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Chiral Chromatography Columns Market Research Report Information by Material (Metal-Based Columns, Glass-Based Columns and Plastic-Based Columns), by Product (Prepacked and Empty Columns), by Technology (Liquid Chromatography, Gas Chromatography, Supercritical Fluid Chromatography, Thin Layer Chromatography, Flash Chromatography), by End User (Pharmaceutical & Biotechnology Companies, Academic Institutes, Food & Beverage Manufacturers, Hospitals & Diagnostic Clinics, Environmental Testing Laboratories, Cosmeceutical Companies, Nutraceutical

ID: MRFR/HC/7685-HCR | 120 Pages | Author: Rahul Gotadki| April 2024

Chiral Chromatography Columns Market Forecast

The Chiral chromatography columns market is projected to reach USD 104.34 Million by 2030 at 4.20% CAGR during the forecast period 2022-2030.

Market Overview:

Chiral chromatography columns are analytical instruments used to separate optical isomers. The columns hold a stationary phase containing enantiomer within them. Approximately 60% of all pharmaceutical drugs are chiral and the production processes need application of chiral chromatography. The market is driven by various factors such as increase in life science R&D expenditure, rise in production of chiral drugs and the increasing demand for analytical instruments. However, the lack of skilled professionals may hamper the growth of the market.

COVID-19 Analysis

The present COVID-19 pandemic has impacted people all over the world and forced the closure of operational facilities across the world. During the lockdown, the healthcare business faced extraordinary challenges such as supply chain disruptions, resulting in an increase in warehouse inventories of manufactured goods. The market for chromatography instruments and consumables did not hamper to a great extent.

Furthermore, the COVID-19 pandemic also created growth opportunities for the companies involved in the chiral chromatography columns industry. This is due to the increased R&D efforts to produce drugs for COVID-19 such as repurposing the development of approved antiviral drugs as candidates for COVID-19. For instance, chloroquine and its hydroxyl analog hydroxychloroquine (HCQ) administered as racemates showed inhibitory effects on COVID-19 and demand for these racemates grew exponentially. Manufacturers were focused on developing single enantiomeric versions of these racemic drugs. Furthermore, large number of racemic drugs requiring application of chiral chromatography columns for separation of compounds is further increasing demand.

Market Dynamics


  • Increasing availability of funds and growth in investment activities

Chiral chromatography columns are used extensively for separation of various pharmaceutical compounds. With respect to R&D activities; emerging startups and clinical-stage companies are dependent on leading players and investment firms for technology transfer and scale-up of production processes, respectively. An increasing number of investment activities for R&D processes is expected to support growth of chiral chromatography columns market during the forecast period. For instance, JSR Life Sciences, LLC (US), a subsidiary to JSR Corporation (Japan) during March, 2021 announced the launch of its ‚ÄėJSR Life Sciences Corporate Venture Fund‚Äô for emerging life science companies to accelerate novel therapies and innovative technologies. Thus, the increasing R&D investments drives the growth of the chiral chromatography columns market.

  • Higher dependence on chromatography tests for drug approvals

  • Technological advancements in chiral chromatography columns

Market Opportunities

  • Development of sustainable production processes

Large amounts of organic solvents are required for conventional HPLC techniques and it results in generation of large amount of wastes. Similarly, non-renewable and expensive gases such as Helium are used in gas chromatography when combined with mass spectrometry.

The manufacturers of chiral chromatography columns can focus their efforts on development of more green and affordable products. Moreover, large number of contract research organizations in Asia-Pacific region can help researchers scale-up production processof chiral chromatography columnsat an affordable cost.

Market Restraints

  • Dearth of skilled professionals

Running column chromatography procedures and implementing the results require expertise and skilled professionals. Such professionals should be knowledgeable regarding the different components of the chromatography process along with being updated with the technological advancements and performing complex analytical calculations as well.

The lack of such skilled professionals may hamper growth of the market as irregularities in the performance of these techniques may result in significant losses to the companies. However, companies are setting up training initiatives to overcome this restraint.  

Value Chain Analysis

The global chiral chromatography columns market is projected to exhibit significant growth over the forecast period, which can be attributed to factors such asan increase in life science R&D expenditure, high dependence on chromatography tests for drug approvals, a rise in the production of racemic drugs, and the increasing demand for biopharmaceutical products. The value chain analysis for the chiral chromatography columns industry comprises four major components, which start with research & product development, followed by the manufacturing of the products, distribution& sales, and ends with post marketing surveillance.

