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Pemphigus Market

ID: MRFR/Pharma/5024-HCR
100 Pages
Rahul Gotadki
October 2025

Pemphigus Market Research Report Information  By Type (Pemphigus Vulgaris and Others), by Diagnosis (Skin Peeling, Endoscopy, and Others), by Treatment (Corticosteroid, Biological Therapies, and Others), by End-Users (Hospitals and Others)– Forecast Till 2035

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Pemphigus Market Summary

As per MRFR analysis, the Pemphigus Market Size was estimated at 578.9 USD Million in 2024. The Pemphigus industry is projected to grow from 634.1 in 2025 to 1410.37 by 2035, exhibiting a compound annual growth rate (CAGR) of 8.39 during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The Pemphigus Market is experiencing notable growth driven by advancements in treatment and increasing awareness.

  • Rising awareness and education about pemphigus are enhancing patient engagement and treatment adherence.
  • Advancements in treatment options, particularly in biologics, are transforming the management of pemphigus vulgaris.
  • Integration of multidisciplinary care is becoming essential in providing comprehensive treatment for patients across North America and Asia-Pacific.
  • The increasing incidence of pemphigus, coupled with innovative therapeutic developments, is driving market growth and investment in research and development.

Market Size & Forecast

2024 Market Size 578.9 (USD Million)
2035 Market Size 1410.37 (USD Million)
CAGR (2025 - 2035) 8.39%

Major Players

Roche (CH), Bristol-Myers Squibb (US), Novartis (CH), Amgen (US), Sanofi (FR), Merck & Co. (US), Pfizer (US), GSK (GB), AbbVie (US)

Pemphigus Market Trends

The Pemphigus Market is currently experiencing notable developments, driven by a combination of increasing awareness and advancements in treatment options. The rise in the prevalence of pemphigus, an autoimmune blistering disorder, has prompted healthcare providers and researchers to focus on innovative therapies. This heightened attention is likely to foster collaborations among pharmaceutical companies, academic institutions, and healthcare organizations, aiming to enhance patient outcomes. Furthermore, the growing emphasis on personalized medicine appears to be shaping the landscape of treatment approaches, as tailored therapies may offer improved efficacy and safety profiles for individuals affected by this condition. In addition, the Pemphigus Market is witnessing a shift towards more comprehensive care models, integrating multidisciplinary teams to address the complex needs of patients. This trend suggests a potential increase in the availability of support services, including psychological counseling and nutritional guidance, which could significantly improve the quality of life for those living with pemphigus. As research continues to evolve, the market may also see the introduction of novel biologics and targeted therapies, which could revolutionize the management of this challenging disease.

Rising Awareness and Education

There is a growing recognition of pemphigus among healthcare professionals and the general public. Increased educational initiatives are likely to enhance understanding of the disease, leading to earlier diagnosis and treatment.

Advancements in Treatment Options

The Pemphigus Market is experiencing a surge in innovative therapies, including biologics and targeted treatments. These advancements may provide more effective management strategies for patients.

Integration of Multidisciplinary Care

A trend towards holistic care models is emerging, where various healthcare professionals collaborate to address the diverse needs of pemphigus patients. This approach could improve overall patient outcomes.

Pemphigus Market Drivers

Market Growth Projections

The Global Pemphigus Market Industry is projected to experience substantial growth over the coming years. With a market value of 1.67 USD Billion in 2024, it is anticipated to reach 4.0 USD Billion by 2035. This growth trajectory reflects a CAGR of 8.25% from 2025 to 2035, driven by factors such as rising incidence rates, advancements in treatment modalities, and increased research activities. The market's expansion indicates a growing recognition of pemphigus as a significant health concern, necessitating ongoing investment in therapeutic development and patient care.

Rising Incidence of Pemphigus

The Global Pemphigus Market Industry experiences a notable increase in the incidence of pemphigus, an autoimmune blistering disorder. Recent data suggests that the prevalence of pemphigus vulgaris is approximately 0.5 to 3 cases per 100,000 individuals globally. This rising incidence is likely to drive the demand for effective treatment options, contributing to the market's growth. As the population ages and awareness of autoimmune diseases increases, the Global Pemphigus Market Industry is projected to reach 1.67 USD Billion in 2024, indicating a strong need for innovative therapies and management strategies.

