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Non Alcoholic Fatty Liver Disease Market

ID: MRFR/HC/40511-HCR
100 Pages
Rahul Gotadki
October 2025

Non-Alcoholic Fatty Liver Disease NAFLD Market Research Report By Diagnosis Method (Ultrasound, CT Scan, MRI, Liver Biopsy), By Treatment Type (Lifestyle Changes, Medications, Surgical Procedures, Nutritional Supplements), By Patient Demographics (Adults, Children, Elderly), By Complication Type (Fibrosis, Cirrhosis, Hepatocellular Carcinoma) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2035

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Non Alcoholic Fatty Liver Disease Market Summary

As per MRFR analysis, the Non-Alcoholic Fatty Liver Disease (NAFLD) Market Size was estimated at 2.01 USD Billion in 2024. The NAFLD industry is projected to grow from 2.13 in 2025 to 3.808 by 2035, exhibiting a compound annual growth rate (CAGR) of 5.98 during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The Non-Alcoholic Fatty Liver Disease (NAFLD) market is experiencing significant growth driven by increased awareness and technological advancements.

  • North America remains the largest market for NAFLD, driven by rising healthcare expenditure and awareness initiatives.
  • The Asia-Pacific region is emerging as the fastest-growing market, fueled by increasing urbanization and lifestyle changes.
  • Ultrasound technology continues to dominate the diagnostic segment, while liver biopsy is gaining traction as the fastest-growing method.
  • The increasing prevalence of NAFLD and advancements in diagnostic technologies are key drivers propelling market growth.

Market Size & Forecast

2024 Market Size 2.01 (USD Billion)
2035 Market Size 3.808 (USD Billion)
CAGR (2025 - 2035) 5.98%

Major Players

Gilead Sciences (US), Bristol-Myers Squibb (US), Novo Nordisk (DK), Intercept Pharmaceuticals (US), Pfizer (US), Eli Lilly and Company (US), AbbVie (US), Merck & Co. (US), Amgen (US)

Non Alcoholic Fatty Liver Disease Market Trends

The Non-Alcoholic Fatty Liver Disease (NAFLD) Market is currently experiencing notable growth, driven by increasing awareness of liver health and the rising prevalence of obesity and metabolic disorders. As healthcare professionals and patients alike become more informed about the implications of NAFLD, there is a growing demand for effective diagnostic tools and treatment options. This trend is further supported by advancements in medical research, which are leading to the development of innovative therapies aimed at managing and potentially reversing the condition. Furthermore, the integration of technology in healthcare, such as telemedicine and digital health solutions, is enhancing patient access to care and facilitating early diagnosis, which may contribute to improved outcomes for individuals affected by NAFLD. In addition to the advancements in treatment and diagnosis, the Non-Alcoholic Fatty Liver Disease NAFLD Market is also witnessing a shift towards lifestyle interventions. Health professionals are increasingly advocating for dietary modifications and exercise regimens as essential components of managing NAFLD. This holistic approach appears to resonate with patients, as it empowers them to take charge of their health. Moreover, the collaboration between various stakeholders, including pharmaceutical companies, healthcare providers, and patient advocacy groups, is likely to foster a more comprehensive understanding of NAFLD, ultimately leading to better management strategies and improved patient outcomes.

Rising Awareness and Education

There is a growing emphasis on educating both healthcare providers and patients about Non-Alcoholic Fatty Liver Disease. This trend is likely to enhance early detection and treatment, as more individuals recognize the importance of liver health.

Technological Integration in Healthcare

The incorporation of digital health technologies is transforming the Non-Alcoholic Fatty Liver Disease NAFLD Market. Telemedicine and mobile health applications are facilitating remote monitoring and consultations, which may improve patient engagement and adherence to treatment.

Focus on Lifestyle Modifications

An increasing number of healthcare professionals are promoting lifestyle changes as a primary strategy for managing Non-Alcoholic Fatty Liver Disease. This trend underscores the importance of diet and exercise in the overall treatment plan, potentially leading to better health outcomes.

