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US Pemphigus Market

ID: MRFR/Pharma/17389-HCR
100 Pages
Garvit Vyas
October 2025

US Pemphigus Market Research Report By Type (Pemphigus Vulgaris, Pemphigus Foliaceus, Pemphigus Vegetans, Paraneoplastic Pemphigus), By End User (Laboratories, Hospitals and Clinics, Academic and Research Institutes), By Diagnosis (Skin Peeling, Skin Biopsy, Blood Tests, Endoscopy), By Treatment (Initial Therapy, Maintenance Therapy, Immunosuppressants, Biological Therapies, Intravenous Immunoglobulin (IVIG) Therapy, Other Medication), By Region - Growth & Industry Forecast 2025 To 2035

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US Pemphigus Market Summary

As per analysis, the US Pemphigus Market is projected to grow from USD 121.57 Million in 2024 to USD 272.09 Million by 2035, exhibiting a compound annual growth rate (CAGR) of 7.6% during the forecast period (2025 - 2035).

Key Market Trends & Highlights

The US Pemphigus Market is poised for growth driven by advancements in treatment options and increased awareness.

  • Pemphigus Vulgaris remains the largest segment, accounting for a substantial share of the market.
  • The Pemphigus Foliaceus segment is experiencing rapid growth, reflecting a shift in treatment focus.
  • Corticosteroids continue to dominate the market, while biologics are emerging as the fastest-growing treatment option.
  • Rising incidence of pemphigus and advancements in biologic therapies are key drivers propelling market expansion.

Market Size & Forecast

2024 Market Size 121.57 (USD Million)
2035 Market Size 272.09 (USD Million)
CAGR (2025 - 2035) 7.6%

Major Players

Amgen Inc (US), Bristol-Myers Squibb Company (US), Genentech Inc (US), Johnson & Johnson (US), Novartis Pharmaceuticals Corporation (US), Pfizer Inc (US), Roche Holding AG (US), Sanofi (US), AbbVie Inc (US)

US Pemphigus Market Trends

The US Pemphigus Market is currently experiencing a notable evolution, driven by advancements in therapeutic options and a growing understanding of the disease. Pemphigus, an autoimmune disorder characterized by blistering skin lesions, has garnered increased attention from healthcare professionals and researchers alike. This heightened focus has led to the development of innovative treatments, including biologics and targeted therapies, which appear to offer improved efficacy and safety profiles. Furthermore, the rising prevalence of pemphigus in the United States has prompted a more robust dialogue surrounding early diagnosis and management strategies, potentially enhancing patient outcomes. In addition to therapeutic advancements, the US Pemphigus Market is witnessing a shift in patient awareness and advocacy. Organizations dedicated to autoimmune diseases are actively working to educate both patients and healthcare providers about pemphigus, which may lead to earlier recognition and intervention. This increased awareness could foster a more informed patient population, ultimately influencing treatment adherence and satisfaction. As the landscape of the US Pemphigus Market continues to evolve, ongoing research and collaboration among stakeholders will likely play a crucial role in shaping future developments and improving the quality of care for individuals affected by this challenging condition.

Emergence of Targeted Therapies

The US Pemphigus Market is seeing a rise in the adoption of targeted therapies, which are designed to specifically address the underlying mechanisms of the disease. These therapies may offer enhanced efficacy compared to traditional treatments, potentially leading to better patient outcomes. As research progresses, the availability of these innovative options is likely to expand, providing healthcare providers with more tools to manage pemphigus effectively.

Increased Patient Advocacy

There is a growing movement among patient advocacy groups focused on pemphigus, which is contributing to heightened awareness and education about the condition. These organizations are working to empower patients by providing resources and support, which may lead to improved diagnosis and treatment adherence. This trend suggests a shift towards a more patient-centered approach in the US Pemphigus Market.

Focus on Early Diagnosis

The emphasis on early diagnosis in the US Pemphigus Market is becoming increasingly pronounced. Healthcare professionals are recognizing the importance of identifying pemphigus at its onset to initiate timely treatment. This focus may lead to better management of the disease and improved quality of life for patients, as early intervention is often associated with more favorable outcomes.

US Pemphigus Market Drivers

Increased Research Funding

The US Pemphigus Market benefits from increased research funding aimed at understanding and treating pemphigus. Government agencies, such as the National Institutes of Health (NIH), have allocated substantial resources to research initiatives focused on autoimmune diseases, including pemphigus. This funding supports clinical trials, basic research, and the development of new therapeutic approaches. The growing interest in pemphigus research is reflected in the rising number of publications and clinical studies, which enhance the understanding of disease mechanisms and potential treatment targets. As research progresses, it is anticipated that new therapies will emerge, further driving the US Pemphigus Market. The collaboration between academic institutions and pharmaceutical companies is also likely to foster innovation, leading to the development of novel treatment options that address unmet medical needs in the pemphigus patient population.

