Chromatography Resin Market Research Report‚ÄĒGlobal Forecast till 2030

Chromatography Resin Market Research Report Information By Type (Natural Resin, Synthetic Resin, Inorganic Media) Technique (Ion-exchange chromatography, Affinity chromatography, Hydrophobic interaction chromatography, Size exclusion chromatography, Multi-modal chromatography, Others) Forecast 2030

ID: MRFR/CnM/5581-CR | 110 Pages | Author: Anshula Mandaokar | October 2022         

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Chromatography Resin Market Overview

The global chromatography resin market was valued at USD  12,771.5 million in 2021 and is projected to reach USD  22,750.0 million by 2030 at a CAGR of 6.96%.

Chromatography is a process to split or separate a blend of colored components into individual elements. Chromatography resins help in the isolation of desired components from a mixture of compounds. They are incorporated into chromatography devices and are used in diagnostic test development and separation of biomolecules. Choice of resins is very crucial to ensure an effective and accurate separation of individual components.

Chromatography resins are media used to capture and polish mAbs, antibody fragments, vaccines, and other biomolecules using a stationary phase. There are multiple types of ion-exchange resin. Most commercial resins are made of polystyrene sulfonate.

COVID-19 Impact on the Chromatography Resin Market

The outbreak of COVID-19 has had a positive impact on the global chromatography resin market. This is attributed to the development of effective vaccines and treatments by companies and governments worldwide, which resulted in the employment of robust analytical methods by researchers across the globe.

Researchers used chromatography, a strong laboratory-based analytical approach, to better understand the Sars-CoV-2 virus and develop new medicines, vaccines, and diagnostic tools to aid in the fight against the Covid-19 epidemic. Because of its central role in viral pathogenesis, the SARS-CoV-2 virus's spike protein has piqued researchers' interest as a vaccine target. While many researchers have attempted to classify the spike protein's glycopeptides and glycans, intact protein analysis utilizing reversed-phase liquid chromatography (RPLC) may provide novel analytical insights. More effective medicines can be identified and developed by refining functional and structural understanding of the intact spike protein. Liquid chromatography coupled with mass spectrometry was used to quantify remdesivir in the blood plasma of a COVID-19 patient and thus provide data on its efficacy as a treatment for SARS-CoV-2.

The crucial need for developing the effective treatment for COVID-19 during the year 2020 resulted in high demand for chromatographic techniques, thus, having a positive impact on the global market.

Market Dynamics


  • Use of chromatography techniques in pharmaceuticals & biotechnology industry: The HPLC chromatography technique is considered the most important analytical technique used in the pharmaceutical business to identify and quantify pharmaceuticals. This is used either in the active pharmaceutical ingredient or in the formulations during the research, development, and production of a medicine. The chromatography methods are accurate, precise, quick, specific, and easy; therefore, they are widely used for regular quality control examination of medicines in bulk and pharmaceutical dosage form. They can be used in drug research and development, drug impurity analysis, assay, content uniformity, and drug method development and validation. HPLC's capacity to reveal the structure and determine the amounts of contaminants in pharmaceutical formulations is one of its key advantages. HPLC is particularly well suited to chemicals that are difficult to volatilize, are thermally unstable, and have large molecular weights. As a result, it can measure a medication in both its pure and dose form.


  • High cost of affinity resins: In a typical platform process for the manufacturing of mAb therapies, the steps following fermentation account for over 80% of the total process costs, with chromatography accounting for up to 60% of the downstream expenses. Protein A resin is the most significant contributor to the entire cost. Traditional chromatographic medium with non-proteinaceous ligands cost roughly half as much as Protein A resin. The cost of resin for a large column (diameter >1 m) can surpass USD 1 million. The fact that most antibody therapies require frequent and substantial doses of Protein A makes the expense of Protein A resin even more difficult.


  • Increasing demand for biosimilars: Each biosimilar is made using the same amino acid starting materials and the same precise, step-by-step processes as its reference drug — a well-tested, widely-used biologic drug that’s already been on the market for years. All biosimilars are prescription drugs. Biosimilars are intended to provide a more cost-effective alternative to high-priced branded biologics. This will help in easy accessibility of medicines and appropriate therapies for the patients.


