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US Endometrial Cancer Market

ID: MRFR/MED/15168-HCR
100 Pages
Garvit Vyas
February 2026

US Endometrial Cancer Market Research Report: Size, Share, Trend Analysis By Types of Treatment (Surgery, Radiation Therapy, Chemotherapy, Hormonal Therapy, Targeted Therapy), By Diagnosis Method (Biopsy, Imaging Tests, Pelvic Exam, Endometrial Sampling), By End Users (Hospitals, Cancer Research Centers, Diagnostic Laboratories, Ambulatory Surgical Centers) and By Stage of Cancer (Early Stage, Locally Advanced Stage, Metastatic Stage) - Growth Outlook & Industry Forecast 2025 To 2035

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US Endometrial Cancer Market Summary

As per analysis, the US Endometrial Cancer Market is projected to grow from USD 3.84 Billion in 2024 to USD 7.02 Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 5.63% during the forecast period (2025 - 2035).

Key Market Trends & Highlights

The US Endometrial Cancer Market is poised for growth driven by advancements in treatment and increased awareness.

  • Personalized treatment approaches are gaining traction, enhancing patient outcomes in the Endometrial Cancer Market.
  • Technological integration in diagnostics is revolutionizing early detection and treatment planning.
  • Increased awareness and education about endometrial cancer are contributing to higher screening rates.
  • The rising incidence of endometrial cancer and advancements in treatment modalities are key drivers of market growth.

Market Size & Forecast

2024 Market Size 3.84 (USD Billion)
2035 Market Size 7.02 (USD Billion)
CAGR (2025 - 2035) 5.63%

Major Players

Merck & Co. (US), Bristol-Myers Squibb (US), Pfizer Inc. (US), AstraZeneca (US), Genentech (US), Eli Lilly and Company (US), Novartis (US), Amgen Inc. (US), Bayer AG (US)

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US Endometrial Cancer Market Trends

The US Endometrial Cancer Market is currently experiencing notable shifts driven by advancements in treatment modalities and increasing awareness surrounding women's health issues. The rise in the prevalence of endometrial cancer has prompted healthcare providers to focus on early detection and innovative therapeutic approaches. This market is characterized by a growing emphasis on personalized medicine, which tailors treatment plans to individual patient profiles, thereby enhancing efficacy and minimizing adverse effects. Furthermore, the integration of technology in diagnostics and treatment is reshaping the landscape, allowing for more precise interventions and improved patient outcomes. In addition, the US Endometrial Cancer Market is witnessing a surge in research initiatives aimed at understanding the underlying mechanisms of the disease. This research is likely to lead to the development of novel therapies and improved screening methods. The collaboration between academic institutions and pharmaceutical companies appears to be fostering an environment conducive to innovation. As awareness campaigns continue to educate the public about risk factors and symptoms, it is anticipated that more women will seek medical advice, potentially leading to earlier diagnoses and better prognoses. Overall, the market is poised for growth as it adapts to the evolving needs of patients and healthcare providers alike.

Personalized Treatment Approaches

The US Endometrial Cancer Market is increasingly leaning towards personalized treatment strategies. This trend reflects a broader shift in oncology towards tailoring therapies based on individual genetic profiles and tumor characteristics. Such approaches may enhance treatment effectiveness and reduce side effects, thereby improving patient quality of life.

Technological Integration in Diagnostics

Advancements in technology are significantly impacting the US Endometrial Cancer Market, particularly in diagnostic procedures. The adoption of innovative imaging techniques and molecular diagnostics is facilitating earlier detection and more accurate assessments of the disease, which could lead to improved treatment outcomes.

Increased Awareness and Education

There is a growing emphasis on awareness and education regarding endometrial cancer in the US. Public health campaigns are likely to play a crucial role in informing women about risk factors and symptoms, potentially leading to earlier diagnoses and a more proactive approach to treatment.

US Endometrial Cancer Market Drivers

Government Initiatives and Funding

Government initiatives and funding play a crucial role in shaping the US Endometrial Cancer Market. The National Cancer Institute (NCI) and other federal agencies have been actively involved in research and funding programs aimed at understanding and combating endometrial cancer. For example, the NCI allocates substantial resources to research projects focused on prevention, early detection, and treatment of endometrial cancer. Additionally, public health campaigns aimed at educating women about risk factors and symptoms are likely to increase early diagnosis rates. Such initiatives not only enhance awareness but also encourage the development of new therapies and diagnostic tools, thereby fostering growth within the US Endometrial Cancer Market. The ongoing commitment of government bodies to address this health issue is expected to create a favorable environment for market expansion.

