全球器官芯片市场概览
p预计到 2032 年,器官芯片市场规模将达到 2.3 亿美元,预测期内(2023-2032 年)的复合年增长率为 11.7%。器官芯片 (OOC) 是带有生物相容性微流体室的小型塑料装置,其中包含 3D 培养中的多个活体人体细胞,可模拟身体器官的重要生理功能。这些细胞被置于人工复制人体各个方面的环境中,例如形态、运动、流动、电刺激和液体梯度。

制药公司与大学衍生企业之间的合作销售协议数量有所增加,新的先进器官芯片 (OOC) 模型也纷纷进入市场。预计先进器官专用模型和人体芯片模型的推出将进一步提高器官芯片市场未来的增长率。
市场规模较小主要是因为 OOC 尚未完全商业化。它们仍处于研发阶段,只有有限数量的最终用户在使用。
随着新型先进器官芯片 (OOC) 系统模型的推出,制药公司和大学衍生公司之间的联合销售协议的普及率显著上升。随着增强型器官特异性模型和人体芯片模型的开发,器官芯片市场的未来增长率可能会进一步提高。
此外,预计市场增长将受到增强药物筛选程序的推动,这导致主要行业参与者增加研发活动。此外,预计战略性努力和技术发展也将在预测的未来促进市场的增长。
市场增长主要受两个关键因素的影响:通过使用器官芯片 (OOC) 模型显着降低药物开发成本,以及政府和非政府组织提供资金。预计高复合年增长率 (CAGR) 的增长可能归因于制药公司和大学衍生公司之间越来越多的合作销售协议,以及市场上引入新的复杂器官芯片 (OOC) 技术模型。
即将推出的复杂器官专用模型和人体芯片模型可能会进一步提高器官芯片市场的未来增长率。
2024 年 6 月:Emulate, Inc. 推出了新版本的器官芯片平台,旨在更好地模拟人体肝功能。此次升级有望提高药物代谢研究的准确性。
2024 年 4 月,CN Bio 在 B 轮融资首轮结束之际获得了 2100 万美元,其中 Bayland Capital 和 CN Innovations Holdings Ltd 贡献了巨额资金。
器官芯片市场趋势
p器官芯片模型能够大幅降低药物开发成本,以及政府和非政府实体的资助是影响市场增长的主要因素。由于制药公司与大学衍生企业之间合作销售协议数量的增加,以及新型先进器官芯片模型的进入市场,预计该市场将以如此高的复合年增长率增长。预计先进器官专用模型和人体芯片模型的推出将在未来进一步提高器官芯片市场的增长率。迄今为止,政府和非政府实体的资助一直是全球器官芯片行业的主要驱动力。 OOC 模型能够大幅降低药物开发成本,这将成为未来市场的主要驱动力。此外,改进的药物筛选方法、主要参与者的研发投入增加、战略举措和技术进步的不断提高,预计也将在预测期内推动市场增长。
驱动因素
ul- 各大公司对器官芯片研究的投资不断增加 研发(rd)
- 利用器官芯片进行药物筛选的需求日益增长
- 器官芯片公司越来越关注整合方法、用于人类疾病模型的器官芯片(OOC)、个性化药物测试以及使用MOOC进行测试的监管状态
- 政府对器官芯片研发的倡议和资金不断增加:Mimetas 和 InSphero 等主要公司一直在与美国和欧洲的政府机构和大学合作,开发新型有效的器官芯片。例如,2018 年,InSphero 获得了 1000 万美元的政府资助,用于上述器官芯片模型的研发。
- 政府对药品审批的严格监管
- 器官芯片模型的复杂性
- 肺芯片:它是器官芯片市场中最大的细分市场,2018 年的市场份额约为 20%。肺芯片是一个复杂的活体呼吸人体肺的三维模型,放置在微芯片。
- 心脏芯片:这是一种用于生成三维心脏组织的装置。该装置用于研究心脏药物研发和心脏毒性测试,以实现个性化医疗和受损心脏组织的再生。
- 肝脏芯片:该芯片可生成生化和代谢信息,并显示肝脏功能。芯片中的荧光生物传感器细胞可显示肝细胞功能的变化,包括细胞死亡或自由基损伤。肝脏芯片的重要应用包括测试一般毒性、机械毒性和营养代谢。
- 肠道芯片:这些芯片用于研究人体肠道的生理学和病理生理学。它也可用作研究工具,用于代谢、营养、感染和药物药代动力学以及个性化医疗等应用。
- 肾脏芯片:肾脏芯片由器官芯片、细胞和试剂组成。这些芯片用于测试一般毒性、机械毒性和肾脏中的药物转运。
- 皮肤芯片:这些芯片用于刺激炎症、水肿和药物性皮肤病治疗。皮肤芯片用于在微流体系统中培养皮肤组织,该系统可控制人体皮肤的多种物理和生化参数。
- 血脑屏障芯片:这些芯片用于维持脑稳态、进行免疫细胞化学分析(用于分析细胞形态和蛋白质标记物表达)、进行通透性测定以及进行钙成像(用于研究大脑的神经元功能)。