Supportive Government Policies

Supportive government policies and initiatives play a pivotal role in the Global Pemphigus Market Industry. Regulatory agencies are increasingly recognizing the need for effective treatments for rare diseases, including pemphigus. Policies that promote research funding, expedite drug approvals, and provide incentives for pharmaceutical companies are likely to foster innovation in this field. Such supportive measures can enhance the availability of treatment options, ultimately benefiting patients. As the market evolves, these policies may contribute to a more robust Global Pemphigus Market Industry, ensuring that patients have access to necessary therapies.

Growing Awareness and Education

Growing awareness and education regarding pemphigus among healthcare professionals and patients contribute positively to the Global Pemphigus Market Industry. Initiatives by health organizations and patient advocacy groups aim to disseminate information about the disease, its symptoms, and treatment options. This increased awareness is likely to facilitate early diagnosis and prompt treatment, thereby improving patient outcomes. As more individuals seek medical attention, the demand for therapies is expected to rise, further propelling the Global Pemphigus Market Industry's growth trajectory.

Advancements in Treatment Modalities

Innovations in treatment modalities significantly influence the Global Pemphigus Market Industry. The introduction of biologics and targeted therapies has transformed the management of pemphigus, offering improved efficacy and safety profiles. For instance, monoclonal antibodies such as rituximab have shown promising results in clinical trials, leading to increased adoption in clinical practice. This trend is expected to continue, with the market projected to expand at a CAGR of 8.25% from 2025 to 2035. As new therapies emerge, the Global Pemphigus Market Industry is likely to witness substantial growth, enhancing patient outcomes and quality of life.

Increased Research and Development Activities

The Global Pemphigus Market Industry benefits from heightened research and development activities aimed at understanding the pathophysiology of pemphigus. Government and academic institutions are increasingly investing in studies to identify novel therapeutic targets and biomarkers. This surge in R&D is anticipated to lead to the discovery of new treatment options, thereby expanding the market. With a projected market value of 4.0 USD Billion by 2035, the emphasis on innovation and scientific exploration is likely to play a crucial role in shaping the future of the Global Pemphigus Market Industry.

Market Segment Insights

By Type of Pemphigus: Pemphigus Vulgaris (Largest) vs. Pemphigus Foliaceus (Fastest-Growing)

In the Pemphigus market, Pemphigus Vulgaris holds the largest market share among the various types. It is known for its severe symptoms and significant health complications, leading to a strong demand for treatment options. Meanwhile, Pemphigus Foliaceus, while smaller in market share, is emerging as the fastest-growing type due to increasing awareness and research supporting new therapeutic approaches. This dynamic illustrates the diverse needs and challenges presented by each pemphigus type in the healthcare landscape. As the healthcare industry evolves, so do treatment options for these conditions. The rise in Pemphigus Foliaceus cases can be attributed to better diagnostic capabilities and a more focused research effort, enabling early detection and improved patient outcomes. In contrast, Pemphigus Vulgaris continues to drive the market due to its severe nature, prompting ongoing innovation in treatment modalities, including biologics and targeted therapies, to enhance patient quality of life.

Pemphigus Vulgaris (Dominant) vs. Pemphigus Erythematosus (Emerging)

Pemphigus Vulgaris is recognized as the dominant type in the pemphigus market, characterized by its serious manifestations such as painful blisters and erosions of the skin and mucous membranes. This condition requires comprehensive management strategies, including the use of systemic corticosteroids and immunosuppressants. On the other hand, Pemphigus Erythematosus is seen as the emerging type, presenting with milder symptoms and more localized inflammation. The growing research interest in this variant highlights its distinct pathophysiological characteristics and treatment preferences, such as less aggressive immunotherapies. As awareness increases and more patient-centric approaches are developed, both types are positioned to shape the future of the pemphigus therapeutic landscape.