Rising Incidence of Pemphigus

The US Pemphigus Market is experiencing a notable increase in the incidence of pemphigus, a rare autoimmune blistering disorder. Recent data suggests that the prevalence of pemphigus vulgaris and pemphigus foliaceus is on the rise, with estimates indicating that approximately 0.5 to 3 cases per 100,000 individuals are diagnosed annually in the United States. This growing patient population necessitates enhanced treatment options and healthcare resources, thereby driving market growth. Furthermore, the increasing awareness among healthcare professionals regarding the symptoms and complications associated with pemphigus contributes to earlier diagnosis and intervention, which is crucial for improving patient outcomes. As the number of diagnosed cases continues to grow, the US Pemphigus Market is likely to expand, attracting pharmaceutical companies to invest in research and development of innovative therapies.

Advancements in Biologic Therapies

The US Pemphigus Market is significantly influenced by advancements in biologic therapies, which have revolutionized the treatment landscape for autoimmune diseases. Biologics, such as monoclonal antibodies, target specific pathways involved in the pathogenesis of pemphigus, offering more effective and personalized treatment options. The introduction of therapies like rituximab has shown promising results in clinical trials, leading to increased adoption among healthcare providers. Market data indicates that the biologics segment is projected to grow at a compound annual growth rate (CAGR) of over 10% in the coming years. This growth is driven by the need for more effective treatments that minimize side effects compared to traditional corticosteroids. As the US Pemphigus Market continues to embrace these innovative therapies, patient outcomes are expected to improve, further stimulating market expansion.

Regulatory Support for New Treatments

The US Pemphigus Market is positively impacted by regulatory support for the approval of new treatments. The Food and Drug Administration (FDA) has implemented expedited review processes for therapies targeting rare diseases, including pemphigus. This regulatory framework encourages pharmaceutical companies to invest in the development of innovative treatments, as it reduces the time and cost associated with bringing new drugs to market. The recent approval of therapies specifically designed for pemphigus has demonstrated the FDA's commitment to addressing the needs of patients with this rare condition. As more treatments receive regulatory approval, the US Pemphigus Market is expected to grow, providing patients with access to a wider array of therapeutic options. This supportive regulatory environment fosters competition among manufacturers, which may lead to improved treatment outcomes and lower costs for patients.

Growing Awareness and Education Initiatives

The US Pemphigus Market is experiencing growth due to increasing awareness and education initiatives aimed at both healthcare professionals and patients. Organizations dedicated to pemphigus advocacy are actively working to disseminate information about the disease, its symptoms, and available treatment options. This heightened awareness is crucial for early diagnosis and effective management of pemphigus, as many patients remain undiagnosed or misdiagnosed. Educational programs and workshops for healthcare providers are being implemented to enhance their understanding of pemphigus and its treatment protocols. As awareness increases, more patients are likely to seek medical attention, leading to a rise in diagnosed cases and, consequently, a growing demand for therapies. The US Pemphigus Market stands to benefit from these initiatives, as they contribute to improved patient outcomes and a more informed healthcare landscape.

Market Segment Insights

By Disease Type: Pemphigus Vulgaris (Largest) vs. Pemphigus Foliaceus (Fastest-Growing)

In the US Pemphigus Market, Pemphigus Vulgaris accounts for the largest share due to its widespread prevalence and the significant severity of its symptoms. This disease type is characterized by painful blisters and mucosal lesions, leading to increased physician visits and awareness. Pemphigus Foliaceus, while smaller in overall market share, has been identified as the fastest-growing segment. Its rise can be attributed to enhanced diagnosis and treatment options, broadening the adoption of therapies among healthcare professionals.

Pemphigus Vulgaris (Dominant) vs. Pemphigus Foliaceus (Emerging)

Pemphigus Vulgaris stands out as the dominant segment in the US Pemphigus Market, given its substantial impact on patients. The disease primarily affects middle-aged individuals and is notable for its chronic nature. Treatment protocols often involve immunosuppressants to manage symptoms and disease progression. On the other hand, Pemphigus Foliaceus is emerging as a significant segment due to increasing awareness and early diagnosis. This variant is less severe but still requires proper management, and the growing availability of targeted therapies is propelling its demand, indicating a shift in physician focus toward this condition.

By Treatment Type: Corticosteroids (Largest) vs. Biologics (Fastest-Growing)

In the US Pemphigus Market, the treatment segment is predominantly led by Corticosteroids, which hold the largest market share due to their established efficacy and immediate action in managing pemphigus symptoms. Immunosuppressants and Plasmapheresis also contribute to the treatment landscape but play a supporting role in comparison to the dominating Corticosteroids and the rise of Biologics, which are becoming more prominent as advanced therapies emerge.