  • Adoption of green chromatography: To lessen the risks to the environment and human health associated with the use of chromatography, scientists have modified the technology such that non-toxic chemicals can be used instead of toxic ones where possible, and the energy consumption is lowered and derived from renewable sources. Acetonitrile, a volatile organic molecule, is the most widely used solvent in chromatography. According to studies, a mixture of propylene carbonate–ethanol–water can be used to substitute this harmful solvent with equivalent efficacy. Other research has indicated that a mixture of ethyl acetate and ethanol can be utilized as a more environmentally acceptable alternative to acetonitrile. Solutions of 0.04% triethylamine in water are also an effective alternative for toxic chemicals used in chromatography


By Type

  • Natural Resin

  • Synthetic Resin

  • Inorganic Media

By Technique

  • Ion-exchange chromatography

  • Affinity chromatography

  • Hydrophobic interaction chromatography

  • Size exclusion chromatography

  • Multi-modal chromatography

  • Others

By Application

  • Pharmaceuticals & biotechnology

  • Food & beverages

  • Water & environment analysis

  • Academics & research

  • Others

By Region

  • North America

  • Europe

  • Asia-Pacific

  • Latin America

  • Middle East & Africa

Regional Analysis

The Global Chromatography resin Market has been studied across five regions: North America, Asia-Pacific, Europe, Latin America, and the Middle East & Africa. North America accounted for a largest market share in 2021. The North American market has been divided into the US and Canada. The US was the largest pharmaceutical market in 2021, generating about USD 12,771.5 million representing around 40% of the global revenue generated worldwide. According to AstraZeneca, North America is expected to continue to lead global pharmaceutical sales in the year 2022 with USD 13,279.8 million.

Asia-Pacific accounted for 21.30% of the global market share in 2021 and is expected to reach a value of USD 22,750.0 million by the end of the forecast period. The growth of the region can be associated with the growth of the pharmaceutical industry in China, India, and Japan.

China has solidified its position as a key player in the global pharmaceutical sector, both as a consumer and as a base for expanding R&D. Domestic and global pharmaceutical companies are expanding and introducing new products in China, which is a key factor for the growth of the chromatography resin market.

Competitive Landscape

Chromatography resin market is expected to register healthy growth throughout the forecast period. The market represents strong numbers in terms of consumption and is expected to grow year on year. Chromatography resin market is highly fragmented, with presence of numerous tier-1, tier-2, and unorganized players.

Some of the key players operating in chromatography resin market Tosoh Corporation (Japan), Thermo Fisher Scientific Inc (US), Repligen Corporation (US), Avantor Performance Materials Inc (US), Merck KGaA (Germany), Bio-Rad Laboratories Inc (US), Pall Corporation (US), Mitsubishi Chemical Corporation (Japan), GE Healthcare (US), R.Grace & Co (US) and Purolite Corporation (US).

Report Overview:

The Chromatography resin market is segmented by Type, Technique, application, and region in the report. In terms of insights, this report has focused on various levels of analysis such as market dynamics, value chain analysis, Porter's five forces, competitive landscape, and company profiles—all of which comprise and discuss views on the global chromatography resin emerging and fast-growing segments, regions, and countries.

Objectives of the Study

  • To get a comprehensive overview of the global chromatography resin market

  • To get wide-ranging information about the key factors driving the market and market opportunities

  • To gain information regarding the key players in the industry, their product portfolio, strategies, and key developments

  • To gain insights about the key country/region in which the market is growing

Intended Audience

  • Industrial sector

  • Academics

  • Pharmaceutical industries

  • Agrochemical industries

Report Scope:

Report Attribute/Metric Details
  Market Size    2030: USD 22,750.0 million
  CAGR    6.96% CAGR (2022-2030)
  Base Year    2021
  Forecast Period    2022-2030
  Historical Data    2020
  Forecast Units    Value (USD Million)
  Report Coverage    Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Application, Type, and Technique
  Geographies Covered   North America ,Europe, Asia-Pacific,Latin America, Middle East & Africa
  Key Vendors   Tosoh Corporation (Japan), Thermo Fisher Scientific Inc (US), Repligen Corporation (US), Avantor Performance Materials Inc (US), Merck KGaA (Germany), Bio-Rad Laboratories Inc (US), Pall Corporation (US), Mitsubishi Chemical Corporation (Japan), GE Healthcare (US), R.Grace & Co (US) and Purolite Corporation (US).
  Key Market Opportunities   Use of chromatography techniques in pharmaceuticals & biotechnology industry
  Key Market Drivers   Increasing demand for biosimilars

Frequently Asked Questions (FAQ) :

The global chromatography resin market would register a growth of 6.96%.

Pharmaceutical and biotechnology industry, will play a crucial role in taking the Chromatography resin market ahead.

High cost of affinity resins, is the key restraining factor for the global chromatography resin  market.

North America holds the largest share in the global chromatography resin market, followed by Europe and the Asia Pacific, respectively.

The rising demands for chromatography tests, increasing research and development projects in the pharmaceutical sector, and rise in drug approvals are the important market drivers for the increase in the global Chromatography Resin Market Revenue.

Key Questions Answered

  • Global Market Outlook
  • In-depth analysis of global and regional trends
  • Analyze and identify the major players in the market, their market share, key developments, etc.
  • To understand the capability of the major players based on products offered, financials, and strategies.
  • Identify disrupting products, companies, and trends.
  • To identify opportunities in the market.
  • Analyze the key challenges in the market.
  • Analyze the regional penetration of players, products, and services in the market.
  • Comparison of major players‚Äô financial performance.
  • Evaluate strategies adopted by major players.
  • Recommendations
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