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Japan Anti VEGF Market

ID: MRFR/HC/50409-HCR
200 Pages
Garvit Vyas
February 2026

Japan Anti-VEGF Market Research Report: Size, Share, Trend Analysis By Product (Eylea, Lucentis, Beovu) and By Disease (Macular Edema, Diabetic Retinopathy, Retinal Vein Occlusion, Age-Related Macular Degeneration) - Growth Outlook & Industry Forecast 2025 To 2035

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Japan Anti VEGF Market Summary

As per Market Research Future analysis, the Japan Anti-VEGF Market Size was estimated at 1624.0 USD Million in 2024. The Japan Anti-VEGF Market is projected to grow from 1693.67 USD Million in 2025 to 2577.0 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 4.2% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The Japan anti-VEGF market is poised for growth driven by increasing demand for innovative treatments and a supportive healthcare environment.

  • The market is witnessing a rising incidence of retinal diseases, which is driving demand for anti-VEGF therapies.
  • Advancements in biotechnology are enhancing the efficacy and safety profiles of anti-VEGF treatments.
  • The largest segment in the market is the age-related macular degeneration (AMD) segment, while the diabetic retinopathy segment is the fastest-growing.
  • Key market drivers include the increasing aging population and rising healthcare expenditure, which are likely to bolster market growth.

Market Size & Forecast

2024 Market Size 1624.0 (USD Million)
2035 Market Size 2577.0 (USD Million)
CAGR (2025 - 2035) 4.29%

Major Players

Regeneron Pharmaceuticals (US), Roche (CH), Novartis (CH), Bayer (DE), Pfizer (US), Amgen (US), Eli Lilly (US), Santen Pharmaceutical (JP)

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Japan Anti VEGF Market Trends

The Anti-VEGF Market is currently experiencing notable growth, driven by increasing prevalence of retinal diseases and the rising geriatric population. In Japan, the demand for innovative therapies targeting vascular endothelial growth factor (VEGF) has surged, as healthcare providers seek effective solutions for conditions such as age-related macular degeneration and diabetic retinopathy. The market landscape is characterized by a strong emphasis on research and development, with pharmaceutical companies investing significantly in novel anti-VEGF agents. This trend is likely to continue, as advancements in biotechnology and personalized medicine pave the way for more effective treatments. Moreover, the regulatory environment in Japan appears to be supportive of new drug approvals, which may further stimulate market growth. The collaboration between government bodies and private sectors is fostering an ecosystem conducive to innovation. Additionally, the increasing awareness among healthcare professionals and patients regarding the benefits of anti-VEGF therapies is expected to enhance market penetration. As the anti vegf market evolves, it may witness the introduction of combination therapies and biosimilars, which could potentially reshape treatment paradigms and improve patient outcomes.

Rising Incidence of Retinal Diseases

The anti vegf market is witnessing a surge in demand due to the increasing incidence of retinal diseases in Japan. Conditions such as age-related macular degeneration and diabetic retinopathy are becoming more prevalent, particularly among the aging population. This trend necessitates the development and availability of effective anti-VEGF therapies to address the growing healthcare needs.

Advancements in Biotechnology

Innovations in biotechnology are playing a crucial role in shaping the anti vegf market. The emergence of novel drug formulations and delivery systems is enhancing the efficacy and safety profiles of anti-VEGF agents. These advancements are likely to attract investment and drive research initiatives aimed at improving treatment outcomes for patients.

Supportive Regulatory Environment

The regulatory framework in Japan appears to be increasingly favorable for the approval of new anti-VEGF therapies. Government initiatives aimed at expediting the review process for innovative treatments may facilitate quicker access to essential medications. This supportive environment is expected to encourage pharmaceutical companies to invest in the development of new anti-VEGF products.

Japan Anti VEGF Market Drivers

Increasing Aging Population

The Anti-VEGF Market in Japan is experiencing growth due to the increasing aging population. As individuals age, they become more susceptible to retinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy. According to recent statistics, approximately 30% of the Japanese population is aged 65 and older, which correlates with a higher prevalence of these conditions. This demographic shift is likely to drive demand for anti-VEGF therapies, as healthcare providers seek effective treatments to manage these diseases. The anti vegf market is thus positioned to expand significantly, as pharmaceutical companies develop innovative solutions tailored to this aging demographic. Furthermore, the government’s focus on improving healthcare access for the elderly may further bolster the market, creating opportunities for growth in the anti vegf market.

