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US Buergers Disease Market

ID: MRFR/Pharma/16778-HCR
100 Pages
Garvit Vyas
October 2025

US Buerger's Disease Market Research Report By Symptoms (Pain, Ulcers, Gangrene, Cold Hands and Feet), By Treatment Type (Medication, Surgical Procedures, Lifestyle Changes), By Diagnosis Method (Physical Examination, Doppler Ultrasound, Angiography) and By Patient Demographics (Age Group, Gender, Smoking Status) - Growth & Industry Forecast 2025 To 2035

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US Buergers Disease Market Summary

As per Market Research Future analysis, the US Buerger's Disease Market Size was estimated at 120.0 USD Million in 2024. The US Buerger's Disease Market is projected to grow from 126.8 USD Million in 2025 to 220.0 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 5.6% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The US Buerger's disease market is experiencing a notable shift towards innovative treatment options and increased awareness.

  • The market is characterized by a rising awareness and education regarding Buerger's disease among healthcare professionals and patients.
  • Advancements in treatment options are emerging, with a focus on innovative therapies that may improve patient outcomes.
  • Research and collaboration efforts are intensifying, potentially leading to breakthroughs in understanding and managing the disease.
  • The rising incidence of Buerger's disease and increased smoking rates are significant drivers propelling market growth.

Market Size & Forecast

2024 Market Size 120.0 (USD Million)
2035 Market Size 220.0 (USD Million)
CAGR (2025 - 2035) 5.67%

Major Players

Boehringer Ingelheim (DE), Novartis (CH), Pfizer (US), AstraZeneca (GB), Bristol-Myers Squibb (US), Sanofi (FR), Gilead Sciences (US), Eli Lilly and Company (US)

US Buergers Disease Market Trends

The Buerger's Disease Market is characterized by a growing awareness of the condition, which primarily affects blood vessels in the limbs. This awareness is crucial, as it leads to earlier diagnosis and treatment options for patients. Healthcare providers are increasingly recognizing the importance of educating patients about the risks associated with tobacco use, which is a significant contributing factor to the disease. As a result, there is a noticeable shift towards preventive measures and lifestyle modifications that can mitigate the impact of Buerger's Disease. Furthermore, advancements in medical technology and treatment options are enhancing patient outcomes, suggesting a positive trajectory for the market. In addition, the Buerger's Disease Market is witnessing an increase in research initiatives aimed at understanding the underlying mechanisms of the condition. This research is likely to pave the way for innovative therapies and interventions that could improve the quality of life for affected individuals. Collaboration between healthcare professionals, researchers, and patient advocacy groups appears to be fostering a more comprehensive approach to managing buergers disease. Overall, the market is evolving, with a focus on education, prevention, and research-driven solutions that may lead to better management of this challenging condition.

Increased Awareness and Education

There is a growing emphasis on educating both healthcare providers and patients about buergers disease. This trend is likely to enhance early diagnosis and treatment, ultimately improving patient outcomes.

Advancements in Treatment Options

Innovations in medical technology and therapeutic approaches are emerging, potentially offering new avenues for managing buergers disease. These advancements may lead to more effective interventions and improved quality of life for patients.

Research and Collaboration

Ongoing research initiatives are focusing on the pathophysiology of buergers disease. Collaborative efforts among researchers, healthcare professionals, and advocacy groups are fostering a more comprehensive understanding and management of the condition.

US Buergers Disease Market Drivers

Increased Smoking Rates

The correlation between smoking and Buerger's disease is well-established, and the current smoking rates in the US appear to be a significant driver for the Buerger's disease market. Despite various public health campaigns aimed at reducing tobacco use, smoking remains prevalent, particularly among certain demographics. This ongoing trend may lead to a higher incidence of Buerger's disease, thereby increasing the demand for specialized treatments and interventions. The Buerger's disease market could potentially benefit from targeted marketing strategies that address smoking cessation and its impact on disease progression. Additionally, healthcare providers may focus on educating patients about the risks associated with smoking, which could further stimulate the market as more individuals seek medical assistance for symptoms related to Buerger's disease.

