ID: MRFR/HC/9715-HCR | 120 Pages | Published By Kinjoll Dey on March 2023
The global needle-free injection system market size is projected to be worth ~USD 422.20 million by 2030, registering a CAGR of ~15.5% during the forecast period (2022 - 2030)
A needle-free injection system is a method of administering medication through the skin using the Lorentz force, shock waves, pressure, or electrophoresis force. Needle-free injection systems can be used repeatedly without running the risk of spreading infections, they are viewed as being superior to hypodermic needles. These injections help eliminate needlestick injuries and pain during drug delivery. The market is driven by factors such as the increasing incidence of communicable diseases due to needlestick injuries, the rise in demand for self-injection devices, and the increase in the population suffering from diabetes. However, a higher cost of development as compared to conventional injection systems, lack of awareness about needle-free injection systems, and limitations regarding intravenous drug administration could hamper the growth of the needle-free injection system market.
The COVID-19 pandemic positively affected the needle-free injection system market because it has brought attention to the need for self-injectable devices and mass vaccinations since the pandemic outbreak began in December 2019. Most of the major needle-free injection system market players have made R&D investments and entered into partnerships and agreements with other business players and governmental organizations to create a needle-free injection system for the disease as the number of cases has increased across regions. For instance, The University of Cambridge selected the needleless vaccine injector from PharmaJet Inc. (US) for the phase-1 trial of the COVID-19 vaccine candidate from DIOSynVax. The trial's objective was to evaluate the vaccine's efficacy when administered without using skin-piercing needles.
Such impacts have increased the demand for needle-free injection systems to overcome the disruptions caused by the pandemic. Hence, the pandemic positively impacted by creating multiple growth opportunities for the needle-free injection system market.
Value Chain Analysis
The value chain analysis of the market comprises four major components starting with the R&D and designing, followed by manufacturing the needle-free injectors devices, distribution & sales, and ending with post-sales services. R&D and designing start with conceptualizing, followed by design, then development, and lastly, testing. Manufacturing consists of 45-50% of the value chain. The sourcing of raw materials is the initial phase in the manufacturing of the products. Then comes distribution and sales, which is essential for any industry. Lastly comes post-sales services, where customer feedback is taken into consideration to improve upon their existing product portfolio.
By Product Insights
Prefilled needle-free injectors are used to package injectable drugs and vaccines. Prefilled syringes may contain drugs such as antithrombotic agents, vaccines, blood stimulants, interferons, and rheumatoid arthritis medications. Due to the rapid adoption of prefilled needle-free injections, these injections have emerged as the fastest-growing choice for unit-dose drugs.
Injectors with refillable needles are a common and environmentally friendly alternative to syringes. Compared to prefilled injectors, fillable needleless injectors have a few advantages, such as better opportunities for extractable and leaching (E&L), which lowers the likelihood of medication interactions. These E&L have the potential to interfere with medication molecules and reduce a drug's efficacy.
The fillable needle-free injectors segment held the largest market share in 2021. The large share of this segment can be attributed to the increasing application of needle-free injections in vaccination, insulin, and other drug delivery.
By Type Insights
Liquid-based needle-free jet injections employ a high-speed jet to puncture the skin and deliver drugs without the use of a needle. They have been used to deliver a number of macromolecules including vaccines and insulin, as well as small molecules, such as anesthetics and antibiotics. Since it reduces the chances of needle stick injuries and other complications, including those arising due to multiple uses of a single needle.
The liquid-based injectors segment held the largest market share in 2021. This is due to the ability of a liquid jet, which is stronger enough to penetrate the skin and the underlying fat layer without harming the skin or the integrity of the drug molecule.
Powder jet injectors deliver vaccines or drugs in dry powdered form into superficial layers of skin. The terms biolistic injectors and gene guns have also been commonly used for these injectors, with the latter term used exclusively for DNA delivery.
Projectile- or depot-based needle-free injectors are systems for delivering a drug into muscles. They develop a drug reserve in the muscles that are gradually released over a predetermined period. It is significantly more sophisticated than previous iterations of the needle free injection technology (NFITs) because the drug is processed into a long, thin depot with sufficient mechanical strength to transmit a driving force to a pointed tip that may be made of the drug itself or an inert substance.
By Technology Insights
Jet injectors are needle-free devices that drive liquid medication through a nozzle orifice, creating a narrow stream under high pressure that penetrates the skin to deliver a drug or vaccine into intradermal, subcutaneous, or intramuscular tissues. These jet-based injectors have the potential to reduce the frequency of needlestick injuries to healthcare providers and to overcome the improper reuse and other drawbacks of needles and syringes in economically developing countries.
