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US Neurodegenerative Disease Market

ID: MRFR/LS/51020-HCR
200 Pages
Rahul Gotadki
October 2025

US Neurodegenerative Disease Market Research Report By Disease Type (Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Huntington's Disease), By Diagnosis Method (Neurological Examination, Imaging Techniques, Cerebrospinal Fluid Analysis, Electrophysiological Tests), By Treatment Type (Medication, Therapy, Rehabilitation, Surgical Interventions) and By Route of Administration (Oral, Injectable, Intravenous, Transdermal)-Forecast to 2035

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US Neurodegenerative Disease Market Summary

As per MRFR analysis, the US neurodegenerative disease market size was estimated at 14.5 USD Billion in 2024. The US neurodegenerative disease market is projected to grow from 15.67 USD Billion in 2025 to 34.0 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 8.05% during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The US neurodegenerative disease market is experiencing transformative growth driven by innovative approaches and demographic shifts.

  • The market is witnessing a rise in personalized medicine, tailoring treatments to individual patient profiles.
  • Investment in research and development is increasing, fostering advancements in therapeutic options.
  • Telehealth services are expanding, enhancing access to care for patients with neurodegenerative diseases.
  • Key market drivers include an aging population and increased incidence of neurodegenerative disorders, alongside advancements in diagnostic technologies.

Market Size & Forecast

2024 Market Size 14.5 (USD Billion)
2035 Market Size 34.0 (USD Billion)
CAGR (2025 - 2035) 8.05%

Major Players

Biogen (US), Eli Lilly (US), Roche (CH), Novartis (CH), AstraZeneca (GB), Merck & Co. (US), Amgen (US), Sanofi (FR), AbbVie (US)

US Neurodegenerative Disease Market Trends

The neurodegenerative disease market is currently experiencing notable transformations driven by advancements in research and technology. Increased awareness of these conditions has led to a surge in demand for innovative therapies and diagnostic tools. As the population ages, the prevalence of neurodegenerative diseases is expected to rise, prompting healthcare systems to adapt and respond effectively. This evolving landscape suggests a potential for growth in both treatment options and supportive care services, as stakeholders seek to address the complex needs of affected individuals. Moreover, the integration of personalized medicine into the neurodegenerative disease market appears to be gaining traction. Tailored therapies that consider genetic and environmental factors may enhance treatment efficacy and patient outcomes. Additionally, collaborations between pharmaceutical companies, research institutions, and healthcare providers are likely to foster the development of novel solutions. As the market continues to evolve, it remains crucial for stakeholders to stay informed about emerging trends and innovations that could shape the future of care for neurodegenerative diseases.

Rise of Personalized Medicine

The neurodegenerative disease market is witnessing a shift towards personalized medicine, which focuses on tailoring treatments to individual patient profiles. This approach may enhance therapeutic effectiveness and minimize adverse effects, as it considers genetic, environmental, and lifestyle factors. As research progresses, the development of targeted therapies could revolutionize treatment paradigms.

Increased Investment in Research and Development

Investment in research and development within the neurodegenerative disease market is on the rise. This trend is driven by the urgent need for effective therapies and diagnostic tools. Public and private funding initiatives are likely to support innovative projects aimed at understanding disease mechanisms and discovering new treatment options.

Expansion of Telehealth Services

The neurodegenerative disease market is experiencing an expansion of telehealth services, which provide remote access to healthcare professionals. This trend may improve patient engagement and access to care, particularly for those in underserved areas. Telehealth could facilitate ongoing monitoring and support for individuals with neurodegenerative conditions.

US Neurodegenerative Disease Market Drivers

Regulatory Support and Incentives

Regulatory support and incentives play a pivotal role in shaping the neurodegenerative disease market. The U.S. Food and Drug Administration (FDA) has implemented various programs aimed at expediting the approval process for therapies targeting neurodegenerative conditions. Initiatives such as the Breakthrough Therapy Designation and Fast Track designation are designed to facilitate the development of promising treatments. This regulatory environment encourages pharmaceutical companies to invest in research and development, potentially leading to a more robust pipeline of therapies. As a result, the neurodegenerative disease market is likely to benefit from an influx of innovative treatment options in the coming years.