Non Alcoholic Fatty Liver Disease Market Drivers

Increasing Prevalence of NAFLD

The rising incidence of Non-Alcoholic Fatty Liver Disease NAFLD is a primary driver for the Non-Alcoholic Fatty Liver Disease NAFLD Market. Recent estimates suggest that approximately 25% of the population may be affected by this condition, with numbers expected to rise due to increasing obesity rates and sedentary lifestyles. This growing prevalence necessitates enhanced healthcare solutions and interventions, thereby propelling market growth. As healthcare providers become more aware of the implications of NAFLD, there is a corresponding increase in demand for diagnostic tools and treatment options. The urgency to address this health crisis is likely to stimulate investments in research and development, further expanding the Non-Alcoholic Fatty Liver Disease NAFLD Market.

Regulatory Support and Guidelines

Regulatory support and the establishment of clinical guidelines are pivotal in shaping the Non-Alcoholic Fatty Liver Disease NAFLD Market. Health authorities are increasingly recognizing the need for standardized protocols for the diagnosis and management of NAFLD. This regulatory framework not only enhances the credibility of treatment options but also encourages healthcare providers to adopt evidence-based practices. The presence of clear guidelines may lead to improved patient outcomes and increased trust in available therapies. As regulatory bodies continue to focus on NAFLD, the market is likely to experience growth driven by enhanced treatment accessibility and adherence to best practices.

Growing Focus on Preventive Healthcare

The increasing emphasis on preventive healthcare is shaping the Non-Alcoholic Fatty Liver Disease NAFLD Market. As awareness of the long-term consequences of NAFLD grows, healthcare providers and patients alike are prioritizing preventive measures. This shift is reflected in the rising demand for lifestyle modification programs, nutritional counseling, and regular health screenings. The market is likely to benefit from initiatives aimed at educating the public about the risks associated with NAFLD, which may lead to earlier interventions and reduced healthcare costs. Consequently, the focus on prevention is expected to drive growth in the Non-Alcoholic Fatty Liver Disease NAFLD Market.

Advancements in Diagnostic Technologies

Technological innovations in diagnostic methods are significantly influencing the Non-Alcoholic Fatty Liver Disease NAFLD Market. Enhanced imaging techniques, such as elastography and MRI, allow for more accurate and non-invasive assessments of liver fat content. These advancements not only improve patient outcomes but also facilitate earlier detection of NAFLD, which is crucial for effective management. The market for diagnostic tools is projected to grow as healthcare systems adopt these technologies to streamline patient care. Furthermore, the integration of artificial intelligence in diagnostics may lead to more personalized treatment plans, thereby enhancing the overall efficiency of the Non-Alcoholic Fatty Liver Disease NAFLD Market.

Rising Investment in Research and Development

Investment in research and development is a crucial driver for the Non-Alcoholic Fatty Liver Disease NAFLD Market. Pharmaceutical companies and research institutions are increasingly allocating resources to discover novel therapies and treatment modalities for NAFLD. This trend is underscored by the growing recognition of NAFLD as a significant public health concern, prompting stakeholders to seek innovative solutions. The potential for lucrative returns on investment in this area is likely to attract more players into the market, fostering competition and accelerating advancements. As a result, the Non-Alcoholic Fatty Liver Disease NAFLD Market is poised for substantial growth in the coming years.

Market Segment Insights

By Diagnosis Method: Ultrasound (Largest) vs. Liver Biopsy (Fastest-Growing)

In the Non-Alcoholic Fatty Liver Disease (NAFLD) market, the diagnosis methods exhibit diverse market shares, with Ultrasound being the largest segment due to its non-invasive nature and cost-effectiveness. Following Ultrasound, CT Scans and MRI also play significant roles, offering advanced imaging techniques. Liver Biopsy, although traditionally regarded as the gold standard for diagnosis, is gaining popularity but has a smaller share in comparison to Ultrasound. This distribution reflects the varying preferences among clinicians and patients based on technological advancements and accessibility.