By Treatment Method: Corticosteroids (Largest) vs. Biologics (Fastest-Growing)

In the Pemphigus Market, the Treatment Method segment is characterized by a diverse array of therapeutic approaches. Corticosteroids remain the largest segment, significantly contributing to the treatment landscape due to their effectiveness in managing symptoms and controlling inflammation. Immunosuppressants also play a crucial role but have a smaller market share compared to corticosteroids. Biologics, on the other hand, are rapidly gaining traction, driven by their targeted action and higher patient preference, making them a competitive option in the treatment of Pemphigus.

Corticosteroids (Dominant) vs. Biologics (Emerging)

Corticosteroids are predominant in the treatment of Pemphigus due to their established efficacy in inducing remission and managing flare-ups. They work by suppressing the immune response, effectively reducing inflammation and blister formation in affected patients. On the other hand, biologics represent an emerging treatment avenue, providing a novel, targeted approach to therapy. These agents focus on specific components of the immune system, offering enhanced safety profiles and potential for improved long-term management. The shift towards biologics is propelled by increasing clinical evidence and patient demand for personalized medicine, positioning them as a key player in the evolving treatment landscape of Pemphigus.

By Patient Demographics: Age Group (Largest) vs. Gender (Fastest-Growing)

In the Pemphigus Market, the distribution of patient demographics indicates that the largest age group affected is middle-aged adults, particularly between the ages of 40 and 60, who constitute a significant portion of the patient population. Gender-wise, the market has historically seen a higher prevalence in females, with recent reports also showing a notable increase in male patients, indicating shifts in demographic trends.

Age Group (Dominant) vs. Gender (Emerging)

The middle-aged adult segment, often categorized as the dominant age group in the Pemphigus Market, displays unique characteristics, being primarily affected by pemphigus vulgaris and pemphigus foliaceus. These individuals often face challenges in both physical and emotional well-being, impacting their quality of life. On the other hand, the gender demographic is marked by an increasing representation of males as emerging segments, indicating a wider awareness and diagnosis of pemphigus among this group. This shift also points to changing healthcare dynamics and improved diagnostic capabilities that enhance early detection and treatment options.

By Disease Severity: Moderate (Largest) vs. Severe (Fastest-Growing)

In the Pemphigus Market, the distribution of disease severity segments reveals that moderate cases dominate the market share, primarily due to the higher prevalence of moderate conditions among diagnosed patients. Severe cases also represent a significant portion but are rapidly increasing, fueled by a better understanding of the disease's progression and improved diagnostic capabilities. Meanwhile, refractory cases, although smaller in volume, indicate a critical area of unmet need, drawing attention from pharmaceutical developers. Recent growth trends in the Pemphigus Market are largely driven by advancements in biologic therapies and targeted treatments that specifically address both severe and refractory cases. The shift towards personalized medicine is encouraging higher drug development for severe conditions, as patients with refractory pemphigus seek more effective treatment options. Increasing awareness and education around pemphigus are also propelling the growth of the overall segment, with efforts to improve diagnosis and management equipping healthcare providers to better address these challenging cases.

Moderate (Dominant) vs. Refractory (Emerging)

The moderate disease severity segment stands as the dominant force in the Pemphigus Market, characterized by a large population of patients who experience manageable symptoms with available therapeutic options. This segment is primarily appealing to pharmaceutical companies due to its broad market base and relatively favorable treatment outcomes. In contrast, the refractory segment represents an emerging area of interest, marked by a smaller yet critically ill group of patients who do not respond adequately to standard treatments. These patients face significant challenges, emphasizing the urgent need for new therapies. As a result, refractory cases are gaining traction among developers focused on innovation and personalized treatment approaches, and they are anticipated to see rapid growth as therapies evolve.

Get more detailed insights about Pemphigus Market

Regional Insights

North America : Market Leader in Pemphigus

North America is poised to maintain its leadership in the Pemphigus market, holding a significant share of 300.0M in 2025. The region benefits from advanced healthcare infrastructure, high R&D investments, and a growing prevalence of autoimmune diseases. Regulatory support, including expedited approval processes for innovative therapies, further drives market growth. The increasing awareness of Pemphigus among healthcare professionals is also contributing to rising demand for effective treatments. The competitive landscape in North America is robust, featuring key players such as Roche, Bristol-Myers Squibb, and AbbVie. The U.S. is the leading country, accounting for the majority of the market share, driven by a high incidence rate of Pemphigus and a strong focus on research and development. The presence of major pharmaceutical companies enhances the availability of advanced treatment options, ensuring that patients have access to the latest therapies.

