Organ Preservation Market Research Report—Global Forecast till 2027

Organ Preservation Market: Information by Solution (University of Wisconsin Solution, Custodial HTK, Collins Solution, Celsior Solution, Perfadex, Citrate Solution), by Preservation Techniques (Static Cold Storage and Dynamic Cold Storage), by Organ Type (Kidney, Liver, Heart, Lungs, Others), by End User (Hospitals & Clinics, Organ Banks, and Others.) and by Region (Americas, Europe, Asia-Pacific, Middle East & Africa)—Forecast till 2027

ID: MRFR/HC/4615-CR | March 2022 | Region: Global | 169 pages         

Organ Preservation Market

The global organ preservation market is expected to cross USD 304.68 million by 2027 at a CAGR of 6.48%.

Segmentation

By Solution University of Wisconsin Solution Custodial HTK Collins Solution Celsior Solution Perfadex Citrate Solution
By Preservation Techniques Static Cold Storage Dynamic Cold Storage
By Organ Type Kidney Liver Heart Lungs
By End User Hospitals & Clinics Organ Banks

Key Players

  • TransMedics GroupInc (US)
  • Bristol Myers Squibb (US)
  • ArtivionInc (US)
  • Xvivo Perfusion AB (US)
  • Accord Healthcare Limited (UK)
  • BioLife SolutionsInc (US)
  • Shanghai Genext Medical Technology Co.Ltd (China)

Drivers

  • Rising number of organ transplant procedures
  • Increasing focus of organ preservation companies on brand protection
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Organ Preservation Market Forecast


The global organ preservation market is expected to cross USD 304.68 million by 2027 at a CAGR of 6.48%.


Market Overview:


Organ preservation is the supply line for organ transplantation. Currently, the pancreas, liver and kidney can be preserved for up to two days by rinsing the organs with the University of Wisconsin (UW) organ preservation solution as well as storing them at hypothermia (0-5 degree C). The UW solution is effective because it used a number of cells impermeant agents such as raffinose, lactobionic acid, hydroxyethyl starch which reduce the cells from inflammation during cold ischemic storage. Rising number of organ transplant procedures act as a major driver in the global organ preservation market during 2021–2027. However, high cost associated with organ transplantation hamper the growth of the organ preservation market during the forecast period. Increasing government initiatives related to organ transplant and organ donation expected to create an opportunity in the global organ preservation market.


COVID-19 Analysis:


The production of organ preservation solutions starts with the procurement of raw materials. Owing to urgent measures taken across the globe, raw material sourcing is a bit difficult. To fight the pandemic, the whole world was under lockdown. Thus, some urgent measures were taken by the governments of certain countries, such as physical distancing and limitation of transport to fight surge ability. Apart from this, the organ preservation market was also facing restrictions on the workforce in the first half of 2020. The workforce is required to source the raw material, assembling raw material into the final product till the packaging, and transporting the final product to the end users.


Market Dynamics:


Market Drivers


  • Increasing focus of organ preservation companies on brand protection


Organ preservation is the supply line for organ transplantation that maintains the function of the organ and tissue during storage. Human organs can be preserved for an average of nine hours with the existing techniques. Organ preservation companies are involved in advancing organ delivery, preservation, and revitalization technologies to ensure that organs can reach people in time and help save lives. The companies involved in the organ preservation market currently focus on brand preservation. A right holder's method and set of measures to prevent third parties from exploiting their intellectual property without authorization are known as brand protection. This helps to protect the company's image, reputation, and overall value. New companies are entering the organ preservation market.

  • Rising number of organ transplant procedures


Market Restraints


  • High cost associated with organ transplantation


Organ-related diseases are a global public health issue. Organ transplantation increases the probability of survival and enhances the quality of life of patients. However, the high cost associated with organ transplantation is a restraining factor for the global organ preservation market. The cost of an organ transplant varies from one private hospital to another; it also varies across countries. The average cost of a kidney transplant was around USD 442,500. According to the American Transplantation Foundation, as of 2021, almost 107,000 people in the US are currently on the waiting list for a life-saving organ transplant. The US saw a 6% increase in deceased donors last year, from 11,870 in 2019 to 12,588 in 2020; this further increases the costs associated with organ transplantation.