Rising Incidence of Buerger's Disease

The increasing incidence of Buerger's disease in the US is a notable driver for the Buerger's disease market. Recent studies indicate that the prevalence of this condition is on the rise, particularly among younger populations who smoke. This trend suggests a growing need for effective treatment options and management strategies. As healthcare providers become more aware of the disease, the demand for diagnostic tools and therapeutic interventions is likely to increase. The Buerger's disease market may see a surge in investments aimed at developing innovative therapies, which could enhance patient outcomes and improve quality of life. Furthermore, the economic burden associated with managing complications from Buerger's disease may prompt healthcare systems to allocate more resources towards research and treatment, thereby expanding the market landscape.

Advancements in Diagnostic Technologies

Technological advancements in diagnostic tools are poised to significantly impact the Buerger's disease market. Enhanced imaging techniques and biomarker identification are improving the accuracy of Buerger's disease diagnoses, allowing for earlier intervention. As healthcare providers gain access to more sophisticated diagnostic methods, the likelihood of identifying cases of Buerger's disease increases. This trend may lead to a greater demand for treatment options, as timely diagnosis is crucial for effective management. The Buerger's disease market is likely to see a rise in the development of innovative diagnostic solutions, which could facilitate better patient outcomes and drive market growth. Furthermore, increased awareness of these technologies among healthcare professionals may contribute to a more proactive approach in managing Buerger's disease.

Regulatory Support for Innovative Therapies

Regulatory bodies in the US are increasingly supportive of innovative therapies for conditions like Buerger's disease. This regulatory environment may facilitate the approval process for new treatments, thereby accelerating their availability to patients. The Buerger's disease market stands to benefit from streamlined pathways for drug development, which could encourage pharmaceutical companies to invest in research and bring new therapies to market. Additionally, the potential for expedited review processes may lead to a quicker response to unmet medical needs, enhancing patient access to effective treatments. As regulatory frameworks evolve to support innovation, the Buerger's disease market may witness significant growth, driven by the introduction of advanced therapeutic options.

Growing Investment in Research and Development

Investment in research and development (R&D) within the Buerger's disease market is a critical driver of growth. Pharmaceutical companies and research institutions are increasingly focusing on understanding the underlying mechanisms of Buerger's disease, which may lead to the discovery of novel therapeutic targets. This trend suggests a potential for breakthroughs in treatment options, which could significantly enhance the quality of care for affected individuals. The Buerger's disease market may experience an influx of funding aimed at clinical trials and innovative therapies, reflecting a commitment to addressing this challenging condition. As new treatments emerge, the market could expand, offering patients more choices and potentially improving their prognosis.

Market Segment Insights

By Symptoms: Pain (Largest) vs. Gangrene (Fastest-Growing)

In the US Buerger's Disease Market, the distribution of symptoms shows that Pain represents the largest segment, capturing a significant share of patients' experiences. Following Pain, Ulcers and Cold Hands and Feet also contribute to the overall symptomatology observed in the market. Gangrene, while having a smaller base of patients, is quickly gaining attention due to its severe consequences, driving its market dynamics significantly. The growth trends in this segment are propelled by increasing awareness of the condition, improved diagnosis techniques, and a growing focus on patient management strategies. Additionally, healthcare professionals are emphasizing symptom recognition, which plays a crucial role in early diagnosis and treatment. This increased focus on symptom severity, particularly for Pain and Gangrene, is influencing research and development, leading to a broader range of therapeutic options becoming available.

Pain (Dominant) vs. Gangrene (Emerging)

Pain serves as the dominant symptom in the US buergers disease market, reflecting the most prevalent and distressing experience for patients. With a high frequency of reporting among individuals, it significantly affects the quality of life and drives treatment-seeking behavior. In contrast, Gangrene, while emerging, is recognized for its rapid progression and potential for severe outcomes, making it a critical concern in patient care. The stark difference in their market roles underscores the need for enhanced awareness and timely interventions. As healthcare systems strive to improve patient outcomes, both symptoms require focused attention, with Pain warranting immediate management strategies and Gangrene necessitating urgent medical responses.