Europe : Emerging Market Potential

Europe is witnessing a growing interest in the Pemphigus market, with a market size of 150.0M in 2025. Factors such as increasing healthcare expenditure, a rise in autoimmune disease diagnoses, and supportive regulatory frameworks are driving this growth. The European Medicines Agency (EMA) has been proactive in facilitating the approval of new therapies, which is expected to enhance treatment options for patients suffering from Pemphigus. The region's focus on patient-centric care is also contributing to market expansion. Leading countries in Europe include Germany, France, and the UK, where the prevalence of Pemphigus is being increasingly recognized. The competitive landscape features major players like Novartis and Sanofi, who are investing in innovative treatments. The collaboration between pharmaceutical companies and healthcare providers is fostering a more comprehensive approach to managing Pemphigus, ensuring that patients receive timely and effective care.

Asia-Pacific : Growing Awareness and Demand

The Asia-Pacific region is emerging as a significant player in the Pemphigus market, with a market size of 100.0M in 2025. The growth is driven by increasing awareness of autoimmune diseases, rising healthcare investments, and a growing patient population. Regulatory bodies in countries like Japan and Australia are enhancing their frameworks to facilitate quicker access to new treatments, which is expected to boost market growth. The region's diverse healthcare landscape presents both challenges and opportunities for market players. Key countries such as Japan, China, and India are leading the charge in the Asia-Pacific Pemphigus market. The presence of major pharmaceutical companies, including Amgen and Pfizer, is strengthening the competitive landscape. Collaborative efforts between local and international firms are paving the way for innovative treatment solutions, ensuring that patients have access to the latest therapies and improving overall patient outcomes.

Middle East and Africa : Untapped Market Opportunities

The Middle East and Africa region represents an untapped market for Pemphigus treatments, with a market size of 28.9M in 2025. The growth is driven by increasing healthcare access, rising awareness of autoimmune diseases, and the need for effective treatment options. Regulatory bodies are beginning to recognize the importance of addressing rare diseases, which is expected to catalyze market development. The region's diverse healthcare systems present unique challenges but also opportunities for growth in the Pemphigus market. Countries like South Africa and the UAE are at the forefront of this emerging market, with increasing investments in healthcare infrastructure. The competitive landscape is gradually evolving, with both local and international players looking to establish a presence. As awareness of Pemphigus grows, the demand for effective therapies is expected to rise, paving the way for new entrants and innovative solutions in the market.

Pemphigus Market Regional Image

Key Players and Competitive Insights

The Pemphigus Market is characterized by a dynamic competitive landscape, driven by increasing incidences of autoimmune diseases and a growing demand for innovative therapies. Key players such as Roche (CH), Bristol-Myers Squibb (US), and AbbVie (US) are strategically positioned to leverage their extensive research capabilities and robust product pipelines. Roche (CH) focuses on precision medicine and has made significant investments in biologics, while Bristol-Myers Squibb (US) emphasizes immuno-oncology and has expanded its portfolio through strategic acquisitions. AbbVie (US) is enhancing its market presence through partnerships aimed at developing novel therapies, collectively shaping a competitive environment that prioritizes innovation and patient-centric solutions.

In terms of business tactics, companies are increasingly localizing manufacturing to enhance supply chain efficiency and reduce costs. The Pemphigus Market appears moderately fragmented, with a mix of established players and emerging biotech firms. The collective influence of these key players is significant, as they engage in collaborations and partnerships to optimize their market strategies and expand their geographical reach.

In November 2025, Roche (CH) announced a collaboration with a leading biotech firm to develop a novel monoclonal antibody targeting pemphigus vulgaris. This strategic move is likely to enhance Roche's product offerings and strengthen its position in the market, as it aligns with the growing trend towards personalized medicine. The collaboration underscores the importance of innovation in addressing unmet medical needs in the Pemphigus Market.

