Cell Line Development Market Research Report: Information By Type (Primary cell, Hybridoma Cell Line, Continuous Cell Line, Recombinant Cell Line), By Product (Equipment, Media and Reagents), Scource Mammalian cells, Non Mammalian cells), Application (Drug Discovery, Bioproduction, Tissue Engineering, Others), Region (North America, Europe, Asia-Pacific, Rest of the World) Forecast till 2027

Cell Line Development Market Overview

The cell line development market is expected to cross USD 10,700 million in 2027 at a CAGR of ~12.5% during the forecast period. Cell line development (CLD) is a process that is being used for a variety of research and drug development and production application such as drug target identification and biologic drug production. The process begins by selecting host cells; the most commonly used host cells are Chinese Hamster Ovary (CHO)or HEK293 cells. The cell line development market growth can be attributed to the growing vaccine production globally, the developing biotechnology sector, and the rising demand for monoclonal antibodies. However, there are pitfalls in the cell line development market, such as complex regulatory scenarios and stem cell research issues.

COVID-19 Analysis

The rising prevalence of COVID-19 is projected to influence cell line development market growth over the forecast period.  As the coronavirus outbreak continues, the majority ofthe pharmaceutical companies experienced a significant loss, thereby hampering the cell line development market.The COVID-19 pandemic has highly affected the economy across the globe; this severely impacts the production process and demand across numerous verticals and disrupts the supply chain.

Many companies halted their manufacturing and supply operations in the initial phase of the pandemic. However, the current situation of COVID-19 is expected to reach normalcy since the medical professionals and health authorities in the countries are taking the necessary steps to fight against the virus. Furthermore, pharmaceutical companies and research institutions worldwide are high have shifted their research activities in finding vaccine for COVID-19, thereby putting the development of other therapeutics on hold.

Market Drivers

Increasing R&D and introduction of new technologies for cell line development

• The rise in research activities in cell line development as a crucial step triggers the demand for cell line development


• Companies are involved in R&D and are collaborating with other companies. For instance, in September 2020,Octapharma (Switzerland), one of the world’s leading manufacturers of therapeutic human proteins, chose Genedata Selector (Switzerland) as its central computational platform to streamline next-generation sequencing-based cell line development and cell culture optimization workflows. The collaboration was carried out toshorten development cycles and increase efficiency.


• Moreover, the introduction of advanced technologies in the cell line development processisanticipated to propel cell line development market growth over the study period. For instance, Lonza Group (Switzerland)—in November 2017—launched a Multiplex Cell line culture that uses a GS Xceed Gene Expression System; this helps in testing multiple drug candidates at the early developmental stage, thereby saving four to six months, which otherwise is required in the conventional development program.

Rise in vaccine productionby using cell line development process

• Cells are being used as a host for many vaccines, such as vaccines for influenza and rabies. These cells are grown under controlled laboratory conditions. Cell culture-based vaccine production is being used for many years—in this process, the virus is propagated in animal cells and harvested. Downstream processing parameters are used for purification, followed by filing and packaging of the vaccine. Therefore, increasing the use of cell lines in vaccine development procedures is boosting the cell line development market growth of cell line development.

Market Restraints

High capital investment and complexity associated with the cell development process

• Cell line development can be tedious and time-consuming atevery stage in the CLD workflow, which acts as a restraint for cell line development market growth. In addition, the risk of contamination, misidentification, and random alternations in cell line development are hindering the growth of the cell line development market

Market Opportunities

Rising adoption of mammalian source for monoclonalantibody production

The cell line development process is initiated via organs or tissues collected from mammalians or non-mammalian sources. The source for this process is a prerequisite for the development of stable cell lines for commercial purposes. Therefore, the rising adoption of mammalian sourcesfor the production of monoclonal antibodies and the increasing demand for expressing complex proteins similar to human beings are anticipated to provide significant growth opportunities.

In addition, the improved quality cell engineering and expression systems for the development of this source are projected to fuel the cell line development market demand. There areapproximately 4,000 mammalian cell linesthat are available for use in biologics production and research. This factor is also likely to serve the mammalian source segment with lucrative opportunities.