Diagnosis Methods: Ultrasound (Dominant) vs. Liver Biopsy (Emerging)

Ultrasound remains the dominant diagnostic method for NAFLD, favored for its safety, affordability, and widespread availability. Its ability to provide real-time imaging with no radiation makes it a preferred choice among healthcare professionals. In contrast, Liver Biopsy, increasingly recognized as the fastest-growing diagnosis method, offers detailed histological insights into liver conditions. This method, while more invasive and associated with certain risks, is being adopted more frequently as advancements in technique and patient safety emerge. The rising recognition of the importance of early diagnosis in NAFLD drives the demand for reliable methods, making these two approaches critical players in the market.

By Treatment Type: Lifestyle Changes (Largest) vs. Nutritional Supplements (Fastest-Growing)

In the Non-Alcoholic Fatty Liver Disease (NAFLD) market, the Treatment Type segment reveals that Lifestyle Changes hold the dominant share. These include dietary modifications, increased physical activity, and behavioral modifications which are integral in managing NAFLD. Meanwhile, Nutritional Supplements are emerging as a rapidly growing segment, attracting interest from healthcare professionals and patients alike due to their potential to complement traditional treatment methods. Both Medications and Surgical Procedures are essential components of the treatment landscape; however, their adoption is relatively stable compared to the dynamic trends seen in Lifestyle Changes and Nutritional Supplements. Medications have maintained a consistent role in managing symptoms, while Surgical Procedures, though critical, are less commonly pursued due to associated risks. With the heightened awareness of NAFLD, lifestyle interventions are increasingly prioritized, driving growth in nutritional strategies.

Lifestyle Changes: Dominant vs. Nutritional Supplements: Emerging

Lifestyle Changes are viewed as the cornerstone of managing Non-Alcoholic Fatty Liver Disease, primarily due to their holistic approach combining diet, exercise, and behavioral modification to encourage sustainable health improvements. This segment is well-supported by clinical evidence and patient testimonials, making it a trusted option among healthcare providers. On the other hand, Nutritional Supplements are gaining momentum as an emerging alternative for patients seeking additional support in their treatment plan. These supplements, which often include ingredients like omega-3 fatty acids, antioxidants, and herbs, are appealing to those looking for less invasive options. The growing trend toward preventive healthcare is further propelling the market for these supplements as awareness and acceptance increase among both patients and clinicians.

By Patient Demographics: Adults (Largest) vs. Elderly (Fastest-Growing)

In the Non-Alcoholic Fatty Liver Disease (NAFLD) market, the adult demographic represents the largest segment, accounting for a significant share of the patient population. Adults frequently suffer from NAFLD due to factors such as obesity, sedentary lifestyles, and metabolic syndromes, which are prevalent in modern society. The elderly segment, while smaller, is currently the fastest-growing group, driven by the increasing age-related risk factors and the rising prevalence of chronic diseases among older populations.

Adults (Dominant) vs. Elderly (Emerging)

The adult segment of the NAFLD market is characterized by a high prevalence rate, largely due to lifestyle-related risk factors. Adults are the dominant demographic, reflecting broader trends in obesity and metabolic diseases. In contrast, the elderly population is emerging as a critical focus due to their rapid growth in NAFLD disease incidence as they age. This group faces unique challenges, including comorbidities and a higher risk of liver complications. This trend underscores the need for targeted interventions within these demographics to manage and treat NAFLD effectively.

By Complication Type: Cirrhosis (Largest) vs. Hepatocellular Carcinoma (Fastest-Growing)

In the Non-Alcoholic Fatty Liver Disease (NAFLD) market, the segment of Complication Type reveals a significant share distribution. Cirrhosis stands out as the largest segment, primarily due to its advanced progression in patients with NAFLD. Meanwhile, Fibrosis also holds a notable portion, but it is Hepatocellular Carcinoma that is rapidly gaining attention as more cases are diagnosed, reflecting the broader implications of NAFLD complications on healthcare resources and patient outcomes. As awareness of NAFLD grows, the acceleration of growth trends in these complications is evident. The rising incidence of Hepatocellular Carcinoma signals an urgent need for effective intervention strategies, notably prompted by the longstanding nature of Fibrosis leading to more severe complications over time. The evolving treatment landscape and increasing research focus on these complications further enhances their market profiles, supported by advancements in diagnostic technologies that facilitate early detection and intervention.

