info@marketresearchfuture.com   📞  +1 (855) 661-4441(US)   📞  +44 1720 412 167(UK)
Certified Global Research Member
Isomar fd.webp Wcrc 57.webp
Key Questions Answered
  • Global Market Outlook
  • In-depth analysis of global and regional trends
  • Analyze and identify the major players in the market, their market share, key developments, etc.
  • To understand the capability of the major players based on products offered, financials, and strategies.
  • Identify disrupting products, companies, and trends.
  • To identify opportunities in the market.
  • Analyze the key challenges in the market.
  • Analyze the regional penetration of players, products, and services in the market.
  • Comparison of major players financial performance.
  • Evaluate strategies adopted by major players.
  • Recommendations
Why Choose Market Research Future?
  • Vigorous research methodologies for specific market.
  • Knowledge partners across the globe
  • Large network of partner consultants.
  • Ever-increasing/ Escalating data base with quarterly monitoring of various markets
  • Trusted by fortune 500 companies/startups/ universities/organizations
  • Large database of 5000+ markets reports.
  • Effective and prompt pre- and post-sales support.

Hydrophobic Interaction Chromatography Market Research Report Information By Product and Service (Resins, Columns, Services, Others), Sample Type (Monoclonal Antibodies, Vaccines, Others), End-User (Research & Academic Institutes) - Forecast Till 2032


ID: MRFR/MED/4905-HCR | 85 Pages | Author: Rahul Gotadki| October 2024

Hydrophobic Interaction Chromatography Market Overview


The Hydrophobic Interaction Chromatography market is anticipated to reach USD 0.44 Billion by 2032 at 7.7% CAGR during the forecast period 2023-2032. Hydrophobic Interaction Chromatography (HIC) is a technology for separating compounds based on their hydrophobicity properties. 
Hydrophobic interaction chromatography (HIC) has emerged as a potent technology for purifying biological substances on an industrial and laboratory scale in recent years. HIC is also commonly utilized in biopharmaceutical businesses for protein purification and separation. The market is being propelled forward by rising demand for monoclonal antibodies and rising research & development investment in biopharmaceuticals. In the hydrophobic interaction chromatography market, Europe is expected to retain the second-largest share. 

The European market is likely to be driven by increased money supplied by the government and commercial organizations for research and development. The need for mAbs has risen dramatically in the last decade, not only in oncology but also in other therapeutic areas such as Alzheimer's disease, autoimmune illnesses, and inflammatory disorders. 

In recent years, these therapeutic domains have gained popularity, as a result of which practically all major pharmaceutical companies have invested in therapeutic antibody research and development. Impurities and aggregates are removed from mAbs using a variety of chromatography resins, including hydrophobic interaction chromatography resins. Hydrophobic interaction chromatography is used in drug discovery applications to capture and polish target proteins during the purification process.


Acquity Premier, a liquid chromatography (LC) solution that utilizes MaxPeak high-performance surface technology, was introduced by Waters in February 2021. Acquity Premier is a universal liquid chromatography solution that integrates the Acquity Premier system with Acquity Premier columns. It is intended to resolve issues with analyte/metal surface interactions in the context of the analysis of organic acids, organophosphates, oligonucleotides, phosphopeptides, acidic glycans, and phospholipids using reversed-phase and hydrophilic interaction chromatography. 


The Acquity Premier columns are equipped with MaxPeak high-performance surface technology, which erects a barrier between the metal surface of the system and the column and the samples. The nonspecific adsorption is either wholly eliminated or mitigated by the technology.  It is intended to resolve the issue of analyte/metal surface interactions in the analysis of organic acids, organophosphates, oligonucleotides, phosphopeptides, acidic glycans, and phospholipids through reversed phase and hydrophilic interaction chromatography. The new ACQUITY PREMIER solution for these analyses reduces the time from sample to results, enhances analyte recovery, and improves assay-to-assay reproducibility. This provides separation scientists with greater confidence in the integrity of their qualitative and quantitative analytical results.


