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US Atherosclerosis Market

ID: MRFR/MED/50446-HCR
200 Pages
Garvit Vyas
February 2026

US Atherosclerosis Market Research Report: Size, Share, Trend Analysis By Stages (Endothelial Damage and Immune Response, Fatty Streak, Plaque Growth, Plaque Rupture), By Diagnosis (Ankle-brachial Index (ABI), Doppler Ultrasound, Echocardiogram, Electrocardiogram (ECG), Blood Tests, Others), By Treatment (Medication, Surgery) and By End-User (Hospitals, Specialty Clinics, Homecare, Others) - Growth Outlook & Industry Forecast 2025 To 2035

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US Atherosclerosis Market Infographic
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US Atherosclerosis Market Summary

As per Market Research Future analysis, the US atherosclerosis market Size was estimated at 12.02 USD Billion in 2024. The US atherosclerosis market is projected to grow from 12.44 USD Billion in 2025 to 17.55 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 3% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The US atherosclerosis market is experiencing robust growth driven by technological advancements and increasing awareness.

  • Technological advancements in treatment are reshaping the atherosclerosis market landscape.
  • Rising awareness and preventive measures are contributing to a growing patient population.
  • Integration of digital health solutions is enhancing patient engagement and monitoring.
  • The increasing prevalence of cardiovascular diseases and advancements in diagnostic technologies are key market drivers.

Market Size & Forecast

2024 Market Size 12.02 (USD Billion)
2035 Market Size 17.55 (USD Billion)
CAGR (2025 - 2035) 3.5%

Major Players

Pfizer Inc (US), AstraZeneca PLC (GB), Bristol-Myers Squibb Company (US), Novartis AG (CH), Sanofi S.A. (FR), Amgen Inc (US), Regeneron Pharmaceuticals Inc (US), Eli Lilly and Company (US)

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US Atherosclerosis Market Trends

The atherosclerosis market is currently experiencing notable developments driven by advancements in medical technology and an increasing awareness of cardiovascular health. The prevalence of atherosclerosis, characterized by the buildup of plaque in arteries, has prompted healthcare providers to seek innovative treatment options. This has led to a surge in research and development activities aimed at creating more effective therapies and diagnostic tools. Furthermore, the aging population in the US is likely to contribute to a higher incidence of atherosclerosis, thereby intensifying the demand for specialized medical interventions. In addition to technological advancements, the atherosclerosis market is influenced by changing lifestyle factors. As more individuals adopt sedentary habits and unhealthy diets, the risk of developing atherosclerosis increases. This trend has prompted public health initiatives focused on prevention and education, which may further shape the market landscape. Moreover, the integration of telemedicine and digital health solutions is emerging as a potential game-changer, allowing for better patient monitoring and management of cardiovascular conditions. Overall, the atherosclerosis market appears poised for growth, driven by a combination of innovation, demographic shifts, and evolving healthcare practices.

Technological Advancements in Treatment

Recent innovations in medical technology are transforming the atherosclerosis market. New therapies, including advanced drug formulations and minimally invasive procedures, are being developed to enhance treatment efficacy. These advancements not only improve patient outcomes but also expand the range of options available to healthcare providers.

Rising Awareness and Preventive Measures

There is a growing emphasis on cardiovascular health awareness among the US population. Public health campaigns are increasingly focusing on educating individuals about the risks associated with atherosclerosis. This heightened awareness is likely to drive demand for preventive measures and early interventions.

Integration of Digital Health Solutions

The incorporation of digital health technologies is reshaping the atherosclerosis market. Telemedicine and mobile health applications are facilitating remote patient monitoring and management. This trend may enhance patient engagement and adherence to treatment plans, ultimately improving health outcomes.

US Atherosclerosis Market Drivers

Rising Healthcare Expenditure

The increasing healthcare expenditure in the US is a significant driver of the atherosclerosis market. As healthcare costs continue to rise, there is a growing emphasis on preventive care and effective management of chronic diseases, including atherosclerosis. In 2025, healthcare spending in the US is projected to exceed $4 trillion, reflecting a commitment to improving health outcomes. This financial investment is likely to enhance access to a range of treatment options, including medications, surgical interventions, and lifestyle modification programs. Furthermore, the focus on value-based care is encouraging healthcare providers to adopt comprehensive strategies for managing atherosclerosis, which may lead to increased demand for innovative therapies and interventions in the market.