Rising Healthcare Expenditure

Japan's increasing healthcare expenditure is a significant driver for the Anti-VEGF Market. The government has been investing heavily in healthcare infrastructure and services, with total healthcare spending reaching approximately $400 billion in recent years. This investment is aimed at improving access to advanced medical treatments, including anti-VEGF therapies. As healthcare budgets expand, there is a growing emphasis on providing effective treatments for retinal diseases, which are prevalent among the aging population. The anti vegf market stands to gain from this trend, as healthcare providers are more likely to adopt innovative therapies that demonstrate clinical efficacy. Additionally, the rising out-of-pocket expenses for patients may lead to increased demand for effective and affordable anti-VEGF options, further propelling market growth.

Growing Awareness and Education

There is a notable increase in awareness and education regarding retinal diseases and their treatments in Japan, which is positively impacting the Anti-VEGF Market. Campaigns aimed at educating both healthcare professionals and patients about the importance of early detection and treatment of conditions like AMD and diabetic retinopathy are gaining traction. This heightened awareness is likely to lead to earlier diagnoses and increased treatment rates, thereby driving demand for anti-VEGF therapies. The anti vegf market is expected to benefit from this trend, as more patients seek out effective treatments upon recognizing the symptoms of retinal diseases. Furthermore, collaborations between healthcare organizations and patient advocacy groups are fostering a more informed public, which may contribute to the overall growth of the anti vegf market.

Supportive Reimbursement Policies

Supportive reimbursement policies in Japan are facilitating access to anti-VEGF therapies, thereby driving growth in the Anti-VEGF Market. The Japanese government has implemented various reimbursement schemes that cover the costs of innovative treatments for retinal diseases. This financial support encourages healthcare providers to prescribe anti-VEGF therapies, as patients are more likely to seek treatment when costs are manageable. The anti vegf market is likely to see increased adoption of these therapies as a result of favorable reimbursement conditions. Additionally, ongoing discussions regarding the expansion of coverage for new and emerging treatments may further enhance market dynamics. As reimbursement policies evolve, they could play a pivotal role in shaping the future landscape of the anti vegf market.

Technological Innovations in Treatment

Technological advancements in the field of ophthalmology are playing a crucial role in the Anti-VEGF Market in Japan. Innovations such as sustained-release drug delivery systems and novel formulations are enhancing the efficacy and convenience of anti-VEGF therapies. For instance, recent developments have led to the creation of injectable treatments that require less frequent administration, which is particularly beneficial for patients with chronic conditions. The anti vegf market is likely to benefit from these innovations, as they improve patient adherence and outcomes. Moreover, the integration of telemedicine and digital health solutions is facilitating better monitoring and management of retinal diseases, potentially increasing the demand for anti-VEGF treatments. As these technologies continue to evolve, they may reshape the landscape of the anti vegf market, driving further growth and investment.

Market Segment Insights

By Product: Eylea (Largest) vs. Beovu (Fastest-Growing)

In the Japan Anti-VEGF Market, Eylea holds a significant share, making it the largest product in this segment. Lucentis also maintains a strong foothold, but Eylea's robust acceptance among healthcare professionals drives its leading position. Beovu, while gaining traction, has not yet reached the levels of market share seen by Eylea and Lucentis, but its innovative formulation shows promise for future growth. The growth trends in the Japan anti vegf market are influenced by increasing incidence rates of retinal disorders, advancing medical technology, and the rising adoption of anti-VEGF therapies. As eye care awareness grows, products like Beovu are expected to emerge, especially as clinical data supports their efficacy. The competitive landscape is demanding, yet the continuous evolution in treatment options indicates a dynamic growth trajectory for all three products.

Eylea (Dominant) vs. Beovu (Emerging)

Eylea is recognized as the dominant player in the Japan anti vegf market, showcasing its effectiveness and safety profile. Prescribed widely for conditions such as wet AMD and diabetic macular edema, it has set a benchmark in treatment, backed by extensive clinical evidence. In contrast, Beovu is an emerging player, positioned to capture a growing audience due to its novel formulation that allows for less frequent dosing. Health care providers are becoming increasingly interested in Beovu's potential to enhance patient compliance and experience. As both products continue to evolve, their impact on patient outcomes and market dynamics will be closely monitored by stakeholders.