Corticosteroids (Dominant) vs. Biologics (Emerging)

Corticosteroids are recognized for their effectiveness in rapidly controlling pemphigus flares and are often the first line of therapy, indicating their dominant position in the market. However, Biologics are increasingly seen as an emerging treatment option due to their targeted action and potential for fewer side effects. The growing prevalence of pemphigus and the ongoing research into effective treatment methodologies are driving the adoption of biologic therapies, making them a significant focus for future market growth. As healthcare systems look to integrate innovative treatments, Biologics are expected to witness a surge in utilization.

By Patient Demographics: Age Group (Largest) vs. Ethnicity (Fastest-Growing)

In the US Pemphigus Market, the patient demographics segment showcases significant diversity among age groups, with individuals aged 50-64 holding the largest proportion of cases, illustrating the age-related susceptibility to the disease. Conversely, younger populations, particularly those aged between 25-39 and 40-49, are also being increasingly diagnosed, indicating a shifting landscape in the age distribution of Pemphigus patients.

Age Group: 50-64 (Dominant) vs. Ethnicity: African American (Emerging)

The age group of 50-64 remains the dominant demographic in the US Pemphigus Market, likely due to the increased incidence of autoimmune diseases in older populations. This group often experiences more severe symptoms and comorbidities, necessitating complex treatment regimens. In contrast, the emerging demographic of African American patients is witnessing a rise in diagnosis, driven by greater awareness and access to healthcare services. This demographic shift indicates a growing recognition of the disease across diverse communities, highlighting the need for tailored treatment options and patient education.

By Route of Administration: Oral (Largest) vs. Intravenous (Fastest-Growing)

In the US Pemphigus Market, the route of administration plays a crucial role in treatment effectiveness and patient compliance. Currently, Oral administration stands out as the largest segment, primarily due to the convenience and ease of use it offers to patients. Intravenous and Subcutaneous routes, although smaller in market share, are gaining traction due to their direct delivery mechanism, which can result in faster therapeutic effects. Topical applications are also utilized but remain less dominant in comparison to Oral and Intravenous routes.

Route of Administration: Oral (Dominant) vs. Intravenous (Emerging)

Oral administration is the dominant route in the Pemphigus treatment landscape, favored for its patient-friendly approach and ease of integration into daily routines. Medications delivered orally can enhance adherence to treatment protocols, leading to better health outcomes. Conversely, the Intravenous route is emerging as the fastest-growing segment, particularly for patients who require rapid symptom control or who have severe presentations of the disease. The ability of IV treatments to deliver medication directly into the bloodstream makes it an attractive option for healthcare providers. As awareness and treatment options expand, Intravenous administration is expected to see significant growth driven by advancements in formulation and delivery technologies.

Get more detailed insights about US Pemphigus Market

Key Players and Competitive Insights

The Pemphigus Market is characterized by a competitive landscape that is increasingly shaped by innovation, strategic partnerships, and a focus on patient-centric solutions. Key players such as Amgen Inc (US), Bristol-Myers Squibb Company (US), and AbbVie Inc (US) are actively engaged in developing novel therapies and expanding their market presence. Amgen Inc (US) has positioned itself as a leader in biologics, emphasizing research and development to enhance treatment efficacy. Meanwhile, Bristol-Myers Squibb Company (US) has been focusing on strategic acquisitions to bolster its portfolio, particularly in immunology, which is crucial for addressing autoimmune diseases like pemphigus. AbbVie Inc (US) is also notable for its commitment to innovation, particularly through its robust pipeline of monoclonal antibodies aimed at treating various forms of pemphigus, thereby shaping the competitive dynamics of the market.

The business tactics employed by these companies reflect a concerted effort to optimize supply chains and localize manufacturing processes. The Pemphigus Market appears to be moderately fragmented, with several players vying for market share. However, the collective influence of major companies is significant, as they leverage their resources to enhance distribution networks and improve access to therapies. This competitive structure fosters an environment where innovation is paramount, and companies are incentivized to differentiate their offerings through advanced research and development.

In December 2025, Amgen Inc (US) announced a collaboration with a leading research institution to explore novel therapeutic targets for pemphigus. This strategic move is likely to enhance Amgen's research capabilities and accelerate the development of new treatment options, positioning the company favorably in a competitive market. Similarly, in November 2025, AbbVie Inc (US) received FDA approval for a new indication of its monoclonal antibody, which is expected to significantly expand its market share and reinforce its commitment to addressing unmet medical needs in pemphigus patients. This approval not only underscores AbbVie's innovative approach but also highlights the importance of regulatory milestones in shaping competitive positioning.