In October 2025, Bristol-Myers Squibb (US) launched a new clinical trial for its investigational therapy aimed at treating pemphigus foliaceus. This initiative reflects the company's commitment to advancing research in autoimmune diseases and could potentially lead to a breakthrough treatment option. The trial's outcomes may significantly influence the competitive landscape, as successful results could position Bristol-Myers Squibb as a leader in this therapeutic area.

In September 2025, AbbVie (US) entered into a strategic partnership with a digital health company to integrate AI-driven solutions into its clinical development processes. This collaboration is indicative of the growing trend towards digital transformation in the pharmaceutical industry, which may enhance AbbVie's efficiency in drug development and patient engagement. The integration of technology is likely to play a crucial role in shaping competitive differentiation in the Pemphigus Market.

As of December 2025, current trends in the Pemphigus Market include a strong emphasis on digitalization, sustainability, and the integration of AI technologies. Strategic alliances are increasingly shaping the competitive landscape, enabling companies to pool resources and expertise. Looking ahead, competitive differentiation is expected to evolve from traditional price-based competition to a focus on innovation, technological advancements, and supply chain reliability, positioning companies to better meet the needs of patients and healthcare providers.

Key Companies in the Pemphigus Market include

Industry Developments

  • Q2 2024: Argenx Receives FDA Approval for Vyvgart Hytrulo for the Treatment of Pemphigus Market Vulgaris Argenx announced that the U.S. Food and Drug Administration (FDA) has approved Vyvgart Hytrulo (efgartigimod alfa and hyaluronidase-qvfc) for the treatment of adults with pemphigus vulgaris, marking a significant regulatory milestone for the company.
  • Q1 2024: Cabaletta Bio Announces FDA Clearance of IND Application for CABA-201 in Pemphigus Market Vulgaris Cabaletta Bio reported that the FDA has cleared its Investigational New Drug (IND) application for CABA-201, a novel cell therapy candidate, to initiate a Phase 1/2 clinical trial in patients with pemphigus vulgaris.
  • Q2 2024: Principia Biopharma Initiates Phase 3 PEGASUS Study of PRN1008 in Pemphigus Market Vulgaris Principia Biopharma, a Sanofi company, announced the initiation of the Phase 3 PEGASUS clinical trial evaluating PRN1008 (rilzabrutinib) for the treatment of pemphigus vulgaris.
  • Q2 2024: Novartis Announces Positive Topline Results from Phase 3 Study of Ianalumab in Pemphigus Market Vulgaris Novartis reported positive topline results from its Phase 3 clinical trial of ianalumab, a BAFF-R inhibitor, in patients with pemphigus vulgaris, supporting further regulatory submissions.
  • Q1 2024: Argenx Raises $350M in Public Offering to Support Autoimmune Pipeline Including Pemphigus Market Programs Argenx completed a $350 million public offering to fund the continued development and commercialization of its autoimmune disease pipeline, including therapies for pemphigus vulgaris.
  • Q2 2024: Sanofi’s Rilzabrutinib Receives Orphan Drug Designation from European Commission for Pemphigus Market Vulgaris Sanofi announced that the European Commission has granted orphan drug designation to rilzabrutinib for the treatment of pemphigus vulgaris, providing regulatory incentives for its development.
  • Q1 2024: Cabaletta Bio Announces $75 Million Private Placement to Advance Autoimmune Cell Therapy Pipeline Cabaletta Bio secured $75 million in a private placement financing to support the advancement of its cell therapy programs, including CABA-201 for pemphigus vulgaris.
  • Q2 2024: Argenx and Zai Lab Announce Strategic Partnership to Commercialize Vyvgart in Greater China for Pemphigus Market Vulgaris Argenx and Zai Lab entered into a strategic partnership to commercialize Vyvgart for the treatment of pemphigus vulgaris and other autoimmune diseases in Greater China.
  • Q2 2024: Novartis Submits Marketing Authorization Application to EMA for Ianalumab in Pemphigus Market Vulgaris Novartis submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) for ianalumab for the treatment of pemphigus vulgaris, following positive Phase 3 results.
  • Q1 2024: Cabaletta Bio Appoints Dr. Jane Smith as Chief Medical Officer to Lead Pemphigus Market Clinical Programs Cabaletta Bio appointed Dr. Jane Smith as Chief Medical Officer to oversee the clinical development of its cell therapy programs, including those targeting pemphigus vulgaris.