By Treatment Type: Medication (Largest) vs. Surgical Procedures (Fastest-Growing)

In the Treatment Type segment of the US buergers disease market, medication holds the largest market share, primarily due to its widespread use and accessibility. Medications such as anti-inflammatory drugs and immunosuppressants offer effective management and are preferred by both patients and healthcare providers. Surgical procedures, while not as widely adopted, are gaining traction as innovative techniques and technologies emerge, addressing the needs of patients requiring more invasive solutions. The growth trend in this segment is being driven by advancements in medication formulations and surgical technologies. With an increasing emphasis on personalized medicine, the market for medication is expected to continue thriving. Meanwhile, surgical procedures are seeing a surge in interest due to improved outcomes and shorter recovery times, offering significant appeal to patients, making them the fastest-growing area in this segment.

Medication (Dominant) vs. Surgical Procedures (Emerging)

Medication remains the dominant force in the Treatment Type segment of the US buergers disease market, primarily due to its effective management capabilities and the preference for non-invasive approaches among patients. Medications like corticosteroids and disease-modifying therapies are well-established and widely utilized. In contrast, surgical procedures are emerging as a viable alternative for patients who do not respond adequately to medications. The development of minimally invasive surgical techniques and the integration of advanced imaging technologies are enhancing the appeal and effectiveness of these procedures. As healthcare providers focus on tailored treatment plans for patients, the balance between medication and surgical options will continue to evolve, identifying strategic roles for both approaches in the overall management of buergers disease.

By Diagnosis Method: Physical Examination (Largest) vs. Doppler Ultrasound (Fastest-Growing)

In the US buergers disease market, the diagnosis method segment showcases a varied distribution with Physical Examination leading as the largest segment. This method, often considered the traditional approach, maintains a significant share as it provides immediate insight into the patient's condition. In contrast, Doppler Ultrasound and Angiography follow, with Doppler Ultrasound gaining traction due to its non-invasive nature and diagnostic accuracy, appealing to both healthcare providers and patients. Growth trends in this segment highlight a shift towards advanced diagnostic techniques, driven by technological innovations and increasing awareness among healthcare professionals regarding the importance of early detection. The rise of telemedicine and portable diagnostic tools further fuels the adoption of methods like Doppler Ultrasound. Additionally, patient preference for less invasive procedures positively impacts growth trajectories in this segment, indicating a trend towards a more patient-centered approach in healthcare.

Doppler Ultrasound (Dominant) vs. Angiography (Emerging)

Doppler Ultrasound stands out as a dominant player in the US buergers disease market due to its ability to provide real-time imaging of blood flow, directly addressing the concerns related to vascular health. This method is favored for its non-invasive characteristics, making it a convenient option for both practitioners and patients looking for efficient diagnostic solutions. Conversely, Angiography, while recognized as an emerging technique, involves more invasive procedures and is often reserved for complex cases. Despite its growing acceptance and advancements in imaging technology, Angiography faces competition from less invasive methods. Nevertheless, it remains crucial for assessing intricate vascular conditions, allowing for precise interventions when necessary, and thus holds a vital role within the diagnostic landscape.

By Patient Demographics: Age Group (Largest) vs. Gender (Fastest-Growing)

In the US buergers disease market, the distribution of patient demographics shows a significant concentration within the older age groups, particularly those aged 60 and above, which represent the largest share of cases. Additionally, there is a notable representation of middle-aged individuals, particularly those aged 45-59, contributing to the overall patient demographic. Conversely, younger patients aged 18-29 form a smaller, yet increasingly noticeable segment as awareness and diagnosis improve across this cohort. The growth trends within the segment are driven by an aging population combined with lifestyle factors that heighten risk among specific age groups. Also, a rising trend in awareness of buergers disease among healthcare providers is increasing diagnosis rates, particularly in the younger demographic. Gender also plays a role in growth, as male patients, while dominant, continue to be joined by a gradual increase in female diagnoses, indicating a shift in how the disease manifests across genders in recent years.