Cirrhosis (Dominant) vs. Fibrosis (Emerging)

Cirrhosis is the dominant complication type within the NAFLD market, characterized by significant liver scarring and hepatic dysfunction. Patients suffering from Cirrhosis often experience severe health implications, leading to increased healthcare utilization and interventions. This condition reflects the late-stage damage of the liver, marking it as a key area for treatment focus. In contrast, Fibrosis is emerging as a critical concern, representing the initial stage of liver scarring that can progress to Cirrhosis. The growing recognition of Fibrosis emphasizes the need for early identification and management of liver disease to prevent further complications. These characteristics position Cirrhosis as a more progressed and impactful condition, while Fibrosis remains crucial for early intervention opportunities in the NAFLD landscape.

Get more detailed insights about Non Alcoholic Fatty Liver Disease Market

Regional Insights

The Non-Alcoholic Fatty Liver Disease NAFLD Market is witnessing a notable regional distribution, with North America holding a significant share, valued at 0.85 USD Billion in 2024 and projected to grow to 1.5 USD Billion by 2035, showcasing its major market presence. Europe follows closely with a valuation of 0.68 USD Billion in 2024, expected to rise to 1.25 USD Billion in 2035, highlighting its importance in the market growth dynamics.

The Asia-Pacific (APAC) region is also experiencing steady growth, with a value of 0.38 USD Billion in 2024 and a forecast of 0.7 USD Billion by 2035, driven by increasing healthcare awareness and lifestyle changes.Meanwhile, South America and the Middle East Africa (MEA) represent smaller market shares, with South America valued at 0.05 USD Billion and projected to reach 0.15 USD Billion, while MEA is valued at 0.05 USD Billion and expected to grow to 0.2 USD Billion.

The diverse regional insights into the Non-Alcoholic Fatty Liver Disease NAFLD Market segmentation reflect varying levels of healthcare infrastructure and awareness, which significantly influence disease management and treatment availability across different geographical regions.

Non Alcoholic Fatty Liver Disease Market Regional Image

Key Players and Competitive Insights

The Non-Alcoholic Fatty Liver Disease NAFLD Market is currently witnessing significant growth driven by increasing awareness of liver health, rising obesity rates, and the growing prevalence of metabolic syndrome. As the understanding of NAFLD progresses, the market landscape has become increasingly competitive, with numerous pharmaceutical companies vying for market share and developing innovative treatment options. Therapies aimed at managing or reversing the effects of NAFLD are being prioritized, propelling research and development efforts forward.

This competitive environment is exacerbated by ongoing clinical trials and the need for effective solutions, which underscores the necessity for key players in the market to differentiate their offerings based on efficacy, safety, and overall patient outcomes. The dynamic nature of the market is shaped by collaborations, partnerships, and an emphasis on scientific innovation, ultimately seeking to address the diverse needs of healthcare providers and patients suffering from this condition.

Genfit is a prominent player within the Non-Alcoholic Fatty Liver Disease NAFLD Market, recognized for its focus on liver disease and its commitment to the development of novel therapies. The company has established a strong pipeline, with certain products that are specifically targeted toward addressing the underlying mechanisms of NAFLD, thereby offering an attractive value proposition. Genfit's strengths lie in its innovative approach to drug development, which emphasizes both the scientific robustness and therapeutic potential of its candidates.

With a keen understanding of the complexities associated with liver diseases, the company has positioned itself as a leader in the development of non-invasive diagnostic tools and treatment options tailored to varying stages of NAFLD. Additionally, Genfit's collaborations and partnerships enhanced its capabilities, allowing for a broader reach and impact within the healthcare sector focused on liver health. Intercept Pharmaceuticals, on the other hand, has made significant strides in the Non-Alcoholic Fatty Liver Disease NAFLD Market by focusing on liver-targeted therapies that have shown promise in clinical trials. 