- 人体芯片:这些是微流体装置,内衬有活体人体细胞,用于药物开发、疾病建模和个性化医疗。这些芯片还用于预测药物在人体内的药代动力学和药效学反应。
- 药物研发:这是器官芯片市场中最大的细分市场,因为许多制药公司都专注于通过器官芯片模型进行药物测试。
- 毒理学研究:这是器官芯片市场中第二大细分市场,因为各大高校和研究中心都专注于器官芯片在药物毒理学测试中的应用,与其他药物毒理学测试相比,这是一种更为先进的模型。方法。
- 其他:器官芯片 (OOC) 的其他应用包括食品饮料和化妆品行业。
- 制药公司:由于越来越多的制药公司使用 OOC 进行研发、药物毒性和疗效测试,该细分市场成为最大的细分市场。
- 研究机构:由于各大高校、研究机构和非营利研究中心都专注于 OOC 在药物毒理学测试中的应用,该细分市场成为器官芯片市场的第二大细分市场。例如,Wyss研究所于2017年从美国食品药品监督管理局(FDA)获得了近560万美元的资助,用于使用其器官芯片技术进行人体测试。
- 其他:包括小型诊所、研究所和从事器官芯片研发的个体研究人员。
欧洲:它是第二大市场,预计在预测期内将保持稳步增长。预计推动市场增长的因素包括:欧盟 (EU) 五个国家(英国、德国、法国、意大利和西班牙)主要 OOC 供应商的建立;政府举措和对研究机构的政府资助;企业和大学之间合作开发创新型 OOC,以及完善的医疗保健基础设施。
亚太地区:器官芯片市场增长最快的地区。此外,该地区拥有韩国、澳大利亚、日本和中国对 OOC 审批的支持性监管框架。这一因素,加上慢性病的高发病率,将在预测期内推动市场发展。
中东和非洲:由于沙特阿拉伯和阿曼等发达国家在该地区的存在,中东器官芯片市场预计将比非洲市场有更大的增长。
器官芯片行业发展
p2024 年 1 月,Emulate 宣布与辉瑞合作开发用于药物发现和安全测试的 OoC 模型。2023 年 9 月,CN Bio 是一家著名的公司,专门从事器官芯片 (OOC) 技术,用于设计和生产具有单个和多个器官的微生理系统 (MPS),与 LifeNet Health LifeSciences(也称为“LifeNet Health”)建立了战略合作伙伴关系。LifeNet Health 是一家全球公认的非营利组织,因其在全人类研究解决方案方面的专业知识而获得认可。此次合作的目的是为 CN Bio 的 PhysioMimix® OOC 系列 MPS 提供经过验证的原代人体细胞。该协议涵盖将LifeNet Health经验证具有高质量和MPS的肝细胞纳入CN Bio的非酒精性脂肪性肝炎 (NASH)“盒装”试剂盒。客户也可以直接从LifeNet Health获取这些细胞。此次合作为客户提供了一种简化的解决方案,以复制公司开发的先进体外肝脏模型,并提高其检测的成功率。
2023年11月,Emulate Inc.宣布推出其全新的Liver-on-a-Chip平台,这是一种可用于体外模拟肝功能的微流体装置。Liver-on-a-Chip平台旨在为研究人员提供更准确、更可靠的方法来研究肝脏疾病并开发新的治疗方法。
InSphero AG宣布推出其全新的Skin-on-a-Chip平台,这是一种可用于体外模拟皮肤功能的微流体装置。皮肤芯片平台旨在为研究人员提供更准确、更可靠的方法来研究皮肤病并开发新的治疗方法。
2023年11月,Organovo Inc.宣布推出其全新的体外肾脏平台,这是一个生物工程肾脏,可用于模拟体内肾脏功能。体外肾脏平台旨在为研究人员提供更准确、更可靠的方法来研究肾脏疾病并开发新的治疗方法。
2023年4月,韩国浦项科技大学 (POSTECH) 和韩国天主教大学恩平圣母医院的研究团队利用3D细胞打印技术成功开发出一款多器官芯片。这款创新芯片旨在精确模拟与2型糖尿病 (T2D) 相关的病理状况。为了模拟糖尿病的致病特征及其后果,研究团队制作了来自胰腺、脂肪组织和肝脏的生物墨水,这些生物墨水与 2 型糖尿病 (T2D) 有显著关联。
随后,研究人员利用 3D 细胞打印技术制造了一个多器官芯片平台,该平台旨在准确复制与 2 型糖尿病 (T2D) 相关的病理特征。
器官芯片市场主要参与者
ulFAQs
What is the current valuation of the Organ on chip Market as of 2024?