Advancements in Diagnostic Technologies

Technological innovations in diagnostic tools are significantly influencing the atherosclerosis market. Enhanced imaging techniques, such as high-resolution ultrasound and advanced MRI, allow for earlier detection and more accurate assessment of atherosclerotic plaques. These advancements facilitate timely intervention, which is crucial for improving patient outcomes. The US market for diagnostic imaging is projected to reach approximately $45 billion by 2026, indicating a robust demand for advanced diagnostic solutions. Furthermore, the integration of artificial intelligence in diagnostic processes is expected to streamline workflows and enhance accuracy. As healthcare providers increasingly adopt these technologies, the atherosclerosis market is likely to expand, driven by the need for precise diagnostics and personalized treatment plans.

Regulatory Support for Innovative Therapies

Regulatory bodies in the US are increasingly supportive of innovative therapies for atherosclerosis, which is positively impacting the atherosclerosis market. The Food and Drug Administration (FDA) has implemented expedited review processes for breakthrough therapies, allowing for faster access to new treatments. This regulatory environment encourages pharmaceutical companies to invest in the development of novel therapies, knowing that they may receive quicker approval. The recent approval of several new drugs targeting atherosclerosis has demonstrated the potential for rapid market entry. As regulatory support continues to evolve, the atherosclerosis market is likely to benefit from an influx of innovative treatment options, ultimately improving patient care and outcomes.

Growing Investment in Research and Development

Investment in research and development (R&D) is a critical driver of the atherosclerosis market. Pharmaceutical companies and research institutions are increasingly allocating resources to discover novel therapies and improve existing treatments. In the US, R&D spending in the healthcare sector has seen a steady increase, with estimates suggesting that it could reach $200 billion by 2025. This influx of funding is likely to accelerate the development of innovative drugs and therapies targeting atherosclerosis. Additionally, collaborations between academia and industry are fostering a conducive environment for breakthroughs in treatment modalities. As new therapies emerge, the atherosclerosis market is poised for growth, reflecting the commitment to addressing this pressing health issue.

Increasing Prevalence of Cardiovascular Diseases

The rising incidence of cardiovascular diseases, particularly atherosclerosis, is a primary driver of the atherosclerosis market. In the US, approximately 697,000 individuals succumb to heart disease annually, highlighting the urgent need for effective treatment options. This alarming statistic underscores the necessity for innovative therapies and interventions. As the population ages, the prevalence of risk factors such as hypertension, diabetes, and obesity continues to escalate, further propelling the demand for atherosclerosis-related treatments. The atherosclerosis market is expected to witness substantial growth, with projections indicating a compound annual growth rate (CAGR) of around 5.5% over the next several years. This trend suggests that healthcare providers and pharmaceutical companies must prioritize the development of new therapies to address the increasing burden of cardiovascular diseases.

Market Segment Insights

By Stage: Plaque Rupture (Largest) vs. Endothelial Damage and Immune Response (Fastest-Growing)

In the US atherosclerosis market, the segment distribution shows that Plaque Rupture holds the largest share, reflecting the critical impact of this phase on patient outcomes and treatment strategies. Following closely, the Endothelial Damage and Immune Response segment is gaining traction due to increasing awareness of early intervention and its significance in preventing the progression to more severe stages. Growth trends in the segment indicate a shift toward more preventive measures, with healthcare providers focusing on addressing endothelial damage as a pivotal step in atherosclerosis management. The rapid growth in the Endothelial Damage and Immune Response sector is driven by advancements in diagnostic technologies and the evolving understanding of immune mechanisms affecting atherosclerosis, promoting innovative therapeutic strategies to mitigate risks early in the disease process.

Plaque Rupture (Dominant) vs. Fatty Streak (Emerging)

Plaque Rupture is recognized as the dominant stage within the US atherosclerosis market due to its direct association with acute cardiovascular events, leading to extensive clinical attention and resource allocation. Its established presence is supported by ongoing research and development aimed at finding effective interventions to manage complications. In contrast, the Fatty Streak stage is emerging as an important focus for early intervention strategies. As clinicians increasingly acknowledge the need to address the initial stages of atherosclerosis, the Fatty Streak segment is gaining visibility. This increasing attention reflects a broader trend towards proactive healthcare models that emphasize early diagnosis and lifestyle modifications to slow disease progression.