By Disease: Macular Edema (Largest) vs. Diabetic Retinopathy (Fastest-Growing)

The Japan Anti-VEGF Market displays a diverse landscape with Macular Edema commanding a significant share due to its prevalence among the aging population. In contrast, Diabetic Retinopathy is emerging as a critical segment, driven by rising diabetes cases and increased awareness of eye health. This shift reflects a growing demand for innovative therapies as patients seek effective solutions to manage their conditions. As healthcare initiatives focus on preventive measures and treatment advancements, both segments are poised to grow. While Macular Edema remains the dominant force, the fastest growth in Diabetic Retinopathy is fueled by technological advancements and the introduction of novel anti-VEGF agents. This dynamic landscape presents opportunities for stakeholders to cater to evolving patient needs and preferences.

Macular Edema (Dominant) vs. Diabetic Retinopathy (Emerging)

Macular Edema is characterized by fluid accumulation in the retina, often associated with diabetes and other retinal disorders, making it a leading concern for ophthalmic healthcare. This segment benefits from strong market support, with established treatment protocols and a well-informed patient base. In contrast, Diabetic Retinopathy, while currently a smaller segment, is rapidly gaining traction due to the increasing incidence of diabetes in Japan. As the healthcare sector emphasizes early detection and treatment, the demand for effective anti-VEGF therapies is surging. This growth is also propelled by patient education and greater access to healthcare resources, creating a fertile ground for new entrants and innovative treatment solutions.

Get more detailed insights about Japan Anti VEGF Market

Key Players and Competitive Insights

The anti-VEGF market in Japan is characterized by a competitive landscape that is both dynamic and multifaceted. Key growth drivers include an increasing prevalence of retinal diseases, advancements in drug formulations, and a growing emphasis on personalized medicine. Major players such as Regeneron Pharmaceuticals (US), Roche (CH), and Novartis (CH) are strategically positioned to leverage these trends. Regeneron Pharmaceuticals (US) focuses on innovation through its flagship product, Eylea, which has seen significant uptake due to its efficacy in treating age-related macular degeneration (AMD). Meanwhile, Roche (CH) emphasizes partnerships and collaborations to enhance its product offerings, particularly in the realm of combination therapies. Novartis (CH) is actively pursuing regional expansion, aiming to penetrate underserved markets within Japan, thereby shaping a competitive environment that is increasingly reliant on innovation and strategic alliances.
Key business tactics employed by these companies include localizing manufacturing and optimizing supply chains to enhance operational efficiency. The market structure appears moderately fragmented, with several players vying for market share. However, the collective influence of key players like Bayer (DE) and Pfizer (US) contributes to a competitive atmosphere where innovation and strategic positioning are paramount.
In October 2025, Bayer (DE) announced a strategic partnership with a local biotech firm to co-develop a novel anti-VEGF therapy aimed at enhancing treatment outcomes for diabetic retinopathy. This collaboration is significant as it not only underscores Bayer's commitment to innovation but also highlights the importance of local expertise in navigating the Japanese regulatory landscape. Such partnerships may enhance Bayer's competitive edge by accelerating the development timeline and improving market access.
In September 2025, Roche (CH) launched a new digital platform designed to facilitate real-time patient monitoring for those undergoing anti-VEGF treatments. This initiative is indicative of Roche's focus on integrating digital health solutions into its therapeutic offerings, potentially improving patient adherence and outcomes. The strategic importance of this move lies in its alignment with the growing trend towards personalized medicine, which is becoming increasingly relevant in the anti-VEGF market.
In August 2025, Novartis (CH) expanded its clinical trial program for a next-generation anti-VEGF agent, aiming to address treatment-resistant cases of AMD. This strategic action reflects Novartis's commitment to addressing unmet medical needs and reinforces its position as a leader in the anti-VEGF space. The implications of this expansion are profound, as it may lead to the introduction of a breakthrough therapy that could redefine treatment paradigms in the coming years.
As of November 2025, current competitive trends in the anti-VEGF market include a pronounced shift towards digitalization, sustainability, and the integration of artificial intelligence (AI) in drug development processes. Strategic alliances are increasingly shaping the landscape, enabling companies to pool resources and expertise to drive innovation. Looking ahead, competitive differentiation is likely to evolve from traditional price-based competition to a focus on technological advancements, innovative therapies, and reliable supply chains. This shift may redefine how companies position themselves in the market, emphasizing the need for agility and responsiveness to changing patient needs.

