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US Anti VEGF Market

ID: MRFR/HC/50451-HCR
200 Pages
Garvit Vyas
February 2026

US Anti-VEGF Market Research Report By Product (Eylea, Lucentis, Beovu) and By Disease (Macular Edema, Diabetic Retinopathy, Retinal Vein Occlusion, Age-Related Macular Degeneration) - Growth & Industry Forecast 2025 To 2035

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US Anti VEGF Market Summary

As per Market Research Future analysis, the US anti-VEGF market size was estimated at 4547.2 USD Million in 2024. The US anti vegf market is projected to grow from 4742.73 USD Million in 2025 to 7227.15 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 4% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The US anti-VEGF market is experiencing robust growth driven by increasing demand for innovative treatments.

  • The largest segment in the US anti-VEGF market is the treatment of age-related macular degeneration (AMD), reflecting a significant patient population.
  • The fastest-growing segment is diabetic retinopathy, driven by rising diabetes prevalence and awareness.
  • Technological advancements in drug delivery systems are enhancing treatment efficacy and patient compliance.
  • Key market drivers include the increasing prevalence of age-related macular degeneration and rising healthcare expenditure on eye care.

Market Size & Forecast

2024 Market Size 4547.2 (USD Million)
2035 Market Size 7227.15 (USD Million)
CAGR (2025 - 2035) 4.3%

Major Players

Regeneron Pharmaceuticals (US), Roche (CH), Novartis (CH), Bayer (DE), Pfizer (US), Amgen (US), Eli Lilly and Company (US), Santen Pharmaceutical (JP), Hikma Pharmaceuticals (GB)

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US Anti VEGF Market Trends

The anti-VEGF market is currently experiencing notable growth, driven by increasing incidences of retinal diseases and the rising prevalence of age-related macular degeneration. This condition, which affects a significant portion of the aging population, necessitates effective treatment options. The market is characterized by a variety of therapeutic agents that inhibit vascular endothelial growth factor, thereby reducing abnormal blood vessel growth in the eye. Furthermore, advancements in drug delivery systems and the development of novel therapies are likely to enhance treatment efficacy and patient compliance. As a result, the anti vegf market appears poised for continued expansion in the coming years. In addition to the growing patient population, the anti vegf market is influenced by ongoing research and development efforts aimed at improving existing therapies. Regulatory approvals for new formulations and combination therapies may further stimulate market dynamics. Moreover, the increasing focus on personalized medicine suggests a shift towards tailored treatment approaches, which could enhance patient outcomes. Overall, the anti vegf market is expected to evolve significantly, reflecting both technological advancements and changing patient needs.

Rising Incidence of Retinal Diseases

The anti vegf market is witnessing growth due to the increasing number of patients diagnosed with retinal diseases. Conditions such as diabetic retinopathy and age-related macular degeneration are becoming more prevalent, necessitating effective treatment options. This trend indicates a growing demand for anti vegf therapies.

Advancements in Drug Delivery Systems

Innovations in drug delivery methods are enhancing the effectiveness of anti vegf treatments. Improved formulations and delivery mechanisms are likely to increase patient adherence and treatment outcomes. This trend suggests a positive trajectory for the anti vegf market as new technologies emerge.

Focus on Personalized Medicine

The shift towards personalized medicine is influencing the anti vegf market. Tailored treatment approaches that consider individual patient characteristics may lead to better therapeutic outcomes. This trend indicates a potential transformation in how anti vegf therapies are developed and administered.

US Anti VEGF Market Drivers

Growing Awareness of Vision Health

The anti vegf market is benefiting from the growing awareness of vision health among the general population. Educational campaigns and initiatives aimed at promoting eye health are encouraging individuals to seek regular eye examinations and treatment for retinal diseases. This heightened awareness is likely to lead to earlier diagnosis and treatment of conditions such as diabetic retinopathy and AMD, which are commonly treated with anti-VEGF therapies. As more patients become informed about the importance of maintaining vision health, the demand for anti-VEGF treatments is expected to rise, further propelling the growth of the anti vegf market.

