2D Chromatography Market: by Product (2D Gas Chromatography and 2D Liquid Chromatography), by Application (Life Science Research, Environmental Analysis, Food & Beverage Testing, and Petrochemical & Natural Gas Analysis), by End User (Biotechnology & Pharmaceutical Industries and Hospitals & Clinics), and by Region (North America, Europe, Asia-Pacific, and Rest of the World)—Forecast to 2027

2D Chromatography Market Forecast

The 2D chromatography market is expected to cross USD 55.40 million by 2027 at a CAGR of 7.4%.

Market Overview:

Two-dimensional or 2D chromatography is a chromatographic technique that separates two complex mixtures through two independent separation stages. The complex mixture from the first system is transmitted to the second column through two chromatographic columns connected in series. Various manufacturers provide 2D chromatography across the world. For instance, Agilent Technologies, Inc. (US) 1290 Infinity II 2D-LC System is marketed globally. This product is used to separate complex mixtures and achieve the highest peak capacity. In addition, it is also used to analyze samples qualitatively or quantitatively with the performance and robustness of the product.

The 2D chromatography market is expected to rise significantly in the forecast period, owing to factors such as growing R&D investments by pharmaceutical & biopharmaceutical companies, rising life science research, and growing applications of 2D chromatography in various sectors such as life science, food industry, petrochemical, and others. Furthermore, collaborations between research laboratories and 2D chromatography manufacturers are anticipated to offer significant growth opportunities in the market during the assessment period.

COVID-19 Analysis

Over the forecast period, the increasing use of chromatography in drug development and research is expected to have an impact on market growth. Researchers use chromatography, a powerful laboratory-based analytical method, to better understand the Sars-CoV-2 virus and develop new medicines, vaccines, and diagnostic tools to fight against the COVID-19 pandemic. According to the WHO, more than 288 COVID-19 vaccines are being researched, with an estimated 184 vaccines currently being investigated in pre-clinical stages and 104 vaccines in various stages of clinical trials as of July 2021. According to the WHO Coronavirus (COVID-19) dashboard, there have been 224.5 million confirmed cases of COVID-19 and a total of 5,530 million vaccine doses administered as of 13th September 2021. Hence, the rising number of administration of doses and a large number of confirmed cases will increase the demand for 2D chromatography to develop effective vaccines during the forecast period.

Market Dynamics

Drivers

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  Rising R&D activities by biopharmaceutical and pharmaceutical companies
  
  
  
  • Two-dimensional chromatography is an analytical tool for determining the components of a drug's formulation, allowing researchers to quantify the formulation and identify any contaminants. In addition, it is used for the separation of complex mixtures such as blood, urine, and environmental substances and to analyze differences between compounds in pharmaceutical and biopharmaceutical companies. Hence, rising R&D activities across the globe drive the growth of the 2D chromatography market. As per the report published by Congressional Budget Office in 2019, the pharmaceutical industry spent USD 83 billion on R&D. Moreover, according to the Pharmaceutical Research and Manufacturers of America (PHRMA), in 2020, the member companies of PHRMA such as Bristol-Myers Squibb Company, AbbVie, Pfizer Inc., Novartis AG, and others has invested USD 91.1 billion in R&D. Moreover, technological advancement is also expected to increase the demand for 2D chromatography. Therefore, the rising R&D activities by biopharmaceutical and pharmaceutical companies will create demand for 2D chromatography for new drug discovery and is driving the market growth.
  
  
  • Similarly, an increase in the number of research-based activities across the globe is fueling the growth of the market. According to ClinicalTrials.gov, there were 386,892 clinical studies registered internationally as of July 2021, a massive increase from 2000, when there were just 2119.
  
  
  
  


• Growing concerns over pollution and pollutants.

• 
  Shortage of skilled professionals in operating the equipment
  
  
  
  • There is an impending shortage of skilled professionals available for the 2D chromatography industry. The appropriate use of 2D chromatography equipment necessitates knowledge of various chromatography procedures as well as competence with relevant experience. The growing importance of 2D chromatography techniques in the drug approval process will further increase the demand for 2D chromatography instruments. There has been an increasing number of Contract Manufacturing Organizations (CMOs) entering the market. However, a shortage of chromatographers is anticipated to restrain the market growth.
  
  
  
  

• 
  Increasing applications of 2D chromatography techniques
  
  
  
  • Two-dimensional chromatography is one of the most preferred separation techniques used for identifying, separating, and quantifying the components of complex mixtures in various industries. It has various applications, such as in environmental laboratories to monitor air quality and in the food industry to separate and analyze additives, vitamins, preservatives, proteins, & amino acids for quality control. Moreover, 2D chromatography is also used in quality control in the production of petroleum chemicals. Thus, the rising applications of 2D chromatography are anticipated to provide significant growth opportunities for the global 2D chromatography market.
  
