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Spain Plasma Fractionation Market

ID: MRFR/HC/47869-HCR
200 Pages
Rahul Gotadki
February 2026

Spain Plasma Fractionation Market Research Report By Product Type (Immunoglobulin, Albumin, Coagulation Factors, Protease Inhibitors), By Application (Neurology, Hematology, General Medicine, Immunology), By End User (Hospitals, Ambulatory Surgical Centers, Blood Banks, Pharmaceutical Companies) and By Technology (Centrifugation, Chromatography, Precipitation, Filtration) -Forecast to 2035

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Spain Plasma Fractionation Market Summary

As per Market Research Future analysis, the Spain plasma fractionation market size was estimated at 795.5 USD Million in 2024. The Spain plasma fractionation market is projected to grow from 847.84 USD Million in 2025 to 1604.4 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 6.5% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The Spain plasma fractionation market is poised for growth driven by increasing demand and technological advancements.

  • The demand for immunoglobulins is rising, indicating a robust market trajectory.
  • Advancements in processing technologies are enhancing efficiency and output in plasma fractionation.
  • the largest segment is immunoglobulins, while the fastest-growing segment is albumin.
  • Key market drivers include the increasing prevalence of chronic diseases and supportive regulatory frameworks.

Market Size & Forecast

2024 Market Size 795.5 (USD Million)
2035 Market Size 1604.4 (USD Million)
CAGR (2025 - 2035) 6.58%

Major Players

Grifols (ES), CSL Behring (AU), Takeda Pharmaceutical Company (JP), Octapharma (CH), Kedrion (IT), Biotest AG (DE), LFB Group (FR), Sangamo Therapeutics (US), Emergent BioSolutions (US)

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Spain Plasma Fractionation Market Trends

This market is currently experiencing notable growth, driven by increasing demand for immunoglobulins and clotting factors. This demand is largely attributed to the rising prevalence of chronic diseases and the growing awareness of the therapeutic benefits of plasma-derived products. In Spain, the healthcare sector is evolving, with a focus on enhancing patient care through advanced treatments. The government is actively supporting initiatives aimed at improving plasma collection and processing, which is expected to bolster the market further. Additionally, the presence of established players in the region contributes to a competitive landscape, fostering innovation and development in plasma fractionation technologies. Moreover, regulatory frameworks in Spain are becoming more conducive to the expansion of the plasma fractionation market. The emphasis on safety and quality assurance in plasma products is paramount, leading to stringent regulations that ensure high standards. This regulatory environment not only protects patients but also encourages manufacturers to invest in research and development. As a result, the market is likely to witness advancements in processing techniques and product offerings, catering to the diverse needs of healthcare providers and patients alike. Overall, the plasma fractionation market in Spain appears poised for sustained growth, driven by both demand and regulatory support.

Rising Demand for Immunoglobulins

The demand for immunoglobulins is increasing, primarily due to their critical role in treating various immune deficiencies and autoimmune disorders. This trend is likely to continue as healthcare providers recognize the importance of these therapies in improving patient outcomes.

Advancements in Processing Technologies

Innovations in plasma processing technologies are emerging, enhancing the efficiency and safety of plasma fractionation. These advancements may lead to higher yields and improved product quality, which could attract more investment in the sector.

Regulatory Support for Plasma Collection

The regulatory landscape in Spain is evolving to support plasma collection initiatives. Enhanced regulations are likely to facilitate better collection practices, ensuring a steady supply of plasma for fractionation, which is essential for meeting growing market demands.

Spain Plasma Fractionation Market Drivers

Supportive Regulatory Framework

The regulatory environment in Spain is becoming increasingly supportive of plasma collection and fractionation activities. Government initiatives aimed at ensuring the safety and efficacy of plasma-derived products are fostering a conducive atmosphere for market growth. Regulatory bodies are streamlining approval processes for new therapies, which may encourage investment in research and development within the plasma fractionation market. Furthermore, the establishment of guidelines for plasma collection and processing is likely to enhance public trust in these products, potentially leading to increased demand. This supportive framework could be pivotal in driving the market forward.

Growing Awareness of Plasma Donation

Public awareness regarding the importance of plasma donation is steadily increasing in Spain, which serves as a significant driver for the plasma fractionation market. Campaigns aimed at educating the population about the life-saving potential of plasma-derived therapies have led to a rise in donor participation. This increase in donations is vital, as it directly impacts the availability of raw plasma for fractionation. Reports suggest that Spain has seen a 15% increase in plasma donations over the past year, indicating a positive trend that could support the growth of the plasma fractionation market. Enhanced donor engagement strategies may further bolster this trend.