Advancements in Treatment Modalities

The US Endometrial Cancer Market is significantly influenced by advancements in treatment modalities. Recent developments in targeted therapies, immunotherapies, and minimally invasive surgical techniques have transformed the treatment landscape for endometrial cancer. For instance, the introduction of drugs such as pembrolizumab and lenvatinib has shown promising results in clinical trials, leading to increased adoption in clinical practice. Furthermore, the National Comprehensive Cancer Network (NCCN) guidelines have been updated to include these novel therapies, which may enhance treatment outcomes for patients. As these advancements continue to emerge, they are likely to attract investment and research funding, thereby propelling the growth of the US Endometrial Cancer Market. The integration of these innovative treatment options is expected to improve patient prognosis and quality of life, further stimulating market demand.

Growing Focus on Personalized Medicine

The US Endometrial Cancer Market is increasingly shifting towards personalized medicine, which tailors treatment strategies based on individual patient characteristics. This approach is gaining traction due to advancements in genomic profiling and biomarker identification, which allow for more precise treatment options. For instance, the use of genetic testing to determine the most effective therapies for specific endometrial cancer subtypes is becoming more prevalent. As healthcare providers adopt personalized treatment plans, the demand for targeted therapies and companion diagnostics is likely to rise. This trend not only enhances treatment efficacy but also aligns with the broader movement towards precision medicine in oncology. Consequently, the growing focus on personalized medicine is expected to significantly influence the US Endometrial Cancer Market, driving innovation and improving patient outcomes.

Rising Incidence of Endometrial Cancer

The US Endometrial Cancer Market is experiencing growth due to the rising incidence of endometrial cancer among women. According to the American Cancer Society, the estimated number of new cases of endometrial cancer in the United States is projected to reach approximately 66,570 in 2021, with a significant increase expected in subsequent years. This upward trend is attributed to various factors, including an aging population and increasing obesity rates, which are known risk factors for the disease. As awareness of the disease grows, healthcare providers are likely to focus more on early detection and treatment options, thereby driving the demand for innovative therapies and diagnostic tools within the US Endometrial Cancer Market. Consequently, this rising incidence is expected to create a robust market environment for stakeholders involved in the development and distribution of endometrial cancer-related products.

Increased Investment in Research and Development

Investment in research and development (R&D) is a key driver of growth in the US Endometrial Cancer Market. Pharmaceutical companies and biotech firms are increasingly allocating resources to develop new therapies and improve existing treatment options for endometrial cancer. The market for endometrial cancer therapeutics is projected to grow substantially, with estimates suggesting a compound annual growth rate (CAGR) of over 5% in the coming years. This growth is fueled by the need for more effective treatments and the potential for novel therapies to address unmet medical needs. Additionally, collaborations between academic institutions and industry players are likely to enhance innovation and expedite the development of new solutions. As R&D efforts continue to expand, the US Endometrial Cancer Market is expected to benefit from a pipeline of innovative products that could transform patient care.

Market Segment Insights

By Treatment Type: Surgery (Largest) vs. Radiation Therapy (Fastest-Growing)

In the US Endometrial Cancer Market, the treatment type segment is primarily dominated by surgery, which accounts for a significant share of the treatment modalities provided to patients. Surgery acts as the standard treatment approach, particularly in the early stages of endometrial cancer, contributing substantially to the overall market. Meanwhile, radiation therapy holds a notable position, often utilized as an adjuvant treatment or for patients who are not suitable candidates for surgery, reflecting a critical role in comprehensive care for endometrial cancer.

Surgery: Dominant vs. Radiation Therapy: Emerging

Surgery remains the dominant treatment option for endometrial cancer, offering potentially curative outcomes through procedures such as hysterectomy and lymphadenectomy. Its strategic use in managing localized cases underscores its foundational role in therapy regimens. Conversely, radiation therapy is emerging as a swift and effective secondary treatment, particularly for patients with advanced disease or those wishing to avoid surgery. As advancements in radiotherapy techniques and technology proliferate, this treatment option is increasingly becoming a preferred choice, leading to improved patient outcomes and significantly expanding its market presence.