  
  
  

• The global 2D chromatography market is projected to exhibit significant growth over the forecast period, which can be attributed to factors such as a rise in the number of players coming forward to launch new 2D chromatography systems and rapid technological advancements in 2D chromatography. Moreover, other factors include the availability of research funding and the growing number of researchers developing 2D chromatography-based novel techniques for unit operations. The value chain analysis for the 2D chromatography industry comprises four major components, which start with the R&D and designing, manufacturing the products, distribution, and ends with post-marketing surveillance.

• 
  2D Gas Chromatography
  
  
  
  • 2D gas chromatography is a high-performance analytical technique that improves the evaluation of complex samples, including petrochemicals, perfumes, and environmental extracts, by increasing separation capacity. This technique allows fast screening of the entire sample and simultaneous monitoring of multiple classes of organic pollutants. For instance, TRACE 1310—a product offered by Thermo Fisher Scientific (US)—is based on the 2D gas chromatography technique.
  
  
  
  


• 
  2D Liquid Chromatography
  
  
  
  • 2D liquid chromatography is a commonly used multidimensional high-performance liquid chromatography (HPLC) chromatography technique. 2D liquid chromatography introduces all the eluents from the first-dimensional chromatographic column into the second-dimensional chromatographic column online so that the entire sample is separated into two dimensions. This product is widely used in the biopharmaceuticals and food & beverage testing industries to address complex mixtures. For instance, the 1290 Infinity II 2D-LC System is one of the products based on 2D liquid chromatography offered by Agilent Technologies, Inc. (US).
  
  
  
  

• Life Science Research

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  • 2D chromatographic approaches cover a wide range of applications today in biotechnology, genomics, proteomics, bioinformatics, pharmaceutical, and biomedical industry for conducting research activities, testing, and manufacturing drugs.
  
  
  
  


• 
  Environmental Analysis
  
  
  
  • 2D chromatography is used to examine and monitor aspects of environmental quality. Pollutant concentrations in water, soil, and air are routinely evaluated using 2D chromatography techniques to separate and determine trace levels of toxic compounds in mixtures. Moreover, this technique has proven to be very useful in city planning and analyzing the influence of industry on specific locations as well as the entire globe.
  
  
  
  

• In food industries, 2D chromatographic methods are used to identify numerous components in food, such as preservatives, additives, flavors, colorants, and complex mixtures of compounds. Many such components may be a cause for concern when present in food products above a certain concentration. For instance, plant-based foods may have pesticide residues, whereas meat may contain veterinary medications. Hence, 2D chromatography systems are used to standardize and validate the nutritional profile of numerous items during the quality control stage, in addition to detecting potentially toxic contaminants in food products. Similarly, in beverage testing, it is used to determine sugar levels and separate the caffeine from drinks.

Petrochemical & Natural Gas Analysis

• From crude oil exploration to finished product refining to research on novel petrochemicals, 2D gas chromatography has become an important analytical tool in practically every phase of the petroleum industry. Furthermore, rapid development in the petroleum industry and rising applications of 2D chromatography techniques to analyze natural gas, fuels, LPG, refined petroleum products, and additional hydrocarbons & chemicals are driving the growth of the petrochemical & natural gas analysis segment. For instance, Middle Distillate Analysis, a 2D gas chromatography technique offered by Intertek Group plc (UK).


• Others


• Others include forensic testing, cosmeceutical applications, research & academic applications, and others.


• By End User

Biotechnology & Pharmaceutical Industries

• The biotechnology & pharmaceutical industries segment is expected to hold the largest market share in 2020 due to the rapid growth of the biotechnology & pharmaceutical industry across the globe. Moreover, rising investment in R&D activities, along with the increase in the importance of chromatography systems in drug R&D, as well as drug impurity analysis, assay, content uniformity, and drug method development & validation, are boosting the market growth.

• 2D chromatography systems are used in hospitals & clinics for performing clinical diagnostic services such as toxicology screening, immunoassay screening, separation & quantitation of established biomarkers, and others. The increasing number of hospitals, clinics, and laboratories may contribute to the growth of this segment.

• Other end users of 2D chromatography are ambulatory surgery centers, research and academic institutes, cancer research laboratories, food & agriculture industries, and others.

• 
  Rising investment in the healthcare industry is driving the North American 2D chromatography market
  
  
  
  • North America holds the largest 2D Chromatography Market share in 2020, owing to the rising investment in the healthcare industry, presence of major key players in the region, and growing oil & gas industry in the US. As per Forbes statistics, in 2019, oil and gas production rose significantly, with natural gas production over 100,000 million cubic feet per day and crude oil production reaching 12,000,000 barrels per day. Moreover, rising food safety concerns and the presence of many research laboratories in the region further fuel the growth of the market.
  