Rising Investment in Biopharmaceuticals

Investment in the biopharmaceutical sector in Spain is on the rise, which is likely to have a positive impact on the plasma fractionation market. As biopharmaceutical companies seek to develop new therapies, the demand for high-quality plasma-derived products is expected to increase. Reports indicate that Spain's biopharmaceutical market is projected to grow at a CAGR of 8% over the next five years. This growth may lead to enhanced collaboration between plasma fractionation facilities and biopharmaceutical companies, fostering innovation and expanding the range of available therapies. Such investment trends could significantly influence the dynamics of the plasma fractionation market.

Increasing Prevalence of Chronic Diseases

The rising incidence of chronic diseases in Spain is a crucial driver for the plasma fractionation market. Conditions such as hemophilia, immune deficiencies, and other blood-related disorders necessitate the use of plasma-derived therapies. As the population ages, the demand for immunoglobulins and clotting factors derived from plasma is expected to grow. Reports indicate that the prevalence of hemophilia in Spain is approximately 1 in 10,000 males, which translates to a significant patient population requiring ongoing treatment. This trend suggests that healthcare providers will increasingly rely on plasma fractionation to meet therapeutic needs, thereby propelling market growth.

Technological Innovations in Plasma Processing

Technological advancements in plasma processing are transforming the plasma fractionation market. Innovations such as improved separation techniques and enhanced purification methods are leading to higher yields and better quality of plasma-derived products. For instance, the introduction of automated systems has streamlined the fractionation process, reducing operational costs and increasing efficiency. In Spain, the market is witnessing a shift towards these advanced technologies, which could potentially enhance the production capacity of plasma-derived therapies. As a result, companies investing in these innovations may gain a competitive edge, further stimulating market expansion.

Market Segment Insights

By Application: Immunology (Largest) vs. Neurology (Fastest-Growing)

The application segment in the Spain plasma fractionation market is notably diverse, with immunology holding the largest share. This sector primarily focuses on developing therapies for autoimmune diseases and other immune-related conditions, which is pivotal for market stability. In contrast, neurology is emerging as the fastest-growing segment, driven by increasing awareness of neurological disorders and their associated treatment options. Growth trends reflect a heightened demand for advanced plasma products used in treating various health issues. Neurology's rapid evolution is fueled by innovations in research and clinical practices, while immunology continues to thrive on established therapies and new developments. Both segments are influenced by an aging population and increased healthcare expenditure, leading to a promising outlook in the Spain plasma fractionation market.

Immunology: Dominant vs. Neurology: Emerging

Immunology is characterized by its extensive range of therapies that address critical health challenges, positioning it as the dominant application in the plasma fractionation market. The segment benefits from substantial investment in research, facilitating the development of advanced immunotherapies. On the other hand, neurology, recognized as the emerging segment, is gaining traction through the development of specific treatments for neurological conditions such as multiple sclerosis and Alzheimer's disease. The demand for neurology products is accelerating as awareness and diagnosis of neurodegenerative diseases increase. Together, these segments illustrate the dynamic landscape of the Spain plasma fractionation market, with immunology setting the benchmark while neurology expands its footprint.

By Product Type: Immunoglobulin (Largest) vs. Albumin (Fastest-Growing)

In the Spain plasma fractionation market, Immunoglobulin holds the largest market share among the product types, driven by its critical role in treating various immune disorders and its widespread application in therapeutic treatments. Albumin also plays a significant role, exhibiting an increasing share as demand rises for its use in liver diseases and as a blood volume expander, although it remains behind Immunoglobulin in overall share. Growth trends in this segment are largely influenced by the rising incidence of chronic diseases and the increasing awareness of plasma-derived therapies. The need for effective treatment options continues to foster market expansion, with Albumin emerging as the fastest-growing product type. This growth is driven by its versatility and increasing application in hospitals and clinics for various therapeutic needs.

Immunoglobulin (Dominant) vs. Albumin (Emerging)

Immunoglobulin is the dominant product type in the Spain plasma fractionation market, widely recognized for its effectiveness in treating autoimmune disorders, infections, and inflammatory conditions. Its robust regulatory support and established clinical applications contribute to its strong presence. In contrast, Albumin is an emerging product type, gaining traction due to its vital role in managing liver conditions and maintaining oncotic pressure in patients. The flexibility of Albumin in various medical applications and its growing demand in surgeries and critical care settings greatly enhance its market position. Both segments are crucial for advancing therapeutic innovations, yet they cater to different medical needs.