Rising Healthcare Expenditure on Eye Care

The anti vegf market is influenced by the rising healthcare expenditure on eye care in the United States. With an increasing focus on preventive care and early intervention, healthcare spending on ophthalmic treatments is expected to rise. According to recent data, the U.S. healthcare expenditure on eye care is projected to reach $40 billion by 2025. This increase in funding is likely to facilitate the development and accessibility of anti-VEGF therapies, making them more available to patients in need. As healthcare providers prioritize eye health, the anti vegf market stands to gain from enhanced investment in research and development, ultimately leading to more effective treatment options.

Increased Research and Development Investments

The anti vegf market is experiencing a surge in research and development investments aimed at discovering new therapeutic options. Pharmaceutical companies are increasingly allocating resources to develop next-generation anti-VEGF agents that may offer improved efficacy and safety profiles. This trend is supported by the growing recognition of the need for innovative treatments to address the limitations of existing therapies. As R&D investments continue to rise, the anti vegf market is likely to witness the introduction of novel therapies that could reshape treatment paradigms and enhance patient outcomes in the management of retinal diseases.

Technological Innovations in Ophthalmic Treatments

Technological advancements in ophthalmic treatments are playing a crucial role in the anti vegf market. Innovations such as sustained-release drug delivery systems and minimally invasive surgical techniques are enhancing the efficacy and safety of anti-VEGF therapies. For instance, recent developments in implantable devices that provide continuous drug release could potentially reduce the frequency of injections required for patients. This not only improves patient compliance but also reduces the overall treatment burden. The anti vegf market is likely to benefit from these advancements, as they may lead to improved therapeutic outcomes and increased adoption of anti-VEGF therapies among healthcare providers.

Increasing Prevalence of Age-Related Macular Degeneration

The anti vegf market is experiencing growth due to the rising prevalence of age-related macular degeneration (AMD) in the United States. As the population ages, the incidence of AMD is projected to increase significantly, with estimates suggesting that by 2030, approximately 3 million Americans will be affected. This condition leads to vision loss and necessitates effective treatment options, driving demand for anti-VEGF therapies. The anti vegf market is responding to this need by developing innovative therapies that target the underlying mechanisms of AMD, thereby improving patient outcomes. Furthermore, the increasing awareness of AMD and its impact on quality of life is likely to encourage more individuals to seek treatment, further propelling the growth of the anti vegf market.

Market Segment Insights

By Product: Eylea (Largest) vs. Beovu (Fastest-Growing)

In the US anti vegf market, the product segment is primarily dominated by Eylea, which holds a significant share due to its established presence and efficacy in treating retinal diseases. Lucentis follows but has seen a decline in preference as new therapies emerge. Beovu, introduced more recently, is gaining traction among healthcare providers, contributing to a shifting landscape in the treatment options available to patients. Growth trends in this segment highlight a clear movement towards newer therapies like Beovu, which offer enhanced dosing schedules and improved patient outcomes. The increasing incidence of retinal diseases, coupled with a growing aging population, drives demand for innovative treatments. Furthermore, ongoing research and development efforts are expected to bolster the presence of these products in the market, with a focus on long-term efficacy and patient convenience.

Eylea (Dominant) vs. Beovu (Emerging)

Eylea stands as the dominant force in the product segment, known for its robust clinical efficacy and comprehensive treatment protocols. Its market position is reinforced by extensive clinical data supporting its use for various retinal diseases, appealing to both healthcare providers and patients. Conversely, Beovu is recognized as the emerging player, capturing interest with its unique dosing regimen and potentially fewer injections required over time. This emerging product is well-positioned to attract a growing segment of patients looking for convenience and effectiveness. As healthcare professionals increasingly adopt Beovu in their treatment paradigms, the competition between these two products could redefine therapeutic choices in the US anti vegf market.