Tosoh Bioscience LLC, a provider of chromatographic solutions for the separation and purification of biomolecules, has announced the introduction of SkillPak 1 mL and 5 mL pre-packed columns in March 2020. These process development columns are intended for the rapid development of methods and the resin screening of monoclonal antibodies, antibody constructs, oligonucleotides, proteins, and viruses. SkillPak 1 mL and 5 mL columns are pre-packed with TOYOPEARL®, TSKgel®, or Ca++Pure-HA™ process chromatography media, providing customers with increased flexibility for the use of process media from Tosoh. 


As a result, they deliver high performance and offer scalability and convenience. Upon receipt, these columns are prepared for use and exhibit exceptional physical strength, as well as optimal flow characteristics specifically designed for industrial downstream processing. In the chromatographic modes of affinity, anion and cation exchange, hydrophobic interaction, and size exclusion, SkillPak 1 mL and 5 mL pre-packed columns are currently available with short delivery periods. The columns are designed to provide optimal performance and can be directly operated with low or medium pressure liquid chromatography systems that are frequently employed.


Hydrophobic Interaction Chromatography Market Segmentation


The hydrophobic interaction chromatography market has been segmented into product and service, sample type, and end-user.


The market, on the basis of products and services, has been segmented into products such as resins, columns, HIC columns, buffers, and other products and services. The resins segment has been segmented into bead-based resins and membrane-based resins. The column segment has been further segmented into empty columns and pre-packed columns.


HIC columns on the basis of material are further segmented into stainless steel columns and glass and plastic columns.


The market, by sample type, has been segmented into monoclonal antibodies, vaccines, and others.


The market, by end-user, has been segmented into pharmaceutical and biopharmaceutical companies, contract research organizations and contract manufacturing organizations, research and academic institutes, and others.


Geographically, the hydrophobic interaction chromatography market has been segmented into the Americas, Europe, Asia-Pacific, and the Middle East and Africa. The American hydrophobic interaction chromatography market is further segmented into North America and South America. North America is further classified as the US and Canada.


The European hydrophobic interaction chromatography market is segmented into Western Europe and Eastern Europe. Western Europe is further classified as Germany, France, the UK, Italy, Spain, and the Rest of Western Europe.


The Asia-Pacific hydrophobic interaction chromatography market is segmented into Japan, China, India, the Republic of Korea, Australia, and the Rest of Asia-Pacific.


The Middle Eastern and African hydrophobic interaction chromatography market is segmented into the Middle East and Africa.


Hydrophobic Interaction Chromatography Market Regional Analysis


The hydrophobic interaction chromatography market consists of four regions, namely, the Americas, Europe, Asia-Pacific, and the Middle East and Africa. The Americas is expected to dominate the hydrophobic interaction chromatography market owing to the presence of government and public funding for protein-based research projects, rising automation of purification equipment, and growing demand for protein-based biologics. Additionally, the increasing research and development expenditure is expected to contribute to the market growth in the region. According to the UNESCO Institutes for Statistics, in the US, the research & development expenditure was 2.79% of the GDP (Gross Domestic Product) in 2015.


Europe is anticipated to hold the second largest position in the hydrophobic interaction chromatography market. It is expected that the increasing funding provided by the government and private organizations towards research and development is anticipated to drive the European market.


The Asia-Pacific hydrophobic interaction chromatography market consists of countries, namely, China, Japan, the Republic of Korea, India, Australia, and the Rest of Asia-Pacific. Asia-Pacific is expected to be the fastest growing region in the hydrophobic interaction chromatography market. Major factors such as a growing number of contract research organizations, developing healthcare infrastructure,  increasing research and development activities in the biotechnology sector and increasing healthcare expenditure influence the market in this region.


The Middle East and Africa holds the least share in the hydrophobic interaction chromatography market due to the presence of stringent government policies and poor economies. However, growing awareness among the population and high investments by private market players in this region can boost the market growth.


Recent Development


According to the European Federation of Pharmaceutical Industries and Associations, the pharmaceutical sector spent EUR 35000 million on research and development in 2016. Furthermore, the growing number of contract research and manufacturing businesses is likely to boost the market growth. According to the UNESCO Institutes for Statistics, research and development expenditure in the United States was 2.79 percent of GDP in 2015. Additionally, rising R&D spending is likely to add to regional market growth. The global market for hydrophobic interaction chromatography is fragmented and competitive for this company. To enhance its market share, this player is focused on product developments, new product launches, and geographical expansions.