Increased Focus on Drug Development

The neurodegenerative disease market is witnessing a surge in drug development efforts, driven by the urgent need for effective treatments. Pharmaceutical companies are increasingly investing in research to develop novel therapies targeting the underlying mechanisms of diseases such as Alzheimer's and Huntington's. The market for neurodegenerative drugs is projected to reach $50 billion by 2027, reflecting a robust pipeline of investigational drugs. This focus on drug development is not only fostering innovation but also attracting significant venture capital investment, which may further accelerate advancements in the neurodegenerative disease market.

Advancements in Diagnostic Technologies

Technological advancements in diagnostic tools are transforming the neurodegenerative disease market. Innovations such as advanced imaging techniques and biomarker identification are enabling earlier and more accurate diagnoses. For instance, the use of PET scans and MRI has improved the detection of neurodegenerative diseases, allowing for timely intervention. The market for diagnostic tools is expected to grow at a CAGR of around 8% through the next decade, reflecting the increasing emphasis on precision medicine. Enhanced diagnostic capabilities not only facilitate better patient outcomes but also drive demand for subsequent therapeutic options, thereby expanding the overall neurodegenerative disease market.

Aging Population and Increased Incidence

The aging population in the United States is a critical driver of the neurodegenerative disease market. As individuals age, the risk of developing neurodegenerative conditions such as Alzheimer's and Parkinson's disease escalates. Current estimates suggest that by 2030, approximately 20% of the U.S. population will be over 65 years old, leading to a projected increase in the prevalence of these diseases. This demographic shift is likely to create a substantial demand for innovative therapies and care solutions within the neurodegenerative disease market. Furthermore, the economic burden associated with these diseases is significant, with costs projected to exceed $1 trillion annually by 2050, emphasizing the urgent need for effective interventions.

Growing Awareness and Education Initiatives

There is a notable increase in awareness and education initiatives surrounding neurodegenerative diseases, which is positively impacting the market. Campaigns aimed at educating the public about the symptoms and early signs of these conditions are crucial for early diagnosis and treatment. Organizations and healthcare providers are increasingly investing in outreach programs, which may lead to a higher rate of diagnosis and treatment initiation. This heightened awareness is likely to contribute to a growing patient population seeking care, thereby driving the neurodegenerative disease market. As more individuals become informed, the demand for both therapeutic and supportive services is expected to rise.

Market Segment Insights

By Disease Type: Alzheimer's Disease (Largest) vs. Parkinson's Disease (Fastest-Growing)

In the US neurodegenerative disease market, Alzheimer's Disease holds a significant share, being recognized as the largest segment. This market share reflects the substantial impact and prevalence of Alzheimer's on the population, driving extensive research & development efforts. Parkinson's Disease, on the other hand, has been gaining traction and is identified as the fastest-growing segment, showcasing a rising interest in its treatment options and the increasing number of diagnosed cases. The growth trends in this segment are influenced by various factors, including aging populations and advancements in technology leading to improved diagnostic methods. Increased awareness about neurodegenerative diseases is also a critical driver, prompting earlier diagnoses and treatment interventions. Furthermore, pharmaceutical companies are investing more in innovative therapies for both Alzheimer's and Parkinson's, pushing these segments further into the spotlight of the US neurodegenerative disease market.

Alzheimer's Disease (Dominant) vs. Parkinson's Disease (Emerging)

Alzheimer's Disease remains the dominant force in the US neurodegenerative disease market, characterized by a high prevalence and significant societal impact. Its long-standing recognition has led to a steady pipeline of therapies aimed at managing symptoms and slowing disease progression. This segment is characterized by a broad range of treatment options, including traditional medications and emerging therapies that target underlying disease mechanisms. On the other hand, Parkinson's Disease is rapidly emerging, driven by increasing diagnosis rates and a growing awareness of the disease's complexities. The focus on innovative treatment approaches is solidifying its position within the market. Enhanced funding for research and the development of personalized medicine strategies are key components shaping both segments' futures.