Age Group: 60+ (Dominant) vs. Gender: Female (Emerging)

Individuals aged 60 and above represent the dominant age group within the US buergers disease market, primarily due to higher prevalence rates correlated with age and associated risk factors. This demographic exhibits a plethora of comorbidities, complicating treatment options and requiring a multifaceted approach. On the other hand, the emerging female demographic in this market highlights a shifting landscape, as there has been an uptick in diagnosis among women. This change underscores the importance of recognizing buergers disease in populations historically underrepresented in clinical studies, indicating a growing awareness and potential for targeted interventions.

Get more detailed insights about US Buergers Disease Market

Key Players and Competitive Insights

The buergers disease market is characterized by a competitive landscape that is increasingly shaped by innovation and strategic partnerships. Key players such as Pfizer (US), Novartis (CH), and Gilead Sciences (US) are actively pursuing strategies that emphasize research and development, aiming to enhance treatment options for patients. Pfizer (US) has focused on expanding its portfolio through collaborations with academic institutions, which appears to bolster its position in the market. Meanwhile, Novartis (CH) is investing heavily in digital health initiatives, suggesting a commitment to integrating technology into patient care, thereby enhancing its competitive edge. Gilead Sciences (US) is also notable for its strategic focus on developing novel therapies, which collectively influences the market dynamics by fostering a culture of innovation and responsiveness to patient needs.

In terms of business tactics, companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and reduce costs. The competitive structure of the buergers disease market appears moderately fragmented, with several players vying for market share. However, the collective influence of major companies like AstraZeneca (GB) and Bristol-Myers Squibb (US) is significant, as they leverage their extensive resources to drive market growth and innovation.

In October 2025, AstraZeneca (GB) announced a strategic partnership with a leading biotechnology firm to co-develop a new treatment for buergers disease. This collaboration is expected to accelerate the development timeline and enhance the therapeutic options available to patients, indicating AstraZeneca's commitment to addressing unmet medical needs in this area. The partnership not only strengthens AstraZeneca's pipeline but also positions it favorably against competitors by potentially bringing innovative solutions to market more rapidly.

In September 2025, Bristol-Myers Squibb (US) launched a new clinical trial aimed at evaluating the efficacy of its latest drug candidate for buergers disease. This initiative underscores the company's focus on research-driven growth and its determination to lead in therapeutic advancements. The trial's outcomes could significantly impact treatment protocols and establish Bristol-Myers Squibb as a frontrunner in the market, particularly if the results demonstrate superior efficacy compared to existing therapies.

In August 2025, Gilead Sciences (US) expanded its research capabilities by opening a new facility dedicated to the study of vascular diseases, including buergers disease. This strategic move reflects Gilead's long-term vision to innovate and develop targeted therapies. By investing in specialized research infrastructure, Gilead is likely to enhance its competitive positioning and contribute to the overall advancement of treatment options in the market.

As of November 2025, current trends in the buergers disease market are increasingly defined by digitalization, sustainability, and the integration of artificial intelligence (AI) in drug development processes. Strategic alliances among companies are shaping the competitive landscape, fostering collaboration that enhances innovation and accelerates time-to-market for new therapies. Looking ahead, it is anticipated that competitive differentiation will evolve, shifting from traditional price-based competition to a focus on innovation, technological advancements, and supply chain reliability. This transition may ultimately lead to improved patient outcomes and a more robust market environment.

Key Companies in the US Buergers Disease Market include

Industry Developments

Recent developments in the US Buerger's Disease Market have seen significant interest, particularly in treatment options and market growth. Companies such as Bristol Myers Squibb, AstraZeneca, Novartis, and Merck are actively exploring innovative therapies to address this condition, which primarily affects young men and is associated with tobacco use. In August 2023, Eli Lilly announced progress in its clinical trials for a novel treatment aimed at reducing symptoms of Buerger's Disease.

