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G-Protein Coupled Receptors Market Research Report Information By Product (Cell Lines, Detection Kits, Cell Culture Reagents, Ligands), Assay Type (Calcium Functional Assays, cAMP Functional Assays, cGMP Assays) and Application (Cardiovascular System, Oncology, Immunology, Respiratory System) - Forecast to 2032


ID: MRFR/HC/6884-HCR | 111 Pages | Author: Rahul Gotadki| April 2024

G-Protein Coupled Receptors Market overview



The G-Protein Coupled Receptors Market size is projected to reach USD 3.9 Billion by 2032 at 7.1% CAGR during the forecast period 2023-2032. A rising need for glycoprotein-coupled receptors is expected to result from the increasing utilization of G-protein coupled receptors in pharmaceutical revelation and improvement forms.


The G-protein coupled receptors market is expected to be pushed by an increase in the incidence of cases of cancer, as well as an increase in the incidence of lifestyle-related diseases like cardiovascular diseases and respiratory ailments. G-protein coupled receptors market are extraordinarily beneficial to researchers for the development of novel pharmaceutical drugs. Additionally, it is projected that increased government support for research and development programs in clinical development would contribute to the market's expansion. Aside from that, the operational and structural study on the pharmacological components of GPCRs reveals the adaptive use of GPCR targets in the treatment of a diverse range of illnesses, which is assisting the G-protein coupled receptors market in its expansion. The high expense associated with maintaining GPCR cell lines is a significant impediment to expanding the G-protein coupled receptors (GPCR) business.


This report contains all the information on the global G-Protein Coupled Receptors Market analysis and its strengths. In addition, the report also contains the culmination of dynamics, segmentation, key players, regional analysis, and other essential factors. And a detailed analysis of the global G-Protein Coupled Receptors Market forecast for 2027 is also included in the report.


Covid 19 Analysis


It has been shown that GPR4 plays an essential role in the pathophysiology of Covid-19 and might be used as a potential treatment target for curing Covid-19 infected patients, depending on the clinical signs of coronavirus-infected individuals. Covid-19-induced hyper-permeability of blood vessels, hyper-inflammatory responses, exudate production, pulmonary edoema, vascular thrombosis, and tissue damage may all be mitigated by using this treatment method.


Market Dynamic


Drivers


The growing number of medications now being tested in clinical and preclinical trials that address these receptors is encouraging. In 2018, around 19 percent of medications in clinical trial phase 1 targeted G protein-coupled receptors, according to the most recent available data. There is a wide range of agents available that boost GPCR activity. Salmeterol and albuterol are beta-adrenergic GPCR agonists that attach and activate beta-adrenergic GPCRs in the lungs, stimulating airway relaxation. They are used to treat several respiratory disorders, including chronic bronchitis and asthma.


Opportunities


The increasing utilization of G-protein coupled receptors in the disclosure and development of pharmaceutical products. Allosteric modulators, biological medicines, and biassed agonists are being developed to achieve these receptors in rising numbers. There are a vast number of FDA-approved medications that target G-protein coupled receptors on the market today. As of 2018, around 700 medicines targeting G protein-coupled receptors have been authorized by the Food and Drug Administration (GPCRs).


Restraints


The high prices linked with G-protein coupled receptors cell lines, on the other hand, would function as a significant growth restriction in the market. Unfavorable reimbursement rules, particularly in developing countries, will offer further obstacles to the G-Protein Coupled Receptors Market growth. 


Challenges


The scarcity of competent individuals or certified expertise may further hinder the market's development pace in the future. Stringent laws and standards governing the authorization procedure will also impede the sector's expansion.


Cumulative Growth Analysis


Due to significant expenditures in cancer research, the authorization of GPCR-targeted medications, and an increasing emphasis on pharmaceutical research, North America dominated the worldwide G-protein coupled receptors market in 2018. According to the FDA, there were 134 GPCR targets licensed in the US or EU in November 2017, and 128 targets were included in the FDA orange book at that time. There are various rising firms in the Asia Pacific area, such as HD Biosciences Co., Ltd., Sosei Heptares, and NB Health Laboratory, all of which have high growth prospects in the following years. Geographical growth is fueled by the amount of enterprises' efforts to appeal to a broader.