By End User: Hospitals (Largest) vs. Pharmaceutical Companies (Fastest-Growing)

In the Spain plasma fractionation market, the distribution of end users shows that hospitals hold a significant share of the market, primarily due to their essential role in patient care and the increasing demand for plasma-derived therapies. Ambulatory surgical centers also contribute to market dynamics, though to a lesser extent, while blood banks serve as crucial providers of plasma for various medical applications. As healthcare requirements evolve, the roles of these end users are becoming more prominent, reflected in their respective market shares. Growth trends within the end-user segment reveal a robust expansion, particularly among pharmaceutical companies, which are recognized as the fastest-growing sector. This growth is driven by advancements in plasma fractionation technologies and an increase in R&D activities aimed at developing new therapies. The demand for more effective treatments and the rising prevalence of chronic diseases are further supporting growth, enabling pharmaceutical companies to capture a larger share of the market while hospitals and blood banks continue to play their vital roles.

Hospitals (Dominant) vs. Pharmaceutical Companies (Emerging)

Hospitals remain the dominant end user in the Spain plasma fractionation market, primarily responsible for administering plasma-derived products to patients and ensuring high-quality healthcare. Their substantial infrastructure and resource allocation for plasma management underscore their critical position. Conversely, pharmaceutical companies are emerging players in this segment, leveraging technological innovations to create novel therapeutics, which are in high demand. The collaboration between hospitals and pharmaceutical companies enhances treatment options, leading to improved patient outcomes. As pharmaceutical companies expand their portfolios, they are likely to alter the competitive landscape, reflecting changes in treatment protocols, thereby positioning themselves as key contributors to the market's future.

By Technology: Centrifugation (Largest) vs. Chromatography (Fastest-Growing)

Centrifugation dominates the Spain plasma fractionation market, capturing the largest market share among technological methods utilized for plasma separation. It is valued for its efficiency in purifying proteins and other plasma components, making it a staple in various medical applications. Chromatography, while currently lower in market share, is gaining traction due to its precision and ability to handle diverse plasma components effectively. The growth trends in this segment are heavily influenced by advancements in processing technology and an increasing demand for high-quality plasma-derived products. Chromatography is particularly benefiting from the rising need for specific plasma proteins in the therapeutic sector, marking it as the fastest-growing method. As the market evolves, both technologies show potential for expansion, driven by innovation and rising healthcare needs.

Technology: Centrifugation (Dominant) vs. Chromatography (Emerging)

Centrifugation is characterized by its established presence in the Spain plasma fractionation market, known for its effectiveness in quickly separating components based on density. This method is widely used in clinical laboratories for the preparation of blood components, playing a crucial role in transfusion medicine. On the other hand, chromatography is emerging as a vital alternative, particularly for its precision and versatility in separating complex mixtures. It offers advanced capabilities in isolating specific proteins, making it increasingly preferred for research and clinical applications. As demands for targeted therapies rise, chromatography is expected to capture a larger share of the market.

Get more detailed insights about Spain Plasma Fractionation Market

Key Players and Competitive Insights

The plasma fractionation market in Spain is characterized by a competitive landscape that is increasingly shaped by innovation, strategic partnerships, and regional expansion. Key players such as Grifols (ES), CSL Behring (AU), and Takeda Pharmaceutical Company (JP) are at the forefront, each employing distinct strategies to enhance their market presence. Grifols (ES), for instance, focuses on expanding its product portfolio through research and development, while CSL Behring (AU) emphasizes strategic acquisitions to bolster its therapeutic offerings. Takeda Pharmaceutical Company (JP) appears to be concentrating on enhancing its global supply chain capabilities, which is crucial for maintaining a competitive edge in this dynamic market.The business tactics employed by these companies reflect a trend towards localizing manufacturing and optimizing supply chains to meet the growing demand for plasma-derived therapies. The market structure is moderately fragmented, with several players vying for market share. However, the collective influence of these key players is significant, as they drive innovation and set industry standards, thereby shaping the competitive environment.

In September Grifols (ES) announced a strategic partnership with a leading biotechnology firm to co-develop next-generation immunoglobulin therapies. This collaboration is expected to enhance Grifols' R&D capabilities and accelerate the introduction of innovative products to the market. Such strategic moves not only strengthen Grifols' position but also reflect a broader trend of collaboration within the industry to address unmet medical needs.

In October CSL Behring (AU) launched a new plasma-derived therapy aimed at treating rare bleeding disorders. This product introduction is significant as it underscores CSL Behring's commitment to expanding its therapeutic offerings and addressing niche markets. The successful launch of this therapy could potentially enhance the company's market share and reinforce its reputation as a leader in the plasma fractionation sector.

In August Takeda Pharmaceutical Company (JP) completed the acquisition of a European plasma collection center, which is anticipated to bolster its supply chain and increase its plasma sourcing capabilities. This acquisition is strategically important as it not only enhances Takeda's operational efficiency but also positions the company to better meet the rising demand for plasma-derived therapies in Europe.