Hydrophobic Interaction Chromatography Key Players


Some of the key players in the global hydrophobic interaction chromatography market are:



  • Bio-Rad Laboratories

  • Sartorius AG

  • Thermo Fisher Scientific

  • GE Healthcare

  • Tosoh Corporation

  • Waters Corporation

  • Geno Technology

  • Sepax Technologies

  • JNC Corporation

  • Agilent Technologies

  • Merck KGaA

  • Mitsubishi Chemical Corporation

  • Danaher Corporation

  • Avantor Performance Materials 


Hydrophobic Interaction Chromatography Market, by Product and Service



  • Products

  • Resins

  • Bead-Based Resins

  • Membrane-Based Resins

  • Columns

  • Empty Columns

  • Prepacked Columns

  • HIC Columns, By Materials

  • Stainless Steel Columns

  • Glass & Plastic Columns

  • Buffers

  • Other Products

  • Services


Hydrophobic Interaction Chromatography Market, by Sample Type



  • Monoclonal Antibodies

  • Vaccines

  • Others


Hydrophobic Interaction Chromatography Market, by End-User



  • Pharmaceutical & Biopharmaceutical Companies

  • Contract Research Organizations & Contract Manufacturing Organizations

  • Research & Academic Institutes

  • Others


Hydrophobic Interaction Chromatography Market, by Region



  • Americas

    • North America

    • US

    • Canada

    • South America



  • Europe

    • Western Europe

      • Germany

      • France

      • Italy

      • Spain

      • UK

      • Rest of Western Europe



    • Eastern Europe



  • Asia-Pacific

    • Japan

    • China

    • India

    • Australia

    • Republic of Korea

    • Rest of Asia-Pacific



  • Middle East & Africa

    • Middle East

    • Africa




Report Attribute/Metric Details
  Market Size   0.44 Billion
  CAGR   7.7% (2023-2032)
  Base Year   2021
  Forecast Period   2023-2032
  Historical Data   2018
  Forecast Units   Value (USD Billion)
  Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
  Segments Covered   Product and Service, Sample Type, and End-user
  Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
  Key Vendors   Bio-Rad Laboratories, Sartorius AG, Thermo Fisher Scientific, GE Healthcare, Tosoh Corporation, Waters Corporation, Geno Technology, Sepax Technologies, JNC Corporation, Agilent Technologies, Merck KGaA, Mitsubishi Chemical Corporation, Danaher Corporation, and Avantor Performance Materials
  Key Market Opportunities   Increasing number of contract research organizations and contract manufacturing organizations
  Key Market Drivers ·  Rising demand for monoclonal antibodies·  Increasing research and development expenditure in biopharmaceuticals


Frequently Asked Questions (FAQ) :

Hydrophobic Interaction Chromatography Market is projected to grow at a 7.7% CAGR between 2023-2032.

The Americas is expected to lead the Hydrophobic Interaction Chromatography Market.

Different end use industries of hydrophobic interaction chromatography include research & academic institutes, biopharmaceutical & pharmaceutical companies, and others.

Increasing expenditure in biopharmaceuticals and demand for monoclonal antibodies are adding market growth.

Lack of skilled labor may limit market growth.

Leading companies partner with us for data-driven Insights
client_1 client_2 client_3 client_4 client_5 client_6 client_7 client_8 client_9 client_10
Kindly complete the form below to receive a free sample of this Report
Please fill in Business Email for Quick Response

We do not share your information with anyone. However, we may send you emails based on your report interest from time to time. You may contact us at any time to opt-out.

Purchase Option
Single User $ 4,950
Multiuser License $ 5,950
Enterprise User $ 7,250
Compare Licenses
Tailored for You
  • Dedicated Research on any specifics segment or region.
  • Focused Research on specific players in the market.
  • Custom Report based only on your requirements.
  • Flexibility to add or subtract any chapter in the study.
  • Historic data from 2014 and forecasts outlook till 2040.
  • Flexibility of providing data/insights in formats (PDF, PPT, Excel).
  • Provide cross segmentation in applicable scenario/markets.