Value Chain Analysis

Raw Material 

Raw materials are the primary input in the cell line development market and are the basic elements of the end-product. The raw material used in cell line development can be classified as high-tech and low-tech materials.  For instance, cell culture media used in cell line development are low-tech materials that include inorganic elements and components such as salts, calcium, basic mineral elements, etc. High-tech raw materials used in the manufacturing of cell culture media include materials such asserum, animal components, growth factors, etc., which are generally derived from donor patients. Thus, the first step in raw material management is segmenting the raw materials according to theirscarcity, cost, and its potential impact on the manufacturing process. 

Suppliers  

The suppliers supply the raw material to the manufacturing company, which is processed, molded, and shaped by the manufacturers for the manufacturing of the cell line. Supplier management is thus crucial for high-value and performance-dependent sectors.

Manufacturers  

In this process, the product strategies are ready, and the manufacturing process of the product starts. The manufacturing process begins with the assembling of raw materials. The sourcing of raw materials is the initial phase in the manufacturing of the devices. Raw materials that are required are base media components, growth matrix components, additives, promoters, and markers. The cost of this process can be reduced by finding substitutes for the raw material. Manufacturing is a fast process, which is followed by the testing of the products.  

Distributors  

The distributor is in charge of delivering the product to the client who initially had ordered the product, whose main goal remains the same to distribute the product on time in its original condition.  

The cell line development industry needs to partner and collaborate with market players such as large hospitals and even distributors of medical supplies

Customer-Retailers  

The customer is the organization that demands the product and sells it; this is likewise the part in the supply chain where the role of a supply chain regularly reaches an end. The cell line development manufacturers need to form a collaboration with large clients, industries, and hospitals. Collaboration between manufacturers and large players also favors market penetration as most consumers are not knowledgeable about the right cell culture media products suitable for their needs. 

Consumers  

The consumer is the end user that purchases the product and uses it. Pharmacy and biotech companies, laboratories are the people that finally implement the product. Thus, the goal is to increase the value for the consumer, which has led to the extension of the supply chain to include final consumers and even post-market reverse logistics. There is an urgent need to leverage social media for generating product awareness and brand attraction. Real-time demand sensing by engaging consumers directly will trump forecast-based supply chain models.

Segment Overview

By Type

• Primary Cell Line

The primary cell line is expected to be the fastest-growing segment in 2020 dueto its various application in cell morphology, genetics, and cell metabolism. In the process of cell development, cells are extracted from normal, embryonic, and malignant tissues. These cells are propagated in vitro.

• Hybridoma Cell line

Hybridoma or (Chinese Hamster Ovary) CHO technology is used to create monoclonalantibodies. Hybrid cell ensures antibody production continuously in dividing cells. Increasing use of these hybrid cells for cell line development is driving the cell line development market growth for this segment. In addition, companies are also positioning themselves competitively in the cell line development landscape. For instance, in February 2017, GE Healthcare (US) entered a three-year collaboration with the Austrian Centre of Industrial Biotechnology to identify new techniques for optimizing CHO cell-line performance. The collaboration’s initial emphasis is on CHO cell-line growth and expression.

• Continuous Cell Line

Continuous cell culture is part of a trend in bioprocessing toward highly productive, streamlined, and interconnected unit operations.Increasing adoption of these types of cell lines in biopharmaceutical industries is driving the cell line development market growth for this segment.

• Recombinant Cell Line

The recombinant protein production used in mammalian cells and insect cell lines is called a recombinant cell line. The recombinant cell line segment held the largest share in 2020, owing to factors such as rising demand for recombinant proteins and the adoption of recombinant cell lines of biotherapeutics.Moreover, increasing demand for toxicity testing is also contributing to the growth of this cell line development market segment.

By Product

• Equipment

Based on the equipment, of global cell line development market is segmented into incubators, centrifuges, bioreactors, storage equipment, microscopes, and others. These equipment are majorly being used for the large-scale development of cell lines for various applications.