The jet-based needle-free injectors segment held the largest market share in 2021 attributed to benefits associated with this technology, including rapid drug administration, improved dosage accuracy, better diffusion into the tissue, and a faster response rate.
The spring-based method is a particularly effective method of powering needle-free injection technology (NFIT) devices. The spring mechanism used by the spring-loaded jet injector is drawn back. A "jet stream" of medication or a vaccination travels through the dermal layers of the skin when a trigger is pressed, releasing the spring. It can be injected intramuscularly, transdermally, or subcutaneously.
Microarray patches, also known as microneedle patches, are made up of microscopic projections that are applied to the body like a small bandage, penetrating the skin's outermost layer painlessly and delivering a drug or vaccine to the top layers of the skin. These microneedles may improve thermostability, usability, and cost-effectiveness.
Other types of technology include vibration-based needle-free injectors and laser-powered needle-free Injectors. Vibration-based technologies are used for pediatric injections, insulin delivery, pain management, and vaccine administration. Additionally, the laser-driven microjet injector can be used to precisely control the dose and depth of drug penetration beneath the skin.
By Site of Delivery Insights
The intradermal injection causes a small, barely noticeable systemic influence. It can be used for local anesthetics and allergy testing in addition to being regularly used for tuberculin skin testing. An intradermal injection is given by inserting a 25-gauge or smaller needle at a 10° angle immediately beneath the epidermis.
An intramuscular injection is a technique used to deliver a medication deep into the muscles. This allows the medication to be absorbed into the bloodstream quickly. These injections are used when other types of delivery methods are not recommended such as oral, intravenous, and subcutaneous.
Subcutaneous injections can be used for a variety of purposes, such as administering vaccines, medications like heparin and insulin, and local anesthetic for medical procedures and intravenous cannulation.
The subcutaneous injectors segment held the largest market share in 2021. This is due to its greater effectiveness as the drug moves into the capillaries when it is injected and from there, it is carried to the bloodstream.
By Usability Inisghts
Disposable needles are frequently used to take blood samples, administer medications, and provide vaccines. They can also be used in place of old needles to stop the transmission of disease. These injections, rather than the conventional Mantoux needle method, are used for the BCG vaccination and tuberculosis skin testing, which lessens patient discomfort.
Reusable needle-free injectors have smaller storage and waste footprints, which reduce the environmental impact of production and patient waste. Reusable needle-free injectors increase safety and usefulness, take up less storage space, produce less waste, and are significantly less expensive than single-use injectors.
The reusable needle-free injectors segment held the largest market share in 2021. This is due to as they are cost-effective in the long run, with only the vial requiring the regular purchase and increasing adoption of reusable needle-free injections.
By Application Insighst
A new generation of needle-free vaccination delivery technologies (jet injectors) has been developed to lower the risks of needle stick injuries to medical professionals and to prevent improperly recycling syringes and needles.
The vaccine delivery segment held the largest market share in 2021 owing to the rising prevalence of chronic diseases and infectious diseases worldwide and the rising demand for patient-centric care.
Patients with type 2 diabetes may find it challenging to accept insulin therapy. A needle-free insulin injector has been developed for patients who are afraid of injections or are reluctant to start insulin therapy, even when it is necessary. The objective of this experiment was to assess the efficiency of insulin delivery in type 2 diabetics using a needle-free insulin injector (NFII) with a conventional insulin pen.
Pain management is the process of treating pain in all of its manifestations, from acute and mild to chronic and complex. Additionally, the pain management segment had a significant position due to the rise in cases of ailments like migraines, arthritis, myofascial pain syndrome, chronic pain, and pain disorders.
Oncology and dermatology are some further application categories. patients are treated with needle-free injectors in oncology, including radiation oncology, medical oncology, and surgical oncology. Additionally, dermatology patients are also treated using needle-free injectors for conditions including psoriasis and skin cancer.
By End User Insighst
Based on end-use, the hospitals and clinics segment accounted for the largest share in 2021. This is due to technological advancement and an increase in demand for vaccinations. For instance, In October 2021, Bengaluru hospitals were used as ZyCoV-D testing locations. For people 12 years of age and older, the needle-free COVID-19 immunisation ZyCoV-D is indicated. In addition, the hospital industry has expanded significantly in recent years due to a rise at hospital admissions and the accessibility of cutting-edge medical treatments in private hospitals.
