americas is categorized into two major regions, North America and South America. North America has been further segmented into the US and Canada. North America is envisaged to be the largest regional market attributing to the rising adoption of herbal medicines, increasing focus of consumers on health and wellness, surging healthcare costs, and boosting demand from pharmaceutical industries, food and beverage companies, and cosmetic industries.



  • Europe:


The European vitamin K2 market encompasses Eastern Europe and Western Europe. It is likely to show significant growth over the forecast period. Western Europe comprises countries such as the UK, Germany, France, Italy, and Spain and rest of the Europe. Growing consumer awareness about vitamin K2 coupled with the increasing demand for vitamin K2 in the UK, France, and Germany are likely to support market growth over the forecast period.



  • Asia-Pacific:


Asia-Pacific comprises China, Japan, India, South Korea, Australia, and the rest of Asia-Pacific. Asia-Pacific is expected to register a moderate growth rate over the forecast period due to the presence of huge opportunities for the market such as, growing aging population, rising concerns about health, and increasing patient pool suffering from vitamin deficiency.



  • Middle East & Africa:


The Middle East & Africa is expected to witness moderate market growth during the forecast period owing to growing health concerns, surging consumption of compound feed, and rising urbanization coupled with increasing disposable income in the UAE, Saudi Arabia, and Bahrain. Consumers are opting for vitamin-fortified foods and supplements which in turn is contributing to the market growth. Moreover, rising government-backed health awareness campaigns are a part of the general efforts to combat heart diseases and osteoporosis, among others in GCC and South Africa.


Competitive Landscape


The competitive landscape provides an overview of key market developments via prominent industry players. The strategies to gain a significant market share in this growing industry have been varying from partnerships and collaborations, product launches, expansions, and others.


The vitamin K2 market is characterized by the presence of global, regional, and local players. The funding levels have improved in the last few years, and the global vitamin K2 providers are investing considerable amounts in innovation and product development. The investment by the players in the region is accelerated due to the demand for increased life expectancy rates, rising disposable income, and rising investment in self-care. Over the last few years, the market players are involved in R&D activities to develop products with higher efficiency and accuracy. In addition, the market players are adopting marketing strategies such as discounted prices, campaigns, and remarketing.


List of Key Companies Covered in this report:



  • Kappa Bioscience (Norway)

  • Lesaffre (France)

  • Viridis BioPharma (India)

  • Seebio Biotech (Shanghai) Co.,Ltd (China)

  • DSM (Netherlands)

  • International Flavors & Fragrances Inc. (US)

  • Kyowa Hakko Bio Co. Ltd (Japan)

  • Purayati (India)

  • Vox Nutrition (US)

  • Anderson Global Group, LLC. (US)


Recent Developments



  • In May 2021, Lesaffre acquired NattoPharma, a specialist in Vitamin K2, expanding its product portfolio in the human nutrition and health market. Additionally, this acquisition enhanced the company’s Vitamin K2 research and marketing segment.

  • In February 2021, Kappa Bioscience expanded its business in the US. The geographical expansion will enhance the company’s customer base and operational facilities resulting in the rise in the production of nutraceuticals.

  • In May 2020, Kappa Bioscience launched an educational program to provide insights on scientific analysis, manufacturing, and formulation of dietary supplements such as Vitamin D3 and K2.


Report Overview:


The study covers the existing short-term and long-term market effects, helping decision-makers draft short-term and long-term plans for businesses by region. The report covers major regions in the Americas, Europe, Asia-Pacific, and the Middle East & Africa. The report analyzes market drivers, restraints, opportunities, challenges, Porter's Five Forces, Value Chain, and impact of COVID-19 on the market.


Scope of the Report & Segmentation


Global Vitamin K2 Market, by Product Type



  • MK-7

  • MK-4

  • Combination Drugs


Global Vitamin K2 Market, by Source



  • Natural

  • Synthetic


Global Vitamin K2 Market, by Form



  • Capsule & Tablet

  • Powder

  • Oil

  • Others


Global Vitamin K2 Market, by Application



  • Nutraceutical and Food

  • Pharmaceutical


Global Vitamin K2 Market, by Region



  • Americas

    • North America

      • US

      • Canada



    • South America



  • Europe

    • Western Europe

      • Germany

      • France

      • UK

      • Italy

      • Spain

      • Rest of Europe



    • Eastern Europe



  • Asia-Pacific

    • China

    • Japan

    • India

    • Australia

    • South Korea

    • Rest of Asia-Pacific



  • Middle East & Africa

    • Middle East

    • Africa





Report Scope:
Report Attribute/Metric Details
  Market Size   2027: USD 703.82 Million
  CAGR   31.08%
  Base Year   2020
  Forecast Period   2021-2027
  Historical Data   2018 & 2019
  Forecast Units   Value (USD Million)
  Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Product Type, Source, Form, Application and Region
  Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
  Key Vendors   â€¢ Kappa Bioscience (Norway) • Lesaffre (France) • Viridis BioPharma (India) • Seebio Biotech (Shanghai) Co.,Ltd (China) • DSM (Netherlands) • International Flavors & Fragrances Inc. (US) • Kyowa Hakko Bio Co. Ltd (Japan) • Purayati (India) • Vox Nutrition (US) • Anderson Global Group, LLC. (US)
  Key Market Opportunities   â€¢ Stringent regulations for nutracueticals
  Key Market Drivers   â€¢ Increasing patient pool suffering from vitamin deficiency • Growing demand for nutraceutical products containing vitamin K2 • Rising cases of osteoporosis and arthritis


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Frequently Asked Questions (FAQ) :

Vitamin K2 market is projected to grow at a 31.08% CAGR between 2021-2027.

Vitamin K2 market is predicted to touch USD 329.63 million by 2025.

The Americas is expected to lead vitamin K2 market.

Rising cases of vitamin deficiency and increasing prevalence of osteoporosis are the key factors driving the vitamin K2 market.

Strict government regulations may limit the vitamin K2 market growth.