• Media and Reagents

Based on the media and reagents segment is further divided into serum, media, and reagents.Media and reagents segment held the largest share in the year 2020. Increasing use of these consumables for cell line development is fueling the cell line development market growth of this segment.An increasing number of laboratory setups for biologics production and R&D activities also contribute to cell line development market growth.

By Source

• Mammalian cells

Mammalian cells are expected to hold the major share in 2021. The key factor attributing to the growth of the cell line development market is the rising adoption of a mammalian source for the production ofmonoclonal antibodies (mAbs). The necessity for expressing complex proteins similar to human beings is alsoexpected to boost the adoption of this productin the coming years.

• Non Mammalian cells

Based on the source of global cell line development, the non-mammalian segmented is segmented into insects and amphibians. Protein therapeutics mAbs peptides and recombinant proteins represent the largest group of new products in development by the biopharmaceutical industry. These protein therapeutics are derived from non-mammalian sources for cell line development; this aids in boosting the cell line development market growth of this segment.

By Application

• Drug Discovery:

Cell line development is a major step for assessing the efficiency of drug discovery, toxicity, and in vitro testing. The advantages of cell line development in this process include reduced time, effort, and cost, which minimizes the chance of research drugs failing at the clinical trial stage. This is attributing to the cell line development market growth of this segment.

• Bioproduction:

The bioproduction segment held the largest share in 2020 due to factors such as the wideavailability of cell lines for bioproduction, the increasing number of antibiotics, and vaccine production. These factors are contributing to the cell line development market growth of this segment.

• Tissue Engineering

Tissue engineering is the construction of bioartificial tissues in vitro as well as within vivo methods of cell growth and function via implantation of suitable cells isolated from donor tissue and biocompatible scaffold materials. Increasing adoption of the cell line for tissue engineering is boosting the cell line development market growth of this segment.

• Others

Others include toxicity testing,regenerative medicine, etc.The increasing use of cell lines in these applications is driving the cell line development market growth of this segment.

By Region

North America:

The market in North America accounted for the largest share in 2020 due to the presence of constant technological developments followed by new discoveries triggering the adoption of novel procedures for bioproduction. The presence of well-established players involved in new launches and collaborationsfor cell line development, such as Thermo Fisher Scientific Inc. (US), American Type Culture Collection (ATCC), and Sigma-Aldrich Corporation (US), which provide high-quality biologics services, is contributing to the cell line development market growth. For instance, in October 2019, ATCC (US)launcheda portfolio of exosomes (i.e., extracellular vesicles) derived from human cells to serve as reference materials or standards for a variety of research applications. The first two exosomes available to researchers are derived from the A549 non-small cell lung cancer (NSCLC) cell line and hTERT-immortalized mesenchymal stem cells.

Europe:

The European cell line development market is driven bysupportive government initiatives for cell line development procedures and growing awareness pertaining to monoclonal antibodyapplications in cancer treatment.

Asia-Pacific:

The Asia-Pacific is expected to witness rapid growth in the global cell line development market. Asia-Pacific regional market is anticipated to witness lucrative growth due to increasing healthcare expenditure by government and private sector companies. For instance, in India, the Department of Science and Technology (DST), Department of Biotechnology (DBT), Department of Scientific & Industrial Research (DSIR)  are regulating the production and guidelines for biotechnology products. These organizations provide guidelines related to manufacturing or transferring of technology and generating manpower for productionraising funds.

Rest of the World:

The cell line development market in the rest of the world is driven bytechnological development in the biotechnology industry, manufacturing, screening technologies, and assays. The increasing number of government initiatives for improving the healthcare sector is another factor boosting the growth of the cell line development market in this region.

Competitive Landscape

The cell line development market is profitable, both for existing players as well as new entrants. A substantial level of competitive rivalry is witnessed among the market players. Based on the analysis, that market players have adopted different strategies and innovative research and development techniques to expand their business and secure their position in the global cell line development market. For instance, in 2018, Denali Therapeutics (US) entered into a partnership with Lonza (Switzerland) to develop and produce biologic medicines using the latter’s cell line development technology GS Xceed.The prominent players are involved in strategic agreements, product launches, and joint ventures to sustain their market positions.