Key Companies in the Japan Anti VEGF Market include

Industry Developments

Recent developments in the Japan Anti-VEGF Market indicate significant activity among major players, including Roche, Astellas Pharma, Bayer, and Regeneron. Notably, the Japanese government has prioritized initiatives to enhance healthcare accessibility, moving to expand reimbursement policies for anti-VEGF therapies, directly impacting market growth. In October 2023, it was reported that Roche received approval for its new anti-VEGF drug aimed at treating retinal disorders, which is expected to boost its market share substantially.

In terms of mergers and acquisitions, in May 2023, Bayer announced the acquisition of a local biotech specializing in drug delivery systems that augment anti-VEGF therapy efficacy, marking a strategic move to enhance its portfolio. Additionally, a collaboration between Daiichi Sankyo and Bristol Myers Squibb was established to jointly research anti-VEGF treatments, leveraging each company's strengths in drug development. Over the past two years, the market has witnessed a rise in investment in Research and Development by companies like Takeda Pharmaceutical and Novartis, reflecting a growing focus on innovative therapeutic options.

This investment trend is expected to catalyze advancements in treatment efficacy and patient outcomes, further driving the expansion of the anti-VEGF market in Japan.

Future Outlook

Japan Anti VEGF Market Future Outlook

The Anti VEGF Market in Japan is projected to grow at a 4.29% CAGR from 2025 to 2035, driven by increasing prevalence of retinal diseases and advancements in treatment options.

New opportunities lie in:

  • Development of combination therapies to enhance efficacy and patient compliance.
  • Expansion of telemedicine platforms for remote patient monitoring and consultations.
  • Investment in AI-driven diagnostics to streamline treatment pathways and improve outcomes.

By 2035, the anti-VEGF market is expected to solidify its position as a key segment in ophthalmic therapeutics.

Market Segmentation

Japan Anti VEGF Market Disease Outlook

  • Macular Edema
  • Diabetic Retinopathy
  • Retinal Vein Occlusion
  • Age-Related Macular Degeneration

Japan Anti VEGF Market Product Outlook

  • Eylea
  • Lucentis
  • Beovu

Report Scope

MARKET SIZE 2024 1624.0(USD Million)
MARKET SIZE 2025 1693.67(USD Million)
MARKET SIZE 2035 2577.0(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 4.29% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Regeneron Pharmaceuticals (US), Roche (CH), Novartis (CH), Bayer (DE), Pfizer (US), Amgen (US), Eli Lilly (US), Santen Pharmaceutical (JP)
Segments Covered Product, Disease
Key Market Opportunities Emerging biologics and personalized therapies drive growth in the anti vegf market.
Key Market Dynamics Rising demand for innovative anti-VEGF therapies driven by regulatory support and competitive market dynamics in Japan.
Countries Covered Japan
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FAQs

What is the expected market size of the Japan Anti-VEGF Market in 2024?

The Japan Anti-VEGF Market is expected to be valued at 1.3 billion USD in 2024.

What is the forecasted compound annual growth rate for the Japan Anti-VEGF Market from 2025 to 2035?

The market is projected to grow at a CAGR of 4.304% from 2025 to 2035.

How much is the Japan Anti-VEGF Market expected to be worth in 2035?

By 2035, the Japan Anti-VEGF Market is expected to reach a value of 2.06 billion USD.

Which product segment is leading in the Japan Anti-VEGF Market and what is its market size in 2024?

The Eylea segment is leading with a market size of 0.5 billion USD in 2024.

What are the expected market sizes for Lucentis and Beovu in 2024?

In 2024, Lucentis is expected to be valued at 0.4 billion USD, while Beovu is also projected at 0.4 billion USD.

What is the expected market size of the Eylea segment in 2035?

The Eylea segment is anticipated to expand to 0.79 billion USD by 2035.

Who are the major players in the Japan Anti-VEGF Market?

Key players include Roche, Astellas Pharma, Bayer, Eisai, and Otsuka Pharmaceutical.

What is the projected market size for Lucentis in 2035?

Lucentis is expected to increase to a value of 0.63 billion USD by 2035.

What challenges and opportunities are present in the Japan Anti-VEGF Market?

The market faces challenges related to competition and regulatory issues but also presents opportunities for innovation and increased awareness.

What can be expected regarding the performance of the Beovu segment in 2035?

Beovu is projected to grow to a market size of 0.64 billion USD by 2035.

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