By Diagnosis: Blood Tests (Largest) vs. Ankle-brachial Index (ABI) (Fastest-Growing)

In the US atherosclerosis market, Blood Tests hold the largest market share, attributed to their widespread use and efficiency in diagnosing a range of cardiovascular conditions. The popularity of Blood Tests stems from their ability to provide crucial insights into cholesterol levels and other biomarkers, making them a preferred choice among healthcare providers. Following closely are methods like Doppler Ultrasound and Electrocardiogram (ECG), but they account for a smaller share of the market. The growth trends within this segment indicate a rising demand for non-invasive diagnostic tools such as the Ankle-brachial Index (ABI), which is currently the fastest-growing method. This trend is driven by increasing awareness of atherosclerosis and the need for early detection. Additionally, technological advancements in ultrasound and the development of more sophisticated blood tests are fueling expansion in this sector, as practitioners seek reliable and efficient diagnostic options.

Blood Tests (Dominant) vs. Ankle-brachial Index (ABI) (Emerging)

Blood Tests are a dominant force in the diagnostic landscape of the US atherosclerosis market, providing essential data for the assessment of lipid profiles and inflammatory markers. Their non-invasive nature and ability to conduct multiple tests from a single sample makes them highly valued among clinicians. Conversely, the Ankle-brachial Index (ABI) is an emerging diagnostic tool that measures the blood flow in limbs and assists in identifying peripheral arterial diseases. The ABI’s rise in favor is linked to its efficiency and accuracy in identifying at-risk patients, making it a vital asset in preventive healthcare strategies. As healthcare systems continue to emphasize early intervention, the ABI is rapidly gaining traction, complementing traditional blood tests.

By Treatment: Medication (Largest) vs. Surgery (Fastest-Growing)

In the US atherosclerosis market, the treatment segment is primarily dominated by medication, which holds the largest market share. Medication comprises various pharmaceutical products aimed at managing cholesterol levels and improving cardiovascular health. In contrast, surgery is emerging as a significant option for patients requiring more immediate intervention, contributing to its rapid growth. The distinct approaches of both treatment methods cater to varying patient needs, establishing a clear market hierarchy where medication is currently the preferred choice among healthcare providers. The growth trends within the treatment segment highlight a shift in patient management strategies, with an increasing emphasis on surgical interventions for those with severe atherosclerosis. Advancements in minimally invasive techniques and surgical technologies are propelling the surgery segment forward, making it faster-growing. Furthermore, rising awareness and education about atherosclerosis management among patients and healthcare professionals are driving demand for these treatment options, thus shaping the future landscape of the treatment segment.

Treatment: Medication (Dominant) vs. Surgery (Emerging)

Medication is the dominant treatment in the US atherosclerosis market, leveraging a wide range of drugs that effectively lower cholesterol levels and prevent cardiovascular events. It is characterized by its accessibility and the extensive clinical research supporting its efficacy. Patients often favor medication due to the non-invasive nature and ease of administration. On the other hand, surgery is an emerging option that is becoming more prevalent, especially in cases where medication alone proves inadequate. Surgical interventions, including angioplasty and bypass procedures, are gaining traction owing to advancements in techniques and increased success rates. As healthcare professionals look for proactive measures, surgery is anticipated to capture more of the market, reflecting a balance of traditional management with innovative surgical solutions.

By End-User: Hospitals (Largest) vs. Specialty Clinics (Fastest-Growing)

In the US atherosclerosis market, the distribution of the end-user segment reveals that hospitals hold the largest share, demonstrating their critical role in patient care. These institutions provide advanced diagnostic and therapeutic solutions for managing atherosclerosis, accounting for a significant portion of the market revenue. Specialty clinics, on the other hand, are rapidly gaining traction due to their focused approach and specialized treatments, making them the fastest-growing segment in the market. Growth trends in this segment are driven by the increasing prevalence of cardiovascular diseases, leading to heightened demand for targeted care. The rise in preventive healthcare and advancements in medical technology further stimulate the expansion of specialty clinics, as they offer innovative solutions tailored to individual patient needs. This dynamic environment fosters competition among hospitals and specialty clinics, enhancing service delivery and patient outcomes.