The Organ on chip Market was valued at approximately 410.67 USD Million in 2024.
What is the projected market valuation for the Organ on chip Market in 2035?
The market is projected to reach approximately 2025.47 USD Million by 2035.
What is the expected CAGR for the Organ on chip Market during the forecast period 2025 - 2035?
The expected CAGR for the Organ on chip Market during the forecast period 2025 - 2035 is 15.57%.
Which application segment is expected to generate the highest revenue in the Organ on chip Market?
The Personalized Medicine segment is anticipated to generate the highest revenue, with projections reaching 675.47 USD Million.
How do pharmaceutical companies contribute to the Organ on chip Market?
Pharmaceutical Companies are projected to contribute approximately 800.0 USD Million to the market by 2035.
What are the key technologies driving the Organ on chip Market?
Key technologies include Cell Culture, which is expected to reach 800.0 USD Million, and Microfluidics, projected at 500.0 USD Million.
Which type of organ-on-chip is expected to have the highest market value?
What materials are primarily used in the production of organ-on-chip devices?
Who are the leading companies in the Organ on chip Market?
What is the expected growth trend for the Organ on chip Market in the coming years?
Research Approach
Research Methodology on Organ on Chip Market
Introduction
Organ-on-Chip (OoC) technology is an innovative technology that is revolutionizing the biomedical research field. It involves the creation of miniature lab-on-chip systems containing living cells, micro-channels, sensors, actuators and other related components. It has enabled researchers to bypass the traditional bottlenecks associated with animal studies, enabling them to develop more effective drugs that have a higher rate of success and faster results than conventional drug development studies. This technology has also enabled researchers to simulate more complex human physiology more accurately, which in turn has allowed the development of personalized medicines and treatments.
The purpose of this research project is to understand the current market size of the Organ-on-Chip technology, identify the key products in the market, determine the future growth of the technology, and assess the market potential of the technology.
Research Objectives
- To analyze the market size of the Organ-on-Chip technology.
- To identify key players in the Organ-on-Chip technology market.
- To understand the growth potential of the technology.
- To identify threats and opportunities in the Organ-on-Chip technology market.
Research Questions
- What is the current market size of the Organ-on-Chip technology?
- Who are the leading players in the Organ-on-Chip technology market?
- What is the growth potential of Organ-on-Chip technology?
- What are the threats and opportunities in the Organ-on-Chip technology market?
Research Approach
This research will employ descriptive, as well as exploratory research approaches in order to gain an in-depth understanding of the Organ-on-Chip technology market. Descriptive research is used to analyze the size and scope of the current Organ-on-Chip technology market and identify the key players in the industry. Exploratory research is employed to gain a better understanding of the growth potential of the technology, as well as identify the threats and opportunities present in the market.
Research Design
The research employs both qualitative and quantitative research designs. The qualitative design involves semi-structured interviews with key industry experts and stakeholders, as well as analyzing secondary sources including reports, industry white papers, and other available data. The quantitative design involves surveys and polls, as well as analysis of the data, gathered through qualitative research.
Sampling & Data Collection
The sample size for the research will be 1000 respondents, strategically chosen to provide a comprehensive overview of the Organ-on-Chip technology market. The sample includes representatives from key sectors of the industry, such as manufacturers of technology, agricultural and pharmaceutical companies, research institutions, government agencies, as well as other stakeholders. The data is collected using both primary and secondary methods. Primary methods include surveys and face-to-face interviews, while secondary methods involve analysis of available published documents, industry reports, and other available data.
Data Analysis
The collected data is analyzed using both quantitative and qualitative methods. Quantitative data analysis tools such as SPSS and Excel are utilized to analyze the collected data statistically and to generate results from the surveys and polls. Qualitative data analysis methods, such as content analysis and thematic analysis, are used to analyze the interviews conducted with experts and stakeholders.
Conclusion
The organ-on-chip technology market has enormous potential and could revolutionize the research and drug development sector. This research provides an in-depth understanding of the current market size and scope, the key players in the industry, the potential growth of the technology, as well as the threats and opportunities present in the market. The findings of this research prove to be beneficial for key stakeholders in the industry.
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