Market Opportunities


  • Increasing government initiatives related to organ transplant and organ donation


Organ transplantation helps to save the lives of thousands of patients around the globe every year. However, the shortage of organs for transplantation—which is a global problem—overshadows this success. However—due to increasing government initiatives related to organ transplantation and organ donation and the rising awareness about the need for organ donation—several people from different parts of the world are coming forward to donate organs. In organ transplantation, Asia lags behind much of the rest of the world. Moreover, India lags far behind other countries, even in Asia, in organ transplantation. In 2019, the Government of India initiated the National Organ Transplant Program to organize a system of organ and tissue procurement and distribution for transplantation.


Global Organ Preservation Market Share, by Solution, 2020 (%)
Global Organ Preservation Market Share, By Solution 2020
Source: MRFR Analysis


Value Chain Analysis/Technology Analysis/Regulatory Implications


 The global organ preservation market is growing steadily and is expected to continue growing at the same rate in the near future. This is due to the growing contribution of existing players to make the product more effective. The supply chain analysis for the organ preservation market comprises four major components, which start with the research and product development (R&D), followed by manufacturing of the products, distribution & sales, and ends with post-sales monitoring.


In research and product development, research is undertaken to make the products better and unique. Research & development is a brainstorming process and requires high knowledge and skills. The process of organ preservation solutions development starts with conceptualization, which is followed by the design of the product, then the development, and at last, the testing. The R&D team works on the improvements of product features that focus on the customer needs of developing refined products.


In the manufacturing process, the product strategies are ready and manufacturing the product starts. The manufacturing process begins with the sourcing and processing of raw materials. Manufacturing is a fast process, followed by testing the physical characteristics of the products. The manufacturing process is outsourced by some manufacturers. The manufacturing process can be optimized by understanding the factors affecting the efficiency of production effectively.


Segment Overview


The global organ preservation market has been divided based on solution, preservation techniques, organ type, end user.


By Solution



  • University of Wisconsin Solution


University of Wisconsin solution (UW Solution) is universal for multiple organ preservation. It has been accepted as the gold standard for preserving liver grafts and is known as an intracellular-type solution. The kidneys and other organs are better preserved with the UW solution. The preservation in UW solutions helped in longer and safer kidney preservation for almost two days and liver for 18 hours. This solution also enables a greater rate of graft survival and a reduced rate of primary non-function. Moreover, during the first 12 months following transplantation, UW solution-preserved organs had a lower primary non-function and rejection rate than marginal donor organs.



  • Custodiol HTK


Custodiol histidine-tryptophan-ketoglutarate (HTK) solution is an organ transplant solution used by leading transplant centers across the world to preserve the kidney, liver, heart, lung, and pancreas during organ transplantation. The main advantages of Custodiol HTK solution are reduced risk of post-aggression syndromes, shortened postoperative intensive care period, easier surgical handling due to excellent visibility, and has a high buffering capacity. In addition, the Custodiol HTK solution is ready to use, requires no preparation, filters, or additives, and saves manual labor. Furthermore, it is approved by USFDA as a medical device. Being a multi-organ solution, it is also the solution of organ cleaning during heart surgery. For instance, according to the Centers for Disease Control and Prevention (CDC), heart disease was the leading cause of death in the US from 2015 to 2020.



  • Collins Solution


In 1969 Collins came up with a simple cold storage solution for kidney preservation. This solution comprises low sodium and high potassium intracellular electrolyte composition to prevent trans membranous fluid and electrolyte changes. The Collins solution was further modified to Euro-Collins; a larger glucose concentration boosted the Euro-Collins solution's osmotic efficacy. Furthermore, magnesium sulfate was ruled out due to the development of magnesium phosphate precipitates when magnesium and phosphate were present. Corning Inc. (US) sells Euro-Collins solutions for organ preservation.



  • Celsior Solution


Celsior is a non-pyrogenic, low-potassium organ preservation solution based on glutathione and lactobionate. Lung preservation using Celsior solution lowers reperfusion injury and improves lung function following ischemia and reperfusion. In addition, Celsior cools the organ, lowering its metabolic demands and associated energy consumption.