In October 2025, Bristol-Myers Squibb Company (US) launched a new patient support program aimed at improving treatment adherence among pemphigus patients. This initiative reflects a growing trend among pharmaceutical companies to enhance patient engagement and support, which is increasingly recognized as a critical component of successful treatment outcomes. By investing in patient-centric strategies, Bristol-Myers Squibb is likely to strengthen its brand loyalty and improve its competitive standing in the market.

As of January 2026, the Pemphigus Market is witnessing trends that emphasize digitalization, sustainability, and the integration of artificial intelligence in drug development. Strategic alliances are becoming more prevalent, as companies recognize the value of collaboration in accelerating innovation and improving patient outcomes. The competitive landscape is shifting from traditional price-based competition to a focus on technological advancements and supply chain reliability. This evolution suggests that companies that prioritize innovation and patient-centric solutions will likely emerge as leaders in the Pemphigus Market.

Key Companies in the US Pemphigus Market include

Future Outlook

US Pemphigus Market Future Outlook

The US Pemphigus Market is projected to grow at a 7.6% CAGR from 2025 to 2035, driven by advancements in treatment options, increasing awareness, and rising healthcare expenditure.

New opportunities lie in:

  • Development of targeted biologic therapies for Pemphigus patients.
  • Expansion of telehealth services for remote patient monitoring.
  • Investment in patient education programs to enhance treatment adherence.

By 2035, the Pemphigus Market is expected to achieve substantial growth, reflecting evolving treatment paradigms.

Market Segmentation

US Pemphigus Market Disease Type Outlook

  • Pemphigus Vulgaris
  • Pemphigus Foliaceus
  • Pemphigus Erythematosus
  • Paraneoplastic Pemphigus

US Pemphigus Market Treatment Type Outlook

  • Corticosteroids
  • Immunosuppressants
  • Biologics
  • Plasmapheresis

US Pemphigus Market Patient Demographics Outlook

  • Age Group
  • Gender
  • Ethnicity
  • Socioeconomic Status

US Pemphigus Market Route of Administration Outlook

  • Oral
  • Intravenous
  • Subcutaneous
  • Topical

Report Scope

MARKET SIZE 2024121.57(USD Million)
MARKET SIZE 2025133.16(USD Million)
MARKET SIZE 2035272.09(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR)7.6% (2024 - 2035)
REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR2024
Market Forecast Period2025 - 2035
Historical Data2019 - 2024
Market Forecast UnitsUSD Million
Key Companies ProfiledAmgen Inc (US), Bristol-Myers Squibb Company (US), Genentech Inc (US), Johnson & Johnson (US), Novartis Pharmaceuticals Corporation (US), Pfizer Inc (US), Roche Holding AG (US), Sanofi (US), AbbVie Inc (US)
Segments CoveredDisease Type, Treatment Type, Patient Demographics, Route of Administration
Key Market OpportunitiesAdvancements in targeted therapies and personalized medicine enhance treatment options in the US Pemphigus Market.
Key Market DynamicsRising demand for targeted therapies drives innovation and competition in the US Pemphigus Market.
Countries CoveredUS
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FAQs

What is the current valuation of the US Pemphigus Market?

<p>The US Pemphigus Market was valued at 121.57 USD Million in 2024.</p>

What is the projected market valuation for the US Pemphigus Market by 2035?

<p>The market is projected to reach 272.09 USD Million by 2035.</p>

What is the expected CAGR for the US Pemphigus Market during the forecast period?

<p>The expected CAGR for the US Pemphigus Market from 2025 to 2035 is 7.6%.</p>

Which companies are the key players in the US Pemphigus Market?

<p>Key players include Amgen Inc, Bristol-Myers Squibb Company, Genentech Inc, Johnson & Johnson, Novartis Pharmaceuticals Corporation, Pfizer Inc, Roche Holding AG, Sanofi, and AbbVie Inc.</p>

What are the major disease types contributing to the US Pemphigus Market?

<p>Major disease types include Pemphigus Vulgaris, Pemphigus Foliaceus, Pemphigus Erythematosus, and Paraneoplastic Pemphigus.</p>

How much revenue did Pemphigus Vulgaris generate in 2024?

<p>Pemphigus Vulgaris generated approximately 60.78 USD Million in 2024.</p>

What treatment types are prevalent in the US Pemphigus Market?

<p>Prevalent treatment types include Corticosteroids, Immunosuppressants, Biologics, and Plasmapheresis.</p>

What was the revenue for Corticosteroids in the US Pemphigus Market in 2024?

<p>Corticosteroids generated around 40.79 USD Million in 2024.</p>

How are patient demographics segmented in the US Pemphigus Market?

<p>Patient demographics are segmented by Age Group, Gender, Ethnicity, and Socioeconomic Status.</p>

What routes of administration are utilized in the US Pemphigus Market?

<p>Routes of administration include Oral, Intravenous, Subcutaneous, and Topical.</p>

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