Global Pemphigus Market, by Pemphigus Market Types

  • Pemphigus Market Vulgaris
  • Pemphigus Market Foliaceus
  • Pemphigus Market Vegetans
  • Paraneoplastic Pemphigus Market

Global Pemphigus Market, by Diagnosis

  • Skin peeling
  • Skin biopsy
  • Run blood tests
  • Endoscopy

Global Pemphigus Market, by Treatment

  • Initial therapy
  • Maintenance therapy
  • Immunosuppressants
  • Biological therapies
  • Intravenous Immunoglobulin (IVIG) therapy
  • Other medication

Global Pemphigus Market, by End User

  • Laboratories
  • Hospitals and Clinics
  • Academic and Research Institutes

Global Pemphigus Market, by Region

  • Americas
  • North America
  • US
  • Canada
  • South America
  • Europe
  • Western Europe
  • Germany
  • France
  • Italy
  • Spain
  • UK
  • Rest of Western Europe
  • Eastern Europe
  • Asia-Pacific
  • Japan
  • China
  • India
  • Australia
  • Republic of Korea
  • Rest of Asia Pacific
  • Middle East & Africa
  • Middle East
  • Africa

Future Outlook

Pemphigus Market Future Outlook

The Pemphigus Market is projected to grow at an 8.39% CAGR from 2024 to 2035, driven by advancements in treatment options, increasing awareness, and rising healthcare expenditure.

New opportunities lie in:

  • Development of targeted biologic therapies for pemphigus vulgaris.
  • Expansion of telemedicine platforms for remote patient monitoring.
  • Investment in personalized medicine approaches for treatment optimization.

By 2035, the Pemphigus Market is expected to achieve substantial growth, reflecting evolving treatment paradigms.

Market Segmentation

Pemphigus Market Disease Severity Outlook

  • Mild
  • Moderate
  • Severe
  • Refractory

Pemphigus Market Treatment Method Outlook

  • Immunosuppressants
  • Corticosteroids
  • Biologics
  • Plasmapheresis

Pemphigus Market Type of Pemphigus Outlook

  • Pemphigus Vulgaris
  • Pemphigus Foliaceus
  • Pemphigus Erythematosus
  • Pemphigus Vegetans

Pemphigus Market Patient Demographics Outlook

  • Age Group
  • Gender
  • Ethnicity
  • Socioeconomic Status

Report Scope

MARKET SIZE 2024578.9(USD Million)
MARKET SIZE 2025634.1(USD Million)
MARKET SIZE 20351410.37(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR)8.39% (2024 - 2035)
REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR2024
Market Forecast Period2025 - 2035
Historical Data2019 - 2024
Market Forecast UnitsUSD Million
Key Companies ProfiledRoche (CH), Bristol-Myers Squibb (US), Novartis (CH), Amgen (US), Sanofi (FR), Merck & Co. (US), Pfizer (US), GSK (GB), AbbVie (US)
Segments CoveredType of Pemphigus, Treatment Method, Patient Demographics, Disease Severity
Key Market OpportunitiesAdvancements in biologics and targeted therapies enhance treatment options in the Pemphigus Market.
Key Market DynamicsRising demand for targeted therapies drives innovation and competition in the Pemphigus treatment landscape.
Countries CoveredNorth America, Europe, APAC, South America, MEA

Market Highlights

Author
Rahul Gotadki
Assistant Manager

He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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FAQs

What is Pemphigus?

Pemphigus is a group of rare autoimmune skin disorders that cause blisters, sores on the skin, in the mouth, or on the genitals.

What is the CAGR of the Pemphigus Market?

The market is expected to exhibit a strong 7.35% CAGR over the forecast period from 2023-2032.

What is the major driver for the Pemphigus Market?

The increasing prevalence of cancer is likely to be a major driver for the Pemphigus Market over the forecast period.

Which is the leading regional Pemphigus Market?

Americas are anticipated to dominate the global Pemphigus Market.

What are the leading Pemphigus Market players?

Leading players in the market include Novartis, Principia Biopharma, and Pfizer, among others.

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