Segment Overview

By Material

  • Metal-based Columns

Chiral surfaces are critical components of enantioselective heterogeneous processes such as those used to prepare enantiomerically pure pharmaceuticals. Notable metal-based chiral chromatography columns available in the market include Hypersil Chiral HPLC Columns by Thermo Fisher Scientific (US) and CHIRALPAK & CROWNPAK by Daicel Corporation (Japan). The metal-based columns provide better tensile strength and are suitable for high flow rate process.

  • Glass-based Columns

Glass-based columns are utilized for chromatographic applications as they provide advantage in monitoring of components. Silica impregnated columns are effective in scouting a suitable chiral chromatography separation mode for further analysis.

  • Plastic-based columns

Plastic-based chiral columns are precision-molded in sizes from premium-grade, chemically inert plastics. These columns are more chemically-resistant and appropriate for use with organic solvents and stronger acidsand alkalis.

By Product

  • Prepacked Columns

Pre-packed chromatography columns have a stationary phase already pre-filled within the column and can be used directly after attaching to a chromatography system. This removes the extra steps of column cleaning, sterilization, and re-packing. Product innovations and launches are also driving growth for this segment. For instance, in September 2020, Bio-Works Technologies (Sweden) launched two new resins Work Beads NiMAC and Work Beads Dsalt, which are also sold in pre-packed columns. These resins show high resistance to chelating agents like EDTA and reducing agents like DTT. Prepacked columns are further segmented into analytical columns and preparative columns.

  • Empty Columns

Empty columns are important in works on the principle of specific binding that happens between a lig and in the stationary phase and its binding partner. These bindings may happen between enzyme/substrate, antibody/antigen, or enzyme/inhibitor. Affinity chromatography is the first step if not the only step in the purification process of molecules which boosts the demand for this segment.

By Technology

  • Liquid Chromatography

The solvents are in the mobile phase in liquid chromatography. The identification and quantification of food compositions, pharmaceuticals, and other bioactive molecules are gaining wide application in analytical laboratories. The reagents used for HPLC analysis are most important for increasing and decreasing retention time.

  • Gas Chromatography

Gas chromatography is mostly used when the mixture's chemical components are volatile and thermally stable. GC reagents have applications in various industries from research to manufacturing, including chemical, pharmaceutical, food & beverage, and space research.

  • Supercritical Fluid Chromatography

Supercritical fluid chromatography uses a supercritical fluid such as supercritical carbon dioxide as the mobile phase in the food industry. Supercritical fluid chromatography reagent is used in a state above the critical temperature and critical pressure where gases and liquids can coexist. The lower viscosity of supercritical fluids makes SFC a faster method than HPLC.

  • Thin Layer Chromatography

Thin-layer chromatography (TLC) is a chromatography technique used to separate non-volatile mixtures.TLC is an affinity-based method used to separate compounds in a mixture. It is a highly versatile separation method that is widely used for both qualitative and quantitative sample analysis.

  • Flash Chromatography

Flash chromatography is a process in which a vertical glass (column) is placed and is packed with the solid stationary phase from which the mobile phase (liquid form) is passed through it by gravity or some external pressure. The eluent which is a liquid, under gas pressure normally nitrogen or compressed air is rapidly pushed through a short glass column.

By End User

  • Pharmaceutical & Biotechnology Companies

Pharmaceutical companies use chromatography to prepare large quantities of extremely pure materials and analyze the purified compounds for trace contaminants. The rising use of chromatography in the pharmaceutical industry is for the separation of chiral compounds. Separating specific amino acid, protein, or other biomolecules from a sample are some of the applications of chiral chromatography to the biotechnology industry. Assessing yield, cost, and purity of products such as inulin, growth hormone, interferons, erythropoietin, and others is important in this industry.

  • Academic Institutes

Research & academic institutes mostly utilize chiral chromatography for educational purposes or develop new separation techniques on a pilot scale. The growing number of research organizations and availability of research grants may contribute to the growth of this segment.

  • Food & Beverage Manufacturers

Chiral chromatography is extensively used in the food & beverage industry for the food testing purposes. Some of the applications of chromatography in the food & beverage industry include quality control, separation of food additives and preservatives, vitamins, proteins, and amino acids. In beverage testing, chromatographic methods are employed to assess the sugar level and separation of caffeine from drinks. Similarly, food companies identify components such as flavors, colorants, additives, and preservatives in food. Liquid chromatography and gas chromatography are two common column chromatography techniques used for this in this industry.