Value Chain Analysis


According to the reports, the global G-Protein Coupled Receptors Market is segmented based on product, assay type, application, and regions. The widest choice of cell lines for assays led to the highest overall revenue of cell lines in 2018. Cell lines are essential in cellular impedance tests for GPCR target identification, contributing to the expected revenue share. Detection kits have gained significant popularity because of their ease of use, robustness, and high sensitivity. Proposed detection tactics based upon nonlabelled systems, such as resonant waveguide grating or impedance-based sensors, could also help the market flourish.


Because cAMP is an essential intracellular 2nd messenger in GPCR signal transduction, cAMP assays commanded the highest profit share in 2018. The market is driven by an extensive product array of test kits for measuring cAMP mediator levels. Using calcium flux assays has several benefits, including excellent specificity, simplicity of estimating calcium flow, and user configurability.


Segmentation Overview


The market is segmented based on product, assay type, application, and regions. The global G-Protein Coupled Receptors Market trends are expected to witness decent growth during the forecast period.


G-Protein Coupled Receptors Market By Application


Based on the Application, the market is segmented into Cardiovascular systems, Oncology, Immunology, Respiratory systems, Central Nervous systems, and Others.


G-Protein Coupled Receptors Market By end-users


Based on the propulsion types, the market is segmented into Cell Lines, Detection Kits, Cell Culture Reagents, and Ligands.


Regional Analysis


According to the reports, based on the region, the global G-Protein Coupled Receptors Market is divided into America, Europe, Asia Pacific, and the middle east and Africa. Americas is the biggest market for G protein-coupled receptors because of the significant expenditures in disease research that drive the industry's expansion.


The European G protein-coupled receptors market share is expected to see increased demand as more medications targeting GPCRs is licensed for use. European Union approval of 134 GPCR sites for medicines in November 2017 and FDA orange book listing of 128 GPCR targets fueled the expansion of the G protein-coupled receptors industry in this area in the year.


The fastest-growing region in the Asia-Pacific region. Due to the advent of various new businesses, including HD Biosciences Co. Ltd. and NB Health Laboratory, this area is becoming more competitive. For the G protein-coupled receptor in this area to grow, more and more firms are taking steps to expand their market position. G-protein coupled receptors market outlook are in high need in the Middle East and Africa due to increased healthcare costs and public funding.


Competitive landscape


The government's funding for research and development efforts in the market for G-protein coupled receptors market value is increasing. The federal government is funding research and innovation for biosensors, sedate targets, orphan drug receptors, and high-throughput screening technologies to attach the nucleotides guanosine triphosphate (GTP) and guanosine diphosphate (GDP), as well as for other applications (GDP).


G-Protein Coupled Receptors Market Major Key Players



  • Thermo Fisher Scientific, Inc. (US)

  • Abcam PLC (UK)

  • QIAGEN (Germany)

  • Promega Corporation (US)

  • PerkinElmer Inc. (US)

  • Enzo Life Sciences, Inc. (US)

  • BD (US)

  • Cisbio (Europe)

  • Merck Group (Germany)

  • HD Biosciences Co., Ltd (China)