The company is committed to offering patients effective treatments that address both the inflammatory and fibrotic aspects of the disease. Intercept's expertise in the field is backed by extensive clinical research, which lends credibility to its product offerings and positions it favorably against competitors. The company has capitalized on its understanding of the essential role that metabolism and liver function play in overall health, leading to the development of targeted therapies that set it apart in the NAFLD landscape.

Intercept Pharmaceuticals' strategic focus on advancing its therapeutic pipeline, combined with its robust data supporting the efficacy of its offerings, reinforces its competitive standing and enhances its reputation among healthcare providers and patients alike in the realm of liver disease management.

Key Companies in the Non Alcoholic Fatty Liver Disease Market market include

Industry Developments

  • Q1 2024: FDA approves Madrigal Pharmaceuticals' liver disease drug Madrigal Pharmaceuticals received FDA approval for its drug resmetirom, the first approved treatment for nonalcoholic steatohepatitis (NASH), a severe form of non-alcoholic fatty liver disease.
  • Q1 2024: Madrigal Pharmaceuticals Announces FDA Approval of Rezdiffra (resmetirom) for the Treatment of Adults with Noncirrhotic NASH with Moderate to Advanced Fibrosis Madrigal Pharmaceuticals announced that the U.S. FDA approved Rezdiffra (resmetirom) for adults with noncirrhotic NASH with moderate to advanced fibrosis, marking the first approved therapy for this condition.
  • Q2 2024: Pfizer Invests $100 Million in NASH Drug Developer Akero Therapeutics Pfizer made a $100 million equity investment in Akero Therapeutics to support the development of its lead NASH drug candidate, efruxifermin, which is in late-stage clinical trials.
  • Q2 2024: Akero Therapeutics Announces $100 Million Private Placement Financing Akero Therapeutics announced a $100 million private placement financing led by Pfizer to advance its clinical programs for nonalcoholic steatohepatitis (NASH).
  • Q2 2024: Gilead Sciences and Novo Nordisk Announce Research Collaboration to Advance NASH Combination Therapies Gilead Sciences and Novo Nordisk entered a research collaboration to develop and commercialize combination therapies for nonalcoholic steatohepatitis (NASH).
  • Q2 2024: Inventiva Announces FDA Fast Track Designation for Lanifibranor in NASH Inventiva received FDA Fast Track designation for its investigational drug lanifibranor for the treatment of nonalcoholic steatohepatitis (NASH).
  • Q3 2024: Novo Nordisk to Acquire NASH Drugmaker Versanis for $1.1 Billion Novo Nordisk agreed to acquire Versanis, a biotechnology company developing therapies for nonalcoholic steatohepatitis (NASH), in a deal valued at $1.1 billion.
  • Q3 2024: Versanis Bio Announces Acquisition by Novo Nordisk Versanis Bio announced its acquisition by Novo Nordisk, which aims to expand its pipeline in metabolic and liver diseases, including NASH.
  • Q3 2024: 89bio Raises $60 Million in Public Offering to Advance NASH Pipeline 89bio completed a $60 million public offering to fund the continued development of its lead NASH drug candidate, pegozafermin.
  • Q4 2024: FDA Grants Breakthrough Therapy Designation to Viking Therapeutics’ VK2809 for NASH Viking Therapeutics received FDA Breakthrough Therapy designation for VK2809, an investigational treatment for nonalcoholic steatohepatitis (NASH).
  • Q1 2025: Gilead Sciences Announces Opening of New Research Facility Focused on Liver Diseases Gilead Sciences opened a new research facility dedicated to advancing therapies for liver diseases, including nonalcoholic fatty liver disease (NAFLD) and NASH.
  • Q2 2025: Eli Lilly Announces Partnership with Regulus Therapeutics to Develop NAFLD Therapies Eli Lilly entered a partnership with Regulus Therapeutics to co-develop novel therapies targeting nonalcoholic fatty liver disease (NAFLD).