  • Hospitals & Diagnostic Clinics

Therapeutic drug monitoring, toxicology, and doping analyses are the major applications of chromatography in clinical applications. Diagnostic laboratories use chromatographictechniquesfor the diagnosis of human metabolic disorders which are used by hospitals for therapeutic purpose.

  • Environmental Testing Laboratories

Environmental testing laboratoriesutilize chromatography for materials analysis in biological, pharmaceutical, chemical and food sectors, where it is utilized to determine contents in food and beverages. Moreover, the environmental testing laboratories use chromatographic techniques for monitoring safety of samples related to water and sewage.

  • Cosmeceutical Companies

During cosmetics production, chromatography systems are typically used in the initial part of the process, during ingredient discovery and purification. Active constituents used in cosmetics can either be synthesized in a laboratory or extracted from crude natural products.

  • Nutraceutical Companies

Among the dietary supplementary products growing in popularity are nutraceuticals. Increasing adoption of nutraceuticals in developed countries to fortify food and increase immunity is expected to increase the production of nutraceuticals. Separation and purification of dietary supplements is expected to increase the market share of this segment during the forecast period.

Regional Analysis

  • North America

North America held the largest market share in chromatography columns in 2020 due to factors like presence of key players like Thermo Fisher Scientific Inc. (US), Agilent Technologies, Inc. (US), and Bio-Rad Laboratories, Inc. (US). Furthermore, the increasing R&D investment drives the chiral chromatography columns market in the region. For instance, according to American Association for the Advancement of Science (AAAS), the funding for National Institutes of Health (NIH) for fiscal year 2022 was increased by 15% compared to fiscal year 2021.

  • Europe

The Europe chiral chromatography columns market is accounted to hold a significant market share in 2020. Europe also houses several key players in the region, such as, Merck KGaA (Germany), Biotage (Sweden), and KNAUER WissenschaftlicheGeräte GmbH (Germany). These key players are also launching new products and investing in production facilities, further driving market growth. For instance, in August 2021, CARBOGEN AMCIS (Switzerland) signed a co-investment agreement with one of its key European customers. The investment includes the additions to the CARBOGEN AMCIS Neuland site of a medium pressure chromatography column (200L), a preparative 20 cm HPLC system and short path distillation equipment. This agreement is following a previous USD 6.5 million investment made in 2017 by the same customer for CARBOGEN AMCIS’ Neuland site.

  • Asia-Pacific

The rapid growth of the Asia-Pacific market is due to the developing infrastructure for research and increasing manufacturing companies, and an increase in the number of academic institutes. Countries like Japan in this region have well developed healthcare infrastructure along with the presence of key company headquarters like Daicel Corporation (Japan), and Shimadzu Corporation (Japan), whereas India is rapidly developing in the healthcare R&D space. China had spent the highest R&D expenditure up till 2020 which had increased by 10.3% in 2020. These factors enable the Asia-Pacific region to grow at the highest CAGR during forecast period.

  • Rest of the World

The Rest of the World region is segmented into the Middle East, Africa, and Latin America. The chiral chromatography columns market in the region is driven by technological developments and the growing number of research studies. Government initiatives to bring technological advancements in the region and global players expanding R&D capabilities in the region, drive growth for market here.

Competitive Landscape

The global chiral chromatography columns market is characterized by the presence of many global, regional, and local vendors catering to the demand created by research scientists and pharmaceutical and biotechnology companies operating in the industry. The growing demand from researchers and manufacturers is propelling the chiral chromatography columns market growth. The market is highly competitive, with players competing and partnering to gain a substantial market share. For instance, in January 2021, Sartorius (France) acquired Novasep's (France) chromatography process equipment division. The prominent players are involved in strategic agreements and joint ventures to sustain their market positions.

List of companies with HQ

  • Agilent Technologies, Inc. (US)

  • Thermo Fisher Scientific (US)

  • Waters Corporation (US)

  • Daicel Corporation (Japan)

  • Bio-Rad Laboratories (US)

  • R. Grace and Company (US)

  • PerkinElmer Inc. (US)

  • Shimadzu Corporation (Japan)

  • Sartorius AG (Germany)

  • Danaher Corporation (US)

  • MACHEREY-NAGEL (Germany)

  • KNAUER (Germany)

  • Dishman Carbogen Amcis (India)

  • Others

Recent Developments

  • Cytiva (US) and Pall Corporation (US), both part of Danaher Corporation (US) are expected to invest USD 500 million through 2022. These investments will fuel new sites opening in the US and the UK to hire 2000 associates over the next two years. Similarly, investments have been attracted through UAE-UK Sovereign Investment Partnership agreement that will invest USD 1.3 billion in British life science companies over the coming years.

