Global Collagen and Hyaluronic Acid Intra-Articular Injections Market Overview
The Collagen and Hyaluronic Acid Intra-Articular Injections Market was valued at USD 3.04 billion in 2024. The Collagen and Hyaluronic Acid Intra-Articular Injections Market industry is projected to grow from USD 3.28 billion in 2025 to USD 6.32 billion by 2035, exhibiting a compound annual growth rate (CAGR) of 6.15% during the forecast period (2025-2035).
The rising prevalence of osteoarthritis and joint disorders and growing aging population are driving the growth of the Collagen and Hyaluronic Acid Intra-Articular Injections Market.
As per the Analyst at MRFR, the rising prevalence of osteoarthritis and joint disorders is a significant driver of the Collagen and Hyaluronic Acid Intra-Articular Injections Market. Osteoarthritis, the most common form of arthritis, affects millions worldwide, particularly the aging population. According to the World Health Organization (WHO), osteoarthritis is one of the leading causes of disability, and its incidence is expected to rise as global life expectancy rises. According to the United Nations, more than 130 million people will have osteoarthritis by 2050, creating a significant demand for effective treatments. Joint disorders, such as rheumatoid arthritis, and sports-related injuries add to this growing burden.
FIGURE 1: COLLAGEN AND HYALURONIC ACID INTRA-ARTICULAR INJECTIONS MARKET VALUE (2019-2035) USD BILLION

Source: Secondary Research, Primary Research, MRFR Database, and Analyst Review
Collagen and Hyaluronic Acid Intra-Articular Injections Market Opportunity
GROWING DEMAND FOR MINIMALLY INVASIVE TREATMENTS
The growing demand for minimally invasive treatments is a significant opportunity in the Collagen and Hyaluronic Acid Intra-Articular Injections Market. Patients are increasingly seeking treatments that offer quick recovery times, minimal side effects, and reduced risk of complications, making intra-articular injections an attractive option. According to the American Society of Plastic Surgeons in 2025, minimally invasive procedures increased 7% in 2023, outpacing surgical procedures by 2%. Hyaluronic acid treatment continued to grow, with over 9 million treatments performed.
Advancements in technology and patients' preference for cost-effective procedures, subtle results, and short recovery times have fueled the continued interest. These injections provide a non-surgical approach to managing joint pain and inflammation, aligning with the trend towards less invasive medical interventions. The appeal of minimally invasive treatments is further enhanced by advancements in technology, which have improved the efficacy and safety of these injections. As a result, more patients are opting for intra-articular injections over traditional surgical methods, contributing to an increase in demand.
Additionally, the rising awareness of the benefits of early intervention in joint conditions is prompting patients to seek these treatments earlier, expanding the potential patient base. The demand for minimally invasive treatments is also driven by an aging population and an increase in lifestyle-related joint issues, creating a robust market environment for collagen and hyaluronic acid intra-articular injections. Overall, this trend towards minimally invasive treatments presents a substantial opportunity for market growth and innovation in the development of more effective and patient-friendly intra-articular injection therapies.
Collagen and Hyaluronic Acid Intra-Articular Injections Market Segment Insights
Collagen and Hyaluronic Acid Intra-Articular Injections by Product Type Insights
Based on Product Type, this segment includes Hyaluronic Acid Injection (Single Injection, Multiple Injection), Collagen Injection, Combination of Hyaluronic Acid and Collagen. The Hyaluronic Acid Injection segment dominated the global market in 2024, while it is projected to be the fastest–growing segment during the forecast period.
Both single and multiple injection variants are popular for treating joint disorders and enhancing skin volume. This segment is also projected to be the fastest growing during the forecast period due to increasing demand for non-surgical cosmetic procedures, aging populations, and growing awareness of hyaluronic acid’s effectiveness. Technological advancements and improved formulations are further accelerating their adoption across medical and cosmetic fields, boosting market growth in the coming years.
FIGURE 2: COLLAGEN AND HYALURONIC ACID INTRA-ARTICULAR INJECTIONS MARKET SHARE BY PRODUCT TYPE 2024 AND 2035 (USD BILLION)

Source: Secondary Research, Primary Research, MRFR Database and Analyst Review
Collagen and Hyaluronic Acid Intra-Articular Injections by Application Insights
Based on Application, this segment includes Knee Osteoarthritis, Joint Pain, Veterinary Applications, Post-Operative Recovery, Others. The Knee Osteoarthritis segment dominated the global market in 2024, while it is projected to be the fastest–growing segment during the forecast period.