Future Outlook

Non Alcoholic Fatty Liver Disease Market Future Outlook

The Non-Alcoholic Fatty Liver Disease market is projected to grow at a 5.98% CAGR from 2024 to 2035, driven by rising obesity rates, increased awareness, and advancements in treatment options.

New opportunities lie in:

  • Development of personalized treatment plans leveraging genetic profiling.
  • Expansion of telehealth services for remote patient monitoring.
  • Investment in AI-driven diagnostic tools for early detection.

By 2035, the NAFLD market is expected to be robust, reflecting significant advancements and increased market participation.

Market Segmentation

Non Alcoholic Fatty Liver Disease Market Treatment Type Outlook

  • Lifestyle Changes
  • Medications
  • Surgical Procedures
  • Nutritional Supplements

Non Alcoholic Fatty Liver Disease Market Diagnosis Method Outlook

  • Ultrasound
  • CT Scan
  • MRI
  • Liver Biopsy

Non Alcoholic Fatty Liver Disease Market Complication Type Outlook

  • Fibrosis
  • Cirrhosis
  • Hepatocellular Carcinoma

Non Alcoholic Fatty Liver Disease Market Patient Demographics Outlook

  • Adults
  • Children
  • Elderly

Report Scope

MARKET SIZE 2024 2.01(USD Billion)
MARKET SIZE 2025 2.13(USD Billion)
MARKET SIZE 2035 3.808(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR) 5.98% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Billion
Key Companies Profiled Market analysis in progress
Segments Covered Market segmentation analysis in progress
Key Market Opportunities Emerging therapies targeting metabolic pathways present opportunities in the Non-Alcoholic Fatty Liver Disease NAFLD Market.
Key Market Dynamics Rising prevalence of Non-Alcoholic Fatty Liver Disease drives demand for innovative treatment options and lifestyle interventions.
Countries Covered North America, Europe, APAC, South America, MEA

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FAQs

What is the projected market valuation for the Non-Alcoholic Fatty Liver Disease (NAFLD) market in 2035?

The projected market valuation for the NAFLD market in 2035 is expected to reach 3.808 USD Billion.

What was the overall market valuation of the NAFLD market in 2024?

The overall market valuation of the NAFLD market was 2.01 USD Billion in 2024.

What is the expected CAGR for the NAFLD market during the forecast period 2025 - 2035?

The expected CAGR for the NAFLD market during the forecast period 2025 - 2035 is 5.98%.

Which companies are considered key players in the NAFLD market?

Key players in the NAFLD market include Gilead Sciences, Bristol-Myers Squibb, Novo Nordisk, Intercept Pharmaceuticals, Pfizer, Eli Lilly and Company, AbbVie, Merck & Co., and Amgen.

What are the primary diagnosis methods for NAFLD and their market valuations?

The primary diagnosis methods for NAFLD include Ultrasound valued at 1.536 USD Billion, CT Scan at 0.768 USD Billion, MRI at 0.768 USD Billion, and Liver Biopsy at 0.736 USD Billion.

What treatment types are available for NAFLD and their respective market sizes?

Treatment types for NAFLD include Lifestyle Changes at 1.152 USD Billion, Medications at 1.536 USD Billion, Surgical Procedures at 0.768 USD Billion, and Nutritional Supplements at 0.392 USD Billion.

How does the NAFLD market segment by patient demographics?

The NAFLD market segments by patient demographics include Adults at 2.4 USD Billion, Children at 0.6 USD Billion, and the Elderly at 0.81 USD Billion.

What are the complication types associated with NAFLD and their market valuations?

Complication types associated with NAFLD include Fibrosis valued at 1.515 USD Billion, Cirrhosis at 1.151 USD Billion, and Hepatocellular Carcinoma at 1.142 USD Billion.

What trends are influencing the growth of the NAFLD market?

Trends influencing the growth of the NAFLD market include increasing awareness of liver health, advancements in diagnostic technologies, and a growing focus on lifestyle modifications.

What is the significance of lifestyle changes in the treatment of NAFLD?

Lifestyle changes play a crucial role in the treatment of NAFLD, with a market valuation of 1.152 USD Billion, indicating their importance in managing the disease.

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