Hospitals (Dominant) vs. Specialty Clinics (Emerging)

Hospitals represent the dominant end-user segment in the US atherosclerosis market, characterized by their comprehensive capabilities in managing complex cases of atherosclerosis. They provide access to multidisciplinary teams and state-of-the-art technologies, ensuring that patients receive holistic care. Conversely, specialty clinics are emerging as a significant player, focusing on specific patient demographics and offering personalized treatment plans. These clinics emphasize convenience and accessibility, appealing to patients seeking quicker consultations and specialized care. With their agility and focus, specialty clinics are carving out a niche in the market, driven by a demand for tailored healthcare solutions and an increasing awareness of preventative cardiovascular care.

Get more detailed insights about US Atherosclerosis Market

Key Players and Competitive Insights

The atherosclerosis market exhibits a dynamic competitive landscape characterized by rapid innovation and strategic maneuvering among key players. Major companies such as Pfizer Inc (US), AstraZeneca PLC (GB), and Amgen Inc (US) are actively engaged in enhancing their product portfolios and expanding their market presence. Pfizer Inc (US) has focused on developing novel therapies aimed at reducing cardiovascular risk, while AstraZeneca PLC (GB) emphasizes its commitment to research and development, particularly in the realm of lipid management. Amgen Inc (US) is leveraging its expertise in biologics to introduce advanced treatment options, thereby positioning itself as a leader in the market. Collectively, these strategies foster a competitive environment that prioritizes innovation and patient-centric solutions.In terms of business tactics, companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and responsiveness to market demands. The competitive structure of the atherosclerosis market appears moderately fragmented, with several players vying for market share. However, the influence of key players is substantial, as they drive advancements in treatment options and establish benchmarks for quality and efficacy.
In October Bristol-Myers Squibb Company (US) announced a strategic partnership with a leading digital health firm to integrate AI-driven analytics into its clinical development processes. This move is likely to enhance the company's ability to identify patient populations that would benefit most from its therapies, thereby streamlining clinical trials and accelerating time-to-market for new treatments. Such initiatives underscore the growing importance of technology in shaping drug development and patient engagement strategies.
In September Regeneron Pharmaceuticals Inc (US) launched a new initiative aimed at expanding access to its atherosclerosis treatments through collaborations with healthcare providers and payers. This initiative is expected to improve patient outcomes by ensuring that innovative therapies are accessible to a broader demographic, particularly underserved populations. The strategic focus on access aligns with current healthcare trends emphasizing equity and inclusivity in treatment availability.
In August Novartis AG (CH) unveiled a comprehensive sustainability strategy that includes commitments to reduce its carbon footprint and enhance the environmental profile of its manufacturing processes. This initiative not only addresses growing regulatory pressures but also resonates with the increasing consumer demand for sustainable practices in healthcare. By prioritizing sustainability, Novartis AG (CH) positions itself favorably in a market that is progressively valuing corporate responsibility.
As of November the atherosclerosis market is witnessing trends that emphasize digitalization, sustainability, and the integration of AI technologies. Strategic alliances are becoming increasingly pivotal, as companies collaborate to enhance their capabilities and expand their reach. The competitive differentiation is likely to evolve from traditional price-based competition towards a focus on innovation, technological advancements, and supply chain reliability. This shift suggests that companies that can effectively leverage these trends will be better positioned to thrive in the evolving landscape.

Key Companies in the US Atherosclerosis Market include

Industry Developments

Recent developments in the US Atherosclerosis Market reveal significant advancements and competitive dynamics among major pharmaceutical companies such as AstraZeneca, Takeda, Merck, and Bristol Myers Squibb. In particular, AstraZeneca has made strides with its cardiovascular drug pipeline, targeting therapies that address inflammation linked to atherosclerosis. Meanwhile, Merck recently announced progress in its clinical trials for new atherosclerosis treatments, aiming to provide more effective options for patients.