By Stage of Cancer: Stage I (Largest) vs. Stage III (Fastest-Growing)

In the US Endometrial Cancer Market, stage-based categorization shows that Stage I comprises the largest share, reflecting better diagnosis rates and treatment responses. This early-stage classification is significant due to the predominance of patients being diagnosed at this stage, leading to more favorable outcomes and treatment accessibility. Conversely, Stage II, Stage III, and Stage IV collectively contribute to the overall market but do not match Stage I's market share, indicating a more challenging prognosis as the disease progresses.

Stage I (Dominant) vs. Stage III (Emerging)

Stage I endometrial cancer is considered the dominant segment due to early detection and effective treatment protocols that lead to high recovery rates. Patients usually undergo surgery and may receive adjuvant therapy, resulting in a robust market for related therapeutic agents. Meanwhile, Stage III is emerging as a critical focus in treatment research, characterized by more complex clinical management due to the spread beyond the uterus. Growing awareness and advances in targeted therapies are contributing to an increased market focus on Stage III through novel treatments and enhanced patient management strategies.

By Histological Type: Endometrioid Carcinoma (Largest) vs. Serous Carcinoma (Fastest-Growing)

In the US Endometrial Cancer Market, the distribution of histological types reveals that Endometrioid Carcinoma holds the largest market share, predominantly impacting patient diagnosis and treatment approaches. This type accounts for a significant percentage of cases, reflecting its established presence in the clinical landscape. In contrast, Serous Carcinoma, while not holding the largest share, is recognized as the fastest-growing segment, indicative of a trend towards identifying and managing more aggressive forms of endometrial cancer, shaped by evolving diagnostic techniques and increased awareness among healthcare providers. Growth trends in the US Endometrial Cancer Market are influenced by various factors including advancements in research, rising awareness about different histological types, and improved screening methods. The growth of Serous Carcinoma is underscored by emerging studies and clinical trials focusing on this aggressive variant, as well as a rising incidence rate that necessitates enhanced treatment protocols. Alongside this, Endometrioid Carcinoma remains a focal point due to its prevalence and the ongoing search for better therapeutic strategies to improve patient outcomes.

Endometrioid Carcinoma (Dominant) vs. Clear Cell Carcinoma (Emerging)

Endometrioid Carcinoma is characterized as the dominant histological type in the US Endometrial Cancer Market, presenting a more favorable prognosis compared to other forms. It typically arises from endometrial hyperplasia and is associated with hormone sensitivity, which influences treatment decisions. However, Clear Cell Carcinoma is emerging as a critical concern due to its rarity and aggressive nature, leading to unique clinical challenges. This form often presents at a more advanced stage, necessitating a tailored therapeutic approach. The market dynamics between these two histological types are marked by a shift towards recognizing and addressing the distinct characteristics of Clear Cell Carcinoma, ensuring that clinical practices evolve to accommodate the needs of this patient population.

By Risk Factors: Obesity (Largest) vs. Age (Fastest-Growing)

In the US Endometrial Cancer Market, the distribution of risk factors reveals that obesity stands out as the largest contributor, significantly influencing the prevalence of this cancer type. Following closely is age, which is noted as the fastest-growing risk factor. Data indicates that women over the age of 50 represent a substantial portion of endometrial cancer cases, while the rising obesity rate among the general population necessitates attention to its role as a critical risk factor.

Obesity (Dominant) vs. Age (Emerging)

Obesity, recognized as the dominant risk factor for endometrial cancer in the US, correlates strongly with increased estrogen production, which can stimulate endometrial tissue. This correlation places it at the forefront of public health concerns, particularly given the rising obesity rates across the country. On the other hand, age emerges as a vital risk factor, particularly in women aged 50 and older, where incidences of endometrial cancer are markedly higher. This demographic shift signifies an emerging public health challenge, as an aging population faces compounded health risks.