By Diagnosis Method: Neurological Examination (Largest) vs. Imaging Techniques (Fastest-Growing)

The US neurodegenerative disease market segment for diagnosis methods showcases a diverse landscape. Neurological examinations maintain the largest market share, attributed to their long-standing role in diagnosing conditions like Alzheimer's and Parkinson's. Imaging techniques, while currently smaller in share, are rapidly gaining traction due to advancements in technology and the increasing need for accurate and early diagnosis. In recent years, there has been a significant increase in the adoption of imaging techniques, driven by technological advancements such as MRI and PET scans that provide detailed insights into neurodegenerative conditions. Moreover, the growing prevalence of neurodegenerative diseases has led to greater emphasis on timely and reliable diagnosis, further fueling the growth of segments like cerebrospinal fluid analysis and electrophysiological tests, which are also vital in this market.

Neurological Examination (Dominant) vs. Imaging Techniques (Emerging)

Neurological examinations are the dominant method for diagnosing neurodegenerative diseases, relying primarily on patient history and clinical assessments to identify symptoms and impairments. This method remains widely trusted due to its direct engagement with patients and the ability to observe symptoms in real-time. Conversely, imaging techniques represent an emerging trend within the market; they leverage advanced technologies to visualize brain structures and functions. Techniques like MRI and CT scans are becoming essential for accurate diagnosis, supporting neurological examinations by providing critical visual data that enhances understanding of disease progression. As these technologies advance, they are expected to grow significantly in market share, reflecting the shift towards more comprehensive diagnostic approaches.

By Treatment Type: Medication (Largest) vs. Therapy (Fastest-Growing)

The Treatment Type segment in the US neurodegenerative disease market is characterized by a diverse array of approaches including Medication, Therapy, Rehabilitation, and Surgical Interventions. Among these, Medication holds the largest share, making it the primary treatment option for many patients. Therapy, while smaller in current market share, has emerged rapidly due to increasing awareness and validation of non-pharmacological approaches in neurodegeneration treatment, indicating a dynamic shift in the treatment paradigms. Recent trends indicate a significant growth trajectory for Therapy, driven by innovations in personalized treatment plans and a greater focus on improving quality of life for patients. Additionally, a growing emphasis on holistic approaches to neurodegenerative conditions has fueled interest and investment in Therapy. As the landscape evolves, Rehabilitation and Surgical Interventions are also gaining traction, albeit at a slower pace, as they complement the primary treatment modalities.

Medication (Dominant) vs. Therapy (Emerging)

Medication as the dominant segment leverages established pharmacological advances to treat conditions such as Alzheimer's and Parkinson's effectively, ensuring a high level of reliance from healthcare providers. Its comprehensive nature addresses various symptoms and stages of neurodegeneration, giving it an edge in clinical settings. Meanwhile, Therapy is positioned as an emerging force, increasingly recognized for its efficacy in enhancing cognitive function and emotional well-being. As non-invasive techniques become more sophisticated, Therapy is receiving more attention and investment, particularly in conjunction with Medication. This synergy enhances patient outcomes and underpins the ongoing evolution of treatment strategies within the US neurodegenerative disease market.

By Route of Administration: Oral (Largest) vs. Injectable (Fastest-Growing)

The US neurodegenerative disease market demonstrates diverse preferences in routes of administration, with oral administration being the largest segment. This preference is attributed to patient convenience and ease of use, allowing for wider compliance. Injectable routes follow, primarily influenced by specific therapeutic needs and the effectiveness of delivery systems that target complex conditions. Growth trends indicate a substantial rise in the injectable segment, driven by advances in formulation technologies and an increasing focus on biologics. Patients may also prefer transdermal options for chronic conditions, enhancing their treatment experience. As healthcare systems evolve, the demand for formulations that offer rapid onset and sustained therapeutic outcomes contributes to the growth of these segments.

Oral (Dominant) vs. Injectable (Emerging)

Oral administration has established itself as the dominant route in the US neurodegenerative disease market, favored by patients for its simplicity and non-invasive nature. This segment includes various formulations such as tablets and capsules, providing flexibility and comfort for long-term treatment. On the other hand, the injectable segment is emerging rapidly, driven by the need for more effective delivery of therapeutics that may otherwise be ineffective through oral routes. Innovations in delivery systems, along with an increasing volume of biologics entering the market, are enhancing the appeal of injectables. As these segments evolve, they reflect the changing dynamics of patient preferences and treatment needs.