  • Perfadex


Perfadex is an extracellular dextran-based electrolyte preservation solution with a low potassium content for fast cooling, perfusion, and cold static storage of donor's lungs. The differing metabolic demands and physiology of the lungs aided the development of pulmonary-specific treatments, such as Perfadex, approved for use in pulmonary transplants by the US Food and Drug Administration (FDA).



  • Citrate Solution


Citrate solutions are characterized by high potassium, magnesium, and sodium content and are commonly used for lung and kidney preservation. Citrate is used to replace phosphate and as a buffer to keep the intracellular pH constant. Citrate can be replaced with hydroxyethyl-piperazine-ethane sulphonic acid to offer adequate buffer capacity. Furthermore, In China, hypertonic citrate adenine (HC-A) is the commonly utilized kidney transplant preservation solution. Citrate-based solution with additive adenine as a nutrient improves kidney function after circulation.


By Preservation Techniques


On the basis of the preservation techniques, the market is divided into static cold storage and dynamic cold storage



  • Static Cold Storage (SCS) Technique


In organ transplantation, the shortage of donor organs is the largest problem; therefore, organ preservation plays an important role. The static cold storage (SCS) technique is the standard method for organ preservation. It is a simple and effective way to preserve and transport organs. The static cold storage technique involves flushing the procured organ with a preservation solution at 0–4°C, then immersing it in a preservation solution at the same temperature until the transplantation procedure.



  • Dynamic Cold Storage


Dynamic cold storage is further sub-segmented into hypothermic machine perfusion, normothermic machine perfusion, and oxygen per sufflation.


By Organ Type


On the basis of the organ type, the market is divided into heart, kidney, lungs, liver, and others.



  • Kidney


The kidney can be preserved for 24 to 36 hours in cold storage, which is longer than any other organs such as the heart, lung, and liver. The rising cases of chronic kidney diseases increase the need for kidney transplantation. According to the Department of Health and Human Services, in 2020, around 22,917 kidneys were transplanted in the US. The static cold storage technique has been the standard technique to preserve kidneys for the last 50 years.



  • Liver


The liver can be effectively preserved for two days by rinsing with UW organ preservation solution and storing them in a hypothermic (0-5 degree C) environment. Other techniques such as static cold storage and normothermic machine liver perfusion are also effective techniques for liver preservation. Normothermic machine liver perfusion helps reduce primary nonfunction (PNF), ischemia/reperfusion injury, biliary complications, and early allograft dysfunction (EAD). Normothermic machine perfusion provides more effective liver preservation as compared to static cold storage.



  • Heart


At present, the standard technique of heart preservation is static cold storage in a crystalloid heart preservation solution. This preservation technique helps protect the heart against ischemia-reperfusion injury (IRI) for less than 6 hours. The timeline for heart preservation is around 4 to 6 hours of cold ischemic storage. The viability of the heart depends on the use of preservation solution and its temperature. The solution formulation is based on three ideologies: minimization of reperfusion injury, hypothermic arrest of metabolism, and provision of a physical as well as biochemical environment to sustain the viability of the structural components of the heart.



  • Lungs


Lung transplant is the only alternative in the case of a recipient suffering from end-stage lung failure. In some cases, the availability of donor lungs for transplant is also not enough to save the recipient's life. Static cold preservation is the most used method to preserve lungs. However, this method is only capable of maintaining the quality of lungs for almost eight hours. To overcome this problem, ex-situ lung perfusion (ESLP) is an advanced developed preservation technique that permits for longer preservation time and has been proven to improve lung function.



  • Others


Other organs include the pancreas, small bowel, and skin. Pancreas transplantation is required in patients suffering from type 1 diabetes along with nerve damage, kidney damage, and eye problems. Small bowel transplants are required in patients undergoing bowel or intestinal failure. Skin grafts are required in patients suffering from deep burns, skin cancer, and severe skin infections. Rising prevalence of ailments that lead to organ failure is expected to positively influence the demand of new product which create lucrative growth opportunity for the market.


By End User


On the basis of the end user, the market is divided into hospitals & clinics, organ banks, and others.