By Diagnosis Method: Ultrasound (Largest) vs. Biopsy (Fastest-Growing)

In the US Endometrial Cancer Market, the 'Diagnosis Method' segment is characterized by distinct approaches including Ultrasound, Biopsy, MRI, and CT Scan. Ultrasound currently holds the largest market share, favored for its non-invasive nature and effectiveness in initial assessments, contributing to its widespread adoption among healthcare providers. Biopsy, while smaller in market share, is rapidly gaining traction due to its critical role in definitive diagnosis, underscoring a shift towards more precise methods for cancer confirmation.

Biopsy (Dominant) vs. CT Scan (Emerging)

In the current landscape of diagnosis methods, Biopsy stands out as the dominant technique due to its definitive role in identifying endometrial cancer, often following inconclusive results from imaging tests. Its ability to provide tissue samples allows for accurate histopathological examinations, making it essential for staging and treatment planning. Conversely, CT Scan is an emerging tool in this segment, utilized mainly for evaluating the extent of disease spread after diagnosis. Although it does not replace Biopsy in diagnosis, CT Scan is gaining importance for treatment assessment and follow-up, indicating a broader trend towards integrated diagnostic strategies in oncology.

Get more detailed insights about US Endometrial Cancer Market

Key Players and Competitive Insights

The Endometrial Cancer Market is characterized by a dynamic competitive landscape, driven by a confluence of innovation, strategic partnerships, and a growing emphasis on personalized medicine. Major players such as Merck & Co. (US), Bristol-Myers Squibb (US), and Pfizer Inc. (US) are at the forefront, each adopting distinct strategies to enhance their market presence. Merck & Co. (US) focuses on advancing its immunotherapy portfolio, while Bristol-Myers Squibb (US) emphasizes combination therapies to improve patient outcomes. Pfizer Inc. (US) is leveraging its extensive research capabilities to develop novel therapeutics, thereby contributing to a competitive environment that is increasingly centered around cutting-edge treatment modalities.
In terms of business tactics, companies are localizing manufacturing and optimizing supply chains to enhance efficiency and responsiveness to market demands. The competitive structure of the Endometrial Cancer Market appears moderately fragmented, with several key players exerting influence. This fragmentation allows for a diverse range of treatment options, although it also necessitates strategic collaborations among companies to maintain competitive advantages.
In December 2025, Merck & Co. (US) announced a strategic partnership with a leading biotechnology firm to co-develop a novel immunotherapy specifically targeting endometrial cancer. This collaboration is poised to enhance Merck's therapeutic offerings and potentially accelerate the development timeline for new treatments, reflecting a broader trend towards collaborative innovation in the sector.
In November 2025, Bristol-Myers Squibb (US) revealed promising results from a clinical trial evaluating a combination therapy for endometrial cancer, which demonstrated a significant improvement in patient response rates. This development underscores the company's commitment to advancing treatment options and may position it favorably in the competitive landscape as it seeks to capitalize on the growing demand for effective therapies.
In October 2025, Pfizer Inc. (US) launched a new digital health initiative aimed at improving patient engagement and adherence to treatment protocols for endometrial cancer patients. This initiative not only enhances patient outcomes but also aligns with the industry's shift towards digitalization, indicating Pfizer's proactive approach to integrating technology into its therapeutic strategies.
As of January 2026, current trends in the Endometrial Cancer Market are increasingly defined by digitalization, sustainability, and the integration of artificial intelligence (AI) in drug development. Strategic alliances are becoming pivotal in shaping the competitive landscape, as companies recognize the value of collaboration in driving innovation. Looking ahead, competitive differentiation is likely to evolve from traditional price-based competition towards a focus on technological advancements, innovative treatment solutions, and robust supply chain reliability, thereby enhancing overall patient care and outcomes.

Key Companies in the US Endometrial Cancer Market include

Industry Developments

The US Endometrial Cancer Market has seen significant developments recently, with companies like AstraZeneca and Merck enhancing their drug portfolios. AstraZeneca is focusing on the trials for its pipeline drugs targeting endometrial cancer, indicating a strategic push toward innovative treatments. In June 2023, Celgene announced promising outcomes from their clinical trials, contributing positively to their market valuation. Additionally, Bristol Myers Squibb actively pursued collaborations to innovate therapies in this sector.

In terms of mergers and acquisitions, Eli Lilly announced the acquisition of a biotechnology firm in July 2023, aimed at bolstering its offerings in oncology, including endometrial cancer. Pfizer, also in the spotlight, had a successful merger with a small-scale firm in August 2023 to enhance its Research and Development capabilities around hormone receptor-positive endometrial cancer therapies.