Current market affairs include a notable increase in the valuation of several companies involved in Atherosclerosis treatment, attributed to heightened investment in Research and Development and a growing focus on preventative therapies. Additionally, among the notable merger and acquisition activities, in June 2023, Pfizer completed its acquisition of a biotech firm focused on cardiovascular drugs, indicating strategic consolidation within the sector.

Over the past few years, the market has seen heightened regulatory focus and scientific advancements, including a landmark approval in November 2022 for a new lipid-lowering therapy. Sanofi and Regeneron Pharmaceuticals continue to innovate with their cholesterol-lowering treatments, reflecting the increasing market competitiveness and focusing on reducing cardiovascular risks among the US population.

Future Outlook

US Atherosclerosis Market Future Outlook

The Atherosclerosis Market is projected to grow at a 3.5% CAGR from 2025 to 2035, driven by advancements in treatment options, increasing prevalence, and heightened awareness.

New opportunities lie in:

  • Development of telehealth platforms for remote patient monitoring Investment in AI-driven diagnostic tools for early detection Expansion of personalized medicine approaches targeting specific patient demographics

By 2035, the atherosclerosis market is expected to achieve substantial growth, reflecting evolving healthcare dynamics.

Market Segmentation

US Atherosclerosis Market Stage Outlook

  • Endothelial Damage and Immune Response
  • Fatty Streak
  • Plaque Growth
  • Plaque Rupture

US Atherosclerosis Market End-User Outlook

  • Hospitals
  • Specialty Clinics
  • Homecare
  • Others

US Atherosclerosis Market Diagnosis Outlook

  • Ankle-brachial Index (ABI)
  • Doppler Ultrasound
  • Echocardiogram
  • Electrocardiogram (ECG)
  • Blood Tests
  • Others

US Atherosclerosis Market Treatment Outlook

  • Medication
  • Surgery

Report Scope

MARKET SIZE 2024 12.02(USD Billion)
MARKET SIZE 2025 12.44(USD Billion)
MARKET SIZE 2035 17.55(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR) 3.5% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Billion
Key Companies Profiled Pfizer Inc (US), AstraZeneca PLC (GB), Bristol-Myers Squibb Company (US), Novartis AG (CH), Sanofi S.A. (FR), Amgen Inc (US), Regeneron Pharmaceuticals Inc (US), Eli Lilly and Company (US)
Segments Covered Stage, Diagnosis, Treatment, End-User
Key Market Opportunities Advancements in personalized medicine and digital health technologies enhance treatment options in the atherosclerosis market.
Key Market Dynamics Rising demand for innovative therapies drives competition and regulatory scrutiny in the atherosclerosis treatment landscape.
Countries Covered US
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FAQs

What is the expected market size of the US Atherosclerosis market in 2024?

The US Atherosclerosis market is projected to be valued at 10.5 billion USD in 2024.

How much is the US Atherosclerosis market expected to grow by 2035?

By 2035, the US Atherosclerosis market is expected to reach a value of 15.5 billion USD.

What is the expected CAGR for the US Atherosclerosis market from 2025 to 2035?

The compound annual growth rate (CAGR) for the US Atherosclerosis market is expected to be 3.604% from 2025 to 2035.

Which stage of atherosclerosis has the highest market value in 2024?

In 2024, the Endothelial Damage and Immune Response stage holds the highest market value at 3.5 billion USD.

What is the market value for the Plaque Growth stage of atherosclerosis in 2024?

The Plaque Growth stage is valued at 3.0 billion USD in the US Atherosclerosis market in 2024.

Who are the major players in the US Atherosclerosis market?

Some major players include AstraZeneca, Merck, Amgen, and Pfizer, among others.

What is the market value for the Fatty Streak stage in 2035?

The market value for the Fatty Streak stage is expected to reach 3.8 billion USD by 2035.

What is the projected market value for the Plaque Rupture stage in 2035?

The Plaque Rupture stage is projected to have a market value of 2.0 billion USD by 2035.

What growth drivers are influencing the US Atherosclerosis market?

Increasing prevalence of atherosclerosis-related diseases and advancements in treatment options are key growth drivers.

What challenges does the US Atherosclerosis market currently face?

Challenges include high treatment costs and regulatory hurdles affecting market access.

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