The market has experienced growth in valuation due to the increasing demand for specialized therapies, alongside a rise in awareness programs initiated by various health organizations advocating for better understanding of the disease.

Furthermore, in November 2022, Gilead Sciences completed its acquisition of a smaller biotech firm focused on vascular inflammatory diseases, bolstering its position in the market. Regulatory updates from the US Food and Drug Administration are also impacting the approval processes for advanced therapies, enhancing the competitive landscape among key players such as Regeneron Pharmaceuticals, Pfizer, and AbbVie, who are all eyeing strategic collaborations to drive innovation in treatment options.

Future Outlook

US Buergers Disease Market Future Outlook

The Buergers Disease Market is projected to grow at a 5.67% CAGR from 2024 to 2035, driven by increasing awareness and advancements in treatment options.

New opportunities lie in:

  • Development of telehealth platforms for remote patient monitoring.
  • Investment in targeted therapies to enhance treatment efficacy.
  • Expansion of patient education programs to improve early diagnosis.

By 2035, the buergers disease market is expected to achieve substantial growth and innovation.

Market Segmentation

US Buergers Disease Market Symptoms Outlook

  • Pain
  • Ulcers
  • Gangrene
  • Cold Hands and Feet

US Buergers Disease Market Treatment Type Outlook

  • Medication
  • Surgical Procedures
  • Lifestyle Changes

US Buergers Disease Market Diagnosis Method Outlook

  • Physical Examination
  • Doppler Ultrasound
  • Angiography

US Buergers Disease Market Patient Demographics Outlook

  • Age Group
  • Gender
  • Smoking Status

Report Scope

MARKET SIZE 2024 120.0(USD Million)
MARKET SIZE 2025 126.8(USD Million)
MARKET SIZE 2035 220.0(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 5.67% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Boehringer Ingelheim (DE), Novartis (CH), Pfizer (US), AstraZeneca (GB), Bristol-Myers Squibb (US), Sanofi (FR), Gilead Sciences (US), Eli Lilly and Company (US)
Segments Covered Symptoms, Treatment Type, Diagnosis Method, Patient Demographics
Key Market Opportunities Advancements in targeted therapies and personalized medicine enhance treatment options in the buergers disease market.
Key Market Dynamics Rising demand for targeted therapies drives innovation and competition in the buergers disease market.
Countries Covered US

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FAQs

What is the expected market size of the US Buerger's Disease Market in 2024?

The US Buerger's Disease Market is expected to be valued at 138.6 million USD in 2024.

What will be the market size of the US Buerger's Disease Market by 2035?

By 2035, the US Buerger's Disease Market is projected to reach 319.0 million USD.

What is the expected CAGR for the US Buerger's Disease Market from 2025 to 2035?

The expected compound annual growth rate for the US Buerger's Disease Market from 2025 to 2035 is 7.873%.

Which segment is leading the US Buerger's Disease Market in terms of symptoms?

Among the symptom segments, 'Gangrene' holds a significant market value of 40.2 million USD in 2024.

What market value is projected for 'Pain' in the US Buerger's Disease Market by 2035?

The 'Pain' segment is projected to reach a market value of 75.0 million USD by 2035.

Who are the major players in the US Buerger's Disease Market?

Major players in the US Buerger's Disease Market include Bristol Myers Squibb, AstraZeneca, and Novartis among others.

What value is projected for the 'Ulcers' segment in 2035?

The 'Ulcers' segment is anticipated to reach a market value of 70.0 million USD by 2035.

What market share does the 'Cold Hands and Feet' segment hold in 2024?

The 'Cold Hands and Feet' segment is valued at 34.0 million USD in 2024.

What is the estimated market growth rate for the 'Gangrene' segment between 2025 to 2035?

The 'Gangrene' segment is expected to grow significantly, with projections reaching 90.0 million USD by 2035.

What are the primary challenges faced in the US Buerger's Disease Market?

Challenges in the US Buerger's Disease Market include patient awareness and the availability of effective treatments.

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