Methods of medical care delivered to patients in their homes by trained staff or are self-administered are considered in homecare settings. Moreover, the use of needle free injections systems in the management of chronic illnesses is becoming more and more significant. These devices allow patients to self-administer medication at home, eliminating the need for frequent doctor visits. For instance, needle-free injectors, such jet injectors, are easier to use, more beneficial, and enhance patient compliance in home care settings.
Ambulatory surgery centers also referred to as outpatient surgical centers, are contemporary medical facilities that provide same-day surgical surgery and do not require hospital admissions. Ambulatory surgery centers are anticipated to improve as a result of rising healthcare spending, a shift to outpatient procedures, the availability of needle-free injections, and an increase in the usage of healthcare IT solutions to promote patient and clinician interaction.
Some of the numerous types of end customers include research facilities, pharmaceutical companies, and biotech companies. The pharmaceutical and biotechnology sectors are undergoing a profound shift as their operational horizons expand. Moreover, in 2022, pharmaceutical companies will pay particular attention to remaining flexible and resilient in the face of disruption brought on by a wide variety of needle-free injectors and altering consumer preferences.
One of the key factors fueling the market's expansion is the rise in the number of people with diabetes globally. Additionally, each healthcare worker suffers an average of 4 needlestick injuries per year, according to the WHO. The needle-free injection system market based on the region has been segmented into North America, Europe, Asia-Pacific, and the Rest of the World.
North America's market accounted for the largest share in 2021. This is to the presence of highly developed healthcare infrastructure, high patient awareness levels, increasing cases of chronic illnesses, and high research and development in needle-free injection technology in the region. According to the Occupational Safety and Health Administration (OSHA), in 2020, 5.6 million healthcare personnel in the US were at risk of work-related exposure to blood-borne pathogens via needlestick or other sharps-related injuries.
The industry players are adopting several business strategies to increase their market presence. They are significantly investing in R&D activities to expand their product portfolio, further driving the needle-free injection system market. Some key players in the market are Medical International Technology (MIT) (US), and Pharma Jet (US), and Antares Pharma. (US). Medical International Technology, Inc. (MIT USA), a company based in Colorado, US that specializes in the development, manufacture, marketing, and distribution of needle-free injectors for use in both human and animal inoculations as well as mass inoculations. Another player is PharmaJet.(US), is a medical device company. The company manufactures needle-free drug and vaccine delivery systems. In March 2022, NuGen Medical Devices (Canada) made a partnership with Unifire Inc. (US) to market and distribute its needle-free injection device to US government agencies.
List of companies covered in this report:
The study covers the existing short-term and long-term market effects. It helps decision-makers to draught short-term and long-term business plans by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's five forces, the value chain, and the impact of COVID-19 on the market.
Needle-Free Injection System Market Segmentation:
Global Needle-Free Injection System Market, By Product Outlook
Global Needle-Free Injection System Market, By Type Outlook
Global Needle-Free Injection System Market, By Technology Outlook
Global Needle-Free Injection System Market, By Site of Delivery Outlook
Global Needle-Free Injection System Market, By Usability Outlook
Global Needle-Free Injection System Market, By Application Outlook
Global Needle-Free Injection System Market, By End User Outlook
Global Needle-Free Injection System Market, By Region Outlook
|Market Size||2030: ~USD 422.20 Million|
|CAGR (2022- 2030)||~15.5%|
|Forecast Period||2022- 2030|
|Historical Data||2018 & 2020|
|Forecast Units||Value (USD Million)|
|Report Coverage||Revenue Forecast, Competitive Landscape, Growth Factors, and Trends|
|Segments Covered||Product, Type, Technology, Site of Delivery, Usability, Application, and End Users|
|Geographies Covered||North America, Europe, Asia-Pacific, and the Rest of the World|
|Key Vendors||Medical International Technology (MIT) (US) PharmaJet.(US) Antares Pharma. (US) Endo International (US) Ferring B.V. (Switzerland) Bioject Medical Technologies (US) NuGen Medical Devices (Canada) Portal Instruments (US) Enesi Pharma Limited (UK) Crossject (France)|
|Key Market Opportunities||Rising demand for biosimilars and vaccination processes|
|Key Market Drivers||Increasing incidence of communicable diseases due to needlestick injuries Rise in demand for self-injection devices Increase in Population Suffering from Diabetes|
The global needle-free injection system market size is projected to registering a CAGR of ~15.5% during the forecast period (2022 - 2030)
Hospitals And Clinics, Homecare Settings, Ambulatory Surgical Centers, and Others
North America's market predicted to have largest market share during the forecast period.
Increasing incidence of communicable diseases due to needlestick injuries and Rise in demand for self-injection devices are the growth factors
Investment in R&D activities to expand their product portfolio