By Disease: Age-Related Macular Degeneration (Largest) vs. Diabetic Retinopathy (Fastest-Growing)

In the US anti vegf market, Age-Related Macular Degeneration holds a large share, making it a significant contributor to the overall market dynamics. Its prevalence among the aging population positions it as a dominant segment. In contrast, Diabetic Retinopathy, fueled by the increasing incidence of diabetes, has emerged as a fast-growing segment, capturing attention due to its rising patient demographic. The growth trends in this market segment are driven by advancements in treatment options and heightened awareness of eye health. The rising prevalence of conditions like Diabetic Retinopathy showcases the importance of targeting these diseases effectively. Furthermore, collaborations among healthcare providers and pharmaceutical companies aim to enhance accessibility and improve treatment outcomes, contributing to the expanding market landscape for anti-VEGF therapies.

Macular Edema (Dominant) vs. Retinal Vein Occlusion (Emerging)

Macular Edema is recognized as a dominant segment in the US anti vegf market, largely due to its association with common conditions such as Diabetic Retinopathy and Age-Related Macular Degeneration. Its consistent treatment demand stems from the need to manage vision impairment effectively. In contrast, Retinal Vein Occlusion, while currently considered an emerging segment, shows potential for significant growth. This condition's complex nature and varying prevalence call for targeted treatment strategies, which, along with increased awareness and diagnostic advances, position it as a territory ripe for future development within the market.

Get more detailed insights about US Anti VEGF Market

Key Players and Competitive Insights

The anti-VEGF market is characterized by intense competition and rapid innovation, driven by the increasing prevalence of retinal diseases and the growing demand for effective therapies. Key players such as Regeneron Pharmaceuticals (US), Roche (CH), and Novartis (CH) are at the forefront, leveraging their extensive research capabilities and established market presence. Regeneron Pharmaceuticals (US) focuses on continuous innovation, particularly with its flagship product, Eylea, which has seen significant uptake due to its efficacy in treating age-related macular degeneration (AMD). Roche (CH) emphasizes strategic partnerships and collaborations to enhance its product pipeline, while Novartis (CH) is investing heavily in digital transformation to streamline operations and improve patient access to therapies. Collectively, these strategies contribute to a competitive landscape that is both dynamic and multifaceted.
In terms of business tactics, companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and reduce costs. The market structure appears moderately fragmented, with several players vying for market share, yet dominated by a few key companies that hold substantial influence. This competitive environment fosters innovation and encourages companies to differentiate their offerings through advanced technologies and improved patient outcomes.
In October 2025, Regeneron Pharmaceuticals (US) announced a strategic partnership with a leading telehealth provider to enhance patient access to Eylea. This move is significant as it aligns with the growing trend of digital health solutions, potentially increasing patient adherence and expanding market reach. By integrating telehealth services, Regeneron aims to address barriers to treatment, thereby enhancing its competitive positioning in the anti-VEGF market.
In September 2025, Roche (CH) launched a new clinical trial for its investigational anti-VEGF therapy, which targets a broader range of retinal diseases. This initiative underscores Roche's commitment to innovation and its strategy to diversify its product offerings. The trial's outcomes could potentially reshape treatment paradigms, positioning Roche as a leader in the evolving landscape of retinal therapies.
In August 2025, Novartis (CH) unveiled a new digital platform aimed at improving patient engagement and education regarding its anti-VEGF treatments. This platform is designed to provide personalized information and support, reflecting Novartis's focus on enhancing the patient experience. By leveraging technology, Novartis seeks to strengthen its market presence and foster loyalty among healthcare providers and patients alike.
As of November 2025, current trends in the anti-VEGF market include a pronounced shift towards digitalization, sustainability, and the integration of artificial intelligence in drug development. Strategic alliances are increasingly shaping the competitive landscape, enabling companies to pool resources and expertise. Looking ahead, competitive differentiation is likely to evolve from traditional price-based strategies to a focus on innovation, technological advancements, and supply chain reliability. This shift may redefine how companies compete, emphasizing the importance of delivering superior patient outcomes and enhancing operational efficiencies.