This segment is also projected to be the fastest growing during the forecast period, driven by increasing awareness of early intervention, rising healthcare expenditure, and the growing preference for non-surgical treatments. Additionally, advancements in injection therapies and the growing burden of osteoarthritis worldwide are expected to further propel demand, making this segment a key contributor to overall market expansion in the coming years.
Collagen and Hyaluronic Acid Intra-Articular Injections by Distribution Channel Insights
Based on Distribution Channel, this segment includes Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies. The Hospital Pharmacies segment dominated the global market in 2024, while the Online Pharmacies segment is projected to be the fastest–growing segment during the forecast period. Hospital pharmacies are often the primary source for post-operative and osteoarthritis care, contributing significantly to sales volume.
However, the Online Pharmacies segment is projected to be the fastest growing during the forecast period. This growth is driven by increasing internet penetration, rising consumer preference for convenience, and the availability of a wide range of products at competitive prices. In addition, the expansion of telehealth services and improvements in e-commerce platforms have enhanced the accessibility and reliability of online medication purchases. As digital healthcare adoption increases globally, the online channel is expected to witness substantial growth, especially in urban and tech-savvy regions.
Collagen and Hyaluronic Acid Intra-Articular Injections Regional Insights
Based on the Region, the global Collagen and Hyaluronic Acid Intra-Articular Injections are segmented into North America, Europe, Asia-Pacific, Latin America and Middle East & Africa. The North America dominated the global market in 2024, while the Asia-Pacific is projected to be the fastest–growing segment during the forecast period. Major demand factors driving the North America market are the rising prevalence of osteoarthritis and joint disorders and growing aging population.
The region also benefits from well-established healthcare infrastructure, widespread adoption of advanced medical treatments, and high awareness regarding non-surgical therapeutic options such as intra-articular injections. Additionally, increased healthcare spending and favorable reimbursement policies contribute to market growth in the region. However, the Asia-Pacific region is projected to be the fastest-growing during the forecast period. This growth is driven by a rapidly aging population, rising healthcare expenditure, growing awareness of joint health treatments, and expanding access to healthcare services across emerging economies such as China, India, and Southeast Asian countries.
FIGURE 3: COLLAGEN AND HYALURONIC ACID INTRA-ARTICULAR INJECTIONS MARKET VALUE BY REGION 2024 AND 2035 (USD BILLION)

Source: Secondary Research, Primary Research, MRFR Database, and Analyst Review
Further, the countries considered in the scope of the Application Tracking System Market are the US, Canada, Germany, UK, France, Russia, Italy, Spain, China, India, Japan, South Korea, Malaysia, Thailand, Indonesia, Brazil, Mexico, Argentina, GCC Countries, South Africa and others.
Global Collagen and Hyaluronic Acid Intra-Articular Injections Key Market Players & Competitive Insights
Many global, regional, and local vendors characterize the Collagen and Hyaluronic Acid Intra-Articular Injections Market. The market is highly competitive, with all the players competing to gain market share. Intense competition, rapid advances in technology, frequent changes in government policies, and environmental regulations are key factors that confront market growth. The vendors compete based on cost, product quality, reliability, and government regulations. Vendors must provide cost-efficient, high-quality products to survive and succeed in an intensely competitive market.
The major competitors in the market are Seikagaku Corporation, Bioventus, Inc., Anika Therapeutics, Inc., Zimmer Biomet, Sanofi, Teva Pharmaceutical Industries Ltd., Ferring B.V., Dr. Reddy's Laboratories Ltd., Fidia Farmaceutici S.p.A., Semical Biosurgery, Avanos Medical, Inc., Maxigen Biotech Inc. (MBI) are among others. The Collagen and Hyaluronic Acid Intra-Articular Injections Market is a consolidated market due to increasing competition, acquisitions, mergers and other strategic market developments and decisions to improve operational effectiveness.
Key Companies in the Collagen and Hyaluronic Acid Intra-Articular Injections Market include
- Seikagaku Corporation
- Bioventus, Inc.
- Anika Therapeutics, Inc.
- Zimmer Biomet
- Sanofi
- Teva Pharmaceutical Industries Ltd.
- Ferring B.V.
- Reddy's Laboratories Ltd.
- Fidia Farmaceutici S.p.A.
- Semical Biosurgery
- Avanos Medical, Inc.