Get more detailed insights about US Neurodegenerative Disease Market

Key Players and Competitive Insights

The neurodegenerative disease market is characterized by intense competition and rapid innovation, driven by an increasing prevalence of conditions such as Alzheimer's and Parkinson's disease. Key players are focusing on advanced therapeutic solutions, with a notable emphasis on biologics and personalized medicine. Companies like Biogen (US) and Eli Lilly (US) are at the forefront, leveraging their robust R&D capabilities to develop novel treatments. Biogen, for instance, has been concentrating on enhancing its pipeline of disease-modifying therapies, while Eli Lilly is investing heavily in partnerships to accelerate drug development. This strategic positioning fosters a competitive environment where innovation is paramount, and companies are compelled to differentiate themselves through unique offerings and advanced technologies.

In terms of business tactics, companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and responsiveness to market demands. The competitive structure of the market appears moderately fragmented, with several players vying for market share. However, the influence of major companies like Roche (CH) and Novartis (CH) remains substantial, as they continue to expand their portfolios through strategic acquisitions and collaborations, thereby shaping the overall market dynamics.

In October 2025, Roche (CH) announced a collaboration with a leading biotech firm to develop a novel gene therapy aimed at treating rare neurodegenerative disorders. This strategic move is significant as it not only diversifies Roche's product offerings but also positions the company as a pioneer in gene therapy, potentially leading to breakthroughs in treatment options that could redefine patient care in this space. The collaboration underscores Roche's commitment to innovation and its proactive approach to addressing unmet medical needs.

In September 2025, Eli Lilly (US) launched a new clinical trial for a promising Alzheimer's treatment that utilizes a novel mechanism of action. This initiative is crucial as it reflects the company's dedication to exploring innovative therapeutic avenues, which may enhance its competitive edge in a market that is increasingly leaning towards personalized medicine. The trial's outcomes could significantly impact the treatment landscape, potentially establishing Eli Lilly as a leader in neurodegenerative therapies.

In August 2025, Biogen (US) expanded its partnership with a technology firm to integrate AI-driven analytics into its drug development processes. This strategic action is indicative of the growing trend towards digital transformation within the industry. By harnessing AI, Biogen aims to streamline its R&D efforts, reduce time-to-market for new therapies, and ultimately improve patient outcomes. This move not only enhances operational efficiency but also positions Biogen favorably against competitors who may lag in technological adoption.

As of November 2025, the competitive landscape is increasingly defined by trends such as digitalization, sustainability, and the integration of AI technologies. Strategic alliances are becoming more prevalent, as companies recognize the value of collaboration in driving innovation and enhancing market presence. Looking ahead, it is likely that competitive differentiation will evolve, shifting from traditional price-based competition to a focus on innovation, technological advancements, and supply chain reliability. This transition may redefine how companies approach market entry and product development, emphasizing the importance of agility and responsiveness in a rapidly changing environment.

Key Companies in the US Neurodegenerative Disease Market market include

Industry Developments

In recent developments within the US Neurodegenerative Disease Market, a notable focus has been on Vertex Pharmaceuticals and Acadia Pharmaceuticals, which are advancing their pipelines for treatments related to various neurodegenerative conditions. In October 2023, AbbVie announced positive results from a phase 3 study for its Alzheimer’s drug, indicating progress in addressing cognitive decline. Furthermore, Biogen and Eli Lilly are engaged in collaborative Research and Development efforts aimed at innovative therapies for Alzheimer’s and related disorders, showcasing the trend of strategic partnerships in the industry.

Recent acquisitions include Amgen's strategic purchase of a biotech firm in August 2023, aiming to enhance its capabilities in neurodegenerative disease therapies. Acorda Therapeutics continues to experience growth attributed to its market strategies and product offerings, reflecting a broader trend of increasing market valuation across the sector, which is projected to expand significantly in the coming years. The ongoing investments and mergers signal a robust activity in tackling neurodegenerative diseases, with significant implications for patients and healthcare providers in the US. Major market players such as Roche and Novartis maintain competitive momentum through innovative clinical trials and product launches.