As of November the competitive trends in the plasma fractionation market are increasingly defined by digitalization, sustainability, and the integration of artificial intelligence (AI) in operations. Strategic alliances are becoming more prevalent, as companies recognize the value of collaboration in driving innovation and improving operational efficiencies. Looking ahead, it is likely that competitive differentiation will evolve, shifting from traditional price-based competition to a focus on innovation, technological advancements, and supply chain reliability. This transition may ultimately redefine the competitive landscape, fostering a more dynamic and responsive market environment.

Key Companies in the Spain Plasma Fractionation Market include

Industry Developments

The Spain Plasma Fractionation Market has witnessed significant developments in recent months, with particular focus on the activities of major players like Grifols and Takeda. In September 2023, Grifols announced plans to expand its production capabilities in Spain, emphasizing innovation in immunoglobulin therapies in response to growing demand. Takeda also highlighted its commitment to enhancing plasma collection and fractionation processes, integrating advanced technologies to improve efficiency. Mergers and acquisitions have played a role in shaping the market; Kedrion acquired certain assets from Biotest in early August 2023, reinforcing its position in the plasma market.

Additionally, CSL Behring and Fresenius Kabi are also exploring collaborations to increase capacity and improve patient access to therapies. The market has shown considerable growth due to rising chronic diseases and a robust healthcare framework in Spain, with government initiatives focused on increasing plasma donation rates. Over the past few years, the region has seen a rise in public-private partnerships to bolster research in plasma-derived therapies, with various companies enhancing their Research and Development investments to meet future healthcare needs.

Future Outlook

Spain Plasma Fractionation Market Future Outlook

The Plasma Fractionation Market in Spain is projected to grow at a 6.58% CAGR from 2025 to 2035, driven by increasing demand for immunoglobulins and advancements in technology.

New opportunities lie in:

  • Expansion of contract manufacturing services for biopharmaceutical companies.
  • Development of innovative plasma-derived therapies targeting rare diseases.
  • Investment in automated plasma collection and processing technologies.

By 2035, the plasma fractionation market is expected to achieve robust growth and enhanced competitive positioning.

Market Segmentation

Spain Plasma Fractionation Market End User Outlook

  • Hospitals
  • Ambulatory Surgical Centers
  • Blood Banks
  • Pharmaceutical Companies

Spain Plasma Fractionation Market Technology Outlook

  • Centrifugation
  • Chromatography
  • Precipitation
  • Filtration

Spain Plasma Fractionation Market Application Outlook

  • Neurology
  • Hematology
  • General Medicine
  • Immunology

Spain Plasma Fractionation Market Product Type Outlook

  • Immunoglobulin
  • Albumin
  • Coagulation Factors
  • Protease Inhibitors

Report Scope

MARKET SIZE 2024 795.5(USD Million)
MARKET SIZE 2025 847.84(USD Million)
MARKET SIZE 2035 1604.4(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 6.58% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Grifols (ES), CSL Behring (AU), Takeda Pharmaceutical Company (JP), Octapharma (CH), Kedrion (IT), Biotest AG (DE), LFB Group (FR), Sangamo Therapeutics (US), Emergent BioSolutions (US)
Segments Covered Application, Product Type, End User, Technology
Key Market Opportunities Advancements in plasma-derived therapies drive growth in the plasma fractionation market.
Key Market Dynamics Rising demand for immunoglobulins drives innovation and competition in the plasma fractionation market.
Countries Covered Spain
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FAQs

What is the expected market size of the Spain Plasma Fractionation Market in 2024?

The Spain Plasma Fractionation Market is expected to be valued at 473.2 million USD in 2024.

What will be the projected market value by 2035?

By 2035, the overall market is projected to reach a value of 750.0 million USD.

What is the expected CAGR for the Spain Plasma Fractionation Market from 2025 to 2035?

The market is anticipated to grow at a CAGR of 4.276% from 2025 to 2035.

What are the key product types in the Spain Plasma Fractionation Market?

The market includes key product types such as Immunoglobulin, Albumin, Coagulation Factors, and Protease Inhibitors.

How much is the Immunoglobulin segment valued in 2024?

The Immunoglobulin segment is valued at 158.0 million USD in 2024.

What is the expected value for the Albumin segment by 2035?

The Albumin segment is expected to reach a value of 190.0 million USD by 2035.

Who are the major players in the Spain Plasma Fractionation Market?

Key players in the market include Octapharma, Takeda, Kedrion, Grifols, and CSL Behring.

What value does the Coagulation Factors segment hold in 2024?

The Coagulation Factors segment holds a value of 130.0 million USD in 2024.

What are the growth drivers for the Spain Plasma Fractionation Market?

Growth drivers include increasing demand for immunoglobulin therapies and advancements in plasma processing technologies.

How large is the Protease Inhibitors segment expected to be in 2035?

The Protease Inhibitors segment is expected to grow to 98.0 million USD by 2035.

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