- Maxigen Biotech Inc. (MBI)
Collagen and Hyaluronic Acid Intra-Articular Injections Market Industry Developments
February 2024: MBI received approval for ArtiAid and ArtiAidPlus Intra-articular Injection for marketing authorization from the Saudi Food and Drug Authority.
August 2021: Seikagaku Corporation launched HyLink, an intra-articular single injection viscosupplement for the treatment of knee osteoarthritis.
May 2021: Ono Pharmaceutical Co., Ltd. and Seikagaku Corporation announed that Ono has launched JOYCLU 30mg Intra-articular Injection (generic name: diclofenac etalhyaluronate sodium; “JOYCLU”), a joint function improvement agent, for which Seikagaku received the manufacturing and marketing approval in Japan.
January 2019: Bioventus, a global leader in orthobiologic solutions, launched DUROLANE, a single-injection joint-fluid osteoarthritis (OA) treatment, in Malaysia, and has chosen Athrotech as its exclusive distributor.
Collagen and Hyaluronic Acid Intra-Articular Injections Market Segmentation
Collagen and Hyaluronic Acid Intra-Articular Injections by Product Type Outlook
- Hyaluronic Acid Injection
- Single Injection
- Multiple Injection
- Collagen Injection
- Combination of Hyaluronic Acid and Collagen
Collagen and Hyaluronic Acid Intra-Articular Injections by Application Outlook
- Knee Osteoarthritis
- Joint Pain
- Veterinary Applications
- Post-Operative Recovery
- Others
Collagen and Hyaluronic Acid Intra-Articular Injections by Distribution Channel Outlook
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
Collagen and Hyaluronic Acid Intra-Articular Injections Regional Outlook
- North America
- Europe
- Germany
- UK
- France
- Russia
- Italy
- Spain
- Rest of Europe
- Asia-Pacific
- China
- India
- Japan
- South Korea
- Malaysia
- Thailand
- Indonesia
- Rest of Asia-Pacific
- Latin America
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- Middle East & Africa
- GCC Countries
- South Africa
- Rest of Middle East & Africa
Report Attribute/Metric |
Details |
Market Size 2024 |
USD 3.04 Billion |
Market Size 2025 |
USD 3.28 Billion |
Market Size 2035 |
USD 6.32 Billion |
Compound Annual Growth Rate (CAGR) |
6.15% (2025-2035) |
Base Year |
2024 |
Forecast Period |
2025-2035 |
Historical Data |
2019-2023 |
Forecast Units |
Value (USD Billion) |
Report Coverage |
Revenue Forecast, Competitive Landscape, Growth Factors, and Trends |
Segments Covered |
By Product Type, By Application, By Distribution Channel |
Geographies Covered |
North America, Europe, Asia Pacific, Latin America, Middle East & Africa |
Countries Covered |
The US, Canada, Germany, UK, France, Russia, Italy, Spain, China, India, Japan, South Korea, Malaysia, Thailand, Indonesia, Brazil, Mexico, Argentina, GCC Countries, South Africa |
Key Companies Profiled |
Seikagaku Corporation, Bioventus, Inc., Anika Therapeutics, Inc., Zimmer Biomet, Sanofi, Teva Pharmaceutical Industries Ltd., Ferring B.V., Dr. Reddy's Laboratories Ltd., Fidia Farmaceutici S.p.A., Semical Biosurgery, Avanos Medical, Inc., Maxigen Biotech Inc. (MBI) |
Key Market Opportunities |
·        Growing Demand for Minimally Invasive Treatments |
Key Market Dynamics |
·        Rising Prevalence of Osteoarthritis and Joint Disorders ·        Growing Aging Population |
Frequently Asked Questions (FAQ) :
USD 3.04 Billion is the Collagen and Hyaluronic Acid Intra-Articular Injections Market in 2024
The Hyaluronic Acid Injection segment by Product Type holds the largest market share and grows at a CAGR of 6.34 % during the forecast period.
North America holds the largest market share in the Collagen and Hyaluronic Acid Intra-Articular Injections Market.
Seikagaku Corporation, Bioventus, Inc., Anika Therapeutics, Inc., Zimmer Biomet, Sanofi, Teva Pharmaceutical Industries Ltd., Ferring B.V., Dr. Reddy's Laboratories Ltd., Fidia Farmaceutici S.p.A., Semical Biosurgery, Avanos Medical, Inc., Maxigen Biotech Inc. (MBI) are prominent players in the Collagen and Hyaluronic Acid Intra-Articular Injections Market.
The Knee Osteoarthritis segment dominated the market in 2024.