Future Outlook

US Neurodegenerative Disease Market Future Outlook

The Neurodegenerative Disease Market is projected to grow at 8.05% CAGR from 2024 to 2035, driven by advancements in therapeutics, increasing prevalence, and enhanced diagnostic technologies.

New opportunities lie in:

  • Development of personalized medicine solutions for neurodegenerative disorders.
  • Expansion of telehealth services for remote patient monitoring and consultations.
  • Investment in AI-driven drug discovery platforms targeting neurodegenerative diseases.

By 2035, the neurodegenerative disease market is expected to achieve substantial growth and innovation.

Market Segmentation

US Neurodegenerative Disease Market Disease Type Outlook

  • Alzheimer's Disease
  • Parkinson's Disease
  • Multiple Sclerosis
  • Amyotrophic Lateral Sclerosis
  • Huntington's Disease

US Neurodegenerative Disease Market Treatment Type Outlook

  • Medication
  • Therapy
  • Rehabilitation
  • Surgical Interventions

US Neurodegenerative Disease Market Diagnosis Method Outlook

  • Neurological Examination
  • Imaging Techniques
  • Cerebrospinal Fluid Analysis
  • Electrophysiological Tests

US Neurodegenerative Disease Market Route of Administration Outlook

  • Oral
  • Injectable
  • Intravenous
  • Transdermal

Report Scope

MARKET SIZE 2024 14.5(USD Billion)
MARKET SIZE 2025 15.67(USD Billion)
MARKET SIZE 2035 34.0(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR) 8.05% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Billion
Key Companies Profiled Biogen (US), Eli Lilly (US), Roche (CH), Novartis (CH), AstraZeneca (GB), Merck & Co. (US), Amgen (US), Sanofi (FR), AbbVie (US)
Segments Covered Disease Type, Diagnosis Method, Treatment Type, Route of Administration
Key Market Opportunities Advancements in personalized medicine and digital health technologies enhance treatment options in the neurodegenerative disease market.
Key Market Dynamics Rising demand for innovative therapies drives competition and regulatory scrutiny in the neurodegenerative disease market.
Countries Covered US

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FAQs

What is the expected market size of the US Neurodegenerative Disease Market in 2024?

The expected market size of the US Neurodegenerative Disease Market in 2024 is valued at 4.8 USD Billion.

What is the projected market size of the US Neurodegenerative Disease Market in 2035?

The projected market size of the US Neurodegenerative Disease Market in 2035 is valued at 9.0 USD Billion.

What is the expected compound annual growth rate (CAGR) for the US Neurodegenerative Disease Market from 2025 to 2035?

The expected compound annual growth rate (CAGR) for the US Neurodegenerative Disease Market from 2025 to 2035 is 5.881%.

Which disease type holds the largest market share within the US Neurodegenerative Disease Market?

Alzheimer's Disease holds the largest market share within the US Neurodegenerative Disease Market, with a value of 1.5 USD Billion in 2024.

What is the expected market size for Parkinson's Disease in 2035?

The expected market size for Parkinson's Disease in 2035 is 1.9 USD Billion.

Who are the major players in the US Neurodegenerative Disease Market?

Major players in the US Neurodegenerative Disease Market include Vertex Pharmaceuticals, Acadia Pharmaceuticals, and Biogen among others.

What will be the market size for Multiple Sclerosis in 2024?

The market size for Multiple Sclerosis in 2024 is valued at 0.9 USD Billion.

What is the expected market size for Amyotrophic Lateral Sclerosis by 2035?

The expected market size for Amyotrophic Lateral Sclerosis by 2035 is 1.0 USD Billion.

What are the key growth drivers influencing the US Neurodegenerative Disease Market?

Key growth drivers include rising prevalence of neurodegenerative diseases and advancements in drug development.

What is the expected market size for Huntington's Disease in 2024?

The expected market size for Huntington's Disease in 2024 is valued at 0.9 USD Billion.

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