  • Hospitals & Clinics


A large number of hospitals across the globe have started providing transplantation procedures for critically ill patients, which is expected to promote market growth. In addition, an increase in the number of patients having lung, kidney, and heart diseases such as heart valve disease, coronary artery disease, end-stage renal disease, chronic obstructive pulmonary disease, pulmonary fibrosis, and others will increase the demand for organ transplantation. According to the Health Resources and Services Administration, 39,000 organ transplantations were performed in the year 2020 in the US.



  • Organ Banks


Organ banks is a facility that manages organs for transplant. It provides deceased donors' organs, such as the heart, liver, kidneys, intestines, lungs, and pancreas, to transplant them into another person suffering from organ failure. The demand for organ transplantation has rapidly increased all over the world due to an increase in the number of essential organ failures, rising transplant success rates, and better post-transplant outcomes.



  • Others


Other end users for organ preservation include academic institutes and ambulatory surgical centers.


Academic institutions such as medical colleges also use organ preservation solutions for research purposes as well as treating patients. Ambulatory surgical centers are specialized centers that focus on providing post-transplant treatment and virtual visits through telehealth videoconferencing. The incidence of post-transplant toxicities and febrile neutropenia is expected to increase the demand for preservation solutions in ambulatory surgical centers.


Global Organ Preservation Market Share, by Region, 2020 (%)
Global organ Preservation Market By Region 2020

Source: MRFR Analysis


Regional Analysis


The global organ preservation market, based on region, has been divided into the Americas, Europe, Asia-Pacific, Middle East & Africa.


Americas:


Geographically, the Americas dominated the global organ preservation market due to a variety of factors, including the rising number of organ transplant procedures, increasing instances of multiple organ failure, and growth in the geriatric population. North America and Latin America are the two continents that make up the Americas.


North America is divided into the US and Canada. The US accounts for the largest market share in the North American organ preservation market. In the US, the increasing prevalence of chronic diseases such as chronic kidney disease and cardiovascular diseases and the rising number of organ transplant procedures are the drivers for the organ preservation market in the region. According to the Centers for Disease Control and Prevention, in 2021, more than one in seven, that is, 15% of US adults or 37 million people, are estimated to have chronic kidney disease.


Europe:


Europe is the second-largest market and holds a healthy share in the global organ preservation market. The European market is expected to grow at a sturdy rate during the forecast period due to advanced treatment facilities and rising cases of fatty liver disease. The European region has the best and most established health care systems in the world. With 3.7 doctors per 1,000 inhabitants, Italy has one of the highest ratios in the world, in line with much of Europe. According to WHO, France has the highest-ranking healthcare system in the world.


Asia-Pacific:


Asia-Pacific is estimated to be the fastest-growing market owing to the developing healthcare infrastructure and increasing disposable income in developing countries such as China and India. The rise in the improved healthcare infrastructure promises a high level of research activities in the region. Moreover, several growing economies in the region are taking steps to improve the domestic pharmaceutical market and encouraging global corporations to set up operations in the region, driving the growth of the organ preservation market in Asia-Pacific. For instance, in July 2021, Institute Georges Lopez (France) has established a production plant for organ preservation solutions in Tamil Nadu, India. It will build and run a plant to produce medical devices and solutions for organ cleansing and preservation. With this, the company expanded its position in the Indian market. As a result, such strategies would help drive the overall growth of the market.


Middle East & Africa:


The Middle East & Africa is expected to witness steady growth due to a lack of awareness regarding organ donation, limited access, and the unaffordability of treatment facilities among the population. In addition, the increase in chronic diseases and the rise in the geriatric population in this region indirectly boost the growth of the market. According to WHO, the population of older adults in sub-Saharan Africa is projected to reach 67 million by 2025 and 163 million by 2050. The Middle Eastern population is aging rapidly and, as aging is the main risk factor for lung, cardiovascular, and kidney diseases such as coronary artery disease, heart failure, polycystic kidney disease, and chronic obstructive pulmonary disease (COPD).


Competitive Landscape


The key players operating in the global organ preservation include TransMedics Group, Inc (US), Bristol Myers Squibb (US), Artivion, Inc (US), Xvivo Perfusion AB (US), Accord Healthcare Limited (UK), Dr. Franz Kohler Chemie GmbH (Germany), 21st Century Medicine (US), BioLife Solutions, Inc (US), Shanghai Genext Medical Technology Co., Ltd (China), Paragonix Technologies Inc (US), Waters Medical Systems (US). The growing use of genetic data across healthcare and technological advancements in genetic testing will provide growth opportunities for the market in the future. However, the high cost of genetic testing and shortage of skilled and experienced genetic counselors might hamper the market's growth in the forecast period.