Key Companies in the US Anti VEGF Market include

Industry Developments

In recent months, the US Anti-VEGF Market has witnessed notable developments, particularly as companies like Regeneron Pharmaceuticals and Bayer continue to expand their product offerings and enhance their market presence. Regeneron’s Eylea remains a leading treatment for retinal diseases, and the company is actively pursuing label expansions to bolster its usage. Moreover, in September 2023, Horizon Therapeutics announced a strategic collaboration with AbbVie to develop new treatments in the space, aiming to leverage AbbVie's strong portfolio in eye care.

Notably, Amgen's acquisition of WeWork's subsidiary in August 2023 indicates a focus on integrating new technologies for patient engagement and treatment adherence. Growth in the US Anti-VEGF Market is driven by rising incidences of age-related macular degeneration and diabetic retinopathy, prompting increased investments in Research and Development from key players, including Novartis and Bristol Myers Squibb. With market dynamics shifting, regulatory approvals for innovative therapies are expected to influence the competitive landscape in the future. Over the past two years, significant advancements have included the FDA approval of new anti-VEGF agents, enhancing treatment options for patients across the US.

Future Outlook

US Anti VEGF Market Future Outlook

The Anti VEGF Market is projected to grow at a 4.3% CAGR from 2025 to 2035, driven by increasing prevalence of retinal diseases and advancements in treatment options.

New opportunities lie in:

  • Development of combination therapies to enhance efficacy and patient compliance.
  • Expansion of telehealth services for remote patient monitoring and consultations.
  • Investment in AI-driven diagnostics to streamline treatment pathways and improve outcomes.

By 2035, the anti-VEGF market is expected to solidify its position as a leader in ocular therapeutics.

Market Segmentation

US Anti VEGF Market Disease Outlook

  • Macular Edema
  • Diabetic Retinopathy
  • Retinal Vein Occlusion
  • Age-Related Macular Degeneration

US Anti VEGF Market Product Outlook

  • Eylea
  • Lucentis
  • Beovu

Report Scope

MARKET SIZE 2024 4547.2(USD Million)
MARKET SIZE 2025 4742.73(USD Million)
MARKET SIZE 2035 7227.15(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 4.3% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Regeneron Pharmaceuticals (US), Roche (CH), Novartis (CH), Bayer (DE), Pfizer (US), Amgen (US), Eli Lilly and Company (US), Santen Pharmaceutical (JP), Hikma Pharmaceuticals (GB)
Segments Covered Product, Disease
Key Market Opportunities Advancements in targeted therapies and personalized medicine enhance growth potential in the anti vegf market.
Key Market Dynamics Intensifying competition and regulatory scrutiny drive innovation in the anti VEGF market, reshaping treatment paradigms.
Countries Covered US
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FAQs

What is the expected market size of the US Anti-VEGF Market in 2024?

The US Anti-VEGF Market is expected to be valued at 5.8 billion USD in 2024.

What is the projected market size of the US Anti-VEGF Market by 2035?

By 2035, the US Anti-VEGF Market is anticipated to reach a value of 9.0 billion USD.

What is the expected compound annual growth rate (CAGR) for the US Anti-VEGF Market from 2025 to 2035?

The CAGR for the US Anti-VEGF Market is expected to be 4.075 percent from 2025 to 2035.

Which product has the largest market share within the US Anti-VEGF Market in 2024?

Eylea is projected to hold the largest market share with a valuation of 2.5 billion USD in 2024.

What is the market size of Lucentis within the US Anti-VEGF Market in 2024?

Lucentis is expected to reach a market size of 1.8 billion USD in 2024.

How much is Beovu expected to contribute to the US Anti-VEGF Market by 2035?

Beovu is anticipated to contribute a market size of 2.5 billion USD by 2035.

Who are the key players in the US Anti-VEGF Market?

Major players include Roche, Amgen, Bayer, and Regeneron Pharmaceuticals, among others.

What challenges might the US Anti-VEGF Market face in the coming years?

Potential challenges could include regulatory hurdles and increased competition from emerging therapies.

What opportunities exist for growth in the US Anti-VEGF Market?

Growth opportunities may arise from advancements in treatment methods and the increasing prevalence of eye diseases.

How is the current market for US anti-VEGF products expected to grow regionally?

The market is anticipated to show steady growth across various regions within the United States.

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