  
  
  

• 
  Rising focus on drug development is anticipated to drive the growth of the 2D chromatography market
  
  
  
  • The European 2D chromatography market is driven by the rising focus on drug development, increasing government initiatives to improve laboratory infrastructure, and rising R&D investment by the biopharmaceutical industry. For instance, according to the European Federation of Pharmaceutical Industries and Associations, In Europe, the pharmaceutical industry spent more than USD 44,545.6 million on R&D in 2020.
  
  
  
  

• 
  Growth of agriculture & food industry and developing healthcare infrastructure fueling the Asia-Pacific 2D chromatography market
  
  
  
  • Asia-Pacific is estimated to be the fastest-growing market owing to the developing healthcare infrastructure, growth of agriculture & food industry, and establishments of research organizations. In addition, developing R&D infrastructure and an increasing number of contract research and manufacturing companies in Asia-Pacific helps to drive the growth of the market.
  
  
  
  

• The Rest of the World is segmented into the Middle East, Africa, and Latin America. Government initiatives to increase medical expenditure, advances in 2D chromatographic techniques, and growing demand for 2D chromatography systems by pharmaceutical, agriculture, and food & petrochemical companies in the region are contributing to the growth of the 2D chromatography market.

• The 2D chromatography market is profitable, both for existing players as well as new entrants. Our analysis revealed that market players have adopted different strategies and innovative R&D techniques to expand their business and secure their position in the market. For instance, in February 2021, Thermo Fisher Scientific, Inc. (US) launched vanquish online 2D liquid chromatography system. This product is used for analyzing complex samples across a wide range of industries. Various applications of the vanquish online 2D liquid chromatography system are confident peak identification & purity analysis, legacy methods with UV detection, and non-volatile buffer usage compatible with mass spectrometry (MS) detection. The companies are investing in R&D activities to expand their product portfolio, further driving the 2D chromatography market. In addition, the market players are adopting various strategies such as mergers & acquisitions, contractual agreements, new product launches, and partnering with other players to expand their global footprint.

• Agilent Technologies, Inc. (US)


• LECO Corporation (US)


• Waters Corporation (US)


• Shimadzu Corporation (Japan)


• Restek Corporation (US)


• Sepsolve Analytical Ltd (UK)


• Merck KGaA (Germany)


• Danaher Corporation (US)


• Bio-Rad Laboratories, Inc. (US)


• Thermo Fisher Scientific (US)

• In March 2021, Agilent Technologies Inc. (US) launched Agilent 8697 Headspace Sampler, the first headspace sampler with integrated gas chromatography communication. This product launch will expand the intelligence, diagnostics, and troubleshooting capabilities of 2D gas chromatography platforms.

• The study covers the existing short-term and long-term market effects, as well as helping decision-makers to draught short-term and long-term plans for businesses by region. The report covers major regions in North America, Europe, Asia-Pacific, and the Rest of the World. The report analyzes market drivers, restraints, opportunities, challenges, Porter's Five Forces, Value Chain, and impact of COVID-19 on the market.

• 
  2D Gas Chromatography
  
  
  
  • 
    2D Gas Chromatography Instruments
    
    
    
    • Systems
    
    
    • Detectors
    
    
    • Other Instruments
    
    
    
    
  
  
  • 
    2D Gas Chromatography Consumables
    
    
    
    • Columns
    
    
    • Vials
    
    
    • Other Consumables
    
    
    
    
  
  
  • 2D Gas Chromatography Accessories
  
  
  
  


• 
  2D Liquid Chromatography
  
  
  
  • 
    2D Liquid Chromatography Instruments
    
    
    
    • Systems
    
    
    • Detectors
    
    
    • Other Instruments
    
    
    
    
  
  
  • 
    2D Liquid Chromatography Consumables
    
    
    
    • Columns
    
    
    • Vials
    
    
    • Other Consumables
    
    
    
    
  
  
  • 2D Liquid Chromatography Accessories
  
  
  
  

• Life Science Research


• Environmental Analysis


• Food & Beverage Testing


• Petrochemical & Natural Gas Analysis


• Others

• Biotechnology & Pharmaceutical Industries


• Hospitals & Clinics


• Others

• 
  North America
  
  
  
  • US
  
  
  • Canada
  
  
  
  


• 
  Europe
  
  
  
  • Germany
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• 
  Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • Australia
  
  
  • South Korea
  
  
  • Rest of Asia-Pacific
  
  
  
  


• 
  Rest of the World
  
  
  
  • Middle East & Africa
  
  
  • Latin America