Key Players

• American Type Culture Collection (ATCC) (US)


• Lonza Group AG (Switzerland)


• Thermo Fisher Scientific, Inc. (US)


• GE Healthcare (US)


• Sigma-Aldrich Corporation (US)


• Selexis SA (Switzerland)


• Promega Corporation (US)


• Corning, Inc. (US)


• WuXiAppTec, Inc. (China)


• Sartorious AG (Germany)

Recent Developments

• In October 2019, American Type Culture Collection announced the launch of a mouse cell line authentication service in partnership with the National Institutes for Standards and Technology (NIST). This partnership has helped the company to expand its cell line business portfolio as well as its existing customer base.


• In February 2017, Lonza entered a strategic partnership with Sanofi, to establish mammalian cell culture facilities for the production of monoclonal antibodies in Switzerland. This strategy enabled the company to expand geographically and garner more revenue.

Report Overview:

The study covers the existing short-term and long-term market effect, as well as helping decision-makers to draught short-term and long-term plans for businesses by region. The report covers major regions in North America, Europe, Asia-Pacific, and therest of the world. The report analyzes market drivers, restraints, opportunities, challenges, Porter’s Five Forces, Value Chain, and impact of COVID-19 on the market.

Scope of the Report
The scope of the global cell line development market study includes a market size analysis and a detailed analysis of the manufacturer’s products and strategies. The market has been segmented based on type, product, source, application, and region.

Key Vendors

• American Type Culture Collection (ATCC) (US.)


• Lonza Group AG (Switzerland)


• Thermo Fisher Scientific, Inc. (US.)


• GE Healthcare (US.)


• Sigma-Aldrich Corporation (U.S.)


• Selexis SA (Switzerland)


• Promega Corporation (US)


• Corning, Inc. (US.)


• WuXiAppTec, Inc. (China)


• Sartorious AG (Germany)

Key Market Opportunities

Rising adoption of mammalian cells for monoclonal antibody production

Key Market Drivers

• Increasing R&D and introduction of new technologies for cell line development


• Rise in vaccine production by using cell line development process

 Market Segmentation

Global Cell Line Development, by Type

• Primary Cell line


• Hybridoma Cell line


• Continuous Cell line


• Recombinant Cell line

Global Cell Line Development, by Product

• Equipment


• Incubators


• Centrifuges


• Bioreactors


• Storage Equipments


• Microscopes


• Others


• Media and Reagents

Global Cell Line Development, by Source

• Mammalian Cells


• Non Mammalian Cells
  
  
  
  • Insects
  
  
  • Amphibians
  
  
  
  

Global Cell Line Development, by Application

• Drug Discovery


• Bio-production


• Tissue Engineering


• Others

Global Cell Line Development, by Region

• North America
  
  
  
  • US
  
  
  • Canada
  
  
  
  


• Europe
  
  
  
  • Germany
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • Australia
  
  
  • South Korea
  
  
  • Rest of Asia-Pacific
  
  
  
  


• Rest of the World


• Middle East


• Africa


• Latin America

Report Scope:

Report Attribute/Metric	Details
Market Size	2027: USD 10,700 Million
CAGR	12.5% (2020-2027)
Base Year	2019
Forecast Period	2020-2027
Historical Data	2018
Forecast Units	Value (USD Million)
Report Coverage	Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
Segments Covered	Type, Product, Source, Application
Geographies Covered	North America, Europe, Asia-Pacific, and Rest of the World (RoW)
Key Vendors	American Type Culture Collection (ATCC) (US), Lonza Group AG (Switzerland), Thermo Fisher Scientific Inc. (US), GE Healthcare (US), Sigma-Aldrich Corporation (US), Selexis SA (Switzerland), Promega Corporation (US), Corning Inc. (US), WuXiAppTec Inc. (China), Sartorious AG (Germany)
Key Market Opportunities	Rising adoption of mammalian source for monoclonalantibody production
Key Market Drivers	The rise in research activities in cell line development as a crucial step triggers the demand for cell line development Companies are involved in R&D and are collaborating with other companies. Introduction of advanced technologies Rise in vaccine productionby using cell line development process

Frequently Asked Questions (FAQ) :

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