  • YMC America Inc. (US) completed the combination and expansion of its US operations at Devens, Massachusetts to up-scale large-scale purification systems in July 2021.

  • Techcomp Instruments Ltd (Hong Kong) announced in April 2021 that one of its companies Scion Instruments NL BV (Netherlands), acquired the Teledyne Tekmar Headspace product Lines from Teledyne Instruments, Inc. (US)

  • Dishman Carbogen Amcis Ltd. (India) in August 2020 announced expansion project commissioning new facilities to be constructed in France and Switzerland. This project will incur approximately USD 110 million by 2024 to build new manufacturing units.

  • In April 2020, Boston Pharmaceuticals (US) completed phase I clinical trial to study safety and tolerability of BOS172767 Enantiomers in healthy subjects at Quotient Sciences (UK), a pharmaceutical contract development and manufacturing organization.

  • In January 2019, Chiral Technologies, Inc. (US), a subsidiary of Daicel Corporation (Japan) acquired Arbor Biosciences (US). This acquisition diversified Chiral Technologies‚Äô innovative and cost-effective solutions and services offering.

  • In February 2019, Showa Denko America, Inc. (US), a subsidiary of Showa Denko K. K. (Japan) launched a new applications laboratory in New York City. This laboratory tests samples from customers to suggest best columns to be used for chromatography and helps in executing long-term projects.

Report Overview

The study covers the existing short-term and long-term market effects, as well as helping decision-makers to draught short-term and long-term plans for businesses by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's Five Forces, Value Chain, and impact of COVID-19 on the market.

Scope of the Report

The scope of the global chiral chromatography columns market study includes market size analysis and a detailed analysis of the manufacturer's products and strategies. The market has been segmented based on material, product, technology, end user and region.

Market Segmentation:

Global Chiral Chromatography Columns Market, By Material

  • Metal-based Columns

  • Glass-based Columns

  • Plastic-based Columns

Global Chiral Chromatography Columns Market, By Product

  • Prepacked Columns

  • Empty Columns

Global Chiral Chromatography Columns Market, By Technology

  • Liquid Chromatography

  • Gas Chromatography

  • Supercritical Fluid Chromatography

  • Thin Layer Chromatography

  • Flash Chromatography

Global Chromatography Columns Market, By End User

  • Pharmaceutical & Biotechnology Companies

  • Academic Institutes

  • Food & Beverage Manufacturers

  • Hospitals & Diagnostic Clinics

  • Environmental Testing Laboratories

  • Cosmeceutical Companies

  • Nutraceutical Companies

Global Chromatography Columns Market, By Region

  • North America

    • US

    • Canada

  • Europe

    • Germany

    • France

    • UK

    • Italy

    • Spain

    • Rest of Europe

  • Asia-Pacific

    • China

    • Japan

    • ¬†India

    • ¬†Australia

    • ¬†South Korea

    • ¬†Rest of Asia-Pacific

  • Rest of the World

    • Middle East

    • ¬†Africa

    • Latin America

Report Attribute/Metric Details
  Market Size   USD 104.34 Million
  CAGR   ~4.20%
  Base Year   2021
  Forecast Period   2022-2030
  Historical Data   2020
  Forecast Units   Value (USD Million)
  Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Material, Product, Technology, and End User
  Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
  Key Vendors   Agilent Technologies, Inc. (US),Thermo Fisher Scientific (US),Waters Corporation (US),Daicel Corporation (Japan),Bio-Rad Laboratories (US),W. R. Grace and Company (US),PerkinElmer Inc. (US),Shimadzu Corporation (Japan),Sartorius AG (Germany),Danaher Corporation (US),MACHEREY-NAGEL (Germany),KNAUER (Germany),Dishman Carbogen Amcis (India),Others
¬†¬†Key Market Opportunities ¬†¬†‚ÄĘ Development of sustainable production processes
  Key Market Drivers   Increasing availability of funds and growth in investment activities, Higher dependence on chromatography tests for drug approvals, Technological advancements in chiral chromatography columns

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