The overall market for endometrial cancer treatments in the US is projected to grow, driven by advancements from companies such as Roche and AbbVie. This growth is, in part, due to increased funding for research, as outlined in the National Cancer Institute's latest reports, highlighting the urgency of addressing this challenging disease.

Future Outlook

US Endometrial Cancer Market Future Outlook

The US Endometrial Cancer Market is projected to grow at a 5.63% CAGR from 2025 to 2035, driven by advancements in treatment options, increasing awareness, and early detection initiatives.

New opportunities lie in:

  • Development of personalized immunotherapy treatments for endometrial cancer patients. Expansion of telehealth services for remote patient monitoring and consultations. Investment in AI-driven diagnostic tools to enhance early detection rates.

By 2035, the market is expected to be robust, driven by innovation and increased patient engagement.

Market Segmentation

US Endometrial Cancer Market Risk Factors Outlook

  • Obesity
  • Age
  • Genetic Mutations
  • Hormonal Factors

US Endometrial Cancer Market Treatment Type Outlook

  • Surgery
  • Radiation Therapy
  • Chemotherapy
  • Hormonal Therapy

US Endometrial Cancer Market Stage of Cancer Outlook

  • Stage I
  • Stage II
  • Stage III
  • Stage IV

US Endometrial Cancer Market Diagnosis Method Outlook

  • Ultrasound
  • Biopsy
  • MRI
  • CT Scan

US Endometrial Cancer Market Histological Type Outlook

  • Endometrioid Carcinoma
  • Serous Carcinoma
  • Clear Cell Carcinoma
  • Mixed Cell Carcinoma

Report Scope

MARKET SIZE 2024 3.84(USD Billion)
MARKET SIZE 2025 4.08(USD Billion)
MARKET SIZE 2035 7.02(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR) 5.63% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Billion
Key Companies Profiled Merck & Co. (US), Bristol-Myers Squibb (US), Pfizer Inc. (US), AstraZeneca (US), Genentech (US), Eli Lilly and Company (US), Novartis (US), Amgen Inc. (US), Bayer AG (US)
Segments Covered Treatment Type, Stage of Cancer, Histological Type, Risk Factors, Diagnosis Method
Key Market Opportunities Advancements in personalized medicine and targeted therapies enhance treatment options in the US Endometrial Cancer Market.
Key Market Dynamics Rising demand for innovative therapies drives competition and regulatory scrutiny in the US Endometrial Cancer Market.
Countries Covered US
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FAQs

What is the current valuation of the US Endometrial Cancer Market?

The US Endometrial Cancer Market was valued at 3.84 USD Billion in 2024.

What is the projected market valuation for the US Endometrial Cancer Market by 2035?

The market is projected to reach 7.02 USD Billion by 2035.

What is the expected CAGR for the US Endometrial Cancer Market during the forecast period 2025 - 2035?

The expected CAGR for the market during 2025 - 2035 is 5.63%.

Which treatment types are included in the US Endometrial Cancer Market segments?

The market segments include Surgery, Radiation Therapy, Chemotherapy, and Hormonal Therapy.

What were the valuations for Surgery in the US Endometrial Cancer Market from 2024 to 2035?

Surgery was valued at 1.15 USD Billion in 2024 and is projected to reach 2.05 USD Billion by 2035.

How does the market perform by stage of cancer?

By stage, Stage I was valued at 1.15 USD Billion in 2024 and is expected to grow to 2.05 USD Billion by 2035.

What are the key histological types contributing to the US Endometrial Cancer Market?

Key histological types include Endometrioid Carcinoma, Serous Carcinoma, Clear Cell Carcinoma, and Mixed Cell Carcinoma.

What is the projected growth for Endometrioid Carcinoma in the market?

Endometrioid Carcinoma was valued at 1.92 USD Billion in 2024 and is anticipated to reach 3.42 USD Billion by 2035.

What risk factors are associated with the US Endometrial Cancer Market?

Risk factors include Obesity, Age, Genetic Mutations, and Hormonal Factors.

Which companies are the key players in the US Endometrial Cancer Market?

Key players include Merck & Co., Bristol-Myers Squibb, Pfizer Inc., and AstraZeneca.

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