Report Overview


The following report comprises of ‚Äď



  • Market overview¬†

  • Covid 19 Analysis

  • Market Dynamic

  • Drivers

  • Opportunities

  • Restraints¬†

  • Challenges

  • Cumulative Growth Analysis

  • Value Chain Analysis

  • Segmentation Overview¬†

  • By Application¬†

  • By End-Users

  • Regional Analysis

  • Competitive landscape


Recent Developments


November 2023Structure Therapeutics announces that it has raised $161 million in its initial public offering (IPO). Structure Therapeutics is a clinical-stage biopharmaceutical company developing GPCR-targeted drugs for the treatment of a variety of diseases, including cancer, metabolic disorders, and cardiovascular diseases.Septerna announces that it has raised $100 million in Series A funding. Septerna is a biotechnology company developing GPCR-targeted drugs for the treatment of a variety of diseases, including cancer, neurodegenerative disorders, and pain.Heptares Therapeutics announces that it has entered into a new collaboration with AstraZeneca to develop GPCR-targeted drugs for the treatment of a variety of diseases, including cancer, inflammation, and central nervous system disorders.Sosei Heptares announces that it has received $50 million in upfront payments from AbbVie as part of their collaboration to develop GPCR-targeted drugs for the treatment of neurological diseases.October 2023Eli Lilly announces that it has received FDA approval for Tirzepatide, a dual GLP-1 and GIP receptor agonist for the treatment of type 2 diabetes. Tirzepatide is the first GPCR-targeted drug to be approved by the FDA for the treatment of type 2 diabetes.Amgen announces that it has submitted a New Drug Application (NDA) to the FDA for AMG 330, a bispecific antibody that targets both the EGFR and GPCR C5a receptor for the treatment of non-small cell lung cancer (NSCLC).Boehringer Ingelheim announces that it has entered into a new collaboration with Evotec to develop GPCR-targeted drugs for the treatment of a variety of diseases, including pain, CNS disorders, and metabolic disorders.

Product Outlook



  • Cell Lines

  • Detection Kits

  • Cell Culture Reagents

  • Ligands


Assay Type Outlook



  • cAMP Functional Assays

  • Calcium Functional Assays

  • ő≤-Arrestin Functional Assays

  • Radioligand Binding and GTPő≥S Functional Assays

  • Internalization Assays

  • Trafficking Assays

  • Other Assays


Application Outlook



  • Cancer Research

  • CNS Research

  • Metabolic Research

  • Cardiovascular Research

  • Respiratory Research

  • Inflammation Research

  • Other Application


Regional Outlook



  • North America

    • U.S.

    • Canada



  • Europe

    • Germany

    • U.K.



  • Asia Pacific

    • China

    • India

    • Japan



  • Latin America

    • Brazil



  • Middle East and Africa (MEA)

    • South Africa




Report Attribute/Metric Details
  Market Size   USD 3.9 Billion
  CAGR   7.1%
  Base Year   2021
  Forecast Period   2023-2032
  Historical Data   2020
  Forecast Units   Value (USD Million)
  Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Product, Assay Type, Application
  Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
  Key Vendors   Thermo Fisher Scientific, Inc. (US), Abcam PLC (UK), QIAGEN (Germany), Promega Corporation (US), PerkinElmer Inc. (US), Enzo Life Sciences, Inc. (US), BD (US) Cisbio (Europe), Merck Group (Germany), HD Biosciences Co., Ltd (China)
  Key Market Opportunities   New product launches and R&D Amongst major key Players
  Key Market Drivers ·  The increasing number of drugs under clinical and preclinical studies that target these receptors ·  Existence of a variety of agents that stimulate GPCR activity. ·  The growing use of G-protein coupled receptors in medicate disclosure and advancement forms ·  Increasing number of allosteric modulators, biological drugs, and biased agonists that target these receptors. ·  Presence of a large number of approved drugs that target G-protein coupled receptors.


Frequently Asked Questions (FAQ) :

The G-protein coupled receptors market is projected to reach a valuation of USD 3.9 Billion by 2032.

The G-protein coupled receptors market is projected to grow at approximately 7.1% CAGR during forecast period (2023-2032).

Rising numbers of drugs under clinical and preclinical studies, targeting these receptors.

North America holds the largest share in the global G-protein coupled receptors market, followed by Europe and the Asia Pacific, respectively.

Abcam PLC (UK), Thermo Fisher Scientific, Inc. (US), QIAGEN (Germany), PerkinElmer Inc. (US), Promega Corporation (US), Enzo Life Sciences, Inc. (US), Cisbio (Europe), BD (US), Merck Group (Germany), and HD Biosciences Co., Ltd (China), are some of the major players operating in the G-protein coupled receptors market.

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