List of Key Companies Covered in this report:



  • TransMedics Group, Inc (US)

  • Bristol Myers Squibb (US)

  • Artivion, Inc (US)

  • Xvivo Perfusion AB (US)

  • Accord Healthcare Limited (UK)

  • Franz Köhler Chemie GmbH (Germany)

  • 21st Century Medicine (US)

  • BioLife Solutions, Inc (US)

  • Shanghai Genext Medical Technology Co., Ltd (China)

  • Paragonix Technologies Inc (US)

  • Waters Medical Systems (US)


Recent Developments



  • In Oct July 2021, TransMedics Group, Inc. received FDA clearance for OCS Lung Solution for cold preservation of lungs. This FDA clearance will continue to build the most comprehensive, market-leading portfolio of organ preservation solutions to satisfy the clinical needs of the organ transplantation market.

  • In August 2021, BioLife Solutions, Inc. acquired Sexton Biotechnologies, Inc helped strengthen the company's business and revenue as well as also create new growth opportunities in the market.

  • In September 2020, Xvivo Perfusion AB acquired Organ Assist (Netherlands). The acquisition will accelerate the growth of Xvivo Perfusion’s organ assist’s product portfolio and diversify its product offerings in the organ preservation segment


Report Overview:


The study covers the existing short-term and long-term market effects, helping decision-makers draft short-term and long-term plans for businesses by region. The report covers major regions in the Americas, Europe, Asia-Pacific, Middle East & Africa. The report analyzes market drivers, restraints, opportunities, challenges, Porter's Five Forces, Value Chain, and impact of COVID-19 on the market.


Scope of the Report & Segmentation


Global Organ Preservation Market, by Solution



  • University of Wisconsin Solution

  • Custodiol HTK

  • Collins Solution

  • Celsior Solution

  • Perfadex

  • Citrate Solution


Global Organ Preservation Market, by Preservation Techniques



  • Static Cold Storage (SCS) Technique

  • Dynamic Cold Storage

    • Machine Perfusion

    • Normothermic Machine Perfusion

    • Oxygen Persufflation




Global Organ Preservation Market, by Organ Type



  • Kidney

  • Liver

  • Heart

  • Lungs

  • Others


Global Organ Preservation Market, by End User



  • Hospitals & Clinics

  • Organ Banks

  • Others


Global Organ Preservation   Market, by Region



  • Americas

  • Europe

  • Asia-Pacific

  • Middle East & Africa



Report Scope:
Report Attribute/Metric Details
  Market Size   2027: USD 304.68 Million
  CAGR   6.48%
  Base Year   2020
  Forecast Period   2021-2027
  Historical Data   2018 & 2019
  Forecast Units   Value (USD Million)
  Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Solution, Preservation Techniques, Organ Type, End-User, and Region
  Geographies Covered   Americas, Europe, Asia-Pacific, Middle East & Africa
  Key Vendors   TransMedics Group, Inc (US) Bristol Myers Squibb (US) Artivion, Inc (US) Xvivo Perfusion AB (US) Accord Healthcare Limited (UK) Dr. Franz Köhler Chemie GmbH (Germany) 21st Century Medicine (US) BioLife Solutions, Inc (US) Shanghai Genext Medical Technology Co., Ltd (China) Paragonix Technologies Inc (US) Waters Medical Systems (US)
  Key Market Opportunities   â€˘ Increasing government initiatives related to organ transplant and organ donation
  Key Market Drivers   â€˘ Rising number of organ transplant procedures • Increasing focus of organ preservation companies on brand protection


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Frequently Asked Questions (FAQ) :

Organ Preservation Market is projected to grow at a 6.48% CAGR between 2021-2027.

The Americas is expected to lead the Organ Preservation Market.

Rising prevalence of organ failures and advancement in surgery is boosting market growth.

Unavailability of donors may limit market growth.

Hospitals and clinics, and